Hoon Ryu, PhD
Adjunct Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, Chonbuk National University
MS, Chonbuk National University
BS, Chonbuk National University



Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Chobanian and Avedisian School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System




Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Hoon Ryu, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS067283-05

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01NS067283 01A1

Personnel Agreement for Research Aervices of Hoon Ryu
02/01/2011 - 09/14/2014 (Sub-Project Level Key Person)
PI: Neil W. Kowall, MD
VA Boston Healthcare System


Targeting of BRCA1 in Neuronal DNA Damage Response
06/01/2007 - 08/31/2008 (PI)
Brigham & Women's Hospital NIH NINDS

Anthracycline Therapy in Huntington’s Disease
09/01/2005 - 08/31/2008 (PI)
High Q Foundation

Role of Mitochondrial Protein Kinase A Signaling Pathway to HD
07/01/2004 - 06/30/2005 (PI)
Huntington's Disease Society of America

The Role of Mitochondrial CREB Dysfunction in Huntington’s Disease and Therapeutic Implications
01/01/2004 - 12/31/2004 (PI)
The Hereditary Disease Foundation



Title
Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease (HD)
(PI)



Yr Title Project-Sub Proj Pubs
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 15
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 15
2015 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-05 29
2014 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-04 29
2013 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-03 29
2012 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 5R01NS067283-02 29
2011 Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease 1R01NS067283-01A1 29
2009 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-05 15
2008 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-04 15
2007 Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease 5R01NS052724-03 15
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Oh SY, Woo HY, Lim L, Im H, Lee H, Lee JM, Hong SK, Choi Y, Yi NJ, Lee KW, Suh KS, Ryu HG. Comparison of postoperative ascites replacement strategies on time to first flatus after living donor liver transplantation: Albumin vs. lactated Ringer's solution. Clin Transplant. 2024 Jan; 38(1):e15231. PMID: 38289882
     
  2. Kim D, Ko HY, Chung JI, Park YM, Lee S, Kim SY, Kim J, Chun JH, Han KS, Lee M, Ju YH, Park SJ, Park KD, Nam MH, Kim SH, Shim JK, Park Y, Lim H, Park J, Kim H, Kim S, Park U, Ryu H, Lee SY, Park S, Kang SG, Chang JH, Lee CJ, Yun M. Visualizing Cancer-Originating Acetate Uptake Through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment. Neuro Oncol. 2023 Dec 12. PMID: 38085571
     
  3. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct; 28(10):4485.View Related Profiles. PMID: 37783789
     
  4. Jung JW, Kim H, Park J, Woo J, Jeon E, Lee G, Park M, Kim S, Seo H, Cheon S, Dan K, Lee J, Ryu H, Han D. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Sci Rep. 2023 Sep 14; 13(1):15261. PMID: 37709831; DOI: 10.1038/s41598-023-42161-7;
     
  5. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct; 28(10):4474-4484.View Related Profiles. PMID: 37648779
     
  6. Nam MH, Ko HY, Kim D, Lee S, Park YM, Hyeon SJ, Won W, Chung JI, Kim SY, Jo HH, Oh KT, Han YE, Lee GH, Ju YH, Lee H, Kim H, Heo J, Bhalla M, Kim KJ, Kwon J, Stein TD, Kong M, Lee H, Lee SE, Oh SJ, Chun JH, Park MA, Park KD, Ryu H, Yun M, Lee CJ. Visualizing reactive astrocyte-neuron interaction in Alzheimer's disease using 11C-acetate and 18F-FDG. Brain. 2023 Jul 03; 146(7):2957-2974.View Related Profiles. PMID: 37062541; DOI: 10.1093/brain/awad037;
     
  7. Lim S, Shin S, Sung Y, Lee HE, Kim KH, Song JY, Lee GH, Aziz H, Lukianenko N, Kang DM, Boesen N, Jeong H, Abdildinova A, Lee J, Yu BY, Lim SM, Lee JS, Ryu H, Pae AN, Kim YK. Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice. Exp Mol Med. 2023 Mar; 55(3):612-627. PMID: 36914856; DOI: 10.1038/s12276-023-00959-5;
     
  8. Choi SH, Yousefian-Jazi A, Hyeon SJ, Nguyen PTT, Chu J, Kim S, Kim S, Ryu HL, Kowall NW, Ryu H, Lee J. Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS. J Biomed Sci. 2022 Dec 20; 29(1):106.View Related Profiles. PMID: 36536341; DOI: 10.1186/s12929-022-00890-3;
     
  9. Kim JH, Kang RJ, Hyeon SJ, Ryu H, Joo H, Bu Y, Kim JH, Suk K. Lipocalin-2 Is a Key Regulator of Neuroinflammation in Secondary Traumatic and Ischemic Brain Injury. Neurotherapeutics. 2023 Apr; 20(3):803-821. PMID: 36508119; DOI: 10.1007/s13311-022-01333-5;
     
  10. Kim H, Kim H, Nguyen LT, Ha T, Lim S, Kim K, Kim SH, Han K, Hyeon SJ, Ryu H, Park YS, Kim SH, Kim IB, Hong GS, Lee SE, Choi Y, Cohen LB, Oh U. Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction. Prog Neurobiol. 2022 Dec; 219:102369. PMID: 36330924
     
Showing 10 of 163 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 163 publications over 33 distinct years, with a maximum of 15 publications in 2022

YearPublications
19882
19893
19911
19922
19931
19943
19952
19972
19991
20003
20023
20039
20049
200511
20064
20073
20084
20096
20104
20113
20123
20135
20143
20156
20166
20178
20186
20193
202012
202113
202215
20236
20241


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150 S Huntington Avenue
Jamaica Plain MA 02130
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