Elke Muhlberger, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, Philipps-Universität Marburg
MA, Philipps-Universität Marburg




Virologist;
Expert in molecular biology of Marburg and Ebola viruses and other highly pathogenic viruses;
Experienced in BSL4 work;
Focus on virus-host interaction.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Member
Boston University
Genome Science Institute




Mechanisms of Marburg virus gene expression
05/08/2018 - 04/30/2023 (Multi-PI)
PI: Elke Muhlberger, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R01AI133486-02

Deep characterization of the role biogenesis and function of Ebola virus microRNAs
07/01/2019 - 06/30/2021 (Multi-PI)
PI: Elke Muhlberger, PhD
NIH/National Institute of Allergy & Infectious Diseases
1R21AI147285-01

National Emerging Infectious Diseases Laboratories Operations
06/01/2016 - 05/31/2021 (PI of Sub-Project / SP)
PI: Ronald B. Corley, Ph.D.
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-06

The role of TLR4 signaling in the pathogenesis of filovirus infection
05/10/2018 - 04/30/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI135912-02

Deciphering the pathogenic potential of Lloviu virus, a novel filovirus
02/13/2018 - 01/31/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI137793-02

Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
06/30/2016 - 05/31/2019 (Multi-PI)
PI: Elke Muhlberger, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI126457-02

Deep Characterization of Rousettus Aegyptiacus Immune System: Use of bats/nonhuman primates to compare immune responses during asymtomatic/symptomatic filovirus infections
01/15/2014 - 06/13/2018 (Subcontract PI)
The Geneva Foundation DOD DTRA


Point-of-Care Nanotechnology Diagnostic for Differential Fever Diagnosis
10/01/2015 - 10/31/2017 (SP Co-PI of Sub-Project / SP)
Becton, Dickinson and Company Paul G. Allen Fdn


SPR: Novel SPR Barrier Technology (the "USAID Agreement")
11/01/2015 - 10/31/2016 (Subcontract PI)
SPR Advanced Technologies Inc. USAID


Filovirus replication: initiation mechanism and role of RNA secondary structures
08/05/2014 - 07/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R03AI114293-02

Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Deep characterization of the biogenesis and function of Ebola virus microRNAs 5R21AI147285-02
2020 Mechanisms of Marburg virus gene expression 5R01AI133486-03 3
2020 Integrated Support Services Core 5UC7AI095321-07-8669 1
2019 Deep characterization of the biogenesis and function of Ebola virus microRNAs 1R21AI147285-01
2019 The role of TLR4 signaling in the pathogenesis of filovirus infection 5R21AI135912-02 2
2019 Mechanisms of Marburg virus gene expression 5R01AI133486-02 3
2019 Deciphering the pathogenic potential of Lloviu virus, a novel filovirus 5R21AI137793-02 2
2019 Integrated Support Services Core 5UC7AI095321-06-8669 1
2018 The role of TLR4 signaling in the pathogenesis of filovirus infection 1R21AI135912-01A1 2
2018 Mechanisms of Marburg virus gene expression 1R01AI133486-01A1 3
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Lindstrom-Vautrin J, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020 Sep 18.View Related Profiles. PMID: 32979316
     
  2. Kuhn JH, Adkins S, Alioto D, Alkhovsky SV, Amarasinghe GK, Anthony SJ, Avšic-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bartonicka T, Basler C, Bavari S, Beer M, Bente DA, Bergeron É, Bird BH, Blair C, Blasdell KR, Bradfute SB, Breyta R, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Buzkan N, Calisher CH, Cao M, Casas I, Chamberlain J, Chandran K, Charrel RN, Chen B, Chiumenti M, Choi IR, Clegg JCS, Crozier I, da Graça JV, Dal Bó E, Dávila AMR, de la Torre JC, de Lamballerie X, de Swart RL, Di Bello PL, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Dolja VV, Dolnik O, Drebot MA, Drexler JF, Dürrwald R, Dufkova L, Dundon WG, Duprex WP, Dye JM, Easton AJ, Ebihara H, Elbeaino T, Ergünay K, Fernandes J, Fooks AR, Formenty PBH, Forth LF, Fouchier RAM, Freitas-Astúa J, Gago-Zachert S, Gao GF, García ML, García-Sastre A, Garrison AR, Gbakima A, Goldstein T, Gonzalez JJ, Griffiths A, Groschup MH, Günther S, Guterres A, Hall RA, Hammond J, Hassan M, Hepojoki J, Hepojoki S, Hetzel U, Hewson R, Hoffmann B, Hongo S, Höper D, Horie M, Hughes HR, Hyndman TH, Jambai A, Jardim R, Jiang D, Jin Q, Jonson GB, Junglen S, Karadag S, Keller KE, Klempa B, Klingström J, Kobinger G, Kondo H, Koonin EV, Krupovic M, Kurath G, Kuzmin IV, Laenen L, Lamb RA, Lambert AJ, Langevin SL, Lee B, Lemos ERS, Leroy EM, Li D, Li J, Liang M, Liú W, Liú Y, Lukashevich IS, Maes P, Marciel de Souza W, Marklewitz M, Marshall SH, Martelli GP, Martin RR, Marzano SL, Massart S, McCauley JW, Mielke-Ehret N, Minafra A, Minutolo M, Mirazimi A, Mühlbach HP, Mühlberger E, Naidu R, Natsuaki T, Navarro B, Navarro JA, Netesov SV, Neumann G, Nowotny N, Nunes MRT, Nylund A, Økland AL, Oliveira RC, Palacios G, Pallas V, Pályi B, Papa A, Parrish CR, Pauvolid-Corrêa A, Paweska JT, Payne S, Pérez DR, Pfaff F, Radoshitzky SR, Rahman AU, Ramos-González PL, Resende RO, Reyes CA, Rima BK, Romanowski V, Robles Luna G, Rota P, Rubbenstroth D, Runstadler JA, Ruzek D, Sabanadzovic S, Salát J, Sall AA, Salvato MS, Sarpkaya K, Sasaya T, Schwemmle M, Shabbir MZ, Shí X, Shí Z, Shirako Y, Simmonds P, Širmarová J, Sironi M, Smither S, Smura T, Song JW, Spann KM, Spengler JR, Stenglein MD, Stone DM, Straková P, Takada A, Tesh RB, Thornburg NJ, Tomonaga K, Tordo N, Towner JS, Turina M, Tzanetakis I, Ulrich RG, Vaira AM, van den Hoogen B, Varsani A, Vasilakis N, Verbeek M, Wahl V, Walker PJ, Wang H, Wang J, Wang X, Wang LF, Wèi T, Wells H, Whitfield AE, Williams JV, Wolf YI, Wú Z, Yang X, Yáng X, Yu X, Yutin N, Zerbini FM, Zhang T, Zhang YZ, Zhou G, Zhou X. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol. 2020 Sep 04.View Related Profiles. PMID: 32888050
     
  3. Bruchez A, Sha K, Johnson J, Chen L, Stefani C, McConnell H, Gaucherand L, Prins R, Matreyek KA, Hume AJ, Mühlberger E, Schmidt EV, Olinger GG, Stuart LM, Lacy-Hulbert A. MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. Science. 2020 10 09; 370(6513):241-247.View Related Profiles. PMID: 32855215
     
  4. Luban J, Sattler R, Mühlberger E, Graci JD, Cao L, Weetall M, Trotta C, Colacino JM, Bavari S, Strambio-De-Castillia C, Suder EL, Wang Y, Soloveva V, Cintron-Lue K, Naryshkin NA, Pykett M, Welch EM, O'Keefe K, Kong R, Goodwin E, Jacobson A, Paessler S, Peltz S. The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. bioRxiv. 2020 Aug 05. PMID: 32793904
     
  5. Gao C, Zeng J, Jia N, Stavenhagen K, Matsumoto Y, Zhang H, Li J, Hume AJ, Mühlberger E, van Die I, Kwan J, Tantisira K, Emili A, Cummings RD. SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors. bioRxiv. 2020 Jul 30.View Related Profiles. PMID: 32766577
     
  6. Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles. PMID: 32637964
     
  7. Amraie R, Napoleon MA, Yin W, Berrigan J, Suder E, Zhao G, Olejnik J, Gummuluru S, Muhlberger E, Chitalia V, Rahimi N. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 and are differentially expressed in lung and kidney epithelial and endothelial cells. bioRxiv. 2020 Jun 23.View Related Profiles. PMID: 32607506; DOI: 10.1101/2020.06.22.165803;
     
  8. Pavlovich SS, Darling T, Hume AJ, Davey RA, Feng F, Mühlberger E, Kepler TB. Egyptian Rousette IFN-? Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells. Front Immunol. 2020; 11:435.View Related Profiles. PMID: 32231668
     
  9. Amarasinghe GK, Ayllón MA, Bào Y, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chabi-Jesus C, Chandran K, Chiapponi C, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Griffiths A, Hewson R, Horie M, Hyndman TH, Jiang D, Kitajima EW, Kobinger GP, Kondo H, Kurath G, Kuzmin IV, Lamb RA, Lavazza A, Lee B, Lelli D, Leroy EM, Li J, Maes P, Marzano SL, Moreno A, Mühlberger E, Netesov SV, Nowotny N, Nylund A, Økland AL, Palacios G, Pályi B, Paweska JT, Payne SL, Prosperi A, Ramos-González PL, Rima BK, Rota P, Rubbenstroth D, Shi M, Simmonds P, Smither SJ, Sozzi E, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang LF, Whitfield AE, Williams JV, Zerbini FM, Zhang T, Zhang YZ, Kuhn JH. Taxonomy of the order Mononegavirales: update 2019. Arch Virol. 2019 Jul; 164(7):1967-1980.View Related Profiles. PMID: 31089958
     
  10. Hume AJ, Mühlberger E. Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family. J Mol Biol. 2019 10 04; 431(21):4290-4320.View Related Profiles. PMID: 31260690
     
Showing 10 of 91 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 91 publications over 27 distinct years, with a maximum of 8 publications in 2020

YearPublications
19922
19931
19951
19962
19982
19993
20003
20014
20024
20033
20042
20052
20065
20072
20082
20094
20102
20112
20122
20135
20143
20152
20165
20177
20187
20196
20208

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72 E. Concord St Instructional (L)
Boston MA 02118
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