Hoon Ryu, PhD
Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Chonbuk National University
MS, Chonbuk National University

Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

VA Boston Healthcare System

Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chun H, An H, Lim J, Woo J, Lee J, Ryu H, Lee CJ. Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus. Exp Neurobiol. 2018 Jun; 27(3):155-170. PMID: 30022867.
  2. Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H. Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice. Exp Neurobiol. 2018 Apr; 27(2):103-111. PMID: 29731676.
  3. Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun. 2018 Apr 16; 9(1):1479. PMID: 29662056.
  4. Jang JY, Shim H, Kwon HY, Chung H, Jung PY, Kim S, Ryu H, Bae KS. Improvement of outcomes in patients with pelvic fractures and hemodynamic instability after the establishment of a Korean regional trauma center. Eur J Trauma Emerg Surg. 2017 Dec 27. PMID: 29282484.
  5. Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J. Corrigendum: Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. Front Behav Neurosci. 2017; 11:242. PMID: 29242712.
  6. Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 Feb; 17(1).View Related Profiles. PMID: 29130578.
  7. Li C, Choi HP, Wang X, Wu F, Chen X, Lü X, Jing R, Ryu H, Wang X, Azadzoi KM, Yang JH. Post-Translational Modification of Human Histone by Wide Tolerance of Acetylation. Cells. 2017 Oct 12; 6(4).View Related Profiles. PMID: 29023412.
  8. Park I, Hwang YJ, Kim T, Viswanath ANI, Londhe AM, Jung SY, Sim KM, Min SJ, Lee JE, Seong J, Kim YK, No KT, Ryu H, Pae AN. In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level. J Comput Aided Mol Des. 2017 Oct; 31(10):877-889. PMID: 28879500.
  9. Park KS, Kim MK, Seo Y, Ha T, Yoo K, Hyeon SJ, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Difluoroboron ß-Diketonate Probe Shows "Turn-on" Near-Infrared Fluorescence Specific for Tau Fibrils. ACS Chem Neurosci. 2017 Oct 18; 8(10):2124-2131. PMID: 28737890.
  10. Lee J, Hwang YJ, Kim Y, Lee MY, Hyeon SJ, Lee S, Kim DH, Jang SJ, Im H, Min SJ, Choo H, Pae AN, Kim DJ, Cho KS, Kowall NW, Ryu H. Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington's disease. Acta Neuropathol. 2017 Nov; 134(5):729-748.View Related Profiles. PMID: 28593442.
Showing 10 of 121 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 121 publications over 27 distinct years, with a maximum of 11 publications in 2005


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