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PhD, University of Dundee

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Pathology and Laboratory Medicine Faculty

Research
Publications

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target	5R01CA229530-05
2023	Pathological Reprogramming of DNA Damage Signaling in Neoplastic Cells	5R01ES029079-05
2022	Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target	5R01CA229530-04
2022	Pathological Reprogramming of DNA Damage Signaling in Neoplastic Cells	5R01ES029079-04
2022	Defining Mechanisms of Pathological Trans-Lesion Synthesis During Carcinogenesis	5R01CA215347-05
2021	Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target	3R01CA229530-03S1
2021	Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target	5R01CA229530-03
2021	Pathological Reprogramming of DNA Damage Signaling in Neoplastic Cells	5R01ES029079-03
2021	Defining Mechanisms of Pathological Trans-Lesion Synthesis During Carcinogenesis	5R01CA215347-04	1
2020	Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target	5R01CA229530-02

Showing 10 of 51 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Cheng Z, DiMichele LA, Rojas M, Vaziri C, Mack CP, Taylor JM. Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.). J Mol Cell Cardiol. 2014 Feb; 67:1-11. PMID: 24342076; DOI: 10.1016/j.yjmcc.2013.12.002;

Bakkenist CJ, Vaziri C. Stoichiometry of ubiquitin-binding proteins directs DSB repair. Cell Cycle. 2013 Dec 15; 12(24):3716-7. PMID: 24189535; PMCID: PMC3905061; DOI: 10.4161/cc.26963;

Durando M, Tateishi S, Vaziri C. A non-catalytic role of DNA polymerase ? in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks. Nucleic Acids Res. 2013 Mar 1; 41(5):3079-93. PMID: 23345618; PMCID: PMC3597682; DOI: 10.1093/nar/gkt016;

Yang Y, Durando M, Smith-Roe SL, Sproul C, Greenwalt AM, Kaufmann W, Oh S, Hendrickson EA, Vaziri C. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Res. 2013 Feb 1; 41(4):2296-312. PMID: 23295675; PMCID: PMC3575850; DOI: 10.1093/nar/gks1325;

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS. Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase ? recruitment to DNA damage sites. J Virol. 2012 Aug; 86(15):8097-106. PMID: 22623772; PMCID: PMC3421674; DOI: 10.1128/JVI.00588-12;

Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C. c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Pol? recruitment to stalled replication forks. Mol Biol Cell. 2012 May; 23(10):1943-54. PMID: 22456510; PMCID: PMC3350557; DOI: 10.1091/mbc.E11-10-0829;

Palle K, Vaziri C. Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. Cell Cycle. 2011 May 15; 10(10):1625-38. PMID: 21478670; PMCID: PMC3127162

Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM. The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. Blood. 2011 May 12; 117(19):5078-87. PMID: 21355096; PMCID: PMC3109534; DOI: 10.1182/blood-2010-10-311761;

Day TA, Sproul C, Cordeiro-Stone M, Vaziri C. Analyzing DNA replication dynamics of genotoxin-treated cells using velocity sedimentation. Methods Mol Biol. 2011; 782:159-70. PMID: 21870290; DOI: 10.1007/978-1-61779-273-1_11;

Vaziri C. Linking Cdc7 with the replication checkpoint. Cell Cycle. 2010 Dec 15; 9(24):4787. PMID: 21248484; DOI: 10.4161/cc.9.24.14167;

Showing 10 of 52 results. Show More

Vaziri C, Masai H. Integrating DNA replication with trans-lesion synthesis via Cdc7. Cell Cycle. 2010 Dec 15; 9(24):4818-23. PMID: 21150323

Day TA, Palle K, Barkley LR, Kakusho N, Zou Y, Tateishi S, Verreault A, Masai H, Vaziri C. Phosphorylated Rad18 directs DNA polymerase ? to sites of stalled replication. J Cell Biol. 2010 Nov 29; 191(5):953-66. PMID: 21098111; PMCID: PMC2995173; DOI: 10.1083/jcb.201006043;

Wong PG, Glozak MA, Cao TV, Vaziri C, Seto E, Alexandrow M. Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin. Cell Cycle. 2010 Nov 1; 9(21):4351-63. PMID: 20980834; PMCID: PMC3055186

Song IY, Palle K, Gurkar A, Tateishi S, Kupfer GM, Vaziri C. Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway. J Biol Chem. 2010 Oct 8; 285(41):31525-36. PMID: 20675655; PMCID: PMC2951227; DOI: 10.1074/jbc.M110.138206;

Song IY, Barkley LR, Day TA, Weiss RS, Vaziri C. A novel role for Fanconi anemia (FA) pathway effector protein FANCD2 in cell cycle progression of untransformed primary human cells. Cell Cycle. 2010 Jun 15; 9(12):2375-88. PMID: 20519958

Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010 May; 9(9):1809-18.View Related Profiles.

Spira, Avrum
Anderlind, Christina
Vaziri, Cyrus
Kotton, Darrell
Lu, Jining
Qian, Jun
Wu, Junjie
Cardoso, Wellington

PMID: 20404570

Ohmori H, Hanafusa T, Ohashi E, Vaziri C. Separate roles of structured and unstructured regions of Y-family DNA polymerases. Adv Protein Chem Struct Biol. 2009; 78:99-146. PMID: 20663485; PMCID: PMC3103052; DOI: 10.1016/S1876-1623(08)78004-0;

Day T, Vaziri C. HPV E6 oncoprotein prevents recovery of stalled replication forks independently of p53 degradation. Cell Cycle. 2009 Jul 15; 8(14):2138. PMID: 19587541; PMCID: PMC3095048

Barkley LR, Song IY, Zou Y, Vaziri C. Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle. 2009 May 15; 8(10):1577-88. PMID: 19377277; PMCID: PMC3103051

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24.View Related Profiles.

Spira, Avrum
Vaziri, Cyrus
Schembri, Frank
Liu, Gang
Brody, Jerome
Lu, Jining
Lenburg, Marc
Zhang, Xiaoling

PMID: 19168627; PMCID: PMC2650144; DOI: 10.1073/pnas.0806383106;

Ohashi E, Hanafusa T, Kamei K, Song I, Tomida J, Hashimoto H, Vaziri C, Ohmori H. Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function. Genes Cells. 2009 Feb; 14(2):101-11. PMID: 19170759; PMCID: PMC3103050; DOI: 10.1111/j.1365-2443.2008.01255.x;

Liu P, Slater DM, Lenburg M, Nevis K, Cook JG, Vaziri C. Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells. Cell Cycle. 2009 Jan 1; 8(1):125-36.View Related Profiles.

Vaziri, Cyrus
Lenburg, Marc

PMID: 19106611; PMCID: PMC3032797; DOI: 10.4161/cc.8.1.7528;

Liu P, Pazin DE, Merson RR, Albrecht KH, Vaziri C. The developmentally-regulated Smoc2 gene is repressed by Aryl-hydrocarbon receptor (Ahr) signaling. Gene. 2009 Mar 15; 433(1-2):72-80.View Related Profiles.

Vaziri, Cyrus
Albrecht, Kenneth

PMID: 19146932; PMCID: PMC2652666; DOI: 10.1016/j.gene.2008.12.010;

Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, Vaziri C, Côté J, Panchenko MV. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem. 2008 Oct 24; 283(43):28817-26.View Related Profiles.

Vaziri, Cyrus
Cohen, Herbert
Panchenko, Maria
Chitalia, Vipul

PMID: 18684714; PMCID: PMC2570895; DOI: 10.1074/jbc.M801407200;

Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T. DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex. J Biol Chem. 2008 Apr 4; 283(14):9071-9. PMID: 18245774; PMCID: PMC2431014; DOI: 10.1074/jbc.M709835200;

Liu P, Lu J, Cardoso WV, Vaziri C. The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell. 2008 Jan; 19(1):248-61.View Related Profiles.

Vaziri, Cyrus
Lu, Jining
Cardoso, Wellington

PMID: 17989364; PMCID: PMC2174189; DOI: 10.1091/mbc.E07-05-0510;

Barkley LR, Ohmori H, Vaziri C. Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts. Cell Biochem Biophys. 2007; 47(3):392-408. PMID: 17652783; PMCID: PMC3103048

Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C. The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. J Biol Chem. 2006 Oct 13; 281(41):30631-44. PMID: 16912045

Rocnik EF, Liu P, Sato K, Walsh K, Vaziri C. The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. J Biol Chem. 2006 Aug 11; 281(32):22855-64. PMID: 16774925

Bi X, Barkley LR, Slater DM, Tateishi S, Yamaizumi M, Ohmori H, Vaziri C. Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol Cell Biol. 2006 May; 26(9):3527-40. PMID: 16611994; PMCID: PMC1447421

Bi X, Slater DM, Ohmori H, Vaziri C. DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. J Biol Chem. 2005 Jun 10; 280(23):22343-55. PMID: 15817457

Vaziri C, Saxena S, Jeon Y, Lee C, Murata K, Machida Y, Wagle N, Hwang DS, Dutta A. A p53-dependent checkpoint pathway prevents rereplication. Mol Cell. 2003 Apr; 11(4):997-1008. PMID: 12718885

Weiss RS, Leder P, Vaziri C. Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint. Mol Cell Biol. 2003 Feb; 23(3):791-803. PMID: 12529385; PMCID: PMC140711

Guo N, Faller DV, Vaziri C. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell Growth Differ. 2002 Feb; 13(2):77-86.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 11864911

Zhao X, Demary K, Wong L, Vaziri C, McKenzie AB, Eberlein TJ, Spanjaard RA. Retinoic acid receptor-independent mechanism of apoptosis of melanoma cells by the retinoid CD437 (AHPN). Cell Death Differ. 2001 Sep; 8(9):878-86. PMID: 11526443

Nghiem P, Park PK, Kim Y, Vaziri C, Schreiber SL. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9092-7. PMID: 11481475; PMCID: PMC55378

Hsing A, Faller DV, Vaziri C. DNA-damaging aryl hydrocarbons induce Mdm2 expression via p53-independent post-transcriptional mechanisms. J Biol Chem. 2000 Aug 25; 275(34):26024-31.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 10856296

Denis GV, Vaziri C, Guo N, Faller DV. RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ. 2000 Aug; 11(8):417-24.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas
Denis, Gerald

PMID: 10965846

Guo N, Faller DV, Vaziri C. A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression. J Biol Chem. 2000 Jan 21; 275(3):1715-22.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 10636867

Stice LL, Vaziri C, Faller DV. Regulation of platelet-derived growth factor signaling by activated p21Ras. Front Biosci. 1999 Jan 15; 4:D72-86.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 9889183

Vaziri C, Stice L, Faller DV. Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals. Cell Growth Differ. 1998 Jun; 9(6):465-74.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 9663465

Vaziri C, Faller DV. A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. J Biol Chem. 1997 Jan 31; 272(5):2762-9.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 9006915

Vaziri C, Schneider A, Sherr DH, Faller DV. Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in murine 3T3 fibroblasts. J Biol Chem. 1996 Oct 18; 271(42):25921-7.View Related Profiles.

Vaziri, Cyrus
Sherr, David
Faller, Douglas

PMID: 8824226

Vaziri C, Faller DV. Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 pre-adipocyte fibroblasts. J Biol Chem. 1996 Jun 7; 271(23):13642-8.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 8662875

Vaziri C, Faller DV. Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts. Mol Cell Biol. 1995 Mar; 15(3):1244-53.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas

PMID: 7862118; PMCID: PMC230347

James SR, Vaziri C, Walker TR, Milligan G, Downes CP. The turkey erythrocyte beta-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein alpha subunits. Biochem J. 1994 Dec 1; 304 ( Pt 2):359-64. PMID: 7998968; PMCID: PMC1137501

Vaziri C, Downes CP, Macfarlane SC. Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes. Biochem J. 1993 Sep 15; 294 ( Pt 3):793-9. PMID: 8397510; PMCID: PMC1134531

Vaziri C, Downes CP. Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton. J Biol Chem. 1992 Nov 15; 267(32):22973-81. PMID: 1429646

Vaziri C, Downes CP. G-protein-mediated activation of turkey erythrocyte phospholipase C by beta-adrenergic and P2y-purinergic receptors. Biochem J. 1992 Jun 15; 284 ( Pt 3):917-22. PMID: 1352448; PMCID: PMC1132627

McPhee F, Lowe G, Vaziri C, Downes CP. Phosphatidylinositol synthase and phosphatidylinositol/inositol exchange reactions in turkey erythrocyte membranes. Biochem J. 1991 Apr 1; 275 ( Pt 1):187-92. PMID: 1850237; PMCID: PMC1150031

Dugal R, Bertrand M, Vaziri C, Sanchez G, Cooper SF. [A special dimension of the nonmedical use of drugs. I. Effect of drugs on sports performance]. Union Med Can. 1975 Jun; 104(6):944-52. PMID: 1224414

Bertrand M, Dugal R, Vaziri C, Sanchez G, Cooper SF. [A special dimension of the nonmedical use of drugs. II. Systematic approach to the analytical control of doping]. Union Med Can. 1975 Jun; 104(6):952-60. PMID: 1224415

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