Hoon Ryu, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Chonbuk National University
MS, Chonbuk National University




Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation



Title
Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease (HD)


Yr Title Project-Sub Proj Pubs
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 15
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 15
2015 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-05 29
2014 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-04 29
2013 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-03 29
2012 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-02 29
2011 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 1R01NS067283-01A1 29
2009 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-05 15
2008 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-04 15
2007 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-03 15
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Yoon Y, Kim S, Seol Y, Im H, Park U, Han HB, Choi JH, Ryu H. Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice. Biomedicines. 2022 Apr 07; 10(4). PMID: 35453615; PMCID: PMC9031269; DOI: 10.3390/biomedicines10040865;
     
  2. Kim JH, Kwon O, Bhusal A, Lee J, Hwang EM, Ryu H, Park JY, Suk K. Neuroinflammation Induced by Transgenic Expression of Lipocalin-2 in Astrocytes. Front Cell Neurosci. 2022; 16:839118. PMID: 35281301; PMCID: PMC8904391; DOI: 10.3389/fncel.2022.839118;
     
  3. Gyawali A, Latif S, Choi SH, Hyeon SJ, Ryu H, Kang YS. Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis. J Biomed Sci. 2022 Jan 10; 29(1):2. PMID: 35012534; PMCID: PMC8744235; DOI: 10.1186/s12929-022-00785-3;
     
  4. Lee S, Kim TK, Choi JE, Choi Y, You M, Ryu J, Chun YL, Ham S, Hyeon SJ, Ryu H, Kim HS, Im HI. Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease. Theranostics. 2022; 12(3):1404-1418. PMID: 35154497; PMCID: PMC8771549; DOI: 10.7150/thno.68439;
     
  5. Hwang YJ, Hyeon SJ, Kim Y, Lim S, Lee MY, Kim J, Londhe AM, Gotina L, Kim Y, Pae AN, Cho YS, Seong J, Seo H, Kim YK, Choo H, Ryu H, Min SJ. Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):856-868. PMID: 33771089; PMCID: PMC8008885; DOI: 10.1080/14756366.2021.1900160;
     
  6. Kim C, Yousefian-Jazi A, Choi SH, Chang I, Lee J, Ryu H. Non-Cell Autonomous and Epigenetic Mechanisms of Huntington's Disease. Int J Mol Sci. 2021 Nov 19; 22(22). PMID: 34830381; PMCID: PMC8617801; DOI: 10.3390/ijms222212499;
     
  7. Koh W, Park M, Chun YE, Lee J, Shim HS, Park MG, Kim S, Sa M, Joo J, Kang H, Oh SJ, Woo J, Chun H, Lee SE, Hong J, Feng J, Li Y, Ryu H, Cho J, Lee CJ. Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus. Biol Psychiatry. 2022 04 15; 91(8):740-752. PMID: 34952697
     
  8. Prasad R, Jung H, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease. Sci Rep. 2021 10 08; 11(1):20075. PMID: 34625606; PMCID: PMC8501037; DOI: 10.1038/s41598-021-99562-9;
     
  9. Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, Song EJ, Ryu H, Yu K. Publisher Correction: UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021 Jul 07; 12(1):4257. PMID: 34234153; PMCID: PMC8263558; DOI: 10.1038/s41467-021-24572-0;
     
  10. Hyeon SJ, Park J, Yoo J, Kim SH, Hwang YJ, Kim SC, Liu T, Shim HS, Kim Y, Cho Y, Woo J, Kim KS, Myers RH, Ryu HL, Kowall NW, Song EJ, Hwang EM, Seo H, Lee J, Ryu H. Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease. Prog Neurobiol. 2021 09; 204:102110.View Related Profiles. PMID: 34166773; PMCID: PMC8364511; DOI: 10.1016/j.pneurobio.2021.102110;
     
Showing 10 of 145 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 145 publications over 31 distinct years, with a maximum of 13 publications in 2021

YearPublications
19882
19893
19911
19922
19931
19943
19952
19972
19991
20003
20023
20039
20049
200511
20064
20073
20084
20096
20104
20113
20123
20135
20143
20156
20166
20178
20186
20193
202012
202113
20224


Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
Contact for Mentoring:

150 S Huntington Avenue
Jamaica Plain MA 02130
Google Map


Ryu's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department