Hoon Ryu, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Chonbuk National University
MS, Chonbuk National University




Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 03/31/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation



Title
Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease (HD)


Yr Title Project-Sub Proj Pubs
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 15
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 15
2015 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-05 29
2014 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-04 29
2013 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-03 29
2012 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-02 29
2011 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 1R01NS067283-01A1 29
2009 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-05 15
2008 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-04 15
2007 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-03 15
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Hwang YJ, Hyeon SJ, Kim Y, Lim S, Lee MY, Kim J, Londhe AM, Gotina L, Kim Y, Pae AN, Cho YS, Seong J, Seo H, Kim YK, Choo H, Ryu H, Min SJ. Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):856-868. PMID: 33771089
     
  2. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, Han J, Jung JH, Lee J, Ryu H, Park JY, Hwang EM, Suk K. Hevin-calcyon interaction promotes synaptic reorganization after brain injury. Cell Death Differ. 2021 Mar 22. PMID: 33753902
     
  3. Kim JH, Afridi R, Han J, Jung HG, Kim SC, Hwang EM, Shim HS, Ryu H, Choe Y, Hoe HS, Suk K. Gamma subunit of complement component 8 is a neuroinflammation inhibitor. Brain. 2021 03 03; 144(2):528-552. PMID: 33382892
     
  4. Woo J, Cho H, Seol Y, Kim SH, Park C, Yousefian-Jazi A, Hyeon SJ, Lee J, Ryu H. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants (Basel). 2021 Feb 03; 10(2). PMID: 33546471
     
  5. Han YM, Kim MS, Jo J, Shin D, Kwon SH, Seo JB, Kang D, Lee BD, Ryu H, Hwang EM, Kim JM, Patel PD, Lyons DM, Schatzberg AF, Her S. Decoding the temporal nature of brain GR activity in the NF?B signal transition leading to depressive-like behavior. Mol Psychiatry. 2021 Jan 22. PMID: 33483691
     
  6. Yousefian-Jazi A, Seol Y, Kim J, Ryu HL, Lee J, Ryu H. Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis. Cells. 2020 12 15; 9(12). PMID: 33333804
     
  7. Seol Y, Ki S, Ryu HL, Chung S, Lee J, Ryu H. How Microglia Manages Non-cell Autonomous Vicious Cycling of Aß Toxicity in the Pathogenesis of AD. Front Mol Neurosci. 2020; 13:593724. PMID: 33328884
     
  8. Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production. Nat Neurosci. 2020 12; 23(12):1555-1566. PMID: 33199896
     
  9. Gyawali A, Gautam S, Hyeon SJ, Ryu H, Kang YS. L-Citrulline Level and Transporter Activity Are Altered in Experimental Models of Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2021 Feb; 58(2):647-657. PMID: 33000451
     
  10. Choi JW, Ju YH, Choi Y, Hyeon SJ, Gadhe CG, Park JH, Kim MS, Baek S, Kim Y, Park KD, Pae AN, Ryu H, Lee CJ, Cho BR. PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates. ACS Chem Neurosci. 2020 06 17; 11(12):1801-1810. PMID: 32421307
     
Showing 10 of 133 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 133 publications over 30 distinct years, with a maximum of 12 publications in 2020

YearPublications
19882
19893
19911
19922
19931
19943
19952
19972
19991
20003
20023
20039
20049
200511
20064
20073
20084
20096
20104
20113
20123
20135
20143
20156
20166
20178
20186
20193
202012
20215


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