Hoon Ryu, PhD
Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Chonbuk National University
MS, Chonbuk National University




Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation




Yr Title Project-Sub Proj Pubs
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 8
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 8
2015 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-05 27
2014 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-04 27
2013 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-03 27
2012 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-02 27
2011 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 1R01NS067283-01A1 27
2009 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-05 15
2008 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-04 15
2007 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-03 15
Showing 10 of 12 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chen S, Yu C, Rong L, Li CH, Qin X, Ryu H, Park H. Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington's Disease. Front Mol Neurosci. 2018; 11:478. PMID: 30618623.
     
  2. Lee J, Nguyen PT, Shim HS, Hyeon SJ, Im H, Choi MH, Chung S, Kowall NW, Lee SB, Ryu H. EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 01; 1865(7):1938-1945.View Related Profiles. PMID: 30481590.
     
  3. Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD. Brain injury induces HIF-1a-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018 Nov 12; 9(11):1125. PMID: 30420654.
     
  4. Chun H, An H, Lim J, Woo J, Lee J, Ryu H, Lee CJ. Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus. Exp Neurobiol. 2018 Jun; 27(3):155-170. PMID: 30022867.
     
  5. Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H. Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice. Exp Neurobiol. 2018 Apr; 27(2):103-111.View Related Profiles. PMID: 29731676.
     
  6. Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun. 2018 04 16; 9(1):1479. PMID: 29662056.
     
  7. Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J. Corrigendum: Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. Front Behav Neurosci. 2017; 11:242. PMID: 29242712.
     
  8. Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 02; 17(1).View Related Profiles. PMID: 29130578.
     
  9. Li C, Choi HP, Wang X, Wu F, Chen X, Lü X, Jing R, Ryu H, Wang X, Azadzoi KM, Yang JH. Post-Translational Modification of Human Histone by Wide Tolerance of Acetylation. Cells. 2017 Oct 12; 6(4).View Related Profiles. PMID: 29023412.
     
  10. Park I, Hwang YJ, Kim T, Viswanath ANI, Londhe AM, Jung SY, Sim KM, Min SJ, Lee JE, Seong J, Kim YK, No KT, Ryu H, Pae AN. In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level. J Comput Aided Mol Des. 2017 Oct; 31(10):877-889. PMID: 28879500.
     
Showing 10 of 113 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 113 publications over 27 distinct years, with a maximum of 11 publications in 2005

YearPublications
19882
19893
19911
19922
19931
19943
19952
19972
19991
20003
20023
20039
20049
200511
20064
20073
20084
20096
20104
20113
20123
20135
20143
20156
20166
20178
20186

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