Hoon Ryu | Profiles RNS

Hoon Ryu, PhD

Adjunct Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Neurology

PhD, Chonbuk National University
MS, Chonbuk National University
BS, Chonbuk National University

Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Chobanian and Avedisian School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

VA Boston Healthcare System

Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Personnel Agreement for Research Aervices of Hoon Ryu
02/01/2011 - 09/14/2014 (Sub-Project Level Key Person)
PI: Neil W. Kowall, MD
VA Boston Healthcare System

Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation

Title
Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease (HD) (PI)

Yr	Title	Project-Sub Proj	Pubs
2018	Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline	3RF1AG054156-01S1	15
2016	Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline	1RF1AG054156-01	15
2015	Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease	5R01NS067283-05	29
2014	Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease	5R01NS067283-04	29
2013	Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease	5R01NS067283-03	29
2012	Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease	5R01NS067283-02	29
2011	Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease	1R01NS067283-01A1	29
2009	Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease	5R01NS052724-05	15
2008	Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease	5R01NS052724-04	15
2007	Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease	5R01NS052724-03	15

Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Kim DK, Choi H, Lee W, Choi H, Hong SB, Jeong JH, Han J, Han JW, Ryu H, Kim JI, Mook-Jung I. Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model. Sci Adv. 2024 Mar 15; 10(11):eadi1863. PMID: 38489366; PMCID: PMC10942107; DOI: 10.1126/sciadv.adi1863;

Kang YJ, Hyeon SJ, McQuade A, Lim J, Baek SH, Diep YN, Do KV, Jeon Y, Jo DG, Lee CJ, Blurton-Jones M, Ryu H, Cho H. Neurotoxic Microglial Activation via IFN?-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. Adv Sci (Weinh). 2024 Mar 14; e2304357. PMID: 38482922

Bhusal A, Kim JH, Kim SC, Hwang EM, Ryu H, Ali MS, Park SC, Lee WH, Suk K. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. Cell Rep. 2024 Mar 26; 43(3):113813. PMID: 38393947

Oh SY, Woo HY, Lim L, Im H, Lee H, Lee JM, Hong SK, Choi Y, Yi NJ, Lee KW, Suh KS, Ryu HG. Comparison of postoperative ascites replacement strategies on time to first flatus after living donor liver transplantation: Albumin vs. lactated Ringer's solution. Clin Transplant. 2024 Jan; 38(1):e15231. PMID: 38289882

Kim D, Ko HY, Chung JI, Park YM, Lee S, Kim SY, Kim J, Chun JH, Han KS, Lee M, Ju YH, Park SJ, Park KD, Nam MH, Kim SH, Shim JK, Park Y, Lim H, Park J, Kim H, Kim S, Park U, Ryu H, Lee SY, Park S, Kang SG, Chang JH, Lee CJ, Yun M. Visualizing Cancer-Originating Acetate Uptake Through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment. Neuro Oncol. 2023 Dec 12. PMID: 38085571

Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct; 28(10):4485.View Related Profiles.

Ryu, Hoon
Stein, Thor

PMID: 37783789

Jung JW, Kim H, Park J, Woo J, Jeon E, Lee G, Park M, Kim S, Seo H, Cheon S, Dan K, Lee J, Ryu H, Han D. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Sci Rep. 2023 Sep 14; 13(1):15261. PMID: 37709831; PMCID: PMC10502055; DOI: 10.1038/s41598-023-42161-7;

Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct; 28(10):4474-4484.View Related Profiles.

Ryu, Hoon
Stein, Thor

PMID: 37648779

Nam MH, Ko HY, Kim D, Lee S, Park YM, Hyeon SJ, Won W, Chung JI, Kim SY, Jo HH, Oh KT, Han YE, Lee GH, Ju YH, Lee H, Kim H, Heo J, Bhalla M, Kim KJ, Kwon J, Stein TD, Kong M, Lee H, Lee SE, Oh SJ, Chun JH, Park MA, Park KD, Ryu H, Yun M, Lee CJ. Visualizing reactive astrocyte-neuron interaction in Alzheimer's disease using 11C-acetate and 18F-FDG. Brain. 2023 Jul 03; 146(7):2957-2974.View Related Profiles.

Ryu, Hoon
Stein, Thor

PMID: 37062541; PMCID: PMC10517195; DOI: 10.1093/brain/awad037;

Lim S, Shin S, Sung Y, Lee HE, Kim KH, Song JY, Lee GH, Aziz H, Lukianenko N, Kang DM, Boesen N, Jeong H, Abdildinova A, Lee J, Yu BY, Lim SM, Lee JS, Ryu H, Pae AN, Kim YK. Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice. Exp Mol Med. 2023 Mar; 55(3):612-627. PMID: 36914856; PMCID: PMC10073126; DOI: 10.1038/s12276-023-00959-5;

Showing 10 of 166 results. Show More

Choi SH, Yousefian-Jazi A, Hyeon SJ, Nguyen PTT, Chu J, Kim S, Kim S, Ryu HL, Kowall NW, Ryu H, Lee J. Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS. J Biomed Sci. 2022 Dec 20; 29(1):106.View Related Profiles.

Ryu, Hoon
Kowall, Neil

PMID: 36536341; PMCID: PMC9764677; DOI: 10.1186/s12929-022-00890-3;

Kim JH, Kang RJ, Hyeon SJ, Ryu H, Joo H, Bu Y, Kim JH, Suk K. Lipocalin-2 Is a Key Regulator of Neuroinflammation in Secondary Traumatic and Ischemic Brain Injury. Neurotherapeutics. 2023 Apr; 20(3):803-821. PMID: 36508119; PMCID: PMC10275845; DOI: 10.1007/s13311-022-01333-5;

Kim H, Kim H, Nguyen LT, Ha T, Lim S, Kim K, Kim SH, Han K, Hyeon SJ, Ryu H, Park YS, Kim SH, Kim IB, Hong GS, Lee SE, Choi Y, Cohen LB, Oh U. Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction. Prog Neurobiol. 2022 Dec; 219:102369. PMID: 36330924

Kim JH, Afridi R, Cho E, Yoon JH, Lim YH, Lee HW, Ryu H, Suk K. Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin-Angiotensin System in Astrocyte-Microglia Crosstalk. Mol Cell Proteomics. 2022 Nov; 21(11):100424. PMID: 36220603; PMCID: PMC9650055; DOI: 10.1016/j.mcpro.2022.100424;

Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, Ryu H, Yu SW, Kim JI, Kim YS, Lee SW, Hwang D, Mook-Jung I. Aß-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation. Exp Mol Med. 2022 Sep; 54(9):1461-1471. PMID: 36056186; PMCID: PMC9534996; DOI: 10.1038/s12276-022-00841-w;

Lee S, Shim HS, Park HJ, Chang Y, Han YE, Oh SJ, Lee W, Im H, Seol Y, Ryu H, Kang H, Lee YK, Park S, Yoo J. Elongated nanoporous Au networks improve somatic cell direct conversion into induced dopaminergic neurons for Parkinson's disease therapy. Acta Biomater. 2022 Oct 01; 151:561-575. PMID: 35931279

Lee HN, Hyeon SJ, Kim H, Sim KM, Kim Y, Ju J, Lee J, Wang Y, Ryu H, Seong J. Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease. Acta Neuropathol. 2022 Sep; 144(3):521-536. PMID: 35857122

Latif S, Choi SH, Gyawali A, Hyeon SJ, Kang YS, Ryu H. Antioxidant and Neuroprotective Effects of Paeonol against Oxidative Stress and Altered Carrier-Mediated Transport System on NSC-34 Cell Lines. Antioxidants (Basel). 2022 Jul 18; 11(7). PMID: 35883881; PMCID: PMC9311606; DOI: 10.3390/antiox11071392;

Lee J, Kim S, Kim YH, Park U, Lee J, McKee AC, Kim KH, Ryu H, Lee J. Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy. Biomedicines. 2022 Jul 15; 10(7).View Related Profiles.

McKee, Ann
Ryu, Hoon

PMID: 35885023; PMCID: PMC9313062; DOI: 10.3390/biomedicines10071718;

Ju YH, Bhalla M, Hyeon SJ, Oh JE, Yoo S, Chae U, Kwon J, Koh W, Lim J, Park YM, Lee J, Cho IJ, Lee H, Ryu H, Lee CJ. Astrocytic urea cycle detoxifies Aß-derived ammonia while impairing memory in Alzheimer's disease. Cell Metab. 2022 Aug 02; 34(8):1104-1120.e8. PMID: 35738259

Chang B, Byun J, Kim KK, Lee SE, Lee B, Kim KS, Ryu H, Shin HS, Cheong E. Deletion of Phospholipase C ß1 in the Thalamic Reticular Nucleus Induces Absence Seizures. Exp Neurobiol. 2022 Apr 30; 31(2):116-130. PMID: 35674000; PMCID: PMC9194639; DOI: 10.5607/en22007;

Yoon Y, Kim S, Seol Y, Im H, Park U, Han HB, Choi JH, Ryu H. Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice. Biomedicines. 2022 Apr 07; 10(4). PMID: 35453615; PMCID: PMC9031269; DOI: 10.3390/biomedicines10040865;

Kim JH, Kwon O, Bhusal A, Lee J, Hwang EM, Ryu H, Park JY, Suk K. Neuroinflammation Induced by Transgenic Expression of Lipocalin-2 in Astrocytes. Front Cell Neurosci. 2022; 16:839118.View Related Profiles.

Ryu, Hoon
Kwon, Osung

PMID: 35281301; PMCID: PMC8904391; DOI: 10.3389/fncel.2022.839118;

Gyawali A, Latif S, Choi SH, Hyeon SJ, Ryu H, Kang YS. Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis. J Biomed Sci. 2022 Jan 10; 29(1):2. PMID: 35012534; PMCID: PMC8744235; DOI: 10.1186/s12929-022-00785-3;

Lee S, Kim TK, Choi JE, Choi Y, You M, Ryu J, Chun YL, Ham S, Hyeon SJ, Ryu H, Kim HS, Im HI. Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease. Theranostics. 2022; 12(3):1404-1418. PMID: 35154497; PMCID: PMC8771549; DOI: 10.7150/thno.68439;

Hwang YJ, Hyeon SJ, Kim Y, Lim S, Lee MY, Kim J, Londhe AM, Gotina L, Kim Y, Pae AN, Cho YS, Seong J, Seo H, Kim YK, Choo H, Ryu H, Min SJ. Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):856-868. PMID: 33771089; PMCID: PMC8008885; DOI: 10.1080/14756366.2021.1900160;

Kim C, Yousefian-Jazi A, Choi SH, Chang I, Lee J, Ryu H. Non-Cell Autonomous and Epigenetic Mechanisms of Huntington's Disease. Int J Mol Sci. 2021 Nov 19; 22(22). PMID: 34830381; PMCID: PMC8617801; DOI: 10.3390/ijms222212499;

Koh W, Park M, Chun YE, Lee J, Shim HS, Park MG, Kim S, Sa M, Joo J, Kang H, Oh SJ, Woo J, Chun H, Lee SE, Hong J, Feng J, Li Y, Ryu H, Cho J, Lee CJ. Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus. Biol Psychiatry. 2022 04 15; 91(8):740-752. PMID: 34952697

Prasad R, Jung H, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease. Sci Rep. 2021 10 08; 11(1):20075. PMID: 34625606; PMCID: PMC8501037; DOI: 10.1038/s41598-021-99562-9;

Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, Song EJ, Ryu H, Yu K. Publisher Correction: UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021 Jul 07; 12(1):4257. PMID: 34234153; PMCID: PMC8263558; DOI: 10.1038/s41467-021-24572-0;

Hyeon SJ, Park J, Yoo J, Kim SH, Hwang YJ, Kim SC, Liu T, Shim HS, Kim Y, Cho Y, Woo J, Kim KS, Myers RH, Ryu HL, Kowall NW, Song EJ, Hwang EM, Seo H, Lee J, Ryu H. Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease. Prog Neurobiol. 2021 09; 204:102110.View Related Profiles.

Ryu, Hoon
Kowall, Neil
Myers, Richard

PMID: 34166773; PMCID: PMC8364511; DOI: 10.1016/j.pneurobio.2021.102110;

Elbatrawy AA, Hyeon SJ, Yue N, Osman EEA, Choi SH, Lim S, Kim YK, Ryu H, Cui M, Nam G. "Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking. ACS Sens. 2021 06 25; 6(6):2281-2289. PMID: 34115933

Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, Song EJ, Ryu H, Yu K. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021 06 02; 12(1):3291. PMID: 34078905; PMCID: PMC8172564; DOI: 10.1038/s41467-021-23597-9;

Gyawali A, Hyeon SJ, Ryu H, Kang YS. The Alteration of L-Carnitine Transport and Pretreatment Effect under Glutamate Cytotoxicity on Motor Neuron-Like NSC-34 Lines. Pharmaceutics. 2021 Apr 14; 13(4). PMID: 33919926; PMCID: PMC8070968; DOI: 10.3390/pharmaceutics13040551;

Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, Han J, Jung JH, Lee J, Ryu H, Park JY, Hwang EM, Suk K. Hevin-calcyon interaction promotes synaptic reorganization after brain injury. Cell Death Differ. 2021 09; 28(9):2571-2588. PMID: 33753902; PMCID: PMC8408247; DOI: 10.1038/s41418-021-00772-5;

Kim JH, Afridi R, Han J, Jung HG, Kim SC, Hwang EM, Shim HS, Ryu H, Choe Y, Hoe HS, Suk K. Gamma subunit of complement component 8 is a neuroinflammation inhibitor. Brain. 2021 03 03; 144(2):528-552. PMID: 33382892

Woo J, Cho H, Seol Y, Kim SH, Park C, Yousefian-Jazi A, Hyeon SJ, Lee J, Ryu H. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants (Basel). 2021 Feb 03; 10(2). PMID: 33546471; PMCID: PMC7913624; DOI: 10.3390/antiox10020229;

Han YM, Kim MS, Jo J, Shin D, Kwon SH, Seo JB, Kang D, Lee BD, Ryu H, Hwang EM, Kim JM, Patel PD, Lyons DM, Schatzberg AF, Her S. Decoding the temporal nature of brain GR activity in the NF?B signal transition leading to depressive-like behavior. Mol Psychiatry. 2021 09; 26(9):5087-5096. PMID: 33483691; PMCID: PMC7821461; DOI: 10.1038/s41380-021-01016-1;

Yousefian-Jazi A, Seol Y, Kim J, Ryu HL, Lee J, Ryu H. Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis. Cells. 2020 12 15; 9(12). PMID: 33333804; PMCID: PMC7765192; DOI: 10.3390/cells9122687;

Seol Y, Ki S, Ryu HL, Chung S, Lee J, Ryu H. How Microglia Manages Non-cell Autonomous Vicious Cycling of Aß Toxicity in the Pathogenesis of AD. Front Mol Neurosci. 2020; 13:593724. PMID: 33328884; PMCID: PMC7718019; DOI: 10.3389/fnmol.2020.593724;

Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production. Nat Neurosci. 2020 12; 23(12):1555-1566. PMID: 33199896

Gyawali A, Gautam S, Hyeon SJ, Ryu H, Kang YS. L-Citrulline Level and Transporter Activity Are Altered in Experimental Models of Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2021 Feb; 58(2):647-657. PMID: 33000451

Choi JW, Ju YH, Choi Y, Hyeon SJ, Gadhe CG, Park JH, Kim MS, Baek S, Kim Y, Park KD, Pae AN, Ryu H, Lee CJ, Cho BR. PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates. ACS Chem Neurosci. 2020 06 17; 11(12):1801-1810. PMID: 32421307

Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Sci Rep. 2020 06 01; 10(1):8811.View Related Profiles.

McKee, Ann
Ryu, Hoon
Kowall, Neil
Stein, Thor
Alvarez, Victor

PMID: 32483284; PMCID: PMC7264177; DOI: 10.1038/s41598-020-65916-y;

Lee MY, Lee J, Hyeon SJ, Cho H, Hwang YJ, Shin JY, McKee AC, Kowall NW, Kim JI, Stein TD, Hwang D, Ryu H. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease. Aging Cell. 2020 06; 19(6):e13153.View Related Profiles.

McKee, Ann
Ryu, Hoon
Kowall, Neil
Stein, Thor

PMID: 32419307; PMCID: PMC7294781; DOI: 10.1111/acel.13153;

Yoo J, Kim J, Lee JH, Kim H, Jang SJ, Seo HH, Oh ST, Hyeon SJ, Ryu H, Kim J, Moh SH. Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334. Sci Rep. 2020 02 28; 10(1):3684. PMID: 32111890; PMCID: PMC7048830; DOI: 10.1038/s41598-020-60680-5;

Shin S, Kim D, Song JY, Jeong H, Hyeon SJ, Kowall NW, Ryu H, Pae AN, Lim S, Kim YK. Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy. Prog Neurobiol. 2020 Feb 24; 101782.View Related Profiles.

Ryu, Hoon
Kowall, Neil

PMID: 32105751

Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype. Sci Rep. 2020 02 19; 10(1):2924.View Related Profiles.

Jun, Gyungah
Ryu, Hoon
Friedberg, Jacob
Cherry, Jonathan
Aytan, Nurgul
Au, Rhoda
Stein, Thor
Alvarez, Victor
Xia, Weiming

PMID: 32076055; PMCID: PMC7031423; DOI: 10.1038/s41598-020-59869-5;

Cap KC, Jung YJ, Choi BY, Hyeon SJ, Kim JG, Min JK, Islam R, Hossain AJ, Chung WS, Suh SW, Ryu H, Park JB. Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aß concentrations. Redox Biol. 2020 05; 32:101446. PMID: 32046944; PMCID: PMC7264465; DOI: 10.1016/j.redox.2020.101446;

Heo JY, Nam MH, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon SR, Lee CJ. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol. 2020 01 20; 30(2):276-291.e9.View Related Profiles.

Ryu, Hoon
Kowall, Neil

PMID: 31928877

Lee HN, Sim KM, Kim H, Ju J, Pae AN, Park JB, Ryu H, Seong J. Aß modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism. Sci Rep. 2019 10 29; 9(1):15557. PMID: 31664099; PMCID: PMC6820556; DOI: 10.1038/s41598-019-51914-2;

Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H. Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy. Exp Neurobiol. 2019 Jun; 28(3):362-375.View Related Profiles.

McKee, Ann
Choi, Han-Pil
Ryu, Hoon
Kowall, Neil

PMID: 31308796; PMCID: PMC6614068; DOI: 10.5607/en.2019.28.3.362;

Kim YH, Shim HS, Kim KH, Lee J, Chung BC, Kowall NW, Ryu H, Lee J. Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer's Disease. Exp Neurobiol. 2019 Jun; 28(3):376-389.View Related Profiles.

Ryu, Hoon
Lee, Junghee
Kowall, Neil

PMID: 31308797; PMCID: PMC6614073; DOI: 10.5607/en.2019.28.3.376;

Chen S, Yu C, Rong L, Li CH, Qin X, Ryu H, Park H. Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington's Disease. Front Mol Neurosci. 2018; 11:478. PMID: 30618623; PMCID: PMC6311661; DOI: 10.3389/fnmol.2018.00478;

Lee J, Nguyen PT, Shim HS, Hyeon SJ, Im H, Choi MH, Chung S, Kowall NW, Lee SB, Ryu H. EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways. Biochim Biophys Acta Mol Basis Dis. 2019 07 01; 1865(7):1938-1945.View Related Profiles.

Ryu, Hoon
Kowall, Neil

PMID: 30481590; PMCID: PMC6527469; DOI: 10.1016/j.bbadis.2018.10.042;

Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD. Brain injury induces HIF-1a-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018 11 12; 9(11):1125. PMID: 30420654; PMCID: PMC6232134; DOI: 10.1038/s41419-018-1180-y;

Chun H, An H, Lim J, Woo J, Lee J, Ryu H, Lee CJ. Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus. Exp Neurobiol. 2018 Jun; 27(3):155-170. PMID: 30022867; PMCID: PMC6050417; DOI: 10.5607/en.2018.27.3.155;

Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H. Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice. Exp Neurobiol. 2018 Apr; 27(2):103-111.View Related Profiles.

Year	Publications
1988	2
1989	3
1991	1
1992	2
1993	1
1994	3
1995	2
1997	2
1999	1
2000	3
2002	3
2003	9
2004	9
2005	11
2006	4
2007	3
2008	4
2009	6
2010	4
2011	3
2012	3
2013	5
2014	3
2015	6
2016	6
2017	8
2018	6
2019	3
2020	12
2021	13
2022	15
2023	6
2024	4