John R. Murphy, PhD
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

PhD, University of Connecticut
MS, University of Connecticut

Boston University School of Medicine

Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences

Boston Medical Center

Development of VLS-modified s-Ontak: a second-generation, Treg-depleting immunotherapy
12/15/2016 - 09/14/2017 (PI)
Johns Hopkins University Maryland Tech Dev Co

Training Program in Host-Pathogen Interaction
09/30/2000 - 08/31/2014 (PI)
NIH/National Institute of Allergy & Infe

National Emerging Infectious Diseases Laboratories Operations
06/20/2012 - 07/31/2014 (PI)
NIH/National Institute of Allergy & Infe

National Emerging Infectious Diseases Laboratories Operations
07/01/2006 - 07/31/2014 (PI)
NIH/National Institute of Allergy & Infe

National Center for Emerging Infectious Diseases and Biodefense
09/30/2003 - 06/30/2012 (Co-PI)
NIH/National Institute of Allergy & Infectious Diseases
1 UC6 AI58618 01

National Emerging Infectious Diseases Laboratories Operations
07/01/2006 - 04/30/2012 (Co-PI)
NIH/National Institute of Allergy & Infectious Diseases
1 UC7 AI70088 01

New England Regional Center of Excellence (NERCE)
09/04/2003 - 02/28/2013 (PI)
Harvard Medical School NIH-NIAID

Peptide Activators of Diphtheria Toxin Repressor (Dtxr)
02/01/2005 - 01/01/2011 (PI)

Immuno - Prophylaxis - Core B: Bacteriology (Tularemia - Murphy)
09/15/2003 - 02/28/2009 (PI)

Immuno - Prophylaxis - Core C: Administration (Tularemia)
09/15/2003 - 02/28/2009 (PI)

Immuno - Prophylaxis - Project 2: (Tularemia - Murphy)
09/15/2003 - 02/28/2009 (PI)

Immuno Prophylaxis - Project 3: Diagnostics (Tularemia - Murphy)
09/15/2003 - 02/28/2009 (PI)

Diptheria + Anthrax Toxins: Mechanisms of Cell Entry
07/01/2003 - 12/31/2008 (PI)

Novel Targeted Reagents that Modify Oncogene Expression
04/01/2005 - 03/31/2008 (PI)

Diphtheria Tox Repressor
12/01/1998 - 01/31/2005 (PI)

Mechanism Of Fusion Toxic Entr
05/01/1998 - 11/01/2002 (PI)

Showing 10 of 13 results. Show All Results

Yr Title Project-Sub Proj Pubs
2014 National Emerging Infectious Diseases Laboratories Operations 1UC7AI095321-01 1
2014 Administration 1UC7AI095321-01-6076 1
2014 Facility Maintenance 1UC7AI095321-01-6077 1
2014 Biosecurity 1UC7AI095321-01-6078 1
2014 Environmental Health &Biosafety Regulations and Requirements 1UC7AI095321-01-6079 1
2014 Regulatory Compliance 1UC7AI095321-01-6080 1
2014 Integrated Support Services-Animal 1UC7AI095321-01-6081 1
2013 Community Relations Core 3UC7AI070088-05S3-6807 1
2013 Administration Core 3UC7AI070088-05S3-6811 1
2012 COPI interactions mediate toxin entry: a common shared mechanism of translocation 5U54AI057159-09-5568 361
Showing 10 of 84 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Gupta S, Cheung L, Pokkali S, Winglee K, Guo H, Murphy JR, Bishai WR. Suppressor Cell-Depleting Immunotherapy With Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis. J Infect Dis. 2017 Jun 15; 215(12):1883-1887. PMID: 28863467.
  2. Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011 Sep; 81(5):1390-401.View Related Profiles. PMID: 21797942; DOI: 10.1111/j.1365-2958.2011.07770.x;.
  3. Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK. Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med. 2011 Jul 1; 184(1):57-63. PMID: 21493737; PMCID: PMC3172890; DOI: 10.1164/rccm.201101-0021OC;.
  4. Murphy JR. Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process. Toxins (Basel). 2011 Mar; 3(3):294-308. PMID: 22069710; PMCID: PMC3202816; DOI: 10.3390/toxins3030294;.
  5. Lasalle-Williams M, Nuss R, Le T, Cole L, Hassell K, Murphy JR, Ambruso DR. Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center (CME). Transfusion. 2011 Aug; 51(8):1732-9. PMID: 21332724; DOI: 10.1111/j.1537-2995.2010.03045.x;.
  6. Phasomkusolsil S, Lerdthusnee K, Khuntirat B, Kongtak W, Pantuwatana K, Murphy JR. Effect of temperature on laboratory reared Anopheles dirus Peyton and Harrison and Anopheles sawadwongporni Rattanarithikul and Green. Southeast Asian J Trop Med Public Health. 2011 Jan; 42(1):63-70. PMID: 21323167.
  7. Trujillo C, Taylor-Parker J, Harrison R, Murphy JR. Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry. Mol Microbiol. 2010 May; 76(4):1010-9.View Related Profiles. PMID: 20398220; DOI: 10.1111/j.1365-2958.2010.07159.x;.
  8. Wright DG, Zhang Y, Murphy JR. Effective delivery of antisense peptide nucleic acid oligomers into cells by anthrax protective antigen. Biochem Biophys Res Commun. 2008 Nov 7; 376(1):200-5. PMID: 18774771; PMCID: PMC2581503; DOI: 10.1016/j.bbrc.2008.08.124;.
  9. Chiavolini D, Weir S, Murphy JR, Wetzler LM. Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clin Vaccine Immunol. 2008 Sep; 15(9):1322-9.View Related Profiles. PMID: 18614668; PMCID: PMC2546688; DOI: 10.1128/CVI.00125-08;.
  10. Tamayo AG, Bharti A, Trujillo C, Harrison R, Murphy JR. COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro. Proc Natl Acad Sci U S A. 2008 Apr 1; 105(13):5254-9.View Related Profiles. PMID: 18356299; PMCID: PMC2278175; DOI: 10.1073/pnas.0710100105;.
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 13 distinct years, with a maximum of 5 publications in 2011

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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