Hoon Ryu, PhD
Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Chonbuk National University
MS, Chonbuk National University



Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 06/30/2021 (PI)
NIH/National Institute on Aging
1RF1AG054156-01

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 May 19; 49(5):e333.View Related Profiles. PMID: 28524178.
  2. Choi H, Kim HJ, Kim J, Kim S, Yang J, Lee W, Park Y, Hyeon SJ, Lee DS, Ryu H, Chung J, Mook-Jung I. Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aß-induced impaired axonal transport. Mol Neurodegener. 2017 Feb 28; 12(1):23. PMID: 28241840; DOI: 10.1186/s13024-017-0164-1;.
  3. Lee NY, Kim Y, Ryu H, Kang YS. The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS). Biochem Biophys Res Commun. 2017 Jan 29; 483(1):135-141. PMID: 28043791; DOI: 10.1016/j.bbrc.2016.12.178;.
  4. Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J. Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. Front Behav Neurosci. 2016; 10:214. PMID: 27857685.
  5. Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H. Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS. Exp Neurobiol. 2016 Oct; 25(5):233-240. PMID: 27790057.
  6. Seo Y, Park KS, Ha T, Kim MK, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer''s Disease. ACS Chem Neurosci. 2016 Nov 16; 7(11):1474-1481. PMID: 27576176.
  7. Lee CJ, Ahn H, Lee SB, Shin JY, Park WY, Kim JI, Lee J, Ryu H, Kim S. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC Med Genomics. 2016 Aug 12; 9 Suppl 1:33. PMID: 27534535; PMCID: PMC4989891; DOI: 10.1186/s12920-016-0195-4;.
  8. Jung ES, Choi H, Song H, Hwang YJ, Kim A, Ryu H, Mook-Jung I. p53-dependent SIRT6 expression protects Aß42-induced DNA damage. Sci Rep. 2016 May 09; 6:25628. PMID: 27156849; PMCID: PMC4860716; DOI: 10.1038/srep25628;.
  9. Son SM, Nam DW, Cha MY, Kim KH, Byun J, Ryu H, Mook-Jung I. Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer''s disease. Neurobiol Aging. 2015 Dec; 36(12):3214-27. PMID: 26452999; DOI: 10.1016/j.neurobiolaging.2015.09.005;.
  10. Kim Y, Lee J, Ryu H. Modulation of autophagy by miRNAs. BMB Rep. 2015 Jul; 48(7):371-2.View Related Profiles. PMID: 26129673; PMCID: PMC4577285.
Showing 10 of 75 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 75 publications over 16 distinct years, with a maximum of 10 publications in 2005

YearPublications
20021
20036
20046
200510
20064
20073
20084
20096
20104
20113
20123
20135
20144
20158
20166
20172

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Jamaica Plain MA 02130
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