Brianne Connizzo | Profiles RNS

Brianne K. Connizzo, PhD

Assistant Professor

Boston University College of Engineering

Biomedical Engineering

PhD, University of Pennsylvania

Pronouns: she/her/hers

Websites

	BU College of Engineering
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ORCID : 0000-0002-7818-0537

Dr. Brianne Connizzo is an Assistant Professor in Biomedical Engineering at Boston University. Her postdoctoral studies were completed in the Department of Biological Engineering at the Massachusetts Institute of Technology. Previously, she obtained her Ph.D. in Bioengineering from the University of Pennsylvania and her B.S in Engineering from Smith College. Dr. Connizzo has received numerous awards, most recently the NIH K99/R00 Pathway to Independence Award from the National Institute on Aging.

BU Research

Innate and Hormone-Mediated Sex Differences in Extracellular Matrix Remodeling
08/25/2023 - 07/31/2028 (PI)
NIH/National Institute of General Medical Sciences
5R35GM151127-02

Equipment: MRI: Track 1 Acquisition of an Illumina NextSeq 2000 Sequencing Instrument
09/01/2023 - 08/31/2026 (Multi-PI)
PI: Brianne K. Connizzo, PhD
National Science Foundation
CBET-2320685

Non uniformity in the PDL: structure and function of the dense collar
09/20/2021 - 08/31/2026 (Subcontract PI)
Trustees of Tufts College, Inc NIH NIDCR
5R01DE030128-03

Influence of Sex and Hormone Signaling on Recovery from Exercise
07/01/2023 - 06/30/2025 (PI)
Wu Tsai Human Performance Alliance

Aging and Inflammation in the Etiology of Compression-Induced Tendon Degeneration
07/01/2019 - 12/31/2024 (PI)
NIH/National Institute on Aging
3R00AG063896-05S1

New England Senescence Symposium
07/01/2024 - 09/30/2024 (Subcontract PI)
American Federation for Aging Research Hevolution Fdn

Center for Skeletal Research (Overall Application) - Pilot Awards Subproject Fund
10/01/2021 - 12/31/2023 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIAMS
5P30AR075042-04

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Dayama G, Gupta S, Connizzo BK, Labadorf AT, Myers RH, Lau NC. Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease. bioRxiv. 2024 Oct 25.View Related Profiles.

Labadorf, Adam
Connizzo, Brianne
Lau, Nelson
Myers, Richard

PMID: 39484439; PMCID: PMC11526979; DOI: 10.1101/2024.10.22.619758;

Stowe EJ, Keller MR, Connizzo BK. Cellular senescence impairs tendon extracellular matrix remodeling in response to mechanical unloading. Aging Cell. 2024 Nov; 23(11):e14278. PMID: 39039843; PMCID: PMC11561669; DOI: 10.1111/acel.14278;

Almier N, Leibowitz K, Gower AC, To S, Keller MR, Connizzo BK, Roh DS, Alani RM, Collard M. Targeting the Epigenome Reduces Keloid Fibroblast Cell Proliferation, Migration, and Invasion. J Invest Dermatol. 2025 Feb; 145(2):411-422.e7.View Related Profiles.

Gower, Adam
Connizzo, Brianne
Roh, Daniel
Alani, Rhoda

PMID: 39009280

Aggouras AN, Stowe EJ, Mlawer SJ, Connizzo BK. Aged Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling. J Biomech Eng. 2024 Jul 01; 146(7). PMID: 38584416; PMCID: PMC11080950; DOI: 10.1115/1.4065270;

Aggouras AN, Stowe EJ, Mlawer SJ, Connizzo BK. Aged Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling. bioRxiv. 2024 Jan 30. PMID: 38352312; PMCID: PMC10862756; DOI: 10.1101/2024.01.26.577397;

Mlawer SJ, Frank EH, Connizzo BK. Aged tendons lack adaptive response to acute compressive injury. J Orthop Res. 2024 May; 42(5):973-984. PMID: 38041209; PMCID: PMC11009076; DOI: 10.1002/jor.25752;

Aggouras AN, Connizzo BK. Earlier proteoglycan turnover promotes higher efficiency matrix remodeling in MRL/MpJ tendons. J Orthop Res. 2023 Oct; 41(10):2261-2272. PMID: 36866831; PMCID: PMC10475140; DOI: 10.1002/jor.25542;

Connizzo BK, Sun L, Lacin N, Gendelman A, Solomonov I, Sagi I, Grodzinsky AJ, Naveh GRS. Non-Uniformity in Periodontal Ligament: Mechanics and Matrix Composition. J Dent Res. 2021; 100(2):179- 186.

Siadat SM, Zamboulis DE, Thorpe CT, Ruberti JW, Connizzo BK. Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life. Adv Exp Med Biol. 2021; 1348:45-103. PMID: 34807415

Izu Y, Adams SM, Connizzo BK, Beason DP, Soslowsky LJ, Koch M, Birk DE. Collagen XII Mediated Cellular and Extracellular Mechanisms Regulate Establishment of Tendon Structure and Function. Matrix Biol. 2021; 95:52-67.

Showing 10 of 54 results. Show More

Siadat SM, Zamboulis DE, Thorpe CT, Ruberti JW, Connizzo BK. Adv Exp Med Biol. Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life. 2021; 1348:45-103.

Izu Y, Adams SM, Connizzo BK, Beason DP, Soslowsky LJ, Koch M, Birk DE. Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function. Matrix Biol. 2021 01; 95:52-67. PMID: 33096204; PMCID: PMC7870578; DOI: 10.1016/j.matbio.2020.10.004;

Connizzo BK, Sun L, Lacin N, Gendelman A, Solomonov I, Sagi I, Grodzinsky AJ, Naveh GRS. Nonuniformity in Periodontal Ligament: Mechanics and Matrix Composition. J Dent Res. 2021 02; 100(2):179-186. PMID: 33043806; PMCID: PMC8173347; DOI: 10.1177/0022034520962455;

Connizzo BK, Naveh GRS. In Situ AFM-Based Nanoscale Rheology Reveals Regional Non-Uniformity in Viscoporoelastic Mechanical Behavior of the Murine Periodontal Ligament. J Biomech. 2020; 111:109996.

Connizzo BK, Naveh GRS. In situ AFM-based nanoscale rheology reveals regional non-uniformity in viscoporoelastic mechanical behavior of the murine periodontal ligament. J Biomech. 2020 10 09; 111:109996. PMID: 32861150; PMCID: PMC7654511; DOI: 10.1016/j.jbiomech.2020.109996;

Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ. Age-Associated Changes in the Response of Tendon Explants to Stress Deprivation is Sex-Dependent. Connect Tissue Res. 2020; 61(1):48-62.
Connizzo BK, Grodzinsky AJ. Low-Dose Administration of Dexamethasone is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. J Orthop Res. 2020; 38(1):139-149.

Connizzo BK, Grodzinsky AJ. Lose-Dose Administration of Dexamethasone Is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. J Orthop Res. 2020 01; 38(1):139-149. PMID: 31441099; PMCID: PMC7268908; DOI: 10.1002/jor.24451;

Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ. Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent. Connect Tissue Res. 2020 01; 61(1):48-62. PMID: 31411079; PMCID: PMC6884684; DOI: 10.1080/03008207.2019.1648444;

Connizzo BK, Grodzinsky AJ. Release of Pro-Inflammatory Cytokines from Muscle and Bone Causes Tenocyte Death in a Novel Rotator Cuff In Vitro Explant Culture Model. Connect Tissue Res. 2018; 59(5):423-436.

Connizzo BK, Grodzinsky AJ. Release of pro-inflammatory cytokines from muscle and bone causes tenocyte death in a novel rotator cuff in vitro explant culture model. Connect Tissue Res. 2018 09; 59(5):423-436. PMID: 29447021; PMCID: PMC6240787; DOI: 10.1080/03008207.2018.1439486;

Connizzo BK, Grodzinsky AJ. Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. J Biomech Eng. 2018 05 01; 140(5). PMID: 29238818; PMCID: PMC5816244; DOI: 10.1115/1.4038745;

Connizzo BK, Grodzinsky AJ. Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. J Biomech Eng. 2018; 140(5):0510021-8.
Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Poroviscoelasticity of Biological Connective Tissues at the Nanoscale: Application to Tendon and Skin Biophysics. Acta Biomater. 2018; 70:249-259.

Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics. Acta Biomater. 2018 04 01; 70:249-259.View Related Profiles.

Connizzo, Brianne
Nia, Hadi

PMID: 29425716

Barnum CE, Fey JL, Weiss SN, Barila G, Brown AG, Connizzo BK, Shetye SS, Elovitz MA, Soslowsky LJ. Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy. J Biomech Eng. 2017 Jun 01; 139(6). PMID: 28418563; PMCID: PMC6993786; DOI: 10.1115/1.4036473;

Johnston JM, Connizzo BK, Shetye SS, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and mechanical healing in tendons. J Orthop Res. 2017 12; 35(12):2707-2715. PMID: 28387435; PMCID: PMC5632109; DOI: 10.1002/jor.23571;

Connizzo BK, Grodzinsky AJ. Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology. J Biomech. 2017 03 21; 54:11-18. PMID: 28233551

Barnum CE, Fey JL, Connizzo BK, Shetye SS, Elovitz MA, Soslowsky LJ. Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy. J Biomech Eng. 2017; 139(6).
Johnston JM, Connizzo BK, Shetye SS, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. Collagen V Haploinsufficiency in a Murine Model of Classic Ehlers-Danlos Syndrome is Associated with Deficient Structural and Mechanical Healing in Tendons. J Orthop Res. 2017.

Connizzo BK, Adams SM, Adams TH, Birk DE, Soslowsky LJ. Collagen V expression is crucial in regional development of the supraspinatus tendon. J Orthop Res. 2016 12; 34(12):2154-2161. PMID: 28005290

Connizzo BK, Adams SM, Adams TH, Jawad AF, Birk DE, Soslowsky LJ. Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure-function relationships. J Biomech. 2016 06 14; 49(9):1649-1657. PMID: 27067362

Connizzo BK, Han L, Birk DE, Soslowsky LJ. Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales. Interface Focus. 2016 Feb 06; 6(1):20150043. PMID: 26855746

Connizzo BK, Adams SM, Adams TH, Birk DE, Soslowsky LJ. Collagen V Expression is Crucial for Regional Development of Supraspinatus Tendon. J Orthop Res. 2016; 34(12):2154-2161.
Connizzo BK, Han L, Birk DE, Soslowsky LJ. Collagen V-Heterozygous and -Null Supraspinatus Tendons Exhibit Altered Dynamic Mechanical Behavior at Multiple Hierarchical Scales. Interface Focus. 2016; 6(1):20150043.
Tucker JJ, Riggin CN, Connizzo BK, Mauck RL, Steinberg DR, Kuntz AF, Soslowsky LJ, Bernstein J. Effect of Overuse-Induced Tendinopathy on Tendon Healing in a Rat Supraspinatus Repair Model. J Orthop Res. 2016; 34(1):161-6.
Connizzo BK, Adams SM, Adams TH, Jawad AF, Birk DE, Soslowsky LJ. Multiscale Regression Modeling in Mouse Supraspinatus Tendons Reveals That Dynamic Processes Act as Mediators in Structure-Function Relationships. J Biomech. 2016; S0021-9290:30414-6.

Tucker JJ, Riggin CN, Connizzo BK, Mauck RL, Steinberg DR, Kuntz AF, Soslowsky LJ, Bernstein J. Effect of overuse-induced tendinopathy on tendon healing in a rat supraspinatus repair model. J Orthop Res. 2016 Jan; 34(1):161-6. PMID: 26218457

Ahmadzadeh H, Freedman BR, Connizzo BK, Soslowsky LJ, Shenoy VB. Micromechanical poroelastic finite element and shear-lag models of tendon predict large strain dependent Poisson's ratios and fluid expulsion under tensile loading. Acta Biomater. 2015 Aug; 22:83-91. PMID: 25934322

Connizzo BK, Freedman BR, Fried JH, Sun M, Birk DE, Soslowsky LJ. Regulatory role of collagen V in establishing mechanical properties of tendons and ligaments is tissue dependent. J Orthop Res. 2015 Jun; 33(6):882-8. PMID: 25876927

Sun M, Connizzo BK, Adams SM, Freedman BR, Wenstrup RJ, Soslowsky LJ, Birk DE. Targeted deletion of collagen V in tendons and ligaments results in a classic Ehlers-Danlos syndrome joint phenotype. Am J Pathol. 2015 May; 185(5):1436-47. PMID: 25797646

Connizzo BK, Sarver JJ, Han L, Soslowsky LJ. In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons. J Biomech. 2014 Dec 18; 47(16):3794-8. PMID: 25468300

Connizzo BK, Yannascoli SM, Tucker JJ, Caro AC, Riggin CN, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. The detrimental effects of systemic Ibuprofen delivery on tendon healing are time-dependent. Clin Orthop Relat Res. 2014 Aug; 472(8):2433-9. PMID: 23982408

Connizzo BK, Bhatt PR, Liechty KW, Soslowsky LJ. Diabetes alters mechanical properties and collagen fiber re-alignment in multiple mouse tendons. Ann Biomed Eng. 2014 Sep; 42(9):1880-8. PMID: 24833253

Ahmadzadeh H, Connizzo BK, Freedman BR, Soslowsky LJ, Shenoy VB. Determining the contribution of glycosaminoglycans to tendon mechanical properties with a modified shear-lag model. J Biomech. 2013 Sep 27; 46(14):2497-503. PMID: 23932185

Connizzo BK, Sarver JJ, Birk DE, Soslowsky LJ, Iozzo RV. Effect of age and proteoglycan deficiency on collagen fiber re-alignment and mechanical properties in mouse supraspinatus tendon. J Biomech Eng. 2013 Feb; 135(2):021019. PMID: 23445064

Connizzo BK, Yannascoli SM, Soslowsky LJ. Structure-function relationships of postnatal tendon development: a parallel to healing. Matrix Biol. 2013 Mar 11; 32(2):106-16. PMID: 23357642

Connizzo BK, Yannascoli SM, Soslowsky LJ. Structure-function relationships of postnatal tendon development: A parallel to healing. Matrix Biol. 2013; 32(2):106-16.

Miller KS, Connizzo BK, Feeney E, Soslowsky LJ. Characterizing local collagen fiber re-alignment and crimp behavior throughout mechanical testing in a mature mouse supraspinatus tendon model. J Biomech. 2012 Aug 09; 45(12):2061-5. PMID: 22776688

Miller KS, Connizzo BK, Feeney E, Tucker JJ, Soslowsky LJ. Examining differences in local collagen fiber crimp frequency throughout mechanical testing in a developmental mouse supraspinatus tendon model. J Biomech Eng. 2012 Apr; 134(4):041004. PMID: 22667679

Miller KS, Edelstein L, Connizzo BK, Soslowsky LJ. Effect of preconditioning and stress relaxation on local collagen fiber re-alignment: inhomogeneous properties of rat supraspinatus tendon. J Biomech Eng. 2012 Mar; 134(3):031007. PMID: 22482687

Beason DP, Connizzo BK, Dourte LM, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. Fiber-aligned polymer scaffolds for rotator cuff repair in a rat model. J Shoulder Elbow Surg. 2012 Feb; 21(2):245-50. PMID: 22244068

Miller KS, Connizzo BK, Soslowsky LJ. Collagen fiber re-alignment in a neonatal developmental mouse supraspinatus tendon model. Ann Biomed Eng. 2012 May; 40(5):1102-10. PMID: 22183194

Connizzo BK, Grodzinsky AJ. Tendon Exhibits Complex Poroelastic Behavior at the Nanoscale as Revealed by High-Frequency AFM-Based Rheology. J Biomech. 54:11-18.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 13 distinct years, with a maximum of 7 publications in 2016

Bar chart showing 53 publications over 13 distinct years, with a maximum of 7 publications in 2016

Year	Publications
2011	1
2012	4
2013	4
2014	3
2015	4
2016	7
2017	5
2018	6
2019	2
2020	6
2021	4
2023	2
2024	5

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2020 ORS Annual Meeting 2020: Tendon Section Poster Award

2019 ON/ORS: Education Grant

2019 Experimental Aging Research Participant: NIA Summer Training Program

2018 ORS Annual Meeting 2018: Tendon Section Poster Award

2018 Butler-Williams Scholars Program: Participant

2017 New England Future Faculty Workshop for Women in STEM Fields: Participant

2015 Characterization of Tissue Mechanics, SB3 C 2015: PhD Competition Finalist

2014 University of Pennsylvania Orthopaedic Annual Research Day: Best Poster

2014 Penn Center for Musculoskeletal Disorders Symposium: 2nd Place Biomechanics

2013 University of Pennsylvania Orthopaedic Annual Research Day: Best Poster

2013 Penn Center for Musculoskeletal Disorders Symposium: 2nd Place Biomechanics

2012 Penn Bioengineering Annual Symposium: 2nd Place Poster

2012 ASME SBC: MS Competition Best Paper, Solids, Imaging and Orthopaedics

2012 Penn Center for Musculoskeletal Disorders Symposium: 1st Place Biomechanics

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44 Cummington St, Boston MA 02215
Boston MA 02215
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