Keywords
Last Name

Junghee Lee, PhD

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentNeurology
Address150 S Huntington Avenue
Jamaica Plain MA 02130
Phone(857) 364-6034
ORCID ORCID Icon0000-0002-9530-9806
Other Positions
InstitutionBedford VA - Edith Nourse Rogers Memorial VA Hosp

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim Y, Lee J, Ryu H. Modulation of autophagy by miRNAs. BMB Rep. 2015 Jul; 48(7):371-2. PMID: 26129673.
    View in: PubMed
  2. Kim Y, Kang YS, Lee NY, Kim KY, Hwang YJ, Kim HW, Rhyu IJ, Her S, Jung MK, Kim S, Lee CJ, Ko S, Kowall NW, Lee SB, Lee J, Ryu H. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy. 2015; 11(5):796-811. PMID: 25946189.
    View in: PubMed
  3. Park E, Kim Y, Ryu H, Kowall NW, Lee J, Ryu H. Epigenetic mechanisms of Rubinstein-Taybi syndrome. Neuromolecular Med. 2014 Mar; 16(1):16-24. PMID: 24381114.
    View in: PubMed
  4. Hwang YJ, Han D, Kim KY, Min SJ, Kowall NW, Yang L, Lee J, Kim Y, Ryu H. ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription. Nucleic Acids Res. 2014 Feb; 42(3):1628-43. PMID: 24234436.
    View in: PubMed
  5. Lee J, Hwang YJ, Ryu H, Kowall NW, Ryu H. Nucleolar dysfunction in Huntington's disease. Biochim Biophys Acta. 2014 Jun; 1842(6):785-90. PMID: 24184605.
    View in: PubMed
  6. Lee J, Hwang YJ, Kim KY, Kowall NW, Ryu H. Epigenetic mechanisms of neurodegeneration in Huntington's disease. Neurotherapeutics. 2013 Oct; 10(4):664-76. PMID: 24006238.
    View in: PubMed
  7. Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12066-71. PMID: 23818595.
    View in: PubMed
  8. Lee J, Hwang YJ, Shin JY, Lee WC, Wie J, Kim KY, Lee MY, Hwang D, Ratan RR, Pae AN, Kowall NW, So I, Kim JI, Ryu H. Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. Acta Neuropathol. 2013 May; 125(5):727-39. PMID: 23455440.
    View in: PubMed
  9. Jung MK, Kim KY, Lee NY, Kang YS, Hwang YJ, Kim Y, Sung JJ, McKee A, Kowall N, Lee J, Ryu H. Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS. Mol Neurobiol. 2013 Apr; 47(2):699-710. PMID: 23180277.
    View in: PubMed
  10. Jeon GS, Kim KY, Hwang YJ, Jung MK, An S, Ouchi M, Ouchi T, Kowall N, Lee J, Ryu H. Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of ?-H2AX and DNA damage responses in Huntington's disease. Mol Neurobiol. 2012 Jun; 45(3):550-63. PMID: 22580959.
    View in: PubMed
  11. Ryu H, Jeon GS, Cashman NR, Kowall NW, Lee J. Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS. Lab Invest. 2011 Mar; 91(3):342-52. PMID: 21283077.
    View in: PubMed
  12. Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta Neuropathol. 2011 Apr; 121(4):487-98. PMID: 21161248.
    View in: PubMed
  13. Lee J, Ryu H. Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker? BMB Rep. 2010 Oct; 43(10):649-55. PMID: 21034526.
    View in: PubMed
  14. Lee J, Boo JH, Ryu H. The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start? Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1316-23. PMID: 19716395.
    View in: PubMed
  15. Lee J, Ryu H, Kowall NW. Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice. Biochem Biophys Res Commun. 2009 Sep 11; 387(1):202-6. PMID: 19580782.
    View in: PubMed
  16. Lee J, Ryu H, Kowall NW. Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice. Biochem Biophys Res Commun. 2009 Jul 10; 384(4):524-9. PMID: 19427829.
    View in: PubMed
  17. Lee J, Kannagi M, Ferrante RJ, Kowall NW, Ryu H. Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis. FASEB J. 2009 Jun; 23(6):1739-49. PMID: 19179380.
    View in: PubMed
  18. Lee J, Hagerty S, Cormier KA, Kim J, Kung AL, Ferrante RJ, Ryu H. Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation. Hum Mol Genet. 2008 Jun 15; 17(12):1774-82. PMID: 18319327.
    View in: PubMed
  19. Lee J, Kwon JS, Shin YW, Lee KJ, Park S. Visual self-recognition in patients with schizophrenia. Schizophr Res. 2007 Aug; 94(1-3):215-20. PMID: 17507203.
    View in: PubMed
  20. Ryu H, Lee J, Hagerty SW, Soh BY, McAlpin SE, Cormier KA, Smith KM, Ferrante RJ. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19176-81. PMID: 17142323.
    View in: PubMed
  21. Lee J, Kosaras B, Aleyasin H, Han JA, Park DS, Ratan RR, Kowall NW, Ferrante RJ, Lee SW, Ryu H. Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J. 2006 Nov; 20(13):2375-7. PMID: 17012241.
    View in: PubMed
  22. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 9; 280(49):40398-401. PMID: 16207717.
    View in: PubMed
  23. Ryu H, Lee J, Impey S, Ratan RR, Ferrante RJ. Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13915-20. PMID: 16169904.
    View in: PubMed
  24. Ryu H, Smith K, Camelo SI, Carreras I, Lee J, Iglesias AH, Dangond F, Cormier KA, Cudkowicz ME, Brown RH, Ferrante RJ. Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem. 2005 Jun; 93(5):1087-98. PMID: 15934930.
    View in: PubMed
  25. Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, Lamanna JC, Ratan RR. Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem. 2005 Feb 4; 280(5):3996-4003. PMID: 15557337.
    View in: PubMed
  26. Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J, Lu P, Smith K, Browne S, Beal MF, Kristal BS, Stavrovskaya IG, Hewett S, Rubinsztein DC, Langley B, Ratan RR. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci. 2004 Nov 17; 24(46):10335-42. PMID: 15548647.
    View in: PubMed
  27. Ferrante RJ, Kubilus JK, Lee J, Ryu H, Beesen A, Zucker B, Smith K, Kowall NW, Ratan RR, Luthi-Carter R, Hersch SM. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J Neurosci. 2003 Oct 15; 23(28):9418-27. PMID: 14561870.
    View in: PubMed
  28. Ryu H, Lee J, Zaman K, Kubilis J, Ferrante RJ, Ross BD, Neve R, Ratan RR. Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J Neurosci. 2003 May 1; 23(9):3597-606. PMID: 12736330.
    View in: PubMed
  29. Lee J, Ryu H, Ferrante RJ, Morris SM, Ratan RR. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4843-8. PMID: 12655043.
    View in: PubMed
  30. Ryu H, Lee J, Olofsson BA, Mwidau A, Dedeoglu A, Escudero M, Flemington E, Azizkhan-Clifford J, Ferrante RJ, Ratan RR, Deodoglu A. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):4281-6. PMID: 12640146.
    View in: PubMed
  31. Cai D, Deng K, Mellado W, Lee J, Ratan RR, Filbin MT. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron. 2002 Aug 15; 35(4):711-9. PMID: 12194870.
    View in: PubMed
  32. Ratan RR, Ryu H, Lee J, Mwidau A, Neve RL. In vitro model of oxidative stress in cortical neurons. Methods Enzymol. 2002; 352:183-90. PMID: 12125346.
    View in: PubMed
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