Keywords
Last Name

Yasuo Ido, MD, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7166
ORCID ORCID Icon0000-0002-3036-9971
Other Positions
InstitutionBoston Medical Center

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wu Y, Lee MJ, Ido Y, Fried SK. High fat diet-induced obesity regulates MMP3 to modulate depot- and sex-dependent adipose expansion in C57BL/6J mice. Am J Physiol Endocrinol Metab. 2016 Nov 22; ajpendo.00128.2016. PMID: 27879248.
    View in: PubMed
  2. Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3ß increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Oct; 36(5). PMID: 27534430.
    View in: PubMed
  3. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6. PMID: 27162359.
    View in: PubMed
  4. Ido Y. Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3. J Diabetes Investig. 2016 Jul; 7(4):448-58. PMID: 27181414.
    View in: PubMed
  5. Ido Y, Duranton A, Lan F, Weikel KA, Breton L, Ruderman NB. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. PLoS One. 2015; 10(2):e0115341. PMID: 25647160.
    View in: PubMed
  6. Calamaras TD, Lee C, Lan F, Ido Y, Siwik DA, Colucci WS. The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling. Free Radic Biol Med. 2015 May; 82:137-46. PMID: 25617592.
    View in: PubMed
  7. Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015 Feb 1; 308(3):C249-63. PMID: 25354528.
    View in: PubMed
  8. Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One. 2014; 9(5):e97554. PMID: 24835252.
    View in: PubMed
  9. Grahn TH, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V. Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem. 2014 Apr 25; 289(17):12029-39. PMID: 24627478.
    View in: PubMed
  10. Calamaras TD, Lee C, Lan F, Ido Y, Siwik DA, Colucci WS. Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity. J Biol Chem. 2012 Dec 7; 287(50):42400-6. PMID: 23086944.
    View in: PubMed
  11. Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092. PMID: 22514710.
    View in: PubMed
  12. Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13. PMID: 22378745.
    View in: PubMed
  13. Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y. Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1255-65. PMID: 21724864.
    View in: PubMed
  14. Cacicedo JM, Benjachareonwong S, Chou E, Yagihashi N, Ruderman NB, Ido Y. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3630-9. PMID: 21345991.
    View in: PubMed
  15. Fu D, Wakabayashi Y, Ido Y, Lippincott-Schwartz J, Arias IM. Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1. J Cell Sci. 2010 Oct 1; 123(Pt 19):3294-302. PMID: 20826460.
    View in: PubMed
  16. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E751-60. PMID: 20103737.
    View in: PubMed
  17. Ido Y, Nyengaard JR, Chang K, Tilton RG, Kilo C, Mylari BL, Oates PJ, Williamson JR. Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation. Antioxid Redox Signal. 2010 Jan; 12(1):39-51. PMID: 19624259.
    View in: PubMed
  18. Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene. 2009 May 7; 28(18):1993-2002. PMID: 19347029.
    View in: PubMed
  19. Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41. PMID: 19071085.
    View in: PubMed
  20. Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. 2008 Oct 10; 283(41):27628-35. PMID: 18687677.
    View in: PubMed
  21. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008 Jul 18; 283(29):20015-26. PMID: 18482975.
    View in: PubMed
  22. Ido Y. Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal. 2007 Jul; 9(7):931-42. PMID: 17508915.
    View in: PubMed
  23. Clavreul N, Bachschmid MM, Hou X, Shi C, Idrizovic A, Ido Y, Pimentel D, Cohen RA. S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2454-61. PMID: 16931794.
    View in: PubMed
  24. Pimentel DR, Adachi T, Ido Y, Heibeck T, Jiang B, Lee Y, Melendez JA, Cohen RA, Colucci WS. Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation. J Mol Cell Cardiol. 2006 Oct; 41(4):613-22. PMID: 16806262.
    View in: PubMed
  25. Clavreul N, Adachi T, Pimental DR, Ido Y, Schöneich C, Cohen RA. S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. FASEB J. 2006 Mar; 20(3):518-20. PMID: 16415107.
    View in: PubMed
  26. Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):309-15. PMID: 16126172.
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  27. Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes. 2005 Jun; 54(6):1838-45. PMID: 15919807.
    View in: PubMed
  28. Pennathur S, Ido Y, Heller JI, Byun J, Danda R, Pergola P, Williamson JR, Heinecke JW. Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes. J Biol Chem. 2005 Jun 17; 280(24):22706-14. PMID: 15855169.
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  29. Kuster GM, Pimentel DR, Adachi T, Ido Y, Brenner DA, Cohen RA, Liao R, Siwik DA, Colucci WS. Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation. 2005 Mar 8; 111(9):1192-8. PMID: 15723974.
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  30. Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1204-9. PMID: 15504342.
    View in: PubMed
  31. Ito M, Adachi T, Pimentel DR, Ido Y, Colucci WS. Statins inhibit beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes via a Rac1-dependent mechanism. Circulation. 2004 Jul 27; 110(4):412-8. PMID: 15262848.
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  32. Adachi T, Pimentel DR, Heibeck T, Hou X, Lee YJ, Jiang B, Ido Y, Cohen RA. S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J Biol Chem. 2004 Jul 9; 279(28):29857-62. PMID: 15123696.
    View in: PubMed
  33. Ido Y, Chang K, Williamson JR. NADH augments blood flow in physiologically activated retina and visual cortex. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):653-8. PMID: 14704275.
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  34. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6. PMID: 12546685.
    View in: PubMed
  35. Tomás E, Lin YS, Dagher Z, Saha A, Luo Z, Ido Y, Ruderman NB. Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci. 2002 Jun; 967:43-51. PMID: 12079834.
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  36. Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr. 2002 May; 132(5):904-10. PMID: 11983812.
    View in: PubMed
  37. Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 2002 Jan; 51(1):159-67. PMID: 11756336.
    View in: PubMed
  38. Schmidt RE, Dorsey DA, Beaudet LN, Plurad SB, Parvin CA, Yarasheski KE, Smith SR, Lang HJ, Williamson JR, Ido Y. Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes. J Neuropathol Exp Neurol. 2001 Dec; 60(12):1153-69. PMID: 11764088.
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  39. Misumi S, Takamune N, Ido Y, Hayashi S, Endo M, Mukai R, Tachibana K, Umeda M, Shoji S. Evidence as a HIV-1 self-defense vaccine of cyclic chimeric dodecapeptide warped from undecapeptidyl arch of extracellular loop 2 in both CCR5 and CXCR4. Biochem Biophys Res Commun. 2001 Aug 3; 285(5):1309-16. PMID: 11478800.
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  40. Ido Y, Chang KC, Lejeune WS, Bjercke RJ, Reiser KM, Williamson JR, Tilton RG. Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation. 2001 Aug; 8(4):251-63. PMID: 11528533.
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  41. Dagher Z, Ruderman N, Tornheim K, Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res. 2001 Jun 22; 88(12):1276-82. PMID: 11420304.
    View in: PubMed
  42. Ido Y, Chang K, Woolsey TA, Williamson JR. NADH: sensor of blood flow need in brain, muscle, and other tissues. FASEB J. 2001 Jun; 15(8):1419-21. PMID: 11387243.
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  43. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000 May 26; 275(21):16258-66. PMID: 10748196.
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  44. Dagher Z, Ruderman N, Tornheim K, Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1999 Nov; 265(1):112-5. PMID: 10548499.
    View in: PubMed
  45. Williamson JR, Kilo C, Ido Y. The role of cytosolic reductive stress in oxidant formation and diabetic complications. Diabetes Res Clin Pract. 1999 Sep; 45(2-3):81-2. PMID: 10588358.
    View in: PubMed
  46. Ido Y, Muto N, Inada A, Kohroki J, Mano M, Odani T, Itoh N, Yamamoto K, Tanaka K. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell Prolif. 1999 Feb; 32(1):63-73. PMID: 10371304.
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  47. Schmidt RE, Dorsey DA, Beaudet LN, Plurad SB, Williamson JR, Ido Y. Effect of sorbitol dehydrogenase inhibition on experimental diabetic autonomic neuropathy. J Neuropathol Exp Neurol. 1998 Dec; 57(12):1175-89. PMID: 9862641.
    View in: PubMed
  48. Williamson JR, Ido Y. Understanding retinal cytosolic reductive stress. Invest Ophthalmol Vis Sci. 1998 Jun; 39(7):1295-6. PMID: 9620095.
    View in: PubMed
  49. Ido Y, Vindigni A, Chang K, Stramm L, Chance R, Heath WF, DiMarchi RD, Di Cera E, Williamson JR. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science. 1997 Jul 25; 277(5325):563-6. PMID: 9228006.
    View in: PubMed
  50. Ido Y, Williamson JR. Hyperglycemic cytosolic reductive stress 'pseudohypoxia': implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 1997 Jul; 38(8):1467-70. PMID: 9224273.
    View in: PubMed
  51. Ido Y, Chang K, LeJeune W, Tilton RG, Monafo WW, Williamson JR. Diabetes impairs sciatic nerve hyperemia induced by surgical trauma: implications for diabetic neuropathy. Am J Physiol. 1997 Jul; 273(1 Pt 1):E174-84. PMID: 9252494.
    View in: PubMed
  52. Ido Y, Kilo C, Williamson JR. Cytosolic NADH/NAD+, free radicals, and vascular dysfunction in early diabetes mellitus. Diabetologia. 1997 Jul; 40 Suppl 2:S115-7. PMID: 9248714.
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  53. Chang K, Ido Y, LeJeune W, Williamson JR, Tilton RG. Increased sciatic nerve blood flow in diabetic rats: assessment by "molecular" vs. particulate microspheres. Am J Physiol. 1997 Jul; 273(1 Pt 1):E164-73. PMID: 9252493.
    View in: PubMed
  54. Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, Brock TA, Williamson JR. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest. 1997 May 1; 99(9):2192-202. PMID: 9151791.
    View in: PubMed
  55. Ido Y, Kilo C, Williamson JR. Interactions between the sorbitol pathway, non-enzymatic glycation, and diabetic vascular dysfunction. Nephrol Dial Transplant. 1996; 11 Suppl 5:72-5. PMID: 9044312.
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  56. Tilton RG, Chang K, Nyengaard JR, Van den Enden M, Ido Y, Williamson JR. Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats. Diabetes. 1995 Feb; 44(2):234-42. PMID: 7859946.
    View in: PubMed
  57. Ido Y, McHowat J, Chang KC, Arrigoni-Martelli E, Orfalian Z, Kilo C, Corr PB, Williamson JR. Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine. Diabetes. 1994 Dec; 43(12):1469-77. PMID: 7958501.
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  58. Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T, Nyengaard JR, van den Enden M, Kilo C, Tilton RG. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993 Jun; 42(6):801-13. PMID: 8495803.
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  59. Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR, Williamson JR, McDaniel ML. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes. 1992 Apr; 41(4):552-6. PMID: 1376704.
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  60. Ido Y, Tilton RG, Chang K, Pugliese G, Williamson JR. Rapid measurement of glomerular filtration rate in small animals. Kidney Int. 1992 Feb; 41(2):435-9. PMID: 1552717.
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  61. Yagihashi S, Kamijo M, Ido Y, Mirrlees DJ. Effects of long-term aldose reductase inhibition on development of experimental diabetic neuropathy. Ultrastructural and morphometric studies of sural nerve in streptozocin-induced diabetic rats. Diabetes. 1990 Jun; 39(6):690-6. PMID: 2140802.
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  62. Baba T, Ishizaki T, Ido Y, Aoyagi K, Murabayashi S, Takebe K. Renal effects of nicardipine, a calcium entry blocker, in hypertensive type II diabetic patients with nephropathy. Diabetes. 1986 Nov; 35(11):1206-14. PMID: 3530849.
    View in: PubMed
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