Yan Dai, PhD
|Institution||Boston University School of Medicine|
|Division||Hematology & Medical Oncology|
|Address||72 E. Concord St Instructional (L)|
Boston MA 02118
The research interest of my lab is to uncover novel molecular mechanisms regarding cancer cell growth, migration, and invasion in order to develop new strategies for cancer treatment with particular interests in the role of class III HDAC in cancer development and progression. We employ two experimental systems including cultured primary and cancer cell lines, as well as mice models integrated with a number of epigenetic, molecular, and cell biology approaches to pursue in our studies. The current project in my lab includes: 1) Studying the role of SIRT1 in prostate cancer, lung cancer and breast cancer growth, invasion and metastasis. We have established various xenografts mice models, including prostate cancer and breast cancer orthotopic xenografts mice models, experimental metastatic mice models, and subcutaneous mice models. 2) Elucidating the interaction of SIRT1 and RTK signaling pathway in tumor growth and progression. 3) Studying the transcription regulation of tumor suppressor gene expression by histone deacetylase and chromatin remodeling complex. 4) Screening and developing SIRT1 inhibitors as cancer therapeutics.
- Epigenenic regulation of gene transcription
- Protein acetylation and deacetylation
- Tumor invasion and metastasis
- Orthotopic and metastatic mouse models
- Cell senescence
- Signal transduction
- Prostate, lung and breast cancer
- Sickle cell disease
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