Hoon Ryu, PhD
Adjunct Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, Chonbuk National University
MS, Chonbuk National University
BS, Chonbuk National University



Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Chobanian and Avedisian School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Personnel Agreement for Research Aervices of Hoon Ryu
02/01/2011 - 09/14/2014 (Sub-Project Level Key Person)
PI: Neil W. Kowall, MD
VA Boston Healthcare System


Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation



Title
Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease (HD)
(PI)


Yr Title Project-Sub Proj Pubs
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 15
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 15
2015 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-05 29
2014 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-04 29
2013 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-03 29
2012 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-02 29
2011 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 1R01NS067283-01A1 29
2009 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-05 15
2008 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-04 15
2007 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-03 15
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Yang HL, Park SA, Lee HY, Lee H, Ryu HG, Lee HC, Lee SM, Lee J. Associations of driving pressure and mechanical power with postoperative pulmonary complications in one-lung ventilated surgery. J Clin Anesth. 2025 Sep; 106:111981. PMID: 40876391
     
  2. Lee D, Ryu H. A Variational Quantum Eigensolver Based on the Measurement Scheme Tailored to Multiband Tight-Binding Simulations. J Chem Theory Comput. 2025 Sep 09; 21(17):8434-8445. PMID: 40857661; PMCID: PMC12424172; DOI: 10.1021/acs.jctc.5c00961;
     
  3. Ryu J, Lee J, Ryu H. An approach using geometric diagrams to generic Bell inequalities with multiple observables. Sci Rep. 2025 Aug 24; 15(1):31116. PMID: 40851015; PMCID: PMC12375702; DOI: 10.1038/s41598-025-14814-2;
     
  4. Won W, Lee EH, Gotina L, Chun H, Lee JH, Bhalla M, Park U, Kim D, Kim TY, Choi JW, Kim Y, Park SJ, Lim J, Park JH, Kim HJ, Heo JY, Chung W, Oh MJ, An HJ, Lee J, Oh SJ, Ryu H, Pae AN, Park KD, Lee CJ. Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases. Signal Transduct Target Ther. 2025 Aug 22; 10(1):270.View Related Profiles. PMID: 40846833; PMCID: PMC12373846; DOI: 10.1038/s41392-025-02366-w;
     
  5. Lim L, Kang C, Kim M, Lee J, Lee HY, Oh SY, Ryu HG, Lee H. The effects of restricted visitation on delirium incidence in the intensive care units of a tertiary hospital in South Korea. Acute Crit Care. 2025 Aug; 40(3):452-461. PMID: 40903409; PMCID: PMC12408450; DOI: 10.4266/acc.000500;
     
  6. Kim S, Lee H, Park SA, Yang HL, Ryu HG, Lee HC. Deep Learning-Based Arterial Blood Pressure Waveform Generation Using Photoplethysmography for Non-Invasive Hemodynamic Monitoring. Stud Health Technol Inform. 2025 Aug 07; 329:1916-1917. PMID: 40776294
     
  7. Kim Y, Park M, Lee SM, Ryu HG, Lee HC, Ko T, Shin J, Won SM, Choi SW, Kim YG, Chie EK, Lee J. Optimizing Nursing Data for Al and CDSS: SNOMED CT Mapping Using K-MIMIC. Stud Health Technol Inform. 2025 Aug 07; 329:48-52. PMID: 40775817
     
  8. Yoon S, Won W, Lee S, Han K, Ha E, Lee J, Hyeon SJ, Joo Y, Hong H, Lee H, Song Y, Park KD, Huber BR, Lee J, Edden RAE, Suh M, Ryu H, Lee CJ, Lyoo IK. Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder. Signal Transduct Target Ther. 2025 Jul 28; 10(1):240.View Related Profiles. PMID: 40717119; PMCID: PMC12301456; DOI: 10.1038/s41392-025-02317-5;
     
  9. Lee JG, Lee EJ, Ryu H, Lee JS. Valosin-containing protein, neural proteopathies, and implications for neural regeneration. Neural Regen Res. 2025 Jul 05. PMID: 40618267
     
  10. Ryu H, Cho KW, Ryu J. On the feasibility of a quantum sensing protocol designed with electrically controlled spins in silicon quantum dots. RSC Adv. 2025 Apr 16; 15(16):12067-12075. PMID: 40248232; PMCID: PMC12004227; DOI: 10.1039/d5ra01109d;
     
Showing 10 of 196 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 196 publications over 34 distinct years, with a maximum of 16 publications in 2021

YearPublications
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202014
202116
202215
20236
202412
202513


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