Elke Muhlberger, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, Philipps-Universität Marburg
MA, Philipps-Universität Marburg



Virologist;
Expert in molecular biology of Marburg and Ebola viruses and other highly pathogenic viruses;
Experienced in BSL4 work;
Focus on virus-host interaction.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




MECHANISMS OF MARBURG VIRUS GENE EXPRESSION
05/08/2018 - 04/30/2023 (Co-PI)
PI: Rachel Fearns, PhD
NIH/National Institute of Allergy & Infectious Diseases
1R01AI133486-01A1

NATIONAL EMERGING INFECTIOUS DISEASES LABORATORIES OPERATIONS
06/01/2016 - 05/31/2021 (PI of Sub-Project / SP)
PI: Ronald B. Corley, Ph.D.
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-05

THE ROLE OF TLR4 SIGNALING IN THE PATHOGENESIS OF FILOVIRUS INFECTION
05/10/2018 - 04/30/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R21AI135912-01A1

DECIPHERING THE PATHOGENIC POTENTIAL OF LLOVIU VIRUS, A NOVEL FILOVIRUS
02/13/2018 - 01/31/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R21AI137793-01

ANTIVIRAL RESPONSES IN IPSC-DERIVED HUMAN PRIMARY CELLS TO EBOLA VIRUS INFECTION
06/30/2016 - 05/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI126457-02

DEEP CHARACTERIZATION OF ROUSETTUS AEGYPTIACUS IMMUNE SYSTEM: USE OF BATS/NONHUMAN PRIMATES TO COMPARE IMMUNE RESPONSES DURING ASYMTOMATIC/SYMPTOMATIC FILOVIRUS INFECTIONS
01/15/2014 - 06/13/2018 (PI)
The Geneva Foundation DOD DTRA

POINT-OF-CARE NANOTECHNOLOGY DIAGNOSTIC FOR DIFFERENTIAL FEVER DIAGNOSIS
10/01/2015 - 10/31/2017 (SP Co-PI of Sub-Project / SP)
PI: John H. Connor, PhD
Becton, Dickinson and Company Paul G. Allen Fdn

SPR: NOVEL SPR BARRIER TECHNOLOGY (THE USAID AGREEMENT )
11/01/2015 - 10/31/2016 (PI)
SPR Advanced Technologies Inc. USAID

FILOVIRUS REPLICATION: INITIATION MECHANISM AND ROLE OF RNA SECONDARY STRUCTURES
08/05/2014 - 07/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R03AI114293-02

EARLY HOST IMMUNE RESPONSE IN PROTECTION AGAINST FILOVIRUS INFECTION
06/15/2009 - 05/31/2015 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5U01AI082954-05

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 The role of TLR4 signaling in the pathogenesis of filovirus infection 1R21AI135912-01A1
2018 Mechanisms of Marburg virus gene expression 1R01AI133486-01A1
2018 Deciphering the pathogenic potential of Lloviu virus, a novel filovirus 1R21AI137793-01
2018 Integrated Support Services Core 5UC7AI095321-05-8669 1
2016 Antiviral responses in iPSC-derived human primary cells to Ebola virus infection 1R21AI126457-01
2016 Integrated Support Services Core 2UC7AI095321-03-8669 1
2015 Filovirus replication: initiation mechanism and role of RNA secondary structures 5R03AI114293-02 3
2014 Filovirus replication: initiation mechanism and role of RNA secondary structures 1R03AI114293-01 3
2013 Early Host Immune Response in Protection Against Filovirus Infection 5U01AI082954-05 9
2013 Biomolecule Production Core 3UC7AI070088-05S3-6796 1
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Olsen ME, Cressey TN, Mühlberger E, Connor JH. Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene Expression. J Virol. 2018 Oct 15; 92(20).View Related Profiles. PMID: 30045993.
     
  2. Manhart WA, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Mühlberger E. A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses. Cell Rep. 2018 Sep 04; 24(10):2573-2580.e4.View Related Profiles. PMID: 30184492.
     
  3. Hume A, Mühlberger E. Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner. J Infect Dis. 2018 Aug 28.View Related Profiles. PMID: 30165526.
     
  4. Pavlovich SS, Lovett SP, Koroleva G, Guito JC, Arnold CE, Nagle ER, Kulcsar K, Lee A, Thibaud-Nissen F, Hume AJ, Mühlberger E, Uebelhoer LS, Towner JS, Rabadan R, Sanchez-Lockhart M, Kepler TB, Palacios G. The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity. Cell. 2018 May 17; 173(5):1098-1110.e18.View Related Profiles. PMID: 29706541.
     
  5. Amarasinghe GK, Aréchiga Ceballos NG, Banyard AC, Basler CF, Bavari S, Bennett AJ, Blasdell KR, Briese T, Bukreyev A, Caì Y, Calisher CH, Campos Lawson C, Chandran K, Chapman CA, Chiu CY, Choi KS, Collins PL, Dietzgen RG, Dolja VV, Dolnik O, Domier LL, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Echevarría JE, Fooks AR, Formenty PBH, Fouchier RAM, Freuling CM, Ghedin E, Goldberg TL, Hewson R, Horie M, Hyndman TH, Jiang D, Kityo R, Kobinger GP, Kondo H, Koonin EV, Krupovic M, Kurath G, Lamb RA, Lee B, Leroy EM, Maes P, Maisner A, Marston DA, Mor SK, Müller T, Mühlberger E, Ramírez VMN, Netesov SV, Ng TFF, Nowotny N, Palacios G, Patterson JL, Paweska JT, Payne SL, Prieto K, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Siddell S, Smither SJ, Song Q, Song T, Stenglein MD, Stone DM, Takada A, Tesh RB, Thomazelli LM, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Vázquez-Morón S, Verdugo C, Volchkov VE, Wahl V, Walker PJ, Wang D, Wang LF, Wellehan JFX, Wiley MR, Whitfield AE, Wolf YI, Yè G, Zhang YZ, Kuhn JH. Taxonomy of the order Mononegavirales: update 2018. Arch Virol. 2018 Aug; 163(8):2283-2294. PMID: 29637429.
     
  6. McElroy AK, Mühlberger E, Muñoz-Fontela C. Immune barriers of Ebola virus infection. Curr Opin Virol. 2018 Feb; 28:152-160. PMID: 29452995.
     
  7. Nelson EV, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Ruedas JB, Connor JH, Ebihara H, Mühlberger E. An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening. Antiviral Res. 2017 Oct; 146:21-27.View Related Profiles. PMID: 28807685.
     
  8. Olejnik J, Forero A, Deflubé LR, Hume AJ, Manhart WA, Nishida A, Marzi A, Katze MG, Ebihara H, Rasmussen AL, Mühlberger E. Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages. J Virol. 2017 Jun 01; 91(11).View Related Profiles. PMID: 28331091; DOI: 10.1128/JVI.00179-17;.
     
  9. Bào Y, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Dolnik O, Dye JM, Ebihara H, Formenty P, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Smither SJ, Takada A, Towner JS, Volchkov VE, Wahl-Jensen V, Kuhn JH. Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses. Viruses. 2017 May 11; 9(5). PMID: 28492506.
     
  10. Amarasinghe GK, Bào Y, Basler CF, Bavari S, Beer M, Bejerman N, Blasdell KR, Bochnowski A, Briese T, Bukreyev A, Calisher CH, Chandran K, Collins PL, Dietzgen RG, Dolnik O, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Fang Q, Formenty P, Fouchier RAM, Ghedin E, Harding RM, Hewson R, Higgins CM, Hong J, Horie M, James AP, Jiang D, Kobinger GP, Kondo H, Kurath G, Lamb RA, Lee B, Leroy EM, Li M, Maisner A, Mühlberger E, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Pearson MN, Randall RE, Revill PA, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Smither SJ, Song Q, Stone DM, Takada A, Terregino C, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang B, Wang D, Wang F, Wang LF, Werren JH, Whitfield AE, Yan Z, Ye G, Kuhn JH. Taxonomy of the order Mononegavirales: update 2017. Arch Virol. 2017 Aug; 162(8):2493-2504. PMID: 28389807; DOI: 10.1007/s00705-017-3311-7;.
     
Showing 10 of 75 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 75 publications over 25 distinct years, with a maximum of 7 publications in 2017

YearPublications
19922
19931
19951
19962
19982
19993
20003
20014
20024
20033
20042
20052
20064
20072
20082
20094
20102
20112
20122
20135
20143
20152
20165
20177
20186

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