Keywords
Last Name

Hoon Ryu, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentNeurology
Address150 S Huntington Avenue
Jamaica Plain MA 02130
Phone(857) 364-5910
ORCID ORCID Icon0000-0001-6544-3732
Other Positions
InstitutionVA Boston Healthcare System

 Research Expertise & Professional Interests
Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee NY, Kim Y, Ryu H, Kang YS. The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS). Biochem Biophys Res Commun. 2017 Jan 29; 483(1):135-141. PMID: 28043791.
    View in: PubMed
  2. Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J. Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. Front Behav Neurosci. 2016; 10:214. PMID: 27857685.
    View in: PubMed
  3. Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H. Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS. Exp Neurobiol. 2016 Oct; 25(5):233-240. PMID: 27790057.
    View in: PubMed
  4. Seo Y, Park KS, Ha T, Kim MK, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer's Disease. ACS Chem Neurosci. 2016 Nov 16; 7(11):1474-1481. PMID: 27576176.
    View in: PubMed
  5. Lee CJ, Ahn H, Lee SB, Shin JY, Park WY, Kim JI, Lee J, Ryu H, Kim S. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC Med Genomics. 2016 Aug 12; 9 Suppl 1:33. PMID: 27534535.
    View in: PubMed
  6. Jung ES, Choi H, Song H, Hwang YJ, Kim A, Ryu H, Mook-Jung I. p53-dependent SIRT6 expression protects Aß42-induced DNA damage. Sci Rep. 2016 May 09; 6:25628. PMID: 27156849.
    View in: PubMed
  7. Son SM, Nam DW, Cha MY, Kim KH, Byun J, Ryu H, Mook-Jung I. Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer's disease. Neurobiol Aging. 2015 Dec; 36(12):3214-27. PMID: 26452999.
    View in: PubMed
  8. Kim Y, Lee J, Ryu H. Modulation of autophagy by miRNAs. BMB Rep. 2015 Jul; 48(7):371-2. PMID: 26129673.
    View in: PubMed
  9. Hong C, Seo H, Kwak M, Jeon J, Jang J, Jeong EM, Myeong J, Hwang YJ, Ha K, Kang MJ, Lee KP, Yi EC, Kim IG, Jeon JH, Ryu H, So I. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease. Brain. 2015 Oct; 138(Pt 10):3030-47. PMID: 26133660.
    View in: PubMed
  10. Kim D, Jeon J, Cheong E, Kim DJ, Ryu H, Seo H, Kim YK. Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington's Disease Mouse Model. Mol Neurobiol. 2016 May; 53(4):2276-86. PMID: 25976370.
    View in: PubMed
  11. Ha CM, Park D, Kim Y, Na M, Panda S, Won S, Kim H, Ryu H, Park ZY, Rasenick MM, Chang S. SNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling. J Cell Sci. 2015 May 1; 128(9):1848-61. PMID: 25795301.
    View in: PubMed
  12. Park SY, Chung JS, Kim SH, Kim YW, Ryu H, Kim DH. The safety and prognostic factors for mortality in extremely elderly patients undergoing an emergency operation. Surg Today. 2016 Feb; 46(2):241-7. PMID: 25788220.
    View in: PubMed
  13. Ryu H, Kim J, Hong KH. Atomistic study on dopant-distributions in realistically sized, highly P-doped Si nanowires. Nano Lett. 2015 Jan 14; 15(1):450-6. PMID: 25555203.
    View in: PubMed
  14. Kim Y, Kang YS, Lee NY, Kim KY, Hwang YJ, Kim HW, Rhyu IJ, Her S, Jung MK, Kim S, Lee CJ, Ko S, Kowall NW, Lee SB, Lee J, Ryu H. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy. 2015; 11(5):796-811. PMID: 25946189.
    View in: PubMed
  15. Ryu H, Lee S, Fuechsle M, Miwa JA, Mahapatra S, Hollenberg LC, Simmons MY, Klimeck G. A tight-binding study of single-atom transistors. Small. 2015 Jan 21; 11(3):374-81. PMID: 25293353.
    View in: PubMed
  16. Koh DI, Han D, Ryu H, Choi WI, Jeon BN, Kim MK, Kim Y, Kim JY, Parry L, Clarke AR, Reynolds AB, Hur MW. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15078-83. PMID: 25288747.
    View in: PubMed
  17. Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee da Y, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease. Nat Med. 2014 Aug; 20(8):886-96. PMID: 24973918.
    View in: PubMed
  18. Park E, Kim Y, Ryu H, Kowall NW, Lee J, Ryu H. Epigenetic mechanisms of Rubinstein-Taybi syndrome. Neuromolecular Med. 2014 Mar; 16(1):16-24. PMID: 24381114.
    View in: PubMed
  19. Hwang YJ, Han D, Kim KY, Min SJ, Kowall NW, Yang L, Lee J, Kim Y, Ryu H. ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription. Nucleic Acids Res. 2014 Feb; 42(3):1628-43. PMID: 24234436.
    View in: PubMed
  20. Lee J, Hwang YJ, Ryu H, Kowall NW, Ryu H. Nucleolar dysfunction in Huntington's disease. Biochim Biophys Acta. 2014 Jun; 1842(6):785-90. PMID: 24184605.
    View in: PubMed
  21. Lee J, Hwang YJ, Kim KY, Kowall NW, Ryu H. Epigenetic mechanisms of neurodegeneration in Huntington's disease. Neurotherapeutics. 2013 Oct; 10(4):664-76. PMID: 24006238.
    View in: PubMed
  22. Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12066-71. PMID: 23818595.
    View in: PubMed
  23. Lee J, Hwang YJ, Shin JY, Lee WC, Wie J, Kim KY, Lee MY, Hwang D, Ratan RR, Pae AN, Kowall NW, So I, Kim JI, Ryu H. Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. Acta Neuropathol. 2013 May; 125(5):727-39. PMID: 23455440.
    View in: PubMed
  24. Jung MK, Kim KY, Lee NY, Kang YS, Hwang YJ, Kim Y, Sung JJ, McKee A, Kowall N, Lee J, Ryu H. Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS. Mol Neurobiol. 2013 Apr; 47(2):699-710. PMID: 23180277.
    View in: PubMed
  25. Lee ST, Chu K, Jung KH, Kim JH, Huh JY, Yoon H, Park DK, Lim JY, Kim JM, Jeon D, Ryu H, Lee SK, Kim M, Roh JK. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol. 2012 Aug; 72(2):269-77. PMID: 22926857.
    View in: PubMed
  26. Jeon GS, Kim KY, Hwang YJ, Jung MK, An S, Ouchi M, Ouchi T, Kowall N, Lee J, Ryu H. Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of ?-H2AX and DNA damage responses in Huntington's disease. Mol Neurobiol. 2012 Jun; 45(3):550-63. PMID: 22580959.
    View in: PubMed
  27. Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK. IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux. Hum Mol Genet. 2012 Jan 1; 21(1):101-14. PMID: 21954231.
    View in: PubMed
  28. Ryu H, Jeon GS, Cashman NR, Kowall NW, Lee J. Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS. Lab Invest. 2011 Mar; 91(3):342-52. PMID: 21283077.
    View in: PubMed
  29. Kim CH, Leung A, Huh YH, Yang E, Kim DJ, Leblanc P, Ryu H, Kim K, Kim DW, Garland EM, Raj SR, Biaggioni I, Robertson D, Kim KS. Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase. J Biol Chem. 2011 Mar 18; 286(11):9196-204. PMID: 21209083.
    View in: PubMed
  30. Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta Neuropathol. 2011 Apr; 121(4):487-98. PMID: 21161248.
    View in: PubMed
  31. Lee J, Ryu H. Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker? BMB Rep. 2010 Oct; 43(10):649-55. PMID: 21034526.
    View in: PubMed
  32. McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol Med. 2010 Sep; 2(9):349-70. PMID: 20665636.
    View in: PubMed
  33. Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010 Mar; 112(6):1593-604. PMID: 20067578.
    View in: PubMed
  34. Lee J, Boo JH, Ryu H. The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start? Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1316-23. PMID: 19716395.
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  35. Lee J, Ryu H, Kowall NW. Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice. Biochem Biophys Res Commun. 2009 Sep 11; 387(1):202-6. PMID: 19580782.
    View in: PubMed
  36. Liu ML, Liu MJ, Shen YF, Ryu H, Kim HJ, Klupsch K, Downward J, Hong ST. Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta. J Cell Sci. 2009 Jun 1; 122(Pt 11):1917-26. PMID: 19435805.
    View in: PubMed
  37. Lee J, Ryu H, Kowall NW. Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice. Biochem Biophys Res Commun. 2009 Jul 10; 384(4):524-9. PMID: 19427829.
    View in: PubMed
  38. Noh JY, Lee H, Song S, Kim NS, Im W, Kim M, Seo H, Chung CW, Chang JW, Ferrante RJ, Yoo YJ, Ryu H, Jung YK. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. J Biol Chem. 2009 Apr 24; 284(17):11318-25. PMID: 19240033.
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  39. Lee J, Kannagi M, Ferrante RJ, Kowall NW, Ryu H. Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis. FASEB J. 2009 Jun; 23(6):1739-49. PMID: 19179380.
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  40. Lee J, Sharma S, Kim J, Ferrante RJ, Ryu H. Mitochondrial nuclear receptors and transcription factors: who's minding the cell? J Neurosci Res. 2008 Apr; 86(5):961-71. PMID: 18041090.
    View in: PubMed
  41. Lee J, Hagerty S, Cormier KA, Kim J, Kung AL, Ferrante RJ, Ryu H. Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation. Hum Mol Genet. 2008 Jun 15; 17(12):1774-82. PMID: 18319327.
    View in: PubMed
  42. McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 1; 1207:225-36. PMID: 18374906.
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  43. Stack EC, Ferro JL, Kim J, Del Signore SJ, Goodrich S, Matson S, Hunt BB, Cormier K, Smith K, Matson WR, Ryu H, Ferrante RJ. Therapeutic attenuation of mitochondrial dysfunction and oxidative stress in neurotoxin models of Parkinson's disease. Biochim Biophys Acta. 2008 Mar; 1782(3):151-62. PMID: 18206128.
    View in: PubMed
  44. Guan YJ, Wang X, Wang HY, Kawagishi K, Ryu H, Huo CF, Shimony EM, Kristal BS, Kuhn HG, Friedlander RM. Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. J Neurochem. 2007 Aug; 102(4):1125-38. PMID: 17472707.
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  45. Stack EC, Del Signore SJ, Luthi-Carter R, Soh BY, Goldstein DR, Matson S, Goodrich S, Markey AL, Cormier K, Hagerty SW, Smith K, Ryu H, Ferrante RJ. Modulation of nucleosome dynamics in Huntington's disease. Hum Mol Genet. 2007 May 15; 16(10):1164-75. PMID: 17403718.
    View in: PubMed
  46. Ryu H, Ferrante RJ. Translational therapeutic strategies in amyotrophic lateral sclerosis. Mini Rev Med Chem. 2007 Feb; 7(2):141-50. PMID: 17305588.
    View in: PubMed
  47. Ryu H, Lee J, Hagerty SW, Soh BY, McAlpin SE, Cormier KA, Smith KM, Ferrante RJ. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19176-81. PMID: 17142323.
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  48. Lee J, Kosaras B, Aleyasin H, Han JA, Park DS, Ratan RR, Kowall NW, Ferrante RJ, Lee SW, Ryu H. Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J. 2006 Nov; 20(13):2375-7. PMID: 17012241.
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  49. Lee MS, Kim MK, Ryu H, Shin BC, Kim YS. Qi-training and immunological parameters: a cross-sectional study. Int J Neurosci. 2006 Aug; 116(8):921-6. PMID: 16861157.
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  50. Smith KM, Matson S, Matson WR, Cormier K, Del Signore SJ, Hagerty SW, Stack EC, Ryu H, Ferrante RJ. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. Biochim Biophys Acta. 2006 Jun; 1762(6):616-26. PMID: 16647250.
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  51. Stack EC, Smith KM, Ryu H, Cormier K, Chen M, Hagerty SW, Del Signore SJ, Cudkowicz ME, Friedlander RM, Ferrante RJ. Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice. Biochim Biophys Acta. 2006 Mar; 1762(3):373-80. PMID: 16364609.
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  52. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 9; 280(49):40398-401. PMID: 16207717.
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  53. Stack EC, Kubilus JK, Smith K, Cormier K, Del Signore SJ, Guelin E, Ryu H, Hersch SM, Ferrante RJ. Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice. J Comp Neurol. 2005 Oct 3; 490(4):354-70. PMID: 16127709.
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  54. Ryu H, Lee J, Impey S, Ratan RR, Ferrante RJ. Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13915-20. PMID: 16169904.
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  55. Ryu H, Rosas HD, Hersch SM, Ferrante RJ. The therapeutic role of creatine in Huntington's disease. Pharmacol Ther. 2005 Nov; 108(2):193-207. PMID: 16055197.
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  56. Lee MS, Kim MK, Ryu H. Qi-training (qigong) enhanced immune functions: what is the underlying mechanism? Int J Neurosci. 2005 Aug; 115(8):1099-104. PMID: 16040353.
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  57. Camelo S, Iglesias AH, Hwang D, Due B, Ryu H, Smith K, Gray SG, Imitola J, Duran G, Assaf B, Langley B, Khoury SJ, Stephanopoulos G, De Girolami U, Ratan RR, Ferrante RJ, Dangond F. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Jul; 164(1-2):10-21. PMID: 15885809.
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  58. Ryu H, Smith K, Camelo SI, Carreras I, Lee J, Iglesias AH, Dangond F, Cormier KA, Cudkowicz ME, Brown RH, Ferrante RJ. Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem. 2005 Jun; 93(5):1087-98. PMID: 15934930.
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  59. Krasnikov BF, Kim SY, McConoughey SJ, Ryu H, Xu H, Stavrovskaya I, Iismaa SE, Mearns BM, Ratan RR, Blass JP, Gibson GE, Cooper AJ. Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry. 2005 May 31; 44(21):7830-43. PMID: 15909997.
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  60. Ryu H, Ferrante RJ. Emerging chemotherapeutic strategies for Huntington's disease. Expert Opin Emerg Drugs. 2005 May; 10(2):345-63. PMID: 15934871.
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  61. Lee M, Kang CW, Ryu H. Acute effect of qi-training on natural killer cell subsets and cytotoxic activity. Int J Neurosci. 2005 Feb; 115(2):285-97. PMID: 15764007.
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  62. Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, Lamanna JC, Ratan RR. Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem. 2005 Feb 4; 280(5):3996-4003. PMID: 15557337.
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  63. Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J, Lu P, Smith K, Browne S, Beal MF, Kristal BS, Stavrovskaya IG, Hewett S, Rubinsztein DC, Langley B, Ratan RR. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci. 2004 Nov 17; 24(46):10335-42. PMID: 15548647.
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  64. Lee MS, Ryu H, Song J, Moon SR. Effects of Qi-training (Qigong) on forearm blood gas concentrations. Int J Neurosci. 2004 Nov; 114(11):1503-10. PMID: 15636359.
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  65. Gardian G, Browne SE, Choi DK, Klivenyi P, Gregorio J, Kubilus JK, Ryu H, Langley B, Ratan RR, Ferrante RJ, Beal MF. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. J Biol Chem. 2005 Jan 7; 280(1):556-63. PMID: 15494404.
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  66. Lee MS, Ryu H. Qi-training enhances neutrophil function by increasing growth hormone levels in elderly men. Int J Neurosci. 2004 Oct; 114(10):1313-22. PMID: 15370188.
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  67. Lee MS, Kang CW, Ryu H. Effect of qi training on neutrophil function in young and elderly males. J Altern Complement Med. 2004 Aug; 10(4):681-3. PMID: 15353026.
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  68. Lee MS, Kang CW, Ryu H, Moon SR. Endocrine and immune effects of Qi-training. Int J Neurosci. 2004 Apr; 114(4):529-37. PMID: 15195356.
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  69. Fink JS, Kalda A, Ryu H, Stack EC, Schwarzschild MA, Chen JF, Ferrante RJ. Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage. J Neurochem. 2004 Feb; 88(3):538-44. PMID: 14720203.
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  70. Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW. ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol. 2004 Feb; 6(2):121-8. PMID: 14730312.
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  71. Ferrante RJ, Kubilus JK, Lee J, Ryu H, Beesen A, Zucker B, Smith K, Kowall NW, Ratan RR, Luthi-Carter R, Hersch SM. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J Neurosci. 2003 Oct 15; 23(28):9418-27. PMID: 14561870.
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  72. Khanna S, Roy S, Ryu H, Bahadduri P, Swaan PW, Ratan RR, Sen CK. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem. 2003 Oct 31; 278(44):43508-15. PMID: 12917400.
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  73. Ryu H, Lee J, Zaman K, Kubilis J, Ferrante RJ, Ross BD, Neve R, Ratan RR. Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J Neurosci. 2003 May 1; 23(9):3597-606. PMID: 12736330.
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  74. Lee J, Ryu H, Ferrante RJ, Morris SM, Ratan RR. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4843-8. PMID: 12655043.
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  75. Ohtsuka T, Ryu H, Minamishima YA, Ryo A, Lee SW. Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Oncogene. 2003 Mar 20; 22(11):1678-87. PMID: 12642871.
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  76. Ryu H, Lee J, Olofsson BA, Mwidau A, Dedeoglu A, Escudero M, Flemington E, Azizkhan-Clifford J, Ferrante RJ, Ratan RR, Deodoglu A. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):4281-6. PMID: 12640146.
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  77. Lee MS, Jeong SM, Kim YK, Park KW, Lee MS, Ryu H, Moon SR. Qi-training enhances respiratory burst function and adhesive capacity of neutrophils in young adults: a preliminary study. Am J Chin Med. 2003; 31(1):141-8. PMID: 12723764.
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  78. Lee MS, Jeong SM, Jang HS, Ryu H, Moon SR. Effects of in vitro and in vivo Qi-therapy on neutrophil superoxide generation in healthy male subjects. Am J Chin Med. 2003; 31(4):623-8. PMID: 14587884.
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  79. Ratan RR, Ryu H, Lee J, Mwidau A, Neve RL. In vitro model of oxidative stress in cortical neurons. Methods Enzymol. 2002; 352:183-90. PMID: 12125346.
    View in: PubMed
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