Profile

MD, Wenzhou Medical University
PhD, Medical College of Pennsylvania
MS, Third Military Medical University (China)




Targeting adenosine A2A receptor in the hippocampal-striatum axis for cognition in AD
04/01/2014 - 03/31/2016 (PI)
Wenzhou Medical University

Cellular Basis for Motor, Anti-dyskinesic and Neuroprotective Benefits of A2AR Antagonists in PD Models
02/14/2001 - 04/30/2014 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS041083-11

Adenosine Hypothesis of Schizophrenia
03/20/2009 - 01/31/2014 (PI)
Legacy Research NIH NIMH
R01MH083973

The Effect of Genetic Deletion of the Adenosine A2A receptor on cognition and survival and their Histochemical correlates in two CHDI-R6/2 Transgenic models
06/01/2011 - 05/31/2012 (PI)
CHDI Foundation, Inc.

Dissecting Cellualr Mechanisms Underlying Adenosine A2A Receptor Antagonist-Mediated Motor and Neuroprotective Benefits
06/01/2008 - 05/31/2009 (PI)
CHDI Foundation, Inc.




Yr Title Project-Sub Proj Pubs
2013 Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece 5R01NS041083-11 36
2012 Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece 5R01NS041083-10 36
2011 Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece 5R01NS041083-09 36
2010 Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece 5R01NS041083-08 36
2009 A1/A2A Receptors and Caffeine Psychostimulation 5R01NS048995-05 19
2009 Cellular basis of motor, anti-dyskinesic and neuroprotective benefits of A2A rece 2R01NS041083-07A2 36
2008 A1/A2A Receptors and Caffeine Psychostimulation 5R01NS048995-04 19
2008 Bioinformatics &identification of cis elements for dopamine gene expression 5R01DA019362-05 10
2007 A1/A2A Receptors and Caffeine Psychostimulation 5R01NS048995-03 19
2007 Bioinformatics &identification of cis elements for dopamine gene expression 5R01DA019362-04 10
Showing 10 of 25 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One. 2015; 10(12):e0143563.View Related Profiles. PMID: 26636579; PMCID: PMC4670106; DOI: 10.1371/journal.pone.0143563;.
  2. Shang P, He ZY, Chen JF, Huang SY, Liu BH, Liu HX, Wang XT. Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension Through RhoA/ROCK Signaling Pathway in Mice. J Cardiovasc Pharmacol. 2015 Dec; 66(6):569-75. PMID: 26647014; DOI: 10.1097/FJC.0000000000000305;.
  3. Li W, Silva HB, Real J, Wang YM, Rial D, Li P, Payen MP, Zhou Y, Muller CE, Tomé AR, Cunha RA, Chen JF. Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington''s disease models. Neurobiol Dis. 2015 Jul; 79:70-80.View Related Profiles. PMID: 25892655; DOI: 10.1016/j.nbd.2015.03.030;.
  4. Hoss AG, Labadorf A, Latourelle JC, Kartha VK, Hadzi TC, Gusella JF, MacDonald ME, Chen JF, Akbarian S, Weng Z, Vonsattel JP, Myers RH. miR-10b-5p expression in Huntington''s disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics. 2015; 8:10.View Related Profiles. PMID: 25889241; PMCID: PMC4349621; DOI: 10.1186/s12920-015-0083-3;.
  5. Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF. Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. Biol Psychiatry. 2015 Dec 1; 78(11):763-74. PMID: 25869810; PMCID: PMC4714966; DOI: 10.1016/j.biopsych.2015.02.026;.
  6. Chen JF, Lee CF, Chern Y. Adenosine receptor neurobiology: overview. Int Rev Neurobiol. 2014; 119:1-49. PMID: 25175959; DOI: 10.1016/B978-0-12-801022-8.00001-5;.
  7. Chen JF. Adenosine receptor control of cognition in normal and disease. Int Rev Neurobiol. 2014; 119:257-307. PMID: 25175970; DOI: 10.1016/B978-0-12-801022-8.00012-X;.
  8. Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF. Adenosine A2A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. PLoS One. 2013; 8(11):e80902. PMID: 24312250; PMCID: PMC3842921; DOI: 10.1371/journal.pone.0080902;.
  9. Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-a2 controlling glutamate uptake in astrocytes. J Neurosci. 2013 Nov 20; 33(47):18492-502. PMID: 24259572; PMCID: PMC3834055; DOI: 10.1523/JNEUROSCI.1828-13.2013;.
  10. Su JB, Chen T, Xu F, Wang XQ, Chen JF, Wu G, Jin Y, Wang XH. Glycemic variability in normal glucose regulation subjects with elevated 1-h postload plasma glucose levels. Endocrine. 2014 Jun; 46(2):241-8. PMID: 24030695; DOI: 10.1007/s12020-013-0047-3;.
Showing 10 of 91 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.


Contact for Mentoring: