Adam Labadorf, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Neurology

PhD, Boston University
MS, Colorado State University
BS, Dickinson College

Pronouns: he/him/his



Adam received his PhD in Bioinformatics from Boston University. His primary research interest is to better understand the genomics characteristics of neurodegeneration in human tissue using bioinformatics and machine learning approaches. His neurodegenerative disease research involves identifying commonalities and differences between different neurodegenerative diseases, with the goal of finding common pathological mechanisms that may lead to novel treatment modalities. He has particular expertise in the analysis of post mortem human brain tissue and cerebrospinal fluid transcriptomes, and has made significant contributions to our understanding of Huntington's, Parkinson's, and Chronic Traumatic Encephalopathy (CTE). He also has methodological interests in metatranscriptomics in contexts ranging from Caribbean coral ecologies to connections between the central nervous system and the human microbiome. In addition to his independent research, he serves as Director of Graduate Studies for the BU Bioinformatics Masters program, as Director of Bioinformatics for the VA PTSD Brain Bank, and is a member of the BU Alzheimer's Disease Research Center and BU CTE Center.


Bioinformatics Services for the VA Brain Bank
01/14/2022 - 01/13/2027 (PI)
Department of Veterans Administration


Personnel Agreement for Research Services of Emily Gott
06/05/2023 - 06/04/2024 (PI)
Bedford VA


Bioinformatics Services for the VA Brain Bank
09/21/2020 - 09/20/2021 (PI)
Department of Veterans Administration




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Gallo CM, Kistler SA, Natrakul A, Labadorf AT, Beffert U, Ho A. APOER2 splicing repertoire in Alzheimer's disease: Insights from long-read RNA sequencing. PLoS Genet. 2024 Jul; 20(7):e1011348.View Related Profiles. PMID: 39038048; PMCID: PMC11293713; DOI: 10.1371/journal.pgen.1011348;
     
  2. Wu M, Hanly A, Gibson F, Fisher R, Rogers S, Park K, Zuger A, Kuang K, Kalin JH, Nocco S, Cole M, Xiao A, Agus F, Labadorf A, Beck S, Collard M, Cole PA, Alani RM. The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma. J Clin Invest. 2024 Feb 01; 134(6).View Related Profiles. PMID: 38300709; PMCID: PMC10940100; DOI: 10.1172/JCI171063;
     
  3. Labadorf A, Agus F, Aytan N, Cherry J, Mez J, McKee A, Stein TD. Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain. BMC Med Genomics. 2023 Mar 09; 16(1):49.View Related Profiles. PMID: 36895005; PMCID: PMC9996917; DOI: 10.1186/s12920-023-01471-5;
     
  4. Carrasco Pro S, Hook H, Bray D, Berenzy D, Moyer D, Yin M, Labadorf AT, Tewhey R, Siggers T, Fuxman Bass JI. Widespread perturbation of ETS factor binding sites in cancer. Nat Commun. 2023 Feb 17; 14(1):913.View Related Profiles. PMID: 36808133; PMCID: PMC9938127; DOI: 10.1038/s41467-023-36535-8;
     
  5. Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096.View Related Profiles. PMID: 35663558; PMCID: PMC9160996; DOI: 10.3389/fnins.2022.855096;
     
  6. Ruan Z, Takamatsu-Yukawa K, Wang Y, Ushman ML, Labadorf AT, Ericsson M, Ikezu S, Ikezu T. Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia. Cell Rep. 2022 May 10; 39(6):110791.View Related Profiles. PMID: 35545052; PMCID: PMC9133589; DOI: 10.1016/j.celrep.2022.110791;
     
  7. Gallo CM, Labadorf AT, Ho A, Beffert U. Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns. Genomics. 2022 Mar; 114(2):110318.View Related Profiles. PMID: 35192893; PMCID: PMC8978334; DOI: 10.1016/j.ygeno.2022.110318;
     
  8. Labadorf A. The National PTSD Brain Bank: Progress, Promise, and Vision. Psychiatry. 2022; 85(2):196-200. PMID: 35588489
     
  9. Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443.View Related Profiles. PMID: 34365507; PMCID: PMC8450105; DOI: 10.1093/nar/gkab647;
     
  10. Logue MW, Zhou Z, Morrison FG, Wolf EJ, Daskalakis NP, Chatzinakos C, Georgiadis F, Labadorf AT, Girgenti MJ, Young KA, Williamson DE, Zhao X, Grenier JG, Huber BR, Miller MW. Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD. Neurobiol Stress. 2021 Nov; 15:100398.View Related Profiles. PMID: 34646915; PMCID: PMC8498459; DOI: 10.1016/j.ynstr.2021.100398;
     
Showing 10 of 39 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 39 publications over 14 distinct years, with a maximum of 5 publications in 2016

YearPublications
20101
20112
20121
20134
20154
20165
20172
20183
20192
20203
20214
20224
20232
20242


Active disease process in early CTE differs substantially from late-stage disease

News Medical 3/13/2023

This BU Class Aims to Undo a History of Racism in Science and Healthcare

BU Today 12/12/2022

Researchers Uncover Distinct Transcriptional Changes In Brain With Huntington’s Disease

Mental Daily 11/3/2019

Inflammation and Changes in Brain’s Striatum Precede Huntington’s Symptoms, Study Finds

Huntingtons Disease News 10/29/2019
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