Keywords
Last Name

Stacy Andersen, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGeriatrics
Address72 E. Concord Street
Boston MA 02118
Phone(617) 638-6679
ORCID ORCID Icon0000-0002-2442-6386
 Research Expertise & Professional Interests
Stacy Andersen, PhD has conducted research with the New England Centenarian Study since 2000. Her earlier work involved the investigation of the delay or escape of age-related illnesses and disability in centenarians and their family members. Historically, gerontologists and the lay public assumed that living longer was associated with an increased duration of age-related illnesses. Then, in 1980, Jim Fries proposed his compression of morbidity hypothesis, suggesting that as people live to the limit of human life span, they necessarily postpone or delay age-related diseases towards the end of life. She first investigated this hypothesis in relation to cancer, normally associated with high mortality risk. In this study she documented a 17-year delay in the onset of cancer diagnoses compared with a national cancer database. Much more recently, she published evidence that those truly near the limit of human life span, supercentenarians (age 110+ years), postpone not only morbidity but also functional and cognitive decline. The supercentenarians spend an average of the last 5 years of their lives with one or more age-related diseases whereas younger centenarians spend approximately 9 years with morbidity. These studies demonstrate that extremely long-lived individuals are models for disease-free aging that can help us learn more about health spans and successful aging.

More recently Dr. Andersen has been investigating cognitive function in family members of long-lived individuals in the Long Life Family Study. Analyses of cognitive function in this cohort reveal that family members from the offspring generation perform better on some tests of neuropsychological function than their spouses who do not have familial longevity. In addition, there is familial clustering of exceptional episodic memory performance such that individuals with high-performing family members were more likely to demonstrate better episodic memory than those without high-performing family members. Assessment of more specific deficits in cognitive function consistent with Alzheimer’s disease revealed lower risk of impairment among individuals with familial longevity compared with their spouses. Dr. Andersen’s dissertation research involved an expanded neuropsychological assessment protocol in this cohort. She documented that in spite of average fewer years of education and lower proxies of cognitive reserve, participants with familial longevity performed at the same levels as the referent group. She concluded that individuals with familial longevity may have non-education related advantages that may be conducive to preserved cognitive function. She is now investigating a variety of potential modifiers of cognitive function in this cohort.

 Self-Described Keywords
  • Longevity
  • Cognition
  • Neuropsychological Assessment
  • Dementia
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. J Gerontol A Biol Sci Med Sci. 2017 Mar 15. PMID: 28329165.
    View in: PubMed
  2. Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N. Telomere length is longer in women with late maternal age. Menopause. 2016 Dec 05. PMID: 27922939.
    View in: PubMed
  3. Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, Barzilai N, Milman S. Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity. J Am Geriatr Soc. 2016 Aug; 64(8):1583-91. PMID: 27377170.
    View in: PubMed
  4. Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Viña J, Perls T, Sachdev PS. ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol. 2016 Apr 21; 16:52. PMID: 27098177.
    View in: PubMed
  5. Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Familial Risk for Exceptional Longevity. N Am Actuar J. 2016 Jan 01; 20(1):57-64. PMID: 27041978.
    View in: PubMed
  6. Sebastiani P, Nussbaum L, Andersen SL, Black MJ, Perls TT. Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity". J Gerontol A Biol Sci Med Sci. 2016 Mar; 71(3):340-6. PMID: 25814633.
    View in: PubMed
  7. Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the Long Life Family Study. Aging (Albany NY). 2015 Feb; 7(2):123-32. PMID: 25664523.
    View in: PubMed
  8. Sun F, Sebastiani P, Schupf N, Bae H, Andersen SL, McIntosh A, Abel H, Elo IT, Perls TT. Extended maternal age at birth of last child and women's longevity in the Long Life Family Study. Menopause. 2015 Jan; 22(1):26-31. PMID: 24977462.
    View in: PubMed
  9. Kaufman LB, Setiono TK, Doros G, Andersen S, Silliman RA, Friedman PK, Perls TT. An oral health study of centenarians and children of centenarians. J Am Geriatr Soc. 2014 Jun; 62(6):1168-73. PMID: 24889721.
    View in: PubMed
  10. Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013; 1:38. PMID: 24350207.
    View in: PubMed
  11. Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY). 2013 Sep; 5(9):653-61. PMID: 24244950.
    View in: PubMed
  12. Cosentino S, Schupf N, Christensen K, Andersen SL, Newman A, Mayeux R. Reduced prevalence of cognitive impairment in families with exceptional longevity. JAMA Neurol. 2013 Jul; 70(7):867-74. PMID: 23649824.
    View in: PubMed
  13. Barral S, Cosentino S, Costa R, Andersen SL, Christensen K, Eckfeldt JH, Newman AB, Perls TT, Province MA, Hadley EC, Rossi WK, Mayeux R. Exceptional memory performance in the Long Life Family Study. Neurobiol Aging. 2013 Nov; 34(11):2445-8. PMID: 23759147.
    View in: PubMed
  14. Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT. Genome-wide association study of personality traits in the long life family study. Front Genet. 2013; 4:65. PMID: 23658558.
    View in: PubMed
  15. Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT. Personality factors in the Long Life Family Study. J Gerontol B Psychol Sci Soc Sci. 2013 Sep; 68(5):739-49. PMID: 23275497.
    View in: PubMed
  16. Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012; 7(1):e29848. PMID: 22279548.
    View in: PubMed
  17. Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):395-405. PMID: 22219514.
    View in: PubMed
  18. Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls TT. Whole genome sequences of a male and female supercentenarian, ages greater than 114?years. Front Genet. 2011; 2:90. PMID: 22303384.
    View in: PubMed
  19. Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Retraction. Science. 2011 Jul 22; 333(6041):404. PMID: 21778381.
    View in: PubMed
  20. Barral S, Cosentino S, Costa R, Matteini A, Christensen K, Andersen SL, Glynn NW, Newman AB, Mayeux R. Cognitive function in families with exceptional survival. Neurobiol Aging. 2012 Mar; 33(3):619.e1-7. PMID: 21439683.
    View in: PubMed
  21. Stern RA, Andersen SL, Gavett BE. In: N. W. Kowall & A. E. Budson (Eds.), The Handbook of Alzheimer’s Disease and Other Dementias. Executive Functioning. Wiley-Blackwell. Oxford, UK. 2011; 369-415.
  22. Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Genetic signatures of exceptional longevity in humans. Science. 2010 Jul 1; 2010. PMID: 20595579.
    View in: PubMed
  23. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009; 4(12):e8210. PMID: 20011587.
    View in: PubMed
  24. Givens JL, Frederick M, Silverman L, Anderson S, Senville J, Silver M, Sebastiani P, Terry DF, Costa PT, Perls TT. Personality traits of centenarians' offspring. J Am Geriatr Soc. 2009 Apr; 57(4):683-5. PMID: 19392961.
    View in: PubMed
  25. Adams ER, Nolan VG, Andersen SL, Perls TT, Terry DF. Centenarian offspring: start healthier and stay healthier. J Am Geriatr Soc. 2008 Nov; 56(11):2089-92. PMID: 18811609.
    View in: PubMed
  26. Terry DF, Nolan VG, Andersen SL, Perls TT, Cawthon R. Association of longer telomeres with better health in centenarians. J Gerontol A Biol Sci Med Sci. 2008 Aug; 63(8):809-12. PMID: 18772468.
    View in: PubMed
  27. Terry DF, Sebastiani P, Andersen SL, Perls TT. Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med. 2008 Feb 11; 168(3):277-83. PMID: 18268168.
    View in: PubMed
  28. Perls T, Kohler IV, Andersen S, Schoenhofen E, Pennington J, Young R, Terry D, Elo IT. Survival of parents and siblings of supercentenarians. J Gerontol A Biol Sci Med Sci. 2007 Sep; 62(9):1028-34. PMID: 17895443.
    View in: PubMed
  29. Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL, Wilcox MA, Farrer LA, Barzilai N, Baldwin CT, Asea A. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech Ageing Dev. 2006 Nov; 127(11):862-8. PMID: 17027907.
    View in: PubMed
  30. Schoenhofen EA, Wyszynski DF, Andersen S, Pennington J, Young R, Terry DF, Perls TT. Characteristics of 32 supercentenarians. J Am Geriatr Soc. 2006 Aug; 54(8):1237-40. PMID: 16913991.
    View in: PubMed
  31. Andersen SL, Terry DF, Wilcox MA, Babineau T, Malek K, Perls TT. Cancer in the oldest old. Mech Ageing Dev. 2005 Feb; 126(2):263-7. PMID: 15621206.
    View in: PubMed
  32. Terry DF, Wilcox MA, McCormick MA, Pennington JY, Schoenhofen EA, Andersen SL, Perls TT. Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring. J Am Geriatr Soc. 2004 Dec; 52(12):2074-6. PMID: 15571545.
    View in: PubMed
  33. Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, Asea A. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N Y Acad Sci. 2004 Jun; 1019:502-5. PMID: 15247074.
    View in: PubMed
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