Hoon Ryu, PhD
Adjunct Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, Chonbuk National University
MS, Chonbuk National University
BS, Chonbuk National University



Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Chobanian and Avedisian School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Personnel Agreement for Research Aervices of Hoon Ryu
02/01/2011 - 09/14/2014 (Sub-Project Level Key Person)
PI: Neil W. Kowall, MD
VA Boston Healthcare System


Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation



Title
Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease (HD)
(PI)


Yr Title Project-Sub Proj Pubs
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 15
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 15
2015 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-05 29
2014 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-04 29
2013 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-03 29
2012 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-02 29
2011 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 1R01NS067283-01A1 29
2009 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-05 15
2008 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-04 15
2007 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-03 15
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Nam G, Yeon HR, Park HB, Chang H, Kim JH, Cho BK, Jung H, Yi EC, Kim S, An JY, Lee JE, Lee Y, Lee S, Lim H, Shon WJ, Hwang EM, Ryu H, Chang J, Choi K, Choi EY. CD99-mediated immunological synapse formation potentiates CAR-T cell function. Nat Commun. 2025 Aug 27; 16(1):7987. PMID: 40866332; PMCID: PMC12391334; DOI: 10.1038/s41467-025-63184-w;
     
  2. Won W, Lee EH, Gotina L, Chun H, Lee JH, Bhalla M, Park U, Kim D, Kim TY, Choi JW, Kim Y, Park SJ, Lim J, Park JH, Kim HJ, Heo JY, Chung W, Oh MJ, An HJ, Lee J, Oh SJ, Ryu H, Pae AN, Park KD, Lee CJ. Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases. Signal Transduct Target Ther. 2025 Aug 22; 10(1):270.View Related Profiles. PMID: 40846833; PMCID: PMC12373846; DOI: 10.1038/s41392-025-02366-w;
     
  3. Yoon S, Won W, Lee S, Han K, Ha E, Lee J, Hyeon SJ, Joo Y, Hong H, Lee H, Song Y, Park KD, Huber BR, Lee J, Edden RAE, Suh M, Ryu H, Lee CJ, Lyoo IK. Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder. Signal Transduct Target Ther. 2025 Jul 28; 10(1):240.View Related Profiles. PMID: 40717119; PMCID: PMC12301456; DOI: 10.1038/s41392-025-02317-5;
     
  4. Lee JG, Lee EJ, Ryu H, Lee JS. Valosin-containing protein, neural proteopathies, and implications for neural regeneration. Neural Regen Res. 2025 Jul 05. PMID: 40618267
     
  5. Ryu H, Cho KW, Ryu J. On the feasibility of a quantum sensing protocol designed with electrically controlled spins in silicon quantum dots. RSC Adv. 2025 Apr 16; 15(16):12067-12075. PMID: 40248232; PMCID: PMC12004227; DOI: 10.1039/d5ra01109d;
     
  6. Yousefian-Jazi A, Kim S, Chu J, Choi SH, Nguyen PTT, Park U, Kim MG, Hwang H, Lee K, Kim Y, Hyeon SJ, Rhim H, Ryu HL, Lim G, Stein TD, Lim K, Ryu H, Lee J. Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice. Mol Neurodegener. 2025 Feb 07; 20(1):16.View Related Profiles. PMID: 39920775; PMCID: PMC11806887; DOI: 10.1186/s13024-024-00792-y;
     
  7. Afridi R, Bhusal A, Lee SE, Hwang EM, Ryu H, Kim JH, Suk K. A microglial kinase ITK mediating neuroinflammation and behavioral deficits in traumatic brain injury. Mol Cell Neurosci. 2025 Mar; 132:103994. PMID: 39864680
     
  8. Bhalla M, Joo J, Kim D, Shin JI, Park YM, Ju YH, Park U, Yoo S, Hyeon SJ, Lee H, Lee J, Ryu H, Lee CJ. SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer's disease. Mol Neurodegener. 2025 Jan 15; 20(1):6.View Related Profiles. PMID: 39815261; PMCID: PMC11734448; DOI: 10.1186/s13024-024-00788-8;
     
  9. Kim JH, Jeong HG, Hyeon SJ, Park U, Oh WJ, Hwang J, Lim HH, Ko PW, Lee HW, Lee WH, Ryu H, Suk K. Crosstalk between lipocalin-2 and IL-6 in traumatic brain injury: Closely related biomarkers. Exp Neurol. 2025 Mar; 385:115092. PMID: 39637963
     
  10. Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24; 148(1):46.View Related Profiles. PMID: 39316141; PMCID: PMC11422276; DOI: 10.1007/s00401-024-02804-z;
     
Showing 10 of 184 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 184 publications over 34 distinct years, with a maximum of 15 publications in 2022

YearPublications
19882
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19952
19972
19991
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20039
20049
200511
20064
20073
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20178
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202012
202113
202215
20235
202412
20258


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