Keywords
Last Name

Jiang-Fan Chen, MD, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentNeurology
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 414-1249
ORCID ORCID Icon0000-0003-3582-3448
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
I received my MD training in China and my PhD in Pharmacology from Medical College of Pennsylvania in the USA, as well as postdoctoral training in transgenic mice at SUNY at Stony Brook. During my 8 years at Mass. General Hospital/Harvard Medical School (as postdoctoral fellow, instructor and then assistant professor), I, together with colleagues, generated and characterized adenosine A2A receptor knockout mice, and developed my expertise in adenosine receptor neurobiology. I joined the Dept of Neurology at Boston University School of Medicine in June 2001, and now direct the Molecular Neuropharmacology Lab, investigating the role of adenosine receptors in the development and treatment of neuropsychological disorders such as Parkinson’s disease, stroke, and more recently retinopathy. By coupling genetic knockout models with pharmacological approaches, my work significantly advances our knowledge of A2A receptor action under physiological and pathological conditions, providing support for the use of A2A antagonists as a novel treatment strategy for Parkinson’s disease, and contributes to the understanding of adenosine neurobiology in basal ganglia and neuropsychiatric disorders. I have published >110 papers on adenosine neurobiology in primary neuroscience journals. I have co-chaired several international conferences on “Targeting the adenosine A2A receptor in Parkinson’s disease” (2002 and 2006) and several other international conferences on adenosine biology. Most recently, my lab has made a major effort to generate several novel cell-type specific A2A receptor knockout models and uncover interesting distinct functions of the A2A receptor in various cellular elements. In summary, I have a demonstrated record of successful and productive research in the area of adenosine receptor neurobiology.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chen JF. Adenosine receptor control of cognition in normal and disease. Int Rev Neurobiol. 2014; 119:257-307.
    View in: PubMed
  2. Chen JF, Lee CF, Chern Y. Adenosine receptor neurobiology: overview. Int Rev Neurobiol. 2014; 119:1-49.
    View in: PubMed
  3. Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF. Adenosine A2A Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate Psychostimulant Action and DARPP-32 Phosphorylation. PLoS One. 2013; 8(11):e80902.
    View in: PubMed
  4. Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF. Antagonistic Interaction between Adenosine A2A Receptors and Na+/K+-ATPase-a2 Controlling Glutamate Uptake in Astrocytes. J Neurosci. 2013 Nov 20; 33(47):18492-502.
    View in: PubMed
  5. Su JB, Chen T, Xu F, Wang XQ, Chen JF, Wu G, Jin Y, Wang XH. Glycemic variability in normal glucose regulation subjects with elevated 1-h postload plasma glucose levels. Endocrine. 2014 Jun; 46(2):241-8.
    View in: PubMed
  6. Feng ZH, Li YM, Chen JF, Liu C, Zhao YM. [Maxillofacial surgery instructed by maxillofacial prosthetic restoration]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Sep; 48(9):558-60.
    View in: PubMed
  7. Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR. Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP. Neuropsychopharmacology. 2014 Feb; 39(3):569-78.
    View in: PubMed
  8. Chiu SC, Jhang JS, Chen JF, Fang J, Jian WB. Effects of cross-sectional area on the tunneling-junction array in octahedral PbSe colloidal-nanocrystal solids. Phys Chem Chem Phys. 2013 Oct 14; 15(38):16127-31.
    View in: PubMed
  9. Tung SC, Wang PW, Liu RT, Chen JF, Hsieh CJ, Kuo MC, Yang JW, Lee WC, Cheng MH, Lee TC. Clinical Characteristics of Endogenous Cushing's Syndrome at a Medical Center in Southern Taiwan. Int J Endocrinol. 2013; 2013:685375.
    View in: PubMed
  10. Li M, Chen JF, Wei F. Double intussusceptions with small intestinal adenoma in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013 Nov; 171(1):188-9.
    View in: PubMed
  11. Tao Y, Pan M, Liu S, Fang F, Lu R, Lu C, Zheng M, An J, Xu H, Zhao F, Chen JF, Qu J, Zhou X. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. PLoS One. 2013; 8(8):e71441.
    View in: PubMed
  12. Ning YL, Yang N, Chen X, Xiong RP, Zhang XZ, Li P, Zhao Y, Chen XY, Liu P, Peng Y, Wang ZG, Chen JF, Zhou YG. Adenosine A2A receptor deficiency alleviates blast-induced cognitive dysfunction. J Cereb Blood Flow Metab. 2013 Nov; 33(11):1789-98.
    View in: PubMed
  13. Wu CH, McCloskey EV, Lee JK, Itabashi A, Prince R, Yu W, Li-Yu J, Chionh SB, Zhao Y, Shin CS, Gunawan T, Tsai KS, Chieng PU, Changlai SP, Chan DC, Chen JF, Tanner SB, Hans DB, Kanis JA, Chang YF, Sun ZJ, Yang RS. Consensus of official position of IOF/ISCD FRAX initiatives in Asia-Pacific region. J Clin Densitom. 2014 Jan-Mar; 17(1):150-5.
    View in: PubMed
  14. Luo ZY, Wang YY, Zhao ZS, Li B, Chen JF. The expression of TMPRSS4 and Erk1 correlates with metastasis and poor prognosis in Chinese patients with gastric cancer. PLoS One. 2013; 8(7):e70311.
    View in: PubMed
  15. Chen T, Xu F, Su JB, Wang XQ, Chen JF, Wu G, Jin Y, Wang XH. Glycemic variability in relation to oral disposition index in the subjects with different stages of glucose tolerance. Diabetol Metab Syndr. 2013; 5:38.
    View in: PubMed
  16. Zhang X, Shi HY, Chen JF, Shi D, Lang HW, Wang ZT, Feng L. Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus. Proteome Sci. 2013; 11(1):31.
    View in: PubMed
  17. Ni HF, Chen JF, Zhang MH, Pan MM, Zhang JD, Liu H, Tang RN, Ma KL, Liu BC. FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized rats. Ren Fail. 2013 Aug; 35(7):996-1004.
    View in: PubMed
  18. Augusto E, Matos M, Sévigny J, El-Tayeb A, Bynoe MS, Müller CE, Cunha RA, Chen JF. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci. 2013 Jul 10; 33(28):11390-9.
    View in: PubMed
  19. Mei Y, Ning Y, Cao YJ, Shen J, Pang X, Cui L, Cheng CY, Chen JF. [Evaluation of cucumber'' s chilling tolerance at germination and seedling stages]. Ying Yong Sheng Tai Xue Bao. 2013 Jul; 24(7):1914-22.
    View in: PubMed
  20. Wei CJ, Augusto E, Gomes CA, Singer P, Wang Y, Boison D, Cunha RA, Yee BK, Chen JF. Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain. Biol Psychiatry. 2014 Jun 1; 75(11):855-63.
    View in: PubMed
  21. Chen JJ, Ting CW, Wu YC, Hwang TL, Cheng MJ, Sung PJ, Wang TC, Chen JF. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. Int J Mol Sci. 2013; 14(7):13063-77.
    View in: PubMed
  22. Wang L, Chen WL, Chen JF, Pan CB, Zhao XP. Surgical excision of sialoblastoma in the parotid gland in newborn. Int J Pediatr Otorhinolaryngol. 2013 Aug; 77(8):1268-71.
    View in: PubMed
  23. Liao Y, Chang SH, Miyashita M, Stensel D, Chen JF, Wen LT, Nakamura Y. Associations between health-related physical fitness and obesity in Taiwanese youth. J Sports Sci. 2013 Dec; 31(16):1797-804.
    View in: PubMed
  24. Peng GC, Wang YF, Xiao Y, Chen JF, Yang Y, Ye YL, Sai SQ, Huang JX. [Blood pressure lowering efficacy of telmisartan and amlodipine taking on the morning or at bedtime: ABPM results]. Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Jun; 41(6):484-7.
    View in: PubMed
  25. Liu ZH, Chen JF. Unusual huge erythema annulare centrifugum presentation of second syphilis. QJM. 2014 Mar; 107(3):231-2.
    View in: PubMed
  26. Li C, Wang JX, Le Y, Chen JF. Studies of bicalutamide-excipients interaction by combination of molecular docking and molecular dynamics simulation. Mol Pharm. 2013 Jun 3; 10(6):2362-9.
    View in: PubMed
  27. Jiang H, Gao JR, Chen JF, Ji WB. [Effect of shuganjianpifang on the expression of BCL-2 and BAX in rats livers with hepatic fibrosis]. Zhong Yao Cai. 2013 May; 36(5):776-80.
    View in: PubMed
  28. Pan MM, Zhang MH, Ni HF, Chen JF, Xu M, Phillips AO, Liu BC. Inhibition of TGF-ß1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food Chem Toxicol. 2013 Aug; 58:487-94.
    View in: PubMed
  29. Lazarus M, Chen JF, Urade Y, Huang ZL. Role of the basal ganglia in the control of sleep and wakefulness. Curr Opin Neurobiol. 2013 Oct; 23(5):780-5.
    View in: PubMed
  30. Zhao JX, Zheng YZ, Lu XH, Chen JF, Tao X, Zhou W. Characterizing the role of iodine doping in improving photovoltaic performance of dye-sensitized hierarchically structured ZnO solar cells. Chemphyschem. 2013 Jun 24; 14(9):1977-84.
    View in: PubMed
  31. Chen JF, Lien WC, Huang CY. [Practical strategies to improve communications with school-aged children in the PICU]. Hu Li Za Zhi. 2013 Apr; 60(2):71-8.
    View in: PubMed
  32. Huang WP, Chen JF, Yang JQ, Dong CC, Liang ZX, Chen XG. [Risk factors associated with anastomotic leak in patients with Crohn disease undergoing bowel resections]. Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Apr; 16(4):332-5.
    View in: PubMed
  33. Fu SL, Wang CA, Chen JF. [Optical emission analyses of N2/TMG ECR plasma for deposition of GaN film]. Guang Pu Xue Yu Guang Pu Fen Xi. 2013 Apr; 33(4):1108-11.
    View in: PubMed
  34. Xu H, Zhao FH, Gao XH, Hu SY, Chen JF, Liu ZH, Xu XL, Gao LM, Liu QG, Ma L, Liu YJ, Qiao YL. [Cost-effectiveness analysis on the once-in-a-lifetime cervical cancer screening program for women living in rural and urban areas of China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2013 Apr; 34(4):399-403.
    View in: PubMed
  35. Chen JF, Eltzschig HK, Fredholm BB. Adenosine receptors as drug targets--what are the challenges? Nat Rev Drug Discov. 2013 Apr; 12(4):265-86.
    View in: PubMed
  36. Dai SS, Wang H, Yang N, An JH, Li W, Ning YL, Zhu PF, Chen JF, Zhou YG. Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury. J Exp Med. 2013 Apr 8; 210(4):839-51.
    View in: PubMed
  37. Liu ME, Huang CC, Yang AC, Tu PC, Yeh HL, Hong CJ, Chen JF, Liou YJ, Lin CP, Tsai SJ. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes. PLoS One. 2013; 8(2):e56663.
    View in: PubMed
  38. Wu ZY, Li C, Liang HW, Chen JF, Yu SH. Ultralight, flexible, and fire-resistant carbon nanofiber aerogels from bacterial cellulose. Angew Chem Int Ed Engl. 2013 Mar 4; 52(10):2925-9.
    View in: PubMed
  39. Tao X, Yang YJ, Liu S, Zheng YZ, Fu J, Chen JF. Poly(amidoamine) dendrimer-grafted porous hollow silica nanoparticles for enhanced intracellular photodynamic therapy. Acta Biomater. 2013 May; 9(5):6431-8.
    View in: PubMed
  40. Chia JS, McRae JL, Thomas HE, Fynch S, Elkerbout L, Hill P, Murray-Segal L, Robson SC, Chen JF, d'Apice AJ, Cowan PJ, Dwyer KM. The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice. Diabetes. 2013 Jun; 62(6):2026-35.
    View in: PubMed
  41. Wills AM, Eberly S, Tennis M, Lang AE, Messing S, Togasaki D, Tanner CM, Kamp C, Chen JF, Oakes D, McDermott MP, Schwarzschild MA. Caffeine consumption and risk of dyskinesia in CALM-PD. Mov Disord. 2013 Mar; 28(3):380-3.
    View in: PubMed
  42. Chen CY, Luo CF, Hsu YC, Chen JF, Day YJ. Comparison of the effects of atropine and labetalol on trigeminocardiac reflex-induced hemodynamic alterations during percutaneous microballoon compression of the trigeminal ganglion. Acta Anaesthesiol Taiwan. 2012 Dec; 50(4):153-8.
    View in: PubMed
  43. Chen RC, Yu YT, Su KW, Chen JF, Chen YF. Exploration of water jet generated by Q-switched laser induced water breakdown with different depths beneath a flat free surface. Opt Express. 2013 Jan 14; 21(1):445-53.
    View in: PubMed
  44. Zhang LS, Chen JF, Chen GF, Hu XY, Ding MP. Effects of thioperamide on seizure development and memory impairment induced by pentylenetetrazole-kindling epilepsy in rats. Chin Med J (Engl). 2013 Jan; 126(1):95-100.
    View in: PubMed
  45. Singer P, Wei CJ, Chen JF, Boison D, Yee BK. Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning. Behav Brain Res. 2013 Apr 1; 242:54-61.
    View in: PubMed
  46. Tsai A, Huang CC, Yang AC, Liu ME, Tu PC, Hong CJ, Liou YJ, Chen JF, Lin CP, Tsai SJ. Association of BACE1 Gene Polymorphism with Cerebellar Volume but Not Cognitive Function in Normal Individuals. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):632-7.
    View in: PubMed
  47. Guo W, Kan JT, Cheng ZY, Chen JF, Shen YQ, Xu J, Wu D, Zhu YZ. Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxid Med Cell Longev. 2012; 2012:878052.
    View in: PubMed
  48. Bao SY, Zhang SJ, Lin WJ, Chen JF. [Effect of electroacupuncture on the biochemical indices of bone and bone collagen metabolism and TNF-alpha in osteoporosis model rats without ovaries]. Zhongguo Zhen Jiu. 2012 Dec; 32(12):1108-12.
    View in: PubMed
  49. Lian Q, Wang B, Zhou W, Jin S, Xu L, Huang Q, Lai M, Lu K, Tang L, Zhu H, Lin H, Zhang F, Cao H, Li J, Chen JF, Ge RS. Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats. Neuroscience. 2013 Feb 12; 231:373-83.
    View in: PubMed
  50. Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, Jensen JD, Weng Z, Akbarian S. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol. 2012; 10(11):e1001427.
    View in: PubMed
  51. Chen JF, Ni HF, Pan MM, Liu H, Xu M, Zhang MH, Liu BC. Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats. Am J Physiol Renal Physiol. 2013 Mar 15; 304(6):F676-85.
    View in: PubMed
  52. Chen JF, Chen YF. Dermacase. Can you identify this condition? Lichen amyloidosis. Can Fam Physician. 2012 Nov; 58(11):1233-5.
    View in: PubMed
  53. Jiang YD, Chang CH, Tai TY, Chen JF, Chuang LM. Incidence and prevalence rates of diabetes mellitus in Taiwan: analysis of the 2000-2009 Nationwide Health Insurance database. J Formos Med Assoc. 2012 Nov; 111(11):599-604.
    View in: PubMed
  54. Zhou S, Zhang S, Liu C, Chen JF, Wen J, Loy MM, Wong GK, Du S. Optimal storage and retrieval of single-photon waveforms. Opt Express. 2012 Oct 22; 20(22):24124-31.
    View in: PubMed
  55. Li SL, Zheng QF, Chen JF, Wu N, Yan S, Wang YZ, Lü C, Zhang LJ, Yang Y. [Diagnostic value of enhanced computed tomography plus vascular endothelial growth factor C expression in hilar and mediastinal lymph node metastasis of non-small cell lung cancer]. Zhonghua Yi Xue Za Zhi. 2012 Oct 9; 92(37):2624-7.
    View in: PubMed
  56. Song AM, Hou C, Chen JF, Sun J, Tian T, Li S. [Effect of hypoxia on the expression of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase mRNA in human periodontal ligament fibroblasts in vitro]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2012 Oct; 47(10):599-604.
    View in: PubMed
  57. Duan XJ, Yang LH, Zhang L, Ren FG, Zhang RJ, Chen JF, Qin XY, Liang HZ. [Expressions of Th17 cells and interleukin 17 in patients with primary immune thrombocytopenia and their clinical significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct; 20(5):1154-7.
    View in: PubMed
  58. Chen JF, Yang LH, Chang LX, Feng JJ, Liu JQ. The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia. Hematology. 2012 Sep; 17(5):283-90.
    View in: PubMed
  59. Chen JF, Wang HR, Yang S, Zhao YP, Zhao XH, Chen YC, DU QL, Liu SJ, Shen C, Xu YC. [An association study between transforming growth factor-ß1 receptor 2 gene polymorphisms and essential hypertension]. Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Sep; 46(9):825-30.
    View in: PubMed
  60. Gu XC, Chen JF, Xiao Y, Di P, Xuan HJ, Zhou X, Zhang L, Chen WS. Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza. Plant Cell Rep. 2012 Dec; 31(12):2247-59.
    View in: PubMed
  61. Lin YF, Chiu SC, Wang ST, Fu SK, Chen CH, Xie WJ, Yang SH, Hsu CS, Chen JF, Zhou X, Liu Z, Fang J, Jian WB. Dielectrophoretic placement of quasi-zero-, one-, and two-dimensional nanomaterials into nanogap for electrical characterizations. Electrophoresis. 2012 Aug; 33(16):2475-81.
    View in: PubMed
  62. You H, Hua HY, Chen JF, Zhang Y, Tang F. [Application of SF-36 scale among patients with advanced-schistosomiasis in Jiangsu province]. Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Aug; 33(8):803-7.
    View in: PubMed
  63. Yan MX, Lin RY, Chen JF, Ye F. [Longterm impact on swallowing quality-of-life after partial laryngectomy]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Aug; 47(8):651-6.
    View in: PubMed
  64. Zhao FH, Chen JF, Gao XH, Gao LM, Liu QG, Liu ZH, Xu H, Ma JF, Ma L, Xu XL, Hu SY, Ning Y, Shi JF, Qiao YL. [Effectiveness and health economic analysis of strategies on cervical cancer screening and early diagnosis and treatment]. Zhonghua Zhong Liu Za Zhi. 2012 Aug; 34(8):632-6.
    View in: PubMed
  65. Gong YL, Tao CJ, Hu M, Chen JF, Cao XF, Lv GM, Li P. Expression of lysophosphatidic acid receptors and local invasiveness and metastasis in Chinese pancreatic cancers. Curr Oncol. 2012 Jul; 19(Suppl 2):eS15-21.
    View in: PubMed
  66. Zhang XJ, Xu Z, Gong YL, Tang CJ, Chen JF. Association of TERT rs2736098 polymorphism with cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2012; 13(10):4943-6.
    View in: PubMed
  67. Wei CJ, Singer P, Coelho J, Boison D, Feldon J, Yee BK, Chen JF. Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning. Learn Mem. 2011; 18(7):459-74.
    View in: PubMed
  68. Chen JF, Chern Y. Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies. Handb Exp Pharmacol. 2011; (200):267-310.
    View in: PubMed
  69. Wei CJ, Li W, Chen JF. Normal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies. Biochim Biophys Acta. 2011 May; 1808(5):1358-79.
    View in: PubMed
  70. Chen JF, Yu L, Shen HY, He JC, Wang X, Zheng R. What knock-out animals tell us about the effects of caffeine. J Alzheimers Dis. 2010; 20 Suppl 1:S17-24.
    View in: PubMed
  71. Yu L, Coelho JE, Zhang X, Fu Y, Tillman A, Karaoz U, Fredholm BB, Weng Z, Chen JF. Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling. Physiol Genomics. 2009 May 13; 37(3):199-210.
    View in: PubMed
  72. Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. J Neurosci. 2008 Mar 19; 28(12):2970-5.
    View in: PubMed
  73. Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF. Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Ann Neurol. 2008 Mar; 63(3):338-46.
    View in: PubMed
  74. Chen JF, Pedata F. Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors. Curr Pharm Des. 2008; 14(15):1490-9.
    View in: PubMed
  75. Chen JF, Sonsalla PK, Pedata F, Melani A, Domenici MR, Popoli P, Geiger J, Lopes LV, de Mendonça A. Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog Neurobiol. 2007 Dec; 83(5):310-31.
    View in: PubMed
  76. Huang QY, Yu L, Ferrante RJ, Chen JF. Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice. Neurosci Lett. 2007 May 17; 418(2):175-80.
    View in: PubMed
  77. Huang QY, Wei C, Yu L, Coelho JE, Shen HY, Kalda A, Linden J, Chen JF. Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. J Neurosci. 2006 Nov 1; 26(44):11371-8.
    View in: PubMed
  78. Kalda A, Yu L, Oztas E, Chen JF. Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson's disease. J Neurol Sci. 2006 Oct 25; 248(1-2):9-15.
    View in: PubMed
  79. Shen HY, He JC, Wang Y, Huang QY, Chen JF. Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. J Biol Chem. 2005 Dec 2; 280(48):39962-9.
    View in: PubMed
  80. Yu L, Haverty PM, Mariani J, Wang Y, Shen HY, Schwarzschild MA, Weng Z, Chen JF. Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatum. Physiol Genomics. 2005 Sep 21; 23(1):89-102.
    View in: PubMed
  81. Yu L, Huang Z, Mariani J, Wang Y, Moskowitz M, Chen JF. Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury. Nat Med. 2004 Oct; 10(10):1081-7.
    View in: PubMed
  82. Yu L, Frith MC, Suzuki Y, Peterfreund RA, Gearan T, Sugano S, Schwarzschild MA, Weng Z, Fink JS, Chen JF. Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Res. 2004 Mar 12; 1000(1-2):156-73.
    View in: PubMed
  83. Fink JS, Kalda A, Ryu H, Stack EC, Schwarzschild MA, Chen JF, Ferrante RJ. Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage. J Neurochem. 2004 Feb; 88(3):538-44.
    View in: PubMed
  84. Chen JF, Fredduzzi S, Bastia E, Yu L, Moratalla R, Ongini E, Schwarzschild MA. Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease. Neurology. 2003 Dec 9; 61(11 Suppl 6):S74-81.
    View in: PubMed
  85. Chen JF. The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment. Drug News Perspect. 2003 Nov; 16(9):597-604.
    View in: PubMed
  86. Chen JF, Steyn S, Staal R, Petzer JP, Xu K, Van Der Schyf CJ, Castagnoli K, Sonsalla PK, Castagnoli N, Schwarzschild MA. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. J Biol Chem. 2002 Sep 27; 277(39):36040-4.
    View in: PubMed
Jiang-Fan's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department