Benjamin Wolozin | Profiles RNS

Benjamin Wolozin, MD, PhD

Professor

Boston University School of Medicine

Dept of Pharmacology & Experimental Therapeutics

MD, Albert Einstein College of Medicine

Websites

	Pharmacology & Experimental Therapeutics Faculty
	Wolozin Lab
	Alzheimer's Disease Center
	Laboratory of Neurodegeneration
	Michael J. Fox Foundation

ORCID : 0000-0003-2068-1475

Dr. Wolozin’s research examines the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease, Amyotrophic Lateral Sclerosis and Parkinson’s disease. His laboratory is currently focused on the role of RNA binding proteins and translational regulation in disease processes.

Parkinson’s disease: The research on Parkinson Disease focuses on genetic factors implicated in Parkinson’s disease, including LRRK2, a-synuclein, parkin, PINK1 and DJ-1. Research in our laboratory suggests that genetic mutations linked to Parkinson’s disease act by converging on a biological system that integrates the stress response, regulating autophagy, protein translation and mitochondrial function. Using genetically modified cells (e.g., primary neuronal cultures or cell lines) and genetically modified animals (C. elegans and mice), we have demonstrated that a-synuclein and LRRK2 enhance the sensitivity of dopaminergic neurons to mitochondrial dysfunction. Our work points to particular biochemical pathways mediating the actions of LRRK2. We have recently demonstrated that LRRK2 binds to MKK6, a kinase that lies upstream of p38 and regulates the stress response. LRRK2 regulates membrane localization of its binding proteins, including MKKs, JIPs, rac1 (a small GTPase) and other important proteins mediating the stress response. This work has direct relevance to therapy because it points to chemicals that might protect dopaminergic neurons and modify the course of Parkinson’s disease. For instance, we are investigating the action of SirT1 agonists (such resveratrol, the compound found in red wine or SRT1720, produced by Sirtris Pharmaceuticals), which stimulate synthesis of anti-oxidant enzymes and appear to offer protection in animal models of Parkinson’s disease. We are also investigating the action of brain penetrant analogues of rapamycin, which stimulate the neuron to remove protein aggregates, and offer neuroprotection through mechanisms complementary to SirT1.

Amyotrophic Lateral Sclerosis (ALS): Our current work focuses on a protein, TDP-43, that was recently shown to be the predominant protein that accumulates during the course of the disease. We have shown that TDP-43 is a stress granule protein, and that TDP-43 pathology co-localizes with other stress granule markers in spinal cords of subjects with ALS, as well as those with Frontotemporal Dementia. We are currently examining how TDP-43 and disease-linked mutations in TDP-43 modify synaptic function in neuronal arbors. We are using protein binding assays (immunoprecipitation, mass spectrometry) and imaging assay (fixed cells and live cell imaging) to determine the effects of TDP-43 and its mutations. We use cell lines, primary cultures of hippocampal neurons and human brain samples for our studies.

We also have an active drug discover program related to TDP-43. This program utilizes cells that inducibly over-express TDP-43, as well as lines of C. elegans expressing TDP-43 and studies in primary cultures of hippocampal neurons. We examine the compounds using imaging (in collaboration with Marcie Glicksman at LDDN) and biochemistry.

Alzheimer disease (AD): We have recently extended our work on stress granules to Alzheimer’s disease. As with ALS, we have shown that tau pathology (neurofibrillary tangles) in the AD brain co-localizes with stress granule markers. The amount of stress granule pathology in the AD brain is very striking. Proteins such as TIA-1, G3BP and TTP, strongly accumulate. Interestingly, though, the pattern of accumulation differs based on the stress granule protein. The pathology appears to correlate with binding to tau protein. TIA-1 and TTP both bind to tau, while G3BP does not bind tau. Stress granules might also directly modulate tau pathology, because co-transfecting TIA-1 with tau induces formation of phosphorylated tau inclusions. The work on AD and stress granules uses biochemical/immunochemical studies focusing on proteins implicated in AD (e.g., antibodies to tau) and on stress granule markers. The work also uses extensive imaging assays (fixed cells, live cell imaging, confocal microscopy). We use studies of hippocampal neurons grown culture, transgenic mice expressing P301L tau and human tissues.

Professor
Boston University School of Medicine
Neurology

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2017 Boston University: Spivack Award: Distinguished Scholar in Neuroscience

2016 American Association for the Advancement of Science (AAAS): Fellow

2016 New Economy Magazine, World Media Group: Aquinnah Pharmaceuticals Inc., “Most innovative company in neurodegeneration research, 2016”

2013 Alzheimer Association: Zenith Award

2013 Boston University School of Medicine: Evans Center DOM Collaborator of the Year Award: Basic Sciences

2000 Loyola University Dept. of Pharmacology: Faculty of the Year

2000 Loyola University Medical Center: Graduate School Faculty of the Year

1993 Society for Biological Psychiatry: A. E. Bennett Award

1988 Society for Neuroscience: Donald B. Lindsley Prize

BU Research
NIH RePORTER Research

Genetic Modifiers of Protein Interaction Networks in Tauopathy
08/01/2019 - 03/31/2024 (Multi-PI)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging
5R01AG064932-03

Systems-level functional proteomics analysis assemblies in Alzheimer's disease and mouse models of tauopathy
02/15/2019 - 01/31/2024 (Multi-PI)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging
1RF1AG061706-01

Capturing the molecular complexity of Alzheimer's disease through the lens of RNA binding proteins
06/01/2018 - 03/31/2023 (PI)
NIH/National Institute on Aging
3RF1AG056318-01A1S1

Development of synthetic gene feedback circuits to prevent tau aggregation
02/01/2020 - 01/31/2023 (Multi-PI)
PI: Benjamin Wolozin, MD, PhD
Bright Focus Foundation

Regulation of brain neuroprotection and inflammation by TIA1
08/15/2018 - 05/31/2021 (PI)
NIH/National Institute on Aging
5R21AG059925-02

RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2021 (PI)
NIH/National Institute on Aging
5R01AG050471-05

The Role of Acetylation in regulating pathophysiology of tau
09/01/2014 - 08/31/2019 (Subcontract PI)
Mayo Clinic NIH NINDS
5R01NS089544-05

Targeting Stress Granule Biology in Alzheimer's Disease
07/01/2015 - 06/30/2019 (PI)
Bright Focus Foundation

Transformative science driving new treatments for neurodegenerative diseases
02/07/2018 - 02/06/2019 (PI)
Pfizer, Inc.

INHIBITiON OF TAU PATHOLOGY IN HUMAN NEURONS
07/15/2017 - 07/14/2018 (PI)
Cure Alzheimer's Fund

Showing 10 of 34 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2021	Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology	1U01AG072577-01
2021	Genetic Modifiers of Protein Interaction Networks in Tauopathy	5R01AG064932-03	5
2021	Targeting tau for the development of novel Alzheimer's disease therapeutics	5R44AG060843-03
2020	Genetic Modifiers of Protein Interaction Networks in Tauopathy	5R01AG064932-02	5
2020	Genetic Modifiers of Protein Interaction Networks in Tauopathy	5R01AG064932-02	5
2020	Targeting tau for the development of novel Alzheimer's disease therapeutics	2R44AG060843-02
2020	Capturing the molecular complexity of Alzheimer's disease through the lens of RNA binding proteins	3RF1AG056318-01A1S1	8
2019	Genetic Modifiers of Protein Interaction Networks in Tauopathy	1R01AG064932-01	5
2019	Systems-level functional proteomics analysis assemblies in Alzheimer's disease and mouse models of tauopathy	1RF1AG061706-01	6
2019	Regulation of brain neuroprotection and inflammation by TIA1	5R21AG059925-02	5

Showing 10 of 60 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, Kanaan NM, Wolozin B. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci U S A. 2021 Mar 02; 118(9).View Related Profiles.

Wolozin, Benjamin
Jiang, Lulu
Medalla, Maria
Ash, Peter

PMID: 33619090; PMCID: PMC7936275; DOI: 10.1073/pnas.2014188118;

Sindi S, Solomon A, Kåreholt I, Hovatta I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Peltonen M, Singh Khalsa D, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Ngandu T, Kivipelto M. Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2021 02 25; 76(3):491-498. PMID: 33175128; PMCID: PMC7907495; DOI: 10.1093/gerona/glaa279;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;

Basu A, Ash PE, Wolozin B, Emili A. Protein Interaction Network Biology in Neuroscience. Proteomics. 2021 02; 21(3-4):e1900311.View Related Profiles.

Emili, Andrew
Basu, Avik
Wolozin, Benjamin
Ash, Peter

PMID: 33314619; PMCID: PMC7900949; DOI: 10.1002/pmic.201900311;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;

Jiang L, Zhao J, Cheng JX, Wolozin B. Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins. Front Neurol. 2020; 11:579434.View Related Profiles.

Wolozin, Benjamin
Jiang, Lulu

PMID: 33101187; PMCID: PMC7554625; DOI: 10.3389/fneur.2020.579434;

Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Al Abdullatif A, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 Aug 26; 11(2):208.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Ash, Peter

PMID: 32853540

Reiss AB, Glass AD, Wisniewski T, Wolozin B, Gomolin IH, Pinkhasov A, De Leon J, Stecker MM. Alzheimer's disease: many failed trials, so where do we go from here? J Investig Med. 2020 08; 68(6):1135-1140. PMID: 32699179; PMCID: PMC7872435; DOI: 10.1136/jim-2020-001297;

Ruan QT, Yazdani N, Reed ER, Beierle JA, Peterson LP, Luttik KP, Szumlinski KK, Johnson WE, Ash PEA, Wolozin B, Bryant CD. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. FASEB J. 2020 07; 34(7):9223-9244.View Related Profiles.

Wolozin, Benjamin
Bryant, Camron
Reed, Eric
Beierle, Jacob
Yazdani, Neema
Ash, Peter
Johnson, William

PMID: 32401417; PMCID: PMC8006537; DOI: 10.1096/fj.202000092R;

Webber CJ, Lei SE, Wolozin B. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation. Prog Mol Biol Transl Sci. 2020; 174:187-223. PMID: 32828466

Showing 10 of 198 results. Show More

Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 04 22; 10(4):333-350.e14.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Ash, Peter

PMID: 32325033; PMCID: PMC7938770; DOI: 10.1016/j.cels.2020.03.003;

LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020; 14:285.View Related Profiles.

Wolozin, Benjamin
Luebke, Jennifer
Medalla, Maria

PMID: 32327969; PMCID: PMC7161592; DOI: 10.3389/fnins.2020.00285;

Li M, Reisman J, Morris-Eppolito B, Qian SX, Kazis LE, Wolozin B, Goldstein LE, Xia W. Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer's disease after traumatic brain injury. Alzheimers Res Ther. 2020 03 27; 12(1):33.View Related Profiles.

Wolozin, Benjamin
Goldstein, Lee
Kazis, Lewis

PMID: 32220235; PMCID: PMC7102441; DOI: 10.1186/s13195-020-00589-3;

Ikezu T, Koro L, Wolozin B, Farraye FA, Strongosky AJ, Wszolek ZK. Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo. J Neuroimmune Pharmacol. 2020 12; 15(4):794-800.View Related Profiles.

Wolozin, Benjamin
Farraye, Francis
Ikezu, Tsuneya

PMID: 32180132; PMCID: PMC7718203; DOI: 10.1007/s11481-020-09909-8;

Apicco DJ, Zhang C, Maziuk B, Jiang L, Ballance HI, Boudeau S, Ung C, Li H, Wolozin B. Dysregulation of RNA Splicing in Tauopathies. Cell Rep. 2019 12 24; 29(13):4377-4388.e4.View Related Profiles.

Wolozin, Benjamin
Apicco, Daniel
Jiang, Lulu

PMID: 31875547; PMCID: PMC6941411; DOI: 10.1016/j.celrep.2019.11.093;

Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Rosene, Douglas
Mortazavi, Farzad
Beierle, Jacob
Yazdani, Neema
Ash, Peter
Lin, Weiwei

PMID: 31704785; PMCID: PMC6939476; DOI: 10.1523/JNEUROSCI.1808-19.2019;

Wolozin B, Ivanov P. Stress granules and neurodegeneration. Nat Rev Neurosci. 2019 11; 20(11):649-666. PMID: 31582840; PMCID: PMC6986315; DOI: 10.1038/s41583-019-0222-5;

Wolozin B. The Evolution of Phase-Separated TDP-43 in Stress. Neuron. 2019 04 17; 102(2):265-267. PMID: 30998893; PMCID: PMC6816464; DOI: 10.1016/j.neuron.2019.03.041;

Russo A, Scardigli R, La Regina F, Murray ME, Romano N, Dickson DW, Wolozin B, Cattaneo A, Ceci M. Corrigendum: Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes. Hum Mol Genet. 2019 04 01; 28(7):1226. PMID: 30541120; PMCID: PMC6423413; DOI: 10.1093/hmg/ddy407;

Cruz A, Verma M, Wolozin B. The Pathophysiology of Tau and Stress Granules in Disease. Adv Exp Med Biol. 2019; 1184:359-372.View Related Profiles.

Wolozin, Benjamin
Verma, Mamta

PMID: 32096049

Gan Q, Yao H, Na H, Ballance H, Tao Q, Leung L, Tian H, Zhu H, Wolozin B, Qiu WQ. Effects of Amylin Against Amyloid-ß-Induced Tauopathy and Synapse Loss in Primary Neurons. J Alzheimers Dis. 2019; 70(4):1025-1040.View Related Profiles.

Wolozin, Benjamin
Zhu, Haihao

PMID: 31306122; PMCID: PMC6833957; DOI: 10.3233/JAD-190161;

Ash PEA, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna LFA, Boomhower SR, Newland MC, Sherr DH, Wolozin B. Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology. Toxicol Sci. 2019 01 01; 167(1):105-115.View Related Profiles.

Wolozin, Benjamin
Sherr, David
Ash, Peter

PMID: 30371865; PMCID: PMC6317426; DOI: 10.1093/toxsci/kfy267;

Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol. 2019 02; 137(2):259-277.View Related Profiles.

Wolozin, Benjamin
Jiang, Lulu
Ash, Peter
Ikezu, Tsuneya

PMID: 30465259; PMCID: PMC6377165; DOI: 10.1007/s00401-018-1937-5;

Silva JM, Rodrigues S, Sampaio-Marques B, Gomes P, Neves-Carvalho A, Dioli C, Soares-Cunha C, Mazuik BF, Takashima A, Ludovico P, Wolozin B, Sousa N, Sotiropoulos I. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology. Cell Death Differ. 2019 08; 26(8):1411-1427. PMID: 30442948; PMCID: PMC6748085; DOI: 10.1038/s41418-018-0217-1;

Wolozin B. Disrupted in Dementia. Biol Psychiatry. 2018 10 01; 84(7):474-475. PMID: 30176990

Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun. 2018 08 01; 6(1):71.View Related Profiles.

Wolozin, Benjamin
Apicco, Daniel
Jiang, Lulu
Ash, Peter

PMID: 30068389; PMCID: PMC6069705; DOI: 10.1186/s40478-018-0574-5;

Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neurosci Lett. 2018 09 25; 684:109-114.View Related Profiles.

Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Beierle, Jacob
Hixson, Kathryn
Hokenson, Kristen
Yazdani, Neema
Ash, Peter
Russek, Shelley

PMID: 30003938; PMCID: PMC6330092; DOI: 10.1016/j.neulet.2018.07.015;

Li D, Wang L, Maziuk BF, Yao X, Wolozin B, Cho YK. Directed evolution of a picomolar-affinity, high-specificity antibody targeting phosphorylated tau. J Biol Chem. 2018 08 03; 293(31):12081-12094. PMID: 29899114; PMCID: PMC6078456; DOI: 10.1074/jbc.RA118.003557;

Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Protein Phase Separation: A New Phase in Cell Biology. Trends Cell Biol. 2018 06; 28(6):420-435. PMID: 29602697; PMCID: PMC6034118; DOI: 10.1016/j.tcb.2018.02.004;

Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 01; 21(1):72-80.View Related Profiles.

Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Luebke, Jennifer
Goldberg, Lisa
Medalla, Maria
Yazdani, Neema
Ash, Peter
Cottone, Pietro
Ikezu, Tsuneya
Tripodis, Yorghos

PMID: 29273772; PMCID: PMC5745051; DOI: 10.1038/s41593-017-0022-z;

Wolozin B, Sotiropoulos I. Dendritic TAU-telidge. EBioMedicine. 2017 06; 20:3-4. PMID: 28529034; PMCID: PMC5478231; DOI: 10.1016/j.ebiom.2017.05.013;

Ash PEA, Stanford EA, Al Abdulatif A, Ramirez-Cardenas A, Ballance HI, Boudeau S, Jeh A, Murithi JM, Tripodis Y, Murphy GJ, Sherr DH, Wolozin B. Dioxins and related environmental contaminants increase TDP-43 levels. Mol Neurodegener. 2017 05 05; 12(1):35.View Related Profiles.

Wolozin, Benjamin
Sherr, David
Stanford, Elizabeth
Murphy, George
Ash, Peter
Tripodis, Yorghos

PMID: 28476168; PMCID: PMC5420162; DOI: 10.1186/s13024-017-0177-9;

Russo A, Scardigli R, La Regina F, Murray ME, Romano N, Dickson DW, Wolozin B, Cattaneo A, Ceci M. Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes. Hum Mol Genet. 2017 Apr 15; 26(8):1407-1418. PMID: 28158562; PMCID: PMC6075552; DOI: 10.1093/hmg/ddx035;

Maziuk B, Ballance HI, Wolozin B. Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders. Front Mol Neurosci. 2017; 10:89. PMID: 28420962; PMCID: PMC5378767; DOI: 10.3389/fnmol.2017.00089;

Zhu H, Xue X, Wang E, Wallack M, Na H, Hooker JM, Kowall N, Tao Q, Stein TD, Wolozin B, Qiu WQ. Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease. Neuropharmacology. 2017 Jun; 119:170-181.View Related Profiles.

Wolozin, Benjamin
Zhu, Haihao
Kowall, Neil
Stein, Thor

PMID: 28363773; PMCID: PMC6511375; DOI: 10.1016/j.neuropharm.2017.03.030;

Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lindström J, Paajanen T, Peltonen M, Khalsa DS, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Solomon A. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. J Alzheimers Dis. 2017; 59(4):1459-1470. PMID: 28777749; PMCID: PMC5611796; DOI: 10.3233/JAD-170123;

Kuwahara T, Inoue K, D'Agati VD, Fujimoto T, Eguchi T, Saha S, Wolozin B, Iwatsubo T, Abeliovich A. LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. Sci Rep. 2016 07 18; 6:29945. PMID: 27424887; PMCID: PMC4947924; DOI: 10.1038/srep29945;

Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591]. EBioMedicine. 2016 06; 8:349.View Related Profiles.

Wolozin, Benjamin
Ikezu, Tsuneya

PMID: 27428444; PMCID: PMC4919567; DOI: 10.1016/j.ebiom.2016.05.033;

Ostrowski SM, Johnson K, Siefert M, Shank S, Sironi L, Wolozin B, Landreth GE, Ziady AG. Simvastatin inhibits protein isoprenylation in the brain. Neuroscience. 2016 Aug 04; 329:264-74. PMID: 27180285; PMCID: PMC4905803; DOI: 10.1016/j.neuroscience.2016.04.053;

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep. 2016 May 17; 15(7):1455-1466.View Related Profiles.

Frame, Alissa
Wolozin, Benjamin
Apicco, Daniel
Steffen, Martin
Ash, Peter
Vanderweyde, Tara

PMID: 27160897; PMCID: PMC5325702; DOI: 10.1016/j.celrep.2016.04.045;

Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, Mechas E, Chen J, Wolozin B, LeVine H, Zhu H, Abisambra JF. Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis. J Neurosci. 2016 Jan 20; 36(3):1001-7. PMID: 26791227; PMCID: PMC4719006; DOI: 10.1523/JNEUROSCI.3029-15.2016;

Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332.View Related Profiles.

Yen, Allen
Wolozin, Benjamin
Trengrove, Chelsea
Mostoslavsky, Gustavo
Asai, Hirohide
Kirber, Michael
Aziz, Nadine
Zhou, Qingde
Ikezu, Tsuneya
Bolotina, Victoria

PMID: 26755131; PMCID: PMC4729940; DOI: 10.1038/ncomms10332;

Vanderweyde, T., Wolozin, B. Neuroimmune Pharmacology (Ikezu, Gendelman, eds.). RNA binding proteins in health and disease. Springer. 2016.

Wolozin B, Ikezu T. Syk and Yea Shall Find. EBioMedicine. 2015 Nov; 2(11):1590-1.View Related Profiles.

Wolozin, Benjamin
Ikezu, Tsuneya

PMID: 26870779; PMCID: PMC4740329; DOI: 10.1016/j.ebiom.2015.11.012;

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles.

Wolozin, Benjamin
Asai, Hirohide
Luebke, Jennifer
Medalla, Maria
Ikezu, Seiko
Haydar, Tarik
Ikezu, Tsuneya

PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;

Saha S, Ash PE, Gowda V, Liu L, Shirihai O, Wolozin B. Mutations in LRRK2 potentiate age-related impairment of autophagic flux. Mol Neurodegener. 2015; 10:26.View Related Profiles.

Wolozin, Benjamin
Shirihai, Orian
Ash, Peter

PMID: 26159606; PMCID: PMC4702340; DOI: 10.1186/s13024-015-0022-y;

Wolozin B, Apicco D. RNA binding proteins and the genesis of neurodegenerative diseases. Adv Exp Med Biol. 2015; 822:11-5.View Related Profiles.

Wolozin, Benjamin
Apicco, Daniel

PMID: 25416971; PMCID: PMC4694570; DOI: 10.1007/978-3-319-08927-0_3;

Ash PE, Vanderweyde TE, Youmans KL, Apicco DJ, Wolozin B. Pathological stress granules in Alzheimer's disease. Brain Res. 2014 Oct 10; 1584:52-8.View Related Profiles.

Wolozin, Benjamin
Apicco, Daniel
Youmans, Katherine
Ash, Peter
Vanderweyde, Tara

PMID: 25108040; PMCID: PMC4256948; DOI: 10.1016/j.brainres.2014.05.052;

Boon JY, Dusonchet J, Trengrove C, Wolozin B. Interaction of LRRK2 with kinase and GTPase signaling cascades. Front Mol Neurosci. 2014; 7:64.View Related Profiles.

Wolozin, Benjamin
Trengrove, Chelsea
Boon, Joon Ying
Dusonchet, Julien

PMID: 25071441; PMCID: PMC4087324; DOI: 10.3389/fnmol.2014.00064;

Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Hum Mol Genet. 2014 Sep 15; 23(18):4887-905.View Related Profiles.

Wolozin, Benjamin
Boon, Joon Ying
Dusonchet, Julien
Youmans, Katherine
Guillily, Maria

PMID: 24794857; PMCID: PMC4140468; DOI: 10.1093/hmg/ddu202;

Liu-Yesucevitz L, Lin AY, Ebata A, Boon JY, Reid W, Xu YF, Kobrin K, Murphy GJ, Petrucelli L, Wolozin B. ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor. J Neurosci. 2014 Mar 19; 34(12):4167-74.View Related Profiles.

Ebata, Atsushi
Wolozin, Benjamin
Murphy, George
Boon, Joon Ying
Kobrin, Kendra

PMID: 24647938; PMCID: PMC3960463; DOI: 10.1523/JNEUROSCI.2350-13.2014;

Wolozin B. Neurodegeneration: Twists, Turns and Tangles. In “Discoveries in Modern Science: Exploration, Invention, Technology” (McMillan Reference, Cengage Learning, Farmington Hills, MI). 2014.

Wolozin B. Physiological protein aggregation run amuck: stress granules and the genesis of neurodegenerative disease. Discov Med. 2014 Jan; 17(91):47-52. PMID: 24411700; PMCID: PMC4694572

Saha S, Liu-Yesucevitz L, Wolozin B. Regulation of autophagy by LRRK2 in Caenorhabditis elegans. Neurodegener Dis. 2014; 13(2-3):110-3. PMID: 24192129; PMCID: PMC3946265; DOI: 10.1159/000355654;

Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports. 2013; 1(5):451-63.View Related Profiles.

Leung, Amy
Ebata, Atsushi
Wolozin, Benjamin
Koch, Clarissa
Kotton, Darrell
Seldin, David
Murphy, George
Mostoslavsky, Gustavo
Berk, John
Connors, Lawreen
Monti, Stefano

PMID: 24286032; PMCID: PMC3841264; DOI: 10.1016/j.stemcr.2013.10.003;

Boyd JD, Lee-Armandt JP, Feiler MS, Zaarur N, Liu M, Kraemer B, Concannon JB, Ebata A, Wolozin B, Glicksman MA. A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity. J Biomol Screen. 2014 Jan; 19(1):44-56.View Related Profiles.

Ebata, Atsushi
Wolozin, Benjamin
Zaarur, Nava

PMID: 24019256; PMCID: PMC3913261; DOI: 10.1177/1087057113501553;

Vanderweyde T, Youmans K, Liu-Yesucevitz L, Wolozin B. Role of stress granules and RNA-binding proteins in neurodegeneration: a mini-review. Gerontology. 2013; 59(6):524-33.View Related Profiles.

Wolozin, Benjamin
Vanderweyde, Tara

PMID: 24008580; PMCID: PMC3863624; DOI: 10.1159/000354170;

Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15. PMID: 23747512; PMCID: PMC3730785; DOI: 10.1016/j.ajpath.2013.04.014;

Ravid K, Wolozin B. The Scientist's Pledge. Acad Med. 2013 Jun; 88(6):743.View Related Profiles.

Wolozin, Benjamin
Ravid, Katya

PMID: 23708595; PMCID: PMC3910371; DOI: 10.1097/ACM.0b013e31828f9f96;

McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Abraham, Carmela
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
Goldstein, Lee
Kowall, Neil
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya
Alvarez, Victor

PMID: 23208308; PMCID: PMC3624697; DOI: 10.1093/brain/aws307;

Wolozin B. Regulated protein aggregation: stress granules and neurodegeneration. Mol Neurodegener. 2012; 7:56. PMID: 23164372; PMCID: PMC3519755; DOI: 10.1186/1750-1326-7-56;

Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci. 2012 Jun 13; 32(24):8270-83.View Related Profiles.

Wolozin, Benjamin
Varnum, Megan
Vanderweyde, Tara
Ikezu, Tsuneya

PMID: 22699908; PMCID: PMC3402380; DOI: 10.1523/JNEUROSCI.1592-12.2012;

Youmans KL, Wolozin B. TDP-43: a new player on the AD field? Exp Neurol. 2012 Sep; 237(1):90-5.View Related Profiles.

Wolozin, Benjamin
Youmans, Katherine

PMID: 22691390; PMCID: PMC3910368; DOI: 10.1016/j.expneurol.2012.05.018;

Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A, Wolozin B, Sherman MY. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. 2012 Aug; 11(4):617-27.View Related Profiles.

Meriin, Anatoli
Wilson, Andrew
Wolozin, Benjamin
Kim-Sun, Geunwon
Sherman, Michael
Gabai, Vladimir

PMID: 22510478; PMCID: PMC3433748; DOI: 10.1111/j.1474-9726.2012.00827.x;

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Nowinski, Christopher
Blusztajn, Jan
Moncaster, Juliet
Goldstein, Lee
Wojnarowicz, Mark
Kowall, Neil
Casey, Noel
Minaeva, Olga
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya

PMID: 22593173; PMCID: PMC3739428; DOI: 10.1126/scitranslmed.3003716;

Di Domenico F, Sultana R, Ferree A, Smith K, Barone E, Perluigi M, Coccia R, Pierce W, Cai J, Mancuso C, Squillace R, Wiengele M, Dalle-Donne I, Wolozin B, Butterfield DA. Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease. Antioxid Redox Signal. 2012 Dec 1; 17(11):1490-506.View Related Profiles.

Ferree, Andrew
Wolozin, Benjamin

PMID: 22315971; PMCID: PMC3448940; DOI: 10.1089/ars.2011.4312;

Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Schapira AH, Wolozin B, Bandopadhyay R, Cookson MR, van der Brug MP, Lewis PA. Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLoS One. 2012; 7(1). PMID: 22303433; PMCID: PMC3269322; DOI: 10.1371/annotation/c12e4f9e-5aae-424b-a69f-fddf16976dc5;

Wolozin B. Statins and therapy of Alzheimer's disease: questions of efficacy versus trial design. Alzheimers Res Ther. 2012; 4(1):3. PMID: 22264400; PMCID: PMC3471428; DOI: 10.1186/alzrt101;

Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease? J Alzheimers Dis. 2012; 29(2):329-40.View Related Profiles.

Wolozin, Benjamin
Zhu, Haihao
Ikezu, Tsuneya
Qiu, Wendy

PMID: 22232014; PMCID: PMC3784270; DOI: 10.3233/JAD-2011-111472;

Ferree A, Guillily M, Li H, Smith K, Takashima A, Squillace R, Weigele M, Collins JJ, Wolozin B. Regulation of physiologic actions of LRRK2: focus on autophagy. Neurodegener Dis. 2012; 10(1-4):238-41.View Related Profiles.

Ferree, Andrew
Wolozin, Benjamin
Guillily, Maria

PMID: 22204929; PMCID: PMC3363354; DOI: 10.1159/000332599;

Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. Local RNA translation at the synapse and in disease. J Neurosci. 2011 Nov 9; 31(45):16086-93. PMID: 22072660; PMCID: PMC3241995; DOI: 10.1523/JNEUROSCI.4105-11.2011;

Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Healey D, Schapira AH, Wolozin B, Bandopadhyay R, Cookson MR, van der Brug MP, Lewis PA. Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue. PLoS One. 2011; 6(7):e22489. PMID: 21799870; PMCID: PMC3142158; DOI: 10.1371/journal.pone.0022489;

Chan D, Citro A, Cordy JM, Shen GC, Wolozin B. Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). J Biol Chem. 2011 May 6; 286(18):16140-9. PMID: 21454543; PMCID: PMC3091223; DOI: 10.1074/jbc.M111.234005;

Wolozin B, Gabel C, Ferree A, Guillily M, Ebata A. Watching worms whither: modeling neurodegeneration in C. elegans. Prog Mol Biol Transl Sci. 2011; 100:499-514.View Related Profiles.

Ferree, Andrew
Ebata, Atsushi
Wolozin, Benjamin
Gabel, Christopher
Guillily, Maria

PMID: 21377635; PMCID: PMC3140532; DOI: 10.1016/B978-0-12-384878-9.00015-7;

Wolozin B. Live Report: Rally to Restore Sanity and/or Fear, a Plea for Reason. Skeptical Inquirer. 2011; 35(2).
Wolozin B, Lee A, Li N C, Kazis L E. Pharmaco-epidemiological Studies Using the Veterans Affairs Health System Decision Support System Database. Efficient Decision Support Systems: Practice and Challenges – From Current to Future. 2011.

Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010; 5(10):e13250.View Related Profiles.

McKee, Ann
Wolozin, Benjamin
Sherman, Michael
Zaarur, Nava
Vanderweyde, Tara

PMID: 20948999; PMCID: PMC2952586; DOI: 10.1371/journal.pone.0013250;

Solomon A, Sippola R, Soininen H, Wolozin B, Tuomilehto J, Laatikainen T, Kivipelto M. Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK). Neurodegener Dis. 2010; 7(1-3):180-2. PMID: 20224281; PMCID: PMC7077074; DOI: 10.1159/000295659;

Hsu CH, Chan D, Wolozin B. LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. Neurodegener Dis. 2010; 7(1-3):68-75. PMID: 20173330; PMCID: PMC2859233; DOI: 10.1159/000285509;

Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One. 2010; 5(1):e8730. PMID: 20090955; PMCID: PMC2806920; DOI: 10.1371/journal.pone.0008730;

Carballo-Carbajal I, Weber-Endress S, Rovelli G, Chan D, Wolozin B, Klein CL, Patenge N, Gasser T, Kahle PJ. Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway. Cell Signal. 2010 May; 22(5):821-7. PMID: 20074637; PMCID: PMC3163153; DOI: 10.1016/j.cellsig.2010.01.006;

Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ. 2010; 340:b5465.View Related Profiles.

Wolozin, Benjamin
Kazis, Lewis

PMID: 20068258; PMCID: PMC2806632; DOI: 10.1136/bmj.b5465;

Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010 Mar; 112(6):1593-604.View Related Profiles.

Ferree, Andrew
Wolozin, Benjamin
Ryu, Hoon
Guillily, Maria

PMID: 20067578; PMCID: PMC2856721; DOI: 10.1111/j.1471-4159.2010.06568.x;

Vanderweyde T, Bednar MM, Forman SA, Wolozin B. Iatrogenic risk factors for Alzheimer's disease: surgery and anesthesia. J Alzheimers Dis. 2010; 22 Suppl 3:91-104.View Related Profiles.

Wolozin, Benjamin
Vanderweyde, Tara

PMID: 20858967; PMCID: PMC3108154; DOI: 10.3233/JAD-2010-100843;

Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord. 2009; 28(1):75-80. PMID: 19648749; PMCID: PMC2814023; DOI: 10.1159/000231980;

Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci. 2009 Jul 22; 29(29):9210-8.View Related Profiles.

Ferree, Andrew
Wolozin, Benjamin
Goldstein, Lee
Guillily, Maria

PMID: 19625511; PMCID: PMC3127548; DOI: 10.1523/JNEUROSCI.2281-09.2009;

Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis. 2009; 16(4):731-40. PMID: 19387109; PMCID: PMC2908903; DOI: 10.3233/JAD-2009-1021;

Zerbinatti CV, Cordy JM, Chen CD, Guillily M, Suon S, Ray WJ, Seabrook GR, Abraham CR, Wolozin B. Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Mol Neurodegener. 2008; 3:5.View Related Profiles.

Wolozin, Benjamin
Abraham, Carmela
Chen, Ci-Di
Guillily, Maria

PMID: 18348724; PMCID: PMC2323375; DOI: 10.1186/1750-1326-3-5;

Wolozin B, Saha S, Guillily M, Ferree A, Riley M. Investigating convergent actions of genes linked to familial Parkinson's disease. Neurodegener Dis. 2008; 5(3-4):182-5.View Related Profiles.

Ferree, Andrew
Wolozin, Benjamin
Guillily, Maria

PMID: 18322385; PMCID: PMC2826451; DOI: 10.1159/000113697;

Frasier M, Frausto S, Lewicki D, Golbe L, Wolozin B. DJ-1 Expression Increases in Mice Over-Expressing A30P a-Synuclein. ALZHEIMER’S AND PARKINSON’S DISEASES: INSIGHTS,PROGRESS AND PERSPECTIVES (Eds., Hanin and Fisher, Springer, NY). 2008.

Solomon A, Kåreholt I, Ngandu T, Wolozin B, Macdonald SW, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Serum total cholesterol, statins and cognition in non-demented elderly. Neurobiol Aging. 2009 Jun; 30(6):1006-9. PMID: 18022292

Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 2007; 5:20.View Related Profiles.

Wolozin, Benjamin
Kazis, Lewis

PMID: 17640385; PMCID: PMC1955446; DOI: 10.1186/1741-7015-5-20;

Wolozin B. The Art of Persuasion in Politics, Skeptical Inquirer. 2007; 31(1).

Wolozin B, Bednar MM. Interventions for heart disease and their effects on Alzheimer's disease. Neurol Res. 2006 Sep; 28(6):630-6. PMID: 16945215; PMCID: PMC3913064; DOI: 10.1179/016164106X130515;

Takashima A, Shimojo M, Wolozin B. The players on the gamma-secretase team. Nat Med. 2006 Jul; 12(7):766-7; discussion 767. PMID: 16829940

Bednar MM, Lee TA, Wolozin B, Weiss KB. Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease. Neurology. 2006 Jun 13; 66(11):1785; author reply 1785. PMID: 16769972

Wolozin B, Manger J, Bryant R, Cordy J, Green RC, McKee A. Re-assessing the relationship between cholesterol, statins and Alzheimer's disease. Acta Neurol Scand Suppl. 2006; 185:63-70.View Related Profiles.

McKee, Ann
Wolozin, Benjamin

PMID: 16866913

Cordy, J.M.Wolozin, B. Cholesterol and Alzheimer’s disease. In eds Barrow C.J., Small D.H.. Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer-Verlag. London. 2006; 312.
Wolozin B. Cholesterol, Statins and Alzheimer’s disease: Past, Present and Future. In, ed. Sun, M. K., Research Progress in Alzheimer’s Disease and Dementia. 2006.
Wolozin H, Wolozin B. The Unconscious in Economic Decision-Making. Convergent Voices. Journal of Socio-Economics. 2006.
Wolozin B. Interpreting Clinical Studies of Putative Therapeutics for Alzheimer’s disease. In, ed. Cuello, C., Pharmacological and Mechanisms in Alzheimer’s Therapeutics. 2006.

Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem. 2005 Dec 30; 280(52):42655-68. PMID: 16239214; PMCID: PMC3910375; DOI: 10.1074/jbc.M505910200;

Lee TA, Wolozin B, Weiss KB, Bednar MM. Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. J Alzheimers Dis. 2005 Aug; 7(4):319-24. PMID: 16131734

Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, Kahle P, Wolozin B. Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Exp Neurol. 2005 Apr; 192(2):274-87. PMID: 15755545

Poon HF, Frasier M, Shreve N, Calabrese V, Wolozin B, Butterfield DA. Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease. Neurobiol Dis. 2005 Apr; 18(3):492-8. PMID: 15755676

Snyder H, Mensah K, Hsu C, Hashimoto M, Surgucheva IG, Festoff B, Surguchov A, Masliah E, Matouschek A, Wolozin B. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. J Biol Chem. 2005 Mar 4; 280(9):7562-9. PMID: 15591046

Wolozin B. Cholesterol, statins and dementia. Curr Opin Lipidol. 2004 Dec; 15(6):667-72. PMID: 15529026

Wolozin B. Apolipoprotein E receptor LR11: intersections between neurodegeneration and cholesterol metabolism. Arch Neurol. 2004 Aug; 61(8):1178-80. PMID: 15313831

Frasier M, Wolozin B. Following the leader: fibrillization of alpha-synuclein and tau. Exp Neurol. 2004 Jun; 187(2):235-9. PMID: 15144849

Brown J, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B. Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem. 2004 Aug 13; 279(33):34674-81. PMID: 15148325

Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet. 2004 Apr 1; 13(7):703-14. PMID: 14962978

Ghanbari HA, Ghanbari K, Harris PL, Jones PK, Kubat Z, Castellani RJ, Wolozin BL, Smith MA, Perry G. Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. Aging Cell. 2004 Feb; 3(1):41-4. PMID: 14965355

Wolozin B. Cholesterol and the biology of Alzheimer's disease. Neuron. 2004 Jan 8; 41(1):7-10. PMID: 14715130

Wolozin B, Brown J, Theisler C, Silberman S. The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease. CNS Drug Rev. 2004; 10(2):127-46. PMID: 15179443

Snyder H, Wolozin B. Pathological proteins in Parkinson's disease: focus on the proteasome. J Mol Neurosci. 2004; 24(3):425-42. PMID: 15655264

Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B. SEPT5_v2 is a parkin-binding protein. Brain Res Mol Brain Res. 2003 Oct 7; 117(2):179-89. PMID: 14559152

Perry G, Castellani RJ, Smith MA, Harris PL, Kubat Z, Ghanbari K, Jones PK, Cordone G, Tabaton M, Wolozin B, Ghanbari H. Oxidative damage in the olfactory system in Alzheimer's disease. Acta Neuropathol. 2003 Dec; 106(6):552-6. PMID: 12955399

Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, Girones X, Henry TL, Matsubara E, Zambon D, Wolozin B, Sano M, Cruz-Sanchez FF, Thal LJ, Petanceska SS, Refolo LM. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003 Jul 22; 61(2):199-205. PMID: 12874399

Snyder H, Mensah K, Theisler C, Lee J, Matouschek A, Wolozin B. Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function. J Biol Chem. 2003 Apr 4; 278(14):11753-9. PMID: 12551928

Wolozin B. Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease. Arch Neurol. 2003 Jan; 60(1):16-8. PMID: 12533083

Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 2002 Dec 19; 36(6):1007-19. PMID: 12495618

Egashira N, Iwasaki K, Ishibashi M, Hatip-Al-Khatib I, Wolozin B, Mishima K, Irie K, Fujiwara M. Hypoxia enhances beta-amyloid-induced apoptosis in rat cultured hippocampal neurons. Jpn J Pharmacol. 2002 Dec; 90(4):321-7. PMID: 12501008

Wolozin B. Cholesterol and Alzheimer's disease. Biochem Soc Trans. 2002 Aug; 30(4):525-9. PMID: 12196129

Golts N, Snyder H, Frasier M, Theisler C, Choi P, Wolozin B. Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein. J Biol Chem. 2002 May 3; 277(18):16116-23. PMID: 11850416

Wolozin B, Golts N. Iron and Parkinson's disease. Neuroscientist. 2002 Feb; 8(1):22-32. PMID: 11843096

Ahn BH, Rhim H, Kim SY, Sung YM, Lee MY, Choi JY, Wolozin B, Chang JS, Lee YH, Kwon TK, Chung KC, Yoon SH, Hahn SJ, Kim MS, Jo YH, Min DS. alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem. 2002 Apr 5; 277(14):12334-42. PMID: 11821392

Choi P, Golts N, Snyder H, Chong M, Petrucelli L, Hardy J, Sparkman D, Cochran E, Lee JM, Wolozin B. Co-association of parkin and alpha-synuclein. Neuroreport. 2001 Sep 17; 12(13):2839-43. PMID: 11588587

Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. J Biol Chem. 2001 Oct 19; 276(42):38563-9. PMID: 11504726

Wolozin B. A fluid connection: cholesterol and Abeta. Proc Natl Acad Sci U S A. 2001 May 8; 98(10):5371-3. PMID: 11344276; PMCID: PMC33340

Wolozin B. Peering into proteolysis with presenilins. J Alzheimers Dis. 2001 Apr; 3(2):191-193. PMID: 12214060

Wolozin B, Golts N, Choi P, Frasier M, Snyder H, Palacino, J. Looking beyond b-amyloid: a-Synuclein and Neurodegeneration. Research and Practice in Alzheimer’s disease. 2001; 4.
Wolozin B. Statins and therapy of Alzheimer's disease: questions of efficacy versus trial design. Alzheimer's Research & Therapy. 2001; 4:3.
Wolozin B, Siegel G. Response to letter: Statins and Dementia. Archives Neurol. 2001; 58:1169.
Wolozin B, Siegel G. Response to Letter: Statin-Alzheimer Disease Association Not Yet Proven. Archives Neurol. 2001; 58:10.
Wolozin B, Siegel G. Response to Letter: Statin Therapy and the Prevention of Dementia. Archives Neurol. 2001; 58:1023.
Wolozin B. Peering into proteolylsis with presenilins. 2001; 3:191-193.

Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol. 2000 Oct; 57(10):1439-43. PMID: 11030795

Choi P, Ostrerova-Golts N, Sparkman D, Cochran E, Lee JM, Wolozin B. Parkin is metabolized by the ubiquitin/proteosome system. Neuroreport. 2000 Aug 21; 11(12):2635-8. PMID: 10976934

Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. J Neurosci. 2000 Aug 15; 20(16):6048-54. PMID: 10934254

Wolozin B, Behl C. Mechanisms of neurodegenerative disorders: Part 1: protein aggregates. Arch Neurol. 2000 Jun; 57(6):793-6. PMID: 10867775

Wolozin B, Behl C. Mechanisms of neurodegenerative disorders: Part 2: control of cell death. Arch Neurol. 2000 Jun; 57(6):801-4. PMID: 10867776

Palacino JJ, Berechid BE, Alexander P, Eckman C, Younkin S, Nye JS, Wolozin B. Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells. J Biol Chem. 2000 Jan 7; 275(1):215-22. PMID: 10617607

Sunderland T, Wolozin B, Galasko D, Levy J, Dukoff R, Bahro M, Lasser R, Motter R, Lehtimäki T, Seubert P. Longitudinal stability of CSF tau levels in Alzheimer patients. Biol Psychiatry. 1999 Sep 15; 46(6):750-5. PMID: 10494442

Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B. alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J Neurosci. 1999 Jul 15; 19(14):5782-91. PMID: 10407019

Abrams MT, Kaufmann WE, Rousseau F, Oostra BA, Wolozin B, Taylor CV, Lishaa N, Morel ML, Hoogeveen A, Reiss AL. FMR1 gene expression in olfactory neuroblasts from two males with fragile X syndrome. Am J Med Genet. 1999 Jan 1; 82(1):25-30. PMID: 9916838

Wolozin B. Genes, Behaviour and Health. Alzheimer’s Disease. 1999; 123-144.

Wolozin B, Maheshwari S, Jones C, Dukoff R, Wallace W, Racchi M, Nagula S, Shulman NR, Sunderland T, Bush A. Beta-amyloid augments platelet aggregation: reduced activity of familial angiopathy-associated mutants. Mol Psychiatry. 1998 Nov; 3(6):500-7. PMID: 9857975

Murayama M, Tanaka S, Palacino J, Murayama O, Honda T, Sun X, Yasutake K, Nihonmatsu N, Wolozin B, Takashima A. Direct association of presenilin-1 with beta-catenin. FEBS Lett. 1998 Aug 14; 433(1-2):73-7. PMID: 9738936

Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S, Wolozin B. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9637-41. PMID: 9689133; PMCID: PMC21391

Wolozin B, Alexander P, Palacino J. Regulation of apoptosis by presenilin 1. Neurobiol Aging. 1998 Jan-Feb; 19(1 Suppl):S23-7. PMID: 9562463

Wolozin B, Palacino J. Presenilins and their role in apoptosis. n eds. C. Haass, The Molecular Biology of Alzheimer’s Disease. Harwood Academic Publishers. Australia. 1998; 247-76.

Wallace WC, Akar CA, Lyons WE, Kole HK, Egan JM, Wolozin B. Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity. Brain Res Mol Brain Res. 1997 Dec 15; 52(2):213-27. PMID: 9495542

Goldstein BJ, Wolozin BL, Schwob JE. FGF2 suppresses neuronogenesis of a cell line derived from rat olfactory epithelium. J Neurobiol. 1997 Oct; 33(4):411-28. PMID: 9322158

Luo Y, Hawver DB, Iwasaki K, Sunderland T, Roth GS, Wolozin B. Physiological levels of beta-amyloid peptide stimulate protein kinase C in PC12 cells. Brain Res. 1997 Sep 26; 769(2):287-95. PMID: 9374197

Wolozin B. ICE and apoptosis. Mol Psychiatry. 1997 May; 2(3):184-7. PMID: 9152979

Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacanà E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 1996 Dec 6; 274(5293):1710-3. PMID: 8939861

Vito P, Wolozin B, Ganjei JK, Iwasaki K, Lacanà E, D'Adamio L. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. J Biol Chem. 1996 Dec 6; 271(49):31025-8. PMID: 8940094

Vawter MP, Basaric-Keys J, Li Y, Lester DS, Lebovics RS, Lesch KP, Kulaga H, Freed WJ, Sunderland T, Wolozin B. Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF. Exp Neurol. 1996 Nov; 142(1):179-94. PMID: 8912909

Wolozia B. Reductionist science and Alzheimer's disease: redoubling our effort in redox chemistry. Mol Psychiatry. 1996 Nov; 1(5):352-5. PMID: 9154224

Luo Y, Sunderland T, Roth GS, Wolozin B. Physiological levels of beta-amyloid peptide promote PC12 cell proliferation. Neurosci Lett. 1996 Oct 18; 217(2-3):125-8. PMID: 8916088

Luo Y, Sunderland T, Wolozin B. Physiologic levels of beta-amyloid activate phosphatidylinositol 3-kinase with the involvement of tyrosine phosphorylation. J Neurochem. 1996 Sep; 67(3):978-87. PMID: 8752103

Iwasaki K, Sunderland T, Kusiak JW, Wolozin B. Changes in gene transcription during a beta-mediated cell death. Mol Psychiatry. 1996 Mar; 1(1):65-71. PMID: 9118317

Wolozin BL, Basaric-Keys J, Canter R, Li Y, Vanderputten D, Sunderland T. Differential regulation of APP secretion by apolipoprotein E3 and E4. Ann N Y Acad Sci. 1996 Jan 17; 777:322-6. PMID: 8624107

Wolozin B L, Basaric-Keys J, Canter R, VanderPutten D, Sunderland T. Differential regulation of APP by apolipoprotein E3 and E4. Ann. NY Acad. Sci. 1996; 777:322-326.
Wolozin B, Luo Y, Wood K. Neuronal Loss and Aging in Cellular Aging and Cell Death. John Wiley & Sons, Inc. NY. 1996; 283-302.

Wolozin B, Hirashima N, Luo Y, Li YH, Alkon DL, Etcheberrigaray R, Sunderland T. Transforming growth factor beta induces a beta-responsive calcium fluxes in neurons. Neuroreport. 1995 Jul 10; 6(10):1429-33. PMID: 7488741

Luo YQ, Hirashima N, Li YH, Alkon DL, Sunderland T, Etcheberrigaray R, Wolozin B. Physiological levels of beta-amyloid increase tyrosine phosphorylation and cytosolic calcium. Brain Res. 1995 May 29; 681(1-2):65-74. PMID: 7552293

Lesch KP, Gross J, Franzek E, Wolozin BL, Riederer P, Murphy DL. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry. 1995 Feb 15; 37(4):215-23. PMID: 7711157

Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan Hua, Vitale J, Wadsworth S, Wolozin B, Zhao J. Development of neuropathology similar to Alzheimer's Disease in transgenic mice overexpressing the 717V-F b-amyloid precursor protein. Nature,. 1995; 373:523-528.

Johnson GS, Basaric-Keys J, Ghanbari HA, Lebovics RS, Lesch KP, Merril CR, Sunderland T, Wolozin B. Protein alterations in olfactory neuroblasts from Alzheimer donors. Neurobiol Aging. 1994 Nov-Dec; 15(6):675-80. PMID: 7891821

Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect. 1994; 95(2):157-62. PMID: 7865169

Lesch KP, Gross J, Wolozin BL, Franzek E, Bengel D, Riederer P, Murphy DL. Direct sequencing of the reserpine-sensitive vesicular monamine transporter complementary DNA in unipolar depression and manic depressive illness. Psychiatr Genet. 1994; 4(3):153-60. PMID: 7719701

Wolozin B, Lesch P, Lebovics R, Sunderland T. A.E. Bennett Research Award 1993. Olfactory neuroblasts from Alzheimer donors: studies on APP processing and cell regulation. Biol Psychiatry. 1993 Dec 15; 34(12):824-38. PMID: 8110910

Lesch KP, Wolozin BL, Murphy DL, Reiderer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem. 1993 Jun; 60(6):2319-22. PMID: 7684072

Lesch KP, Gross J, Wolozin BL, Murphy DL, Riederer P. Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+. J Neural Transm Gen Sect. 1993; 93(1):75-82. PMID: 8373557

Lesch KP, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Murphy DL. Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Brain Res Mol Brain Res. 1993 Jan; 17(1-2):31-5. PMID: 8381906

Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P. Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm Gen Sect. 1993; 91(1):67-72. PMID: 8452685

Wolozin B L. The processing of amyloid precursor protein. Foundation Ipsen: Alzheimer Actualities. 1993; 7:6-8.
Lesch K P, Aulakh C S, Wolozin B L, Riederer P, Hill J L,Murphy D L. Norepinephrine, serotonin and vesicular monoamine transporter in depression and bipolar disorder. Expression during long-term antidepressant treatment. Neuropsychopharmacology. 1993; 9:34S-35S.

Lesch KP, Hough CJ, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Akiyoshi J, Chuang DM, Murphy DL. Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain. Eur J Pharmacol. 1992 Oct 1; 227(2):233-7. PMID: 1426031

Wolozin B, Zheng B, Loren D, Lesch KP, Lebovics RS, Lieberburg I, Sunderland T. Beta/A4 domain of APP: antigenic differences between cell lines. J Neurosci Res. 1992 Oct; 33(2):189-95. PMID: 1453487

Wolozin B, Bacic M, Merrill MJ, Lesch KP, Chen C, Lebovics RS, Sunderland T. Differential expression of carboxyl terminal derivatives of amyloid precursor protein among cell lines. J Neurosci Res. 1992 Sep; 33(1):163-9. PMID: 1453480

Lesch KP, Aulakh CS, Wolozin BL, Hill JL, Murphy DL. 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid decreases NMDA receptor mRNA. Eur J Pharmacol. 1992 Sep 1; 227(1):109-11. PMID: 1426022

Lesch KP, Aulakh CS, Wolozin BL, Murphy DL. Serotonin (5-HT) receptor, 5-HT transporter and G protein-effector expression: implications for depression. Pharmacol Toxicol. 1992; 71 Suppl 1:49-60. PMID: 1480560

Wolozin B, Sunderland T, Zheng BB, Resau J, Dufy B, Barker J, Swerdlow R, Coon H. Continuous culture of neuronal cells from adult human olfactory epithelium. J Mol Neurosci. 1992; 3(3):137-46. PMID: 1320921

Lesch KP, Aulakh CS, Tolliver TJ, Hill JL, Wolozin BL, Murphy DL. Differential effects of long-term lithium and carbamazepine administration on Gs alpha and Gi alpha protein in rat brain. Eur J Pharmacol. 1991 Aug 14; 207(4):355-9. PMID: 1783003

Wolozin B L. Immunochemical approaches to the diagnosis of Alzheimer's Disease. In: Becker, R.E., and Giacobini, E. (Eds.) Alzheimer's Disease. Current Research in Early Diagnosis, Taylor and Francis. New York. 1990; 217-235.

Wolozin B, Scicutella A, Davies P. Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):6202-6. PMID: 2970636; PMCID: PMC281933

Hyman BT, Van Hoesen GW, Wolozin BL, Davies P, Kromer LJ, Damasio AR. Alz-50 antibody recognizes Alzheimer-related neuronal changes. Ann Neurol. 1988 Apr; 23(4):371-9. PMID: 3382173

Wolozin B, Davies P. Alzheimer-related neuronal protein A68: specificity and distribution. Ann Neurol. 1987 Oct; 22(4):521-6. PMID: 3435070

Davies P, Wolozin BL. Recent advances in the neurochemistry of Alzheimer's disease. J Clin Psychiatry. 1987 May; 48 Suppl:23-30. PMID: 2883177

Wolozin B L,Davies P. Recent advances in the neurochemistry of Alzheimer's Disease. J. Clin. Psychiatry. 1987; 48:23-30.
Wolozin B L. A neuronal antigen in the brains of Alzheimer patients (Graduate Dissertation). 1987.

Wolozin BL, Pruchnicki A, Dickson DW, Davies P. A neuronal antigen in the brains of Alzheimer patients. Science. 1986 May 2; 232(4750):648-50. PMID: 3083509

Wolozin BL, Nishimura S, Pasternak GW. The binding of kappa- and sigma-opiates in rat brain. J Neurosci. 1982 Jun; 2(6):708-13. PMID: 6283040

Wolozin BL, Myerowitz R, Pratt RF. Specific chemical modification of the readily nitrated tyrosine of the RTEM beta-lactamase and of bacillus cereus beta-lactamase I. The role of the tyrosine in beta-lactamase catalysis. Biochim Biophys Acta. 1982 Feb 18; 701(2):153-63. PMID: 6803835

Wolozin BL, Pasternak GW. Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6181-5. PMID: 6273857; PMCID: PMC349002

Wolozin B L. Towards an understanding of beta-lactamase catalysis. 1980.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 198 publications over 38 distinct years, with a maximum of 11 publications in 2020

Bar chart showing 198 publications over 38 distinct years, with a maximum of 11 publications in 2020

Year	Publications
1980	1
1981	1
1982	2
1986	1
1987	4
1988	2
1990	1
1991	1
1992	6
1993	7
1994	3
1995	4
1996	10
1997	4
1998	5
1999	4
2000	6
2001	10
2002	6
2003	5
2004	10
2005	4
2006	8
2007	3
2008	3
2009	3
2010	8
2011	7
2012	10
2013	6
2014	6
2015	4
2016	7
2017	7
2018	7
2019	8
2020	11
2021	3