Ronald B. Corley, Ph.D.
Director
Boston University
National Emerging Infectious Disease Lab

PhD, Duke University




My research focuses on the relationship between innate and adaptive immunity, and how components of the two discrete systems interact to generate long-lasting protective immune responses. One area of focus has been on the role of IgM antibodies as efficient bridges of innate and adaptive immunity. IgM antibodies serve to concentrate antigens into secondary lymphoid organs, accelerating the production of protective immune responses along with affinity matured antibodies. IgM also contributes to preventing pathogens from initially localizing into vital organs. The innate functions of IgM can be attributed, at least in part, to its ability to concentrate immune complexes in the foci of the spleen, where innate B cells in the marginal zones traffic the complexes to follicular dendritic cells, stromal elements that promote efficient germinal center formation. These functions require native organization around the marginal sinuses for efficient adjuvant effects of IgM.

The laboratory also focuses on the immune consequences of infection with highly pathogenic hemorrhagic fever viruses, including filoviruses. Patients infected with these viruses often fail to make adaptive immune responses and succumb to infection. While this is often attributed to dysfunctional innate immune responses, the nature of the defects in immune responses to these viruses is poorly understood. We are interested in in the very early immune responses to these viruses, in order to map how they affect the ability of infected animals to initiate adaptive immune responses, and identify the components of infection that lead to abnormal cytokine responses that characterize infection with these viruses.

Professor
Boston University School of Medicine
Microbiology


Chair of Microbiology
Boston University School of Medicine
Microbiology


Director
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Staff Scientists/Veterinary Technicians at the NEIDL BSL33/4
05/01/2020 - 10/31/2021 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School China Evergrande Gr


National Emerging Infectious Diseases Laboratories Operations
06/01/2016 - 05/31/2021 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-07

National Emerging Infectious Diseases Laboratories Operations
06/01/2015 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-02

National Emerging Infectious Diseases Laboratories Operations
06/01/2014 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-02

IgM Polymerization and J Chain Expression
02/01/2000 - 01/31/2006 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5 R01 AI31209 13

Functional Characterization of Genes Involved in V(D)J Recombination and DNA Repair
07/01/1998 - 06/30/2003 (Dept Sponsor)
Leukemia Society of America

Cellular and Molecular Events in B Lymphocyte Activation
05/01/1997 - 02/28/2003 (PI)
NIH/National Cancer Institute
5 R01 CA36642 19



Title


Yr Title Project-Sub Proj Pubs
2021 National Emerging Infectious Diseases Laboratories Operations 2UC7AI095321-08 1
2021 Administration 2UC7AI095321-08-8404 1
2021 Core 4: Regulatory Compliance 2UC7AI095321-08-8408 1
2021 Core 5: Integrated Support Services 2UC7AI095321-08-8409 1
2020 National Emerging Infectious Diseases Laboratories Operations 5UC7AI095321-07 1
2020 Administrative Core 5UC7AI095321-07-8664 1
2019 National Emerging Infectious Diseases Laboratories Operations 5UC7AI095321-06 1
2019 Administrative Core 5UC7AI095321-06-8664 1
2018 National Emerging Infectious Diseases Laboratories Operations 5UC7AI095321-05 1
2018 Administrative Core 5UC7AI095321-05-8664 1
Showing 10 of 46 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Calisher CH, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya AE, Haagmans B, Hughes JM, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet JK, Perlman SM, Poon L, Saif L, Subbarao K, Turner M. Science, not speculation, is essential to determine how SARS-CoV-2 reached humans. Lancet. 2021 07 17; 398(10296):209-211.View Related Profiles. PMID: 34237296; PMCID: PMC8257054; DOI: 10.1016/S0140-6736(21)01419-7;
     
  2. Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles. PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;
     
  3. Calisher C, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya A, Haagmans B, Hughes JM, Karesh WB, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet J, Palese P, Perlman S, Poon L, Roizman B, Saif L, Subbarao K, Turner M. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19. Lancet. 2020 03 07; 395(10226):e42-e43.View Related Profiles. PMID: 32087122; PMCID: PMC7159294; DOI: 10.1016/S0140-6736(20)30418-9;
     
  4. Schultz MJ, Isern S, Michael SF, Corley RB, Connor JH, Frydman HM. Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures. J Virol. 2017 Jul 15; 91(14).View Related Profiles. PMID: 28446677; PMCID: PMC5487579; DOI: 10.1128/JVI.00339-17;
     
  5. Olejnik J, Ryabchikova E, Corley RB, Mühlberger E. Intracellular events and cell fate in filovirus infection. Viruses. 2011 Aug; 3(8):1501-31.View Related Profiles. PMID: 21927676; PMCID: PMC3172725; DOI: 10.3390/v3081501;
     
  6. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17.View Related Profiles. PMID: 19648272; PMCID: PMC2860771; DOI: 10.4049/jimmunol.0900399;
     
  7. Busconi L, Bauer JW, Tumang JR, Laws A, Perkins-Mesires K, Tabor AS, Lau C, Corley RB, Rothstein TL, Lund FE, Behrens TW, Marshak-Rothstein A. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol. 2007 Dec 1; 179(11):7397-405.View Related Profiles. PMID: 18025183
     
  8. Corley RB, Morehouse EM, Ferguson AR. IgM accelerates affinity maturation. Scand J Immunol. 2005 Jul; 62 Suppl 1:55-61. PMID: 15953185
     
  9. Ferguson AR, Corley RB. Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice. BMC Immunol. 2005; 6:8. PMID: 15836790; PMCID: PMC1087843; DOI: 10.1186/1471-2172-6-8;
     
  10. Doerre S, Mesires KP, Daley KM, McCarty T, Knoetig S, Corley RB. Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation. J Immunol. 2005 Jan 15; 174(2):983-91. PMID: 15634922
     
Showing 10 of 100 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 80 publications over 31 distinct years, with a maximum of 6 publications in 1985 and 1992

YearPublications
19804
19813
19824
19833
19844
19856
19862
19873
19883
19892
19903
19914
19926
19932
19942
19952
19961
19973
19983
19992
20001
20021
20031
20044
20054
20071
20091
20111
20171
20201
20212


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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

emerging infectious diseases
immunology
microbiology
virology
Contact for Mentoring:

620 Albany St
Boston MA 02118
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