Keywords
Last Name

Neil J. Ganem, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-5382
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology

 Awards and Honors

Start-EndDescription
2010Andor “Insight Awards” Imaging Competition: First Place
2009FASEB: Young Investigator Award
2006Geisel School of Medicine at Dartmouth: John W. Strohbehn Medal for Excellence in Biomedical Research
2005Geisel School of Medicine at Dartmouth: E. Lucille Smith Award for Excellence in Biochemistry
2004-2005Norris Cotton Cancer Center: “Best Graduate Student Paper” Award
2004American Society for Cell Biology: Travel Award
2002Albert J. Ryan Predoctoral Fellowship
2000University of New Hampshire: Presidential Scholar Award
 Research Expertise & Professional Interests
Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213. PMID: 27799497.
    View in: PubMed
  2. Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104. PMID: 26582635.
    View in: PubMed
  3. Shenk EM, Ganem NJ. Generation and Purification of Tetraploid Cells. Methods Mol Biol. 2016; 1413:393-401. PMID: 27193862.
    View in: PubMed
  4. Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F. Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes. Environ Mol Mutagen. 2015 Aug; 56(7):563-80. PMID: 25784636.
    View in: PubMed
  5. Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7. PMID: 25593184.
    View in: PubMed
  6. Lim S, Ganem NJ. Tetraploidy and tumor development. Oncotarget. 2014 Nov 30; 5(22):10959-60. PMID: 25526024.
    View in: PubMed
  7. Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell. 2014 Aug 14; 158(4):833-48. PMID: 25126788.
    View in: PubMed
  8. Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol. 2012 Dec 10; 199(6):871-81. PMID: 23229895.
    View in: PubMed
  9. Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Feb 2; 482(7383):53-8. PMID: 22258507.
    View in: PubMed
  10. Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22. PMID: 19704007.
    View in: PubMed
  11. Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009 Jul 9; 460(7252):278-82. PMID: 19506557.
    View in: PubMed
  12. Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 2008 Aug 15; 22(16):2189-203. PMID: 18662975.
    View in: PubMed
  13. Ganem NJ, Pellman D. Limiting the proliferation of polyploid cells. Cell. 2007 Nov 2; 131(3):437-40. PMID: 17981108.
    View in: PubMed
  14. Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol Biol Cell. 2007 Aug; 18(8):2970-9. PMID: 17538014.
    View in: PubMed
  15. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev. 2007 Apr; 17(2):157-62. PMID: 17324569.
    View in: PubMed
  16. Ganem NJ, Compton DA. Functional roles of poleward microtubule flux during mitosis. Cell Cycle. 2006 Mar; 5(5):481-5. PMID: 16552178.
    View in: PubMed
  17. Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis. Mol Pharmacol. 2006 Apr; 69(4):1158-65. PMID: 16407469.
    View in: PubMed
  18. Ganem NJ, Upton K, Compton DA. Efficient mitosis in human cells lacking poleward microtubule flux. Curr Biol. 2005 Oct 25; 15(20):1827-32. PMID: 16243029.
    View in: PubMed
  19. Ganem NJ, Compton DA. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol. 2004 Aug 16; 166(4):473-8. PMID: 15302853.
    View in: PubMed
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