David Hing-Kwei Chui, MD
Emeritus Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Hematology & Medical Oncology

MD, McGill University



Dr. Chui is a physician-scientist with a long standing clinical and research interest in hemoglobin disorders. He has contributed to the field ranging from population genetics, genotype-phenotype correlation, genetic modifiers, and regulation of HbF expression. He received MD,CM degree from McGill University, Montreal, Canada in 1963. In 1970, he joined the Faculty at the McMaster University, Hamilton, Ontario, Canada, and rose to become a full Professor in 1982. He has always enjoyed teaching and mentoring students, residents and fellows. He served on the Editorial Board of BLOOD (1980-84), American Society of Hematology (ASH) Committee on Educational Affairs and Training (1984-87), NIH Hematology Study Section (1987-91), ASH Scientific Affairs Subcommittee on Hemoglobin/Red Cell (1989-1991), and Chair of Medical Advisory Board, the Thalassemia Foundation of Canada (2000-2002). He was elected to two honorific societies, the American Society for Clinical Investigation (1980) and the Association of American Physicians (1991). In 2003, Dr. Chui joined Boston University School of Medicine, and was appointed a full Professor of Medicine, Pathology and Laboratory Medicine.

Expertise includes: Globin gene mutations; Hemoglobin diseases; Thalassmeias; and Regulation of fetal hemoglobin expression.

Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Center of Excellence in Sickle Cell Disease


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: David Hing-Kwei Chui, MD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Co-Investigator)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01


Sickle Cell - Research Scholar
04/01/2003 - 03/31/2008 (PI)
NIH-NHLBI
5 U54 HL070819-05 (A)


Title


Yr Title Project-Sub Proj Pubs
2015 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-05 16
2014 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-04 16
2013 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-03 16
2012 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-02 16
2011 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 1U01HL107443-01 16
2009 Genetic Modulation of HbF in Beta Thalassemia 5R01DK069646-05 16
2008 AUTOMATED ID OF PROTEINS, VARIANTS &POST-TRANSLATIONAL MODIFICATIONS 5P41RR010888-12-5180 259
2008 Genetic Modulation of HbF in Beta Thalassemia 5R01DK069646-04 16
2007 AUTOMATED ID OF PROTEINS, VARIANTS &POST-TRANSLATIONAL MODIFICATIONS 2P41RR010888-11-8001 259
2007 Genetic Modulation of HbF in Beta Thalassemia 5R01DK069646-03 16
Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1a stimulates fetal haemoglobin gene expression. Br J Haematol. 2022 Apr; 197(1):97-109.View Related Profiles. PMID: 35118652
     
  2. Aygun B, Bello A, Thompson AA, Davis L, Sun Y, Luo HY, Cui S, Chui DHK. Clinical phenotypes of three children with sickle cell disease caused by HbS/Sicilian (dß)0 -thalassemia deletion. Am J Hematol. 2022 04; 97(4):E156-E158.View Related Profiles. PMID: 35045200; DOI: 10.1002/ajh.26470;
     
  3. Patrinos GP, Chui DHK, Hardison RC, Steinberg MH. Strategies to improve pharmacogenomic-guided treatment options for patients with ß-hemoglobinopathies. Expert Rev Hematol. 2021 10; 14(10):883-885.View Related Profiles. PMID: 34490838; PMCID: PMC9306350; DOI: 10.1080/17474086.2021.1977117;
     
  4. Atroshi SD, Al-Allawi N, Chui DHK, Najmabadi H, Khailany RA. A Novel ß0-Thalassemia Mutation, HBB: c.356_357delTT [Codon 118 (-TT)] in an Iraqi Kurd. Hemoglobin. 2021 May; 45(3):212-214. PMID: 34167424; DOI: 10.1080/03630269.2021.1941082;
     
  5. Harris NS, Kavesh M, Beal SG, Winter WE, Chui DHK. When Hemoglobin Reported to Be A, S, and F Are Neither A, S, Nor F: A Tale of Two Patients. J Appl Lab Med. 2021 03 01; 6(2):543-549. PMID: 32995874; DOI: 10.1093/jalm/jfaa087;
     
  6. Solano-Vargas M, Chui DHK, Rodriguez-Romero W. Alpha-thalassemia. Case report alpha-thalassemia in a Costa Rican family, A case report. Clin Case Rep. 2021 Jan; 9(1):291-293. PMID: 33489176; PMCID: PMC7813090; DOI: 10.1002/ccr3.3518;
     
  7. Dai Y, Shaikho EM, Perez J, Wilson CA, Liu LY, White MR, Farrell JJ, Chui DHK, Sebastiani P, Steinberg MH. BCL2L1 is associated with ?-globin gene expression. Blood Adv. 2019 10 22; 3(20):2995-3001.View Related Profiles. PMID: 31648320; PMCID: PMC6849934; DOI: 10.1182/bloodadvances.2019032243;
     
  8. Homsy E, Alghothani L, Chui DHK, Sood N. An Unusual Case of Low Hemoglobin Oxygen Saturation. Ann Am Thorac Soc. 2019 06; 16(6):756-759. PMID: 31149860; DOI: 10.1513/AnnalsATS.201811-829CC;
     
  9. Le CQ, Myers G, Habara A, Jearawiriyapaisarn N, Murphy GJ, Chui DHK, Steinberg MH, Engel JD, Cui S. Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis. Blood. 2019 05 30; 133(22):2455-2459.View Related Profiles. PMID: 30992270; PMCID: PMC6543516; DOI: 10.1182/blood.2018892737;
     
  10. Xu S, Luk K, Yao Q, Shen AH, Zeng J, Wu Y, Luo HY, Brendel C, Pinello L, Chui DHK, Wolfe SA, Bauer DE. Editing aberrant splice sites efficiently restores ß-globin expression in ß-thalassemia. Blood. 2019 05 23; 133(21):2255-2262. PMID: 30704988; PMCID: PMC6533605; DOI: 10.1182/blood-2019-01-895094;
     
Showing 10 of 136 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 131 publications over 35 distinct years, with a maximum of 11 publications in 2013

YearPublications
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201110
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201311
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2011 McGill University Alumni Association: D. Lorne Gales Award
2007-2016 The Best Doctors in America
2002 The Thalassemia Foundation of Canada: Hour Glass Award
2000-2002 The Thalassemia Foundation of Canada: Chair, Medical Advisory Board
1991 Association of American Physicians: elected to membership
1987-1991 NIH: Hematology Study Section
1980-1984 BLOOD: Editorial Board member
1980 American Society for Clinical Investigation: elected to membership
1971-1976 Medical Research Council of Canada: Scholar
1970 Royal College of Physicians of Canada: Fellow
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Genetics
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650 Albany St
Boston MA 02118
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