Stephen Farmer, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, National Institute for Medical Research (NIMR)



Obesity has now reached pandemic proportions, resulting in dramatic increases in the occurrence of its associated disorders including diabetes and cardiovascular disease. Understanding the processes and metabolic perturbations that contribute to the expansion of adipose depots accompanying obesity is critical for the development of appropriate therapeutics. Expansion of white adipose (WAT) tissue depots particularly the intra-abdominal depots contribute to insulin resistance and inflammation that lead to type 2 diabetes, whereas brown adipose (BAT) resists expansion because it oxidizes lipids and, consequently, it is associated with an healthier phenotype. Our studies are focused on identifying the mechanisms regulating the formation and function of white and brown adipocytes (fat cells) using a variety of experimental approaches including overexpression and knock down of specific nuclear factors that we consider to be likely regulators of these processes in cells in culture as well as in mice. At present our focus is on nuclear factors that modulate the activity of the two principal regulators of adipogenesis (fat cell differentiation) peroxisome proliferator-activated receptor gamma (PPARg) and CCAAT/enhancer binding proteins alpha, beta and delta (C/EBPs). We are particularly interested in identifying the factors regulating commitment of mesenchymal progenitors to the adipogenic lineage and are adopting a variety of approaches to achieve this goal, which includes gene profiling to discover novel regulators as well as investigating the role of selected candidate genes.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center




Healthier White Adipose by recruitment of Beige/Brite Adipocytes
04/16/2014 - 02/28/2018 (PI)
NIH/National Diabetes & Digestive & Kidn
5R01DK102199-04

Enhancing Energy Expending Adipocytes in White Adipose Tissue
04/01/2016 - 03/31/2017 (PI)
NIH/National Diabetes & Digestive & Kidn
4R01DK098830-04

Enhancing Energy Expending Adipocytes in White Adipose Tissue
04/01/2013 - 03/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidn
4R01DK098830-04

Cell Culture Approaches to Generating Brown Adipose Tissue for Autologous
10/03/2011 - 09/14/2014 (PI)
Energesis Pharmaceuticals, Inc DOD Army





Yr Title Project-Sub Proj Pubs
2017 Healthier White Adipose by Recruitment of Beige/Brite Adipocytes 5R01DK102199-04 2
2016 Enhancing Energy Expending Adipocytes in White Adipose Tissue 4R01DK098830-04 3
2015 Healthier White Adipose by Recruitment of Beige/Brite Adipocytes 5R01DK102199-02 2
2015 Enhancing Energy Expending Adipocytes in White Adipose Tissue 5R01DK098830-03 3
2014 Healthier White Adipose by Recruitment of Beige/Brite Adipocytes 1R01DK102199-01 2
2014 Enhancing Energy Expending Adipocytes in White Adipose Tissue 3R01DK098830-02S1 3
2014 Enhancing Energy Expending Adipocytes in White Adipose Tissue 5R01DK098830-02 3
2013 Enhancing Energy Expending Adipocytes in White Adipose Tissue 1R01DK098830-01 3
2011 CONTROL OF ADIPOGENESIS AND ENERGY METABOLISM 5R01DK051586-14 21
2010 HORMONAL SIGNALING AND PREADIPOCYTE DIFFERENTIATION 5R01DK058825-10 2
Showing 10 of 41 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. Cell Metab. 2016 Dec 13; 24(6):835-847.View Related Profiles. PMID: 27974179; DOI: 10.1016/j.cmet.2016.10.005;.
  2. Bian H, Lin JZ, Li C, Farmer SR. Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia. Mol Metab. 2016 Oct; 5(10):970-9.View Related Profiles. PMID: 27689009; DOI: 10.1016/j.molmet.2016.08.012;.
  3. Lin JZ, Farmer SR. LSD1-a pivotal epigenetic regulator of brown and beige fat differentiation and homeostasis. Genes Dev. 2016 Aug 15; 30(16):1793-5. PMID: 27601528; PMCID: PMC5024678; DOI: 10.1101/gad.288720.116;.
  4. Lin JZ, Farmer SR. Morphogenetics in brown, beige and white fat development. Adipocyte. 2016 Apr-Jun; 5(2):130-5. PMID: 27386157; DOI: 10.1080/21623945.2016.1140708;.
  5. Beluzi M, Peres SB, Henriques FS, Sertié RA, Franco FO, Santos KB, Knobl P, Andreotti S, Shida CS, Neves RX, Farmer SR, Seelaender M, Lima FB, Batista ML. Pioglitazone treatment increases survival and prevents body weight loss in tumor-bearing animals: possible anti-cachectic effect. PLoS One. 2015; 10(3):e0122660. PMID: 25807446; PMCID: PMC4373945; DOI: 10.1371/journal.pone.0122660;.
  6. McDonald ME, Li C, Bian H, Smith BD, Layne MD, Farmer SR. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Cell. 2015 Jan 15; 160(1-2):105-18.View Related Profiles. PMID: 25579684; PMCID: PMC4384505; DOI: 10.1016/j.cell.2014.12.005;.
  7. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629; PMCID: PMC3567215; DOI: 10.1038/nm.3056;.
  8. Batista ML, Neves RX, Peres SB, Yamashita AS, Shida CS, Farmer SR, Seelaender M. Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia. J Endocrinol. 2012 Dec; 215(3):363-73. PMID: 23033362; DOI: 10.1530/JOE-12-0307;.
  9. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR, Accili D. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppar?. Cell. 2012 Aug 3; 150(3):620-32. PMID: 22863012; PMCID: PMC3413172; DOI: 10.1016/j.cell.2012.06.027;.
  10. Pino E, Wang H, McDonald ME, Qiang L, Farmer SR. Roles for peroxisome proliferator-activated receptor ? (PPAR?) and PPAR? coactivators 1a and 1ß in regulating response of white and brown adipocytes to hypoxia. J Biol Chem. 2012 May 25; 287(22):18351-8.View Related Profiles. PMID: 22493496; PMCID: PMC3365780; DOI: 10.1074/jbc.M112.350918;.
Showing 10 of 90 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 86 publications over 31 distinct years, with a maximum of 6 publications in 1999

YearPublications
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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