Keywords
Last Name

Rhoda Alani, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentDermatology
Address609 Albany St (J Bldg)
Boston MA 02118
Phone(617) 638-5517
ORCID ORCID Icon0000-0003-2741-2665
Other Positions
TitleHerbert Mescon Chair of Dermatology
InstitutionBoston University School of Medicine
DepartmentDermatology

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moriarty WF, Kim E, Gerber SA, Hammers H, Alani RM. Neuropilin-2 promotes melanoma growth and progression in vivo. Melanoma Res. 2016 Aug; 26(4):321-8. PMID: 26881875.
    View in: PubMed
  2. Alani RM, Larson A, Falanga V. Paving a New Path Towards Academic Medicine-A Novel Approach to Graduate Medical Education in the United States. Acad Med. 2016 Aug; 91(8):1039-40. PMID: 27465087.
    View in: PubMed
  3. Zhang C, Barrios MP, Alani RM, Cabodi M, Wong JY. A microfluidic Transwell to study chemotaxis. Exp Cell Res. 2016 Mar 15; 342(2):159-65. PMID: 26988422.
    View in: PubMed
  4. Zhang C, Shenk EM, Blaha LC, Ryu B, Alani RM, Cabodi M, Wong JY. A simple engineered platform reveals different modes of tumor-microenvironmental cell interaction. Biofabrication. 2016 Mar; 8(1):015001. PMID: 26716792.
    View in: PubMed
  5. Rossi M, Tuck J, Kim OJ, Panova I, Symanowski JT, Mahalingam M, Riker AI, Alani RM, Ryu B. Neuropilin-2 gene expression correlates with malignant progression in cutaneous melanoma. Br J Dermatol. 2014 Aug; 171(2):403-8. PMID: 24359286.
    View in: PubMed
  6. Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014 Feb 19; 6(224):224ra24. PMID: 24553385.
    View in: PubMed
  7. Cao J, Wan L, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, Wei W, Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell. 2013 Aug 22; 51(4):409-22. PMID: 23973372.
    View in: PubMed
  8. Howard JD, Moriarty WF, Park J, Riedy K, Panova IP, Chung CH, Suh KY, Levchenko A, Alani RM. Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration. Pigment Cell Melanoma Res. 2013 Sep; 26(5):697-707. PMID: 23773728.
    View in: PubMed
  9. Ryu B, Hwang S, Alani RM. MicroRNAs as an emerging target for melanoma therapy. J Invest Dermatol. 2013 May; 133(5):1137-9. PMID: 23594536.
    View in: PubMed
  10. Yan G, Eller MS, Elm C, Larocca CA, Ryu B, Panova IP, Dancy BM, Bowers EM, Meyers D, Lareau L, Cole PA, Taverna SD, Alani RM. Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol. 2013 Oct; 133(10):2444-52. PMID: 23698071.
    View in: PubMed
  11. Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT. DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis. 2013 Jan; 34(1):86-92. PMID: 23027618.
    View in: PubMed
  12. Jorgensen TJ, Ruczinski I, Yao Shugart Y, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiol. 2012 Oct; 36(5):e288-93. PMID: 22677152.
    View in: PubMed
  13. Ruczinski I, Jorgensen TJ, Shugart YY, Schaad YB, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis. 2012 Sep; 33(9):1692-8. PMID: 22581838.
    View in: PubMed
  14. Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WH, Alani RM, Smith MW, Alberg AJ. A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer. J Invest Dermatol. 2012 May; 132(5):1354-62. PMID: 22336945.
    View in: PubMed
  15. Rushing EC, Stine MJ, Hahn SJ, Shea S, Eller MS, Naif A, Khanna S, Westra WH, Jungbluth AA, Busam KJ, Mahalingam M, Alani RM. Neuropilin-2: a novel biomarker for malignant melanoma? Hum Pathol. 2012 Mar; 43(3):381-9. PMID: 21840568.
    View in: PubMed
  16. Clipp SL, Burke A, Hoffman-Bolton J, Alani R, Liégeois NJ, Alberg AJ. Sun-seeking behavior to increase cutaneous vitamin D synthesis: when prevention messages conflict. Public Health Rep. 2011 Jul-Aug; 126(4):533-9. PMID: 21800747.
    View in: PubMed
  17. Crump NT, Hazzalin CA, Bowers EM, Alani RM, Cole PA, Mahadevan LC. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7814-9. PMID: 21518915.
    View in: PubMed
  18. Zigler M, Villares GJ, Dobroff AS, Wang H, Huang L, Braeuer RR, Kamiya T, Melnikova VO, Song R, Friedman R, Alani RM, Bar-Eli M. Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res. 2011 May 15; 71(10):3494-504. PMID: 21467165.
    View in: PubMed
  19. Ryu B, Moriarty WF, Stine MJ, DeLuca A, Kim DS, Meeker AK, Grills LD, Switzer RA, Eller MS, Alani RM. Global analysis of BRAFV600E target genes in human melanocytes identifies matrix metalloproteinase-1 as a critical mediator of melanoma growth. J Invest Dermatol. 2011 Jul; 131(7):1579-83. PMID: 21451543.
    View in: PubMed
  20. Stine MJ, Wang CJ, Moriarty WF, Ryu B, Cheong R, Westra WH, Levchenko A, Alani RM. Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction. Cancer Res. 2011 Apr 1; 71(7):2433-44. PMID: 21324919.
    View in: PubMed
  21. Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, Marmorstein R, Mahadevan LC, Alani RM, Cole PA. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28; 17(5):471-82. PMID: 20534345.
    View in: PubMed
  22. Bhattacharya R, Kowalski J, Larson AR, Brock M, Alani RM. Id1 promotes tumor cell migration in nonsmall cell lung cancers. J Oncol. 2010; 2010:856105. PMID: 20414347.
    View in: PubMed
  23. Kessides MC, Wheless L, Hoffman-Bolton J, Clipp S, Alani RM, Alberg AJ. Cigarette smoking and malignant melanoma: a case-control study. J Am Acad Dermatol. 2011 Jan; 64(1):84-90. PMID: 20334951.
    View in: PubMed
  24. Silverthorn CF, Alani RM. Glyceraldehyde-3-phosphate dehydrogenase expression is altered by hypoxia in melanoma cells and primary human melanocytes. Melanoma Res. 2010 Feb; 20(1):61-3. PMID: 20051782.
    View in: PubMed
  25. Wheless L, Ruczinski I, Alani RM, Clipp S, Hoffman-Bolton J, Jorgensen TJ, Liégeois NJ, Strickland PT, Alberg AJ. The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2009 Oct; 18(10):2613-9. PMID: 19755654.
    View in: PubMed
  26. Larson AR, Konat E, Alani RM. Melanoma biomarkers: current status and vision for the future. Nat Clin Pract Oncol. 2009 Feb; 6(2):105-17. PMID: 19107110.
    View in: PubMed
  27. Cummings SD, Ryu B, Samuels MA, Yu X, Meeker AK, Healey MA, Alani RM. Id1 delays senescence of primary human melanocytes. Mol Carcinog. 2008 Sep; 47(9):653-9. PMID: 18240291.
    View in: PubMed
  28. Chen J, Ruczinski I, Jorgensen TJ, Yenokyan G, Yao Y, Alani R, Liégeois NJ, Hoffman SC, Hoffman-Bolton J, Strickland PT, Helzlsouer KJ, Alberg AJ. Nonmelanoma skin cancer and risk for subsequent malignancy. J Natl Cancer Inst. 2008 Sep 3; 100(17):1215-22. PMID: 18728282.
    View in: PubMed
  29. DeLuca AM, Srinivas A, Alani RM. BRAF kinase in melanoma development and progression. Expert Rev Mol Med. 2008; 10:e6. PMID: 18279546.
    View in: PubMed
  30. Ryu B, Kim DS, DeLuca AM, Healey MA, Dunlap S, Fackler MJ, Herman J, Alani RM. Id1 expression is transcriptionally regulated in radial growth phase melanomas. Int J Cancer. 2007 Oct 15; 121(8):1705-9. PMID: 17565736.
    View in: PubMed
  31. Ryu B, Kim DS, Deluca AM, Alani RM. Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One. 2007; 2(7):e594. PMID: 17611626.
    View in: PubMed
  32. Fecher LA, Cummings SD, Keefe MJ, Alani RM. Toward a molecular classification of melanoma. J Clin Oncol. 2007 Apr 20; 25(12):1606-20. PMID: 17443002.
    View in: PubMed
  33. Zheng Y, Balasubramanyam K, Cebrat M, Buck D, Guidez F, Zelent A, Alani RM, Cole PA. Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J Am Chem Soc. 2005 Dec 14; 127(49):17182-3. PMID: 16332055.
    View in: PubMed
  34. Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol. 2005 Jul; 25(13):5552-66. PMID: 15964811.
    View in: PubMed
  35. Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL. Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem. 2005 Apr 8; 280(14):13936-43. PMID: 15695519.
    View in: PubMed
  36. Alani RM, Silverthorn CF, Orosz K. Tumor angiogenesis in mice and men. Cancer Biol Ther. 2004 Jun; 3(6):498-500. PMID: 15153806.
    View in: PubMed
  37. Dunlap S, Yu X, Cheng L, Civin CI, Alani RM. High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. J Invest Dermatol. 2004 Feb; 122(2):549-51. PMID: 15009744.
    View in: PubMed
  38. Zheng Y, Thompson PR, Cebrat M, Wang L, Devlin MK, Alani RM, Cole PA. Selective HAT inhibitors as mechanistic tools for protein acetylation. Methods Enzymol. 2004; 376:188-99. PMID: 14975306.
    View in: PubMed
  39. Sikder H, Huso DL, Zhang H, Wang B, Ryu B, Hwang ST, Powell JD, Alani RM. Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors. Cancer Cell. 2003 Oct; 4(4):291-9. PMID: 14585356.
    View in: PubMed
  40. Sikder HA, Devlin MK, Dunlap S, Ryu B, Alani RM. Id proteins in cell growth and tumorigenesis. Cancer Cell. 2003 Jun; 3(6):525-30. PMID: 12842081.
    View in: PubMed
  41. Volpert OV, Alani RM. Wiring the angiogenic switch: Ras, Myc, and Thrombospondin-1. Cancer Cell. 2003 Mar; 3(3):199-200. PMID: 12676576.
    View in: PubMed
  42. Volpert OV, Pili R, Sikder HA, Nelius T, Zaichuk T, Morris C, Shiflett CB, Devlin MK, Conant K, Alani RM. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell. 2002 Dec; 2(6):473-83. PMID: 12498716.
    View in: PubMed
  43. Alani RM, Busam K. Acupuncture granulomas. J Am Acad Dermatol. 2001 Dec; 45(6 Suppl):S225-6. PMID: 11712067.
    View in: PubMed
  44. Polsky D, Young AZ, Busam KJ, Alani RM. The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas. Cancer Res. 2001 Aug 15; 61(16):6008-11. PMID: 11507043.
    View in: PubMed
  45. Alani RM, Young AZ, Shifflett CB. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a. Proc Natl Acad Sci U S A. 2001 Jul 3; 98(14):7812-6. PMID: 11427735.
    View in: PubMed
  46. Alani RM, Hasskarl J, Grace M, Hernandez MC, Israel MA, Münger K. Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9637-41. PMID: 10449746.
    View in: PubMed
  47. Alani RM, Hasskarl J, Münger K. Alterations in cyclin-dependent kinase 2 function during differentiation of primary human keratinocytes. Mol Carcinog. 1998 Dec; 23(4):226-33. PMID: 9869451.
    View in: PubMed
  48. Alani RM, Münger K. Human papillomaviruses and associated malignancies. J Clin Oncol. 1998 Jan; 16(1):330-7. PMID: 9440761.
    View in: PubMed
  49. Jones DL, Alani RM, Münger K. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 1997 Aug 15; 11(16):2101-11. PMID: 9284049.
    View in: PubMed
  50. Oettgen P, Alani RM, Barcinski MA, Brown L, Akbarali Y, Boltax J, Kunsch C, Munger K, Libermann TA. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Mol Cell Biol. 1997 Aug; 17(8):4419-33. PMID: 9234700.
    View in: PubMed
  51. Arbiser JL, Alani R, Flynn E, Wooten V, Byers HR. Effects of thallium ion on cellular components of the skin. J Dermatol. 1997 Mar; 24(3):147-55. PMID: 9114610.
    View in: PubMed
  52. Brown PH, Alani R, Preis LH, Szabo E, Birrer MJ. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene. 1993 Apr; 8(4):877-86. PMID: 8455942.
    View in: PubMed
  53. Birrer MJ, Alani R, Cuttitta F, Preis LH, Sabich AL, Sanders DA, Siegfried JM, Szabo E, Brown PH. Early events in the neoplastic transformation of respiratory epithelium. J Natl Cancer Inst Monogr. 1992; (13):31-7. PMID: 1389694.
    View in: PubMed
  54. Alani R, Brown P, Binétruy B, Dosaka H, Rosenberg RK, Angel P, Karin M, Birrer MJ. The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol Cell Biol. 1991 Dec; 11(12):6286-95. PMID: 1944289.
    View in: PubMed
  55. Konkle BA, Kim S, Iannuzzi MC, Alani R, Collins FS, Ginsburg D. SacI RFLP in the human von Willebrand factor gene. Nucleic Acids Res. 1987 Aug 25; 15(16):6766. PMID: 2888092.
    View in: PubMed
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