Adam Labadorf, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Neurology

PhD, Boston University
MS, Colorado State University
BS, Dickinson College

Pronouns: he/him/his



Adam received his PhD in Bioinformatics from Boston University. His primary research interest is to better understand the genomics characteristics of neurodegeneration in human tissue using bioinformatics and machine learning approaches. His neurodegenerative disease research involves identifying commonalities and differences between different neurodegenerative diseases, with the goal of finding common pathological mechanisms that may lead to novel treatment modalities. He has particular expertise in the analysis of post mortem human brain tissue and cerebrospinal fluid transcriptomes, and has made significant contributions to our understanding of Huntington's, Parkinson's, and Chronic Traumatic Encephalopathy (CTE). He also has methodological interests in metatranscriptomics in contexts ranging from Caribbean coral ecologies to connections between the central nervous system and the human microbiome. In addition to his independent research, he serves as Director of Graduate Studies for the BU Bioinformatics Masters program, as Director of Bioinformatics for the VA PTSD Brain Bank, and is a member of the BU Alzheimer's Disease Research Center and BU CTE Center.


Characterization of the spatial and temporal response to tau in chronic traumatic encephalopathy
12/01/2024 - 11/30/2029 (Multi-PI)
PI: Adam Labadorf, PhD
NIH/National Institute on Aging
1R01AG090553-01

Bioinformatics Services for the VA Brain Bank
01/14/2022 - 01/13/2027 (PI)
Department of Veterans Administration


Personnel Agreement for Research Services of Emily Gott
06/05/2023 - 06/04/2024 (PI)
Bedford VA


Bioinformatics Services for the VA Brain Bank
09/21/2020 - 09/20/2021 (PI)
Department of Veterans Administration




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bellio TA, Krunic A, Campion MS, Dupaguntla R, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppNL-G-F Mice. Aging Cell. 2025 Nov; 24(11):e70148.View Related Profiles. PMID: 41081549; DOI: 10.1111/acel.70148;
     
  2. Krunic A, Bellio TA, Cohen BZ, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Brain DNA Methylation Atlas of AppNL-G-F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline-Induced Resilience. Aging Cell. 2025 Nov; 24(11):e70241.View Related Profiles. PMID: 41081550; DOI: 10.1111/acel.70241;
     
  3. Logue MW, Labadorf A, O'Neill NK, Dickson DW, Dugger BN, Flanagan ME, Frosch MP, Gearing M, Jin LW, Kofler J, Mayeux R, McKee A, Miller CA, Murray ME, Nelson PT, Perrin RJ, Schneider JA, Stein TD, Teich AF, Tobunluepop K, Troncoso JC, Wang SH, Wang Z, Wolozin B, Mez J, Farrer LA. Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. Alzheimers Dement. 2025 Oct; 21(10):e70629.View Related Profiles. PMID: 41059714; PMCID: PMC12505200; DOI: 10.1002/alz.70629;
     
  4. Han X, Zhang Y, Petrosky JN, Bald S, Sherva RM, Labadorf A, Cherry JD, Chung J, Farrell K, Abdolmohammadi B, Durape S, Martin BM, Palmisano JN, Farrell JJ, Alvarez VE, Huber BR, Dwyer B, Daneshvar DH, Dams-O'Connor K, Jun GR, Lunetta KL, Goldstein LE, Katz DI, Cantu RC, Shenton ME, Cummings JL, Reiman EM, Stern RA, Alosco ML, Tripodis Y, Farrer LA, Stein TD, Crary JF, McKee AC, Mez J. A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. Cell Rep Med. 2025 May 20; 6(5):102084.View Related Profiles. PMID: 40239644; PMCID: PMC12147854; DOI: 10.1016/j.xcrm.2025.102084;
     
  5. Dayama G, Gupta S, Connizzo BK, Labadorf AT, Myers RH, Lau NC. Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease. bioRxiv. 2024 Oct 25.View Related Profiles. PMID: 39484439; PMCID: PMC11526979; DOI: 10.1101/2024.10.22.619758;
     
  6. Gallo CM, Kistler SA, Natrakul A, Labadorf AT, Beffert U, Ho A. APOER2 splicing repertoire in Alzheimer's disease: Insights from long-read RNA sequencing. PLoS Genet. 2024 Jul; 20(7):e1011348.View Related Profiles. PMID: 39038048; PMCID: PMC11293713; DOI: 10.1371/journal.pgen.1011348;
     
  7. Wu M, Hanly A, Gibson F, Fisher R, Rogers S, Park K, Zuger A, Kuang K, Kalin JH, Nocco S, Cole M, Xiao A, Agus F, Labadorf A, Beck S, Collard M, Cole PA, Alani RM. The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma. J Clin Invest. 2024 Feb 01; 134(6).View Related Profiles. PMID: 38300709; PMCID: PMC10940100; DOI: 10.1172/JCI171063;
     
  8. Labadorf A, Agus F, Aytan N, Cherry J, Mez J, McKee A, Stein TD. Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain. BMC Med Genomics. 2023 Mar 09; 16(1):49.View Related Profiles. PMID: 36895005; PMCID: PMC9996917; DOI: 10.1186/s12920-023-01471-5;
     
  9. Carrasco Pro S, Hook H, Bray D, Berenzy D, Moyer D, Yin M, Labadorf AT, Tewhey R, Siggers T, Fuxman Bass JI. Widespread perturbation of ETS factor binding sites in cancer. Nat Commun. 2023 Feb 17; 14(1):913.View Related Profiles. PMID: 36808133; PMCID: PMC9938127; DOI: 10.1038/s41467-023-36535-8;
     
  10. Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096.View Related Profiles. PMID: 35663558; PMCID: PMC9160996; DOI: 10.3389/fnins.2022.855096;
     
Showing 10 of 44 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 44 publications over 15 distinct years, with a maximum of 5 publications in 2016

YearPublications
20101
20112
20121
20134
20154
20165
20172
20183
20192
20203
20214
20224
20232
20243
20254


Active disease process in early CTE differs substantially from late-stage disease

News Medical 3/13/2023

This BU Class Aims to Undo a History of Racism in Science and Healthcare

BU Today 12/12/2022

Researchers Uncover Distinct Transcriptional Changes In Brain With Huntington’s Disease

Mental Daily 11/3/2019

Inflammation and Changes in Brain’s Striatum Precede Huntington’s Symptoms, Study Finds

Huntingtons Disease News 10/29/2019
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