Keywords
Last Name

Felicia Chen, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-6739
ORCID ORCID Icon0000-0001-6092-1774
Other Positions
TitleCourtesy Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Research Expertise & Professional Interests
Dr. Chen attends on the Pulmonary Consult service and in the Medical Intensive Care Units at Boston Medical Center and Sturdy Memorial Hospital. She is a member of Dr. Wellington V. Cardoso’s lab.

The abnormalities of the developing respiratory system associated with retinoic acid (RA)-deficiency have been known for decades. However, the cellular and molecular events controlled by RA during lung development remain unclear. Dr. Chen’s research focuses on the various RA-dependent signaling mechanisms involved in primary lung bud formation. By using a combination of pharmacologic, genetic, and organ culture approaches, she has demonstrated the critical role of RA in controlling at least three major pathways, Tgf-beta, Wnt, and Fgf, to allow proper formation of the early lung. Currently, she’s investigating the role of retinoic acid in the differentiation of bronchial and vascular smooth muscles during lung development.

Special interests include:
-Mechanisms of primary lung bud induction
-Lung progenitor biology
-Role of retinoic acid in early lung development
-Lung injury and repair

 Self-Described Keywords
  • Embryonic lung development
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.
    View in: PubMed
  2. Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.
    View in: PubMed
  3. Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.
    View in: PubMed
  4. Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.
    View in: PubMed
  5. Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.
    View in: PubMed
  6. Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79. PMID: 17634193.
    View in: PubMed
  7. Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24. PMID: 16427040.
    View in: PubMed
  8. Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23. PMID: 16036130.
    View in: PubMed
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