Vanessa Xanthakis, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Preventive Medicine & Epidemiology

PhD, Boston University School of Public Health
MS, University of Athens
BS, University of Athens



Dr. Vanessa Xanthakis is a biostatistician with training in applied mathematics and statistics, and has a strong commitment to clinical epidemiological research. Presently, she is an Assistant Professor in the Section of Preventive Medicine and Epidemiology in the Department of Medicine at Chobanian and Avedisian School of Medicine and in the Biostatistics Department at Boston University School of Public Health. She is an investigator at the Framingham Heart Study and serves as the biostatistician on several investigations. She also serves as the Program Director for the Boston University T32 Program in Cardiovascular Epidemiology and the Promotion of Research In MEdical Residency (R38) program. She is the Director of Research Training for the Section of Preventive Medicine and Epidemiology. For the last 12 years, Dr. Xanthakis has focused her research on:

A) the epidemiology of cardiac remodeling and subclinical disease, including identifying cardiovascular disease risk factors;

B) population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function;

C) epidemiology of novel biomarkers including but not limited to natriuretic peptides, adipokines, and vascular growth factors;

D) cardiovascular risk prediction using biomarkers and assessing their incremental prognostic utility (focus of her PhD thesis);

E) epidemiology of heart failure and its precursors; and

F) ideal cardiovascular health and its impact on cardiovascular disease and its precursors.

Associate Professor
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




PRIMER: Promoting Research In MEdical Residency
07/01/2024 - 06/30/2029 (Multi-PI)
PI: Vanessa Xanthakis, PhD
NIH/National Heart, Lung, and Blood Institute
2R38HL143584-05

Molecular Determinants of Atherosclerotic Cardiovascular Disease in Multi-ethnic Populations
04/01/2023 - 03/31/2027 (Subcontract PI)
The University Of Texas Health Science Center At Houston NIH NHLBI
5R01HL168683-02

Epidemiology of Blood Pressure Responses to Perturbation
09/01/2022 - 02/28/2027 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG075703-03

Aortic stiffness, wave reflection, and cerebrovascular flow pulsatility: relations with brain small vessel disease and cognitive function in a middle-aged cohort
07/15/2023 - 06/30/2026 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
1RF1AG079390-01A1

Improving Blood Pressure Screening and Treatment Strategies in Young Adults
07/01/2021 - 05/31/2026 (Subcontract PI)
Kaiser Foundation Research Institute, a division of Kaiser Foundation Hospitals NIH NHLBI
5R01HK158790-04

Multidisciplinary Training Program in Cardiovascular Epidemiology
04/01/2021 - 03/31/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL125232-09

Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease
03/15/2021 - 02/28/2026 (Subcontract PI)
Beth Israel Deaconess Medical Center, Inc. NIH NHLBI
5R01HL155717-03

Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection Fraction
08/15/2021 - 06/30/2025 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL159514-04

Racial/Ethnic Disparities in Heart Failure: A Cross-Cohort Collaboration
04/01/2021 - 03/31/2025 (Subcontract PI)
Kent County Memorial Hospital NIH NHLBI
5R01HL150170-04

Characterization of Molecular and Physiologic Signatures of Impaired Multi-Organ System Reserve Capacity During Exercise in Heart Failure with Preserved Ejection Fraction
04/01/2020 - 03/31/2025 (Subcontract PI)
Massachusetts General Hospital NIH NHLBI
5R01HL151841-03

Showing 10 of 19 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Balte PP, Kim JS, Sun Y, Allen N, Angelini E, Arynchyn A, Barr RG, Blaha M, Bowler R, Carr J, Cole SA, Couper D, Demmer RT, Doyle M, Elkind M, San José Estépar R, Garcia-Bedoya O, Garudadri S, Hansel NN, Hermann EA, Hoffman EA, Humphries SM, Hunninghake GM, Kaplan R, Krishnan JA, Laine A, Lee JS, Lynch DA, Make B, Matsushita K, McKleroy W, Min YI, Naik SN, O'Connor G, O'Driscoll O, Oren E, Podolanczuk AJ, Post WS, Pottinger T, Regan E, Rusk A, Salvatore M, Schwartz DA, Smith B, Sotres-Alvarez D, Umans JG, Vasan RS, Washko G, Wenzel S, Woodruff P, Xanthakis V, Ortega VE, Oelsner EC. Associations of Pre-Pandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study. Am J Respir Crit Care Med. 2025 Apr 16.View Related Profiles. PMID: 40238945
     
  2. Demmer RT, Wu C, Kim JS, Sun Y, Balte P, Cushman M, Boyle R, Tracy RP, Styer LM, Bell TD, Anderson MR, Allen NB, Schreiner PJ, Bowler R, Schwartz DA, Lee JS, Xanthakis V, Rock JM, Bievenue R, Pirzada A, Doyle M, Regan EA, Make BJ, Kanaya AM, Kandula NR, Wenzel SE, Coresh J, Isasi CR, Raffield LM, Elkind MSV, Howard VJ, Ortega VE, Woodruff P, Cole SA, Henderson JM, Mantis NJ, Oelsner EC. Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study. Open Forum Infect Dis. 2025 Mar; 12(3):ofaf123. PMID: 40124199
     
  3. Oelsner EC, Krishnaswamy A, Rustamov R, Balte PP, Ali T, Allen NB, Andrews HF, Anugu P, Arynchyn A, Bateman LA, Cai J, Chang H, Chen L, Elkind MSV, Floyd JS, Gabriel KP, Gharib SA, Gutierrez JD, Stukovsky KH, Howard VJ, Isasi CR, Jager L, Jin L, Judd SE, Kanaya AM, Kandula NR, Kelly MR, Khan SS, Kucharska-Newton A, Lee JS, Levitan EB, Lewis CE, Make BJ, Malloy K, Manly JJ, Mauger D, Min YI, Murabito JM, Murphy CG, Norwood AF, O'Connor GT, Ortega VE, Patel AA, Pirzada A, Regan EA, Ring KB, Rosamond WD, Schwartz DA, Shikany JM, Sotres-Alvarez D, Tarlton C, Tse J, Meneses EMU, Vankineni M, Wenzel SE, Woodruff PG, Xanthakis V, Yang JH, Zakai NA, Zhang Y, Post WS. Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study. PLoS One. 2025; 20(2):e0316198.View Related Profiles. PMID: 39928595; PMCID: PMC11809881; DOI: 10.1371/journal.pone.0316198;
     
  4. Sun N, Prescott B, Ma J, Xanthakis V, Quatromoni PA, Long MT, Walker ME. The cross-sectional association between ultra-processed food intake and metabolic dysfunction-associated steatotic liver disease. Clin Nutr ESPEN. 2025 Apr; 66:215-220.View Related Profiles. PMID: 39880205; DOI: 10.1016/j.clnesp.2025.01.045;
     
  5. Møller AL, Larson MG, Xanthakis V, Vasan RS, Andersson C. Modifiable risk factors and risk of myocardial infarction in offspring with parental disease. Eur J Prev Cardiol. 2025 Jan 27; 32(2):131-138.View Related Profiles. PMID: 38722824; PMCID: PMC11770922; DOI: 10.1093/eurjpc/zwae169;
     
  6. Rade JJ, Kronsberg SS, Kickler TS, Vasan RS, Xanthakis V, Nayor MG, Barton BA. Association of Systemic Thromboxane Generation With Risk of Developing Heart Failure. J Am Coll Cardiol. 2025 Jan 07; 85(1):58-70.View Related Profiles. PMID: 39779056
     
  7. Xia M, An J, Fischer H, Allen NB, Xanthakis V, Zhang Y. Blood Pressure Trajectories During Young Adulthood and Cardiovascular Events in Later Life. Am J Hypertens. 2024 Dec 16; 38(1):38-45. PMID: 39325713
     
  8. Carbonneau M, Li Y, Qu Y, Zheng Y, Wood AC, Wang M, Liu C, Huan T, Joehanes R, Guo X, Yao J, Taylor KD, Tracy RP, Peter D, Liu Y, Johnson WC, Post WS, Blackwell T, Rotter JI, Rich SS, Redline S, Fornage M, Wang J, Ning H, Hou L, Lloyd-Jones D, Ferrier K, Min YI, Carson AP, Raffield LM, Teumer A, Grabe HJ, Völzke H, Nauck M, Dörr M, Domingo-Relloso A, Fretts A, Tellez-Plaza M, Cole S, Navas-Acien A, Wang M, Murabito JM, Heard-Costa NL, Prescott B, Xanthakis V, Mozaffarian D, Levy D, Ma J. DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases. medRxiv. 2024 Nov 20.View Related Profiles. PMID: 39606375; PMCID: PMC11601778; DOI: 10.1101/2024.11.19.24317587;
     
  9. Gaye B, Valentin E, Xanthakis V, Perier MC, Celermajer DS, Shipley M, Marijon E, Song RJ, Empana JP, Ramachandran VS, Jouven X. Author Correction: Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies. Sci Rep. 2024 Sep 06; 14(1):20868.View Related Profiles. PMID: 39242738; PMCID: PMC11379920; DOI: 10.1038/s41598-024-72000-2;
     
  10. Gaye B, Valentin E, Xanthakis V, Perier MC, Celermajer DS, Shipley M, Marijon E, Song RJ, Empana JP, Ramachandran VS, Jouven X. Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies. Sci Rep. 2024 Aug 29; 14(1):20052.View Related Profiles. PMID: 39209972; PMCID: PMC11362490; DOI: 10.1038/s41598-024-70806-8;
     
Showing 10 of 153 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 153 publications over 19 distinct years, with a maximum of 20 publications in 2020

YearPublications
20071
20081
20095
20108
20113
20128
20137
20146
20155
20166
20176
20187
20199
202020
202119
202214
20238
202414
20256


AHA News: Overcoming Midlife Barriers to Exercise and Better Health

U.S. News & World Report 6/9/2021

AHA News: Overcoming Midlife Barriers to Exercise and Better Health

Drugs.com 6/9/2021

Healthy diet, exercise might be key to achieving optimal health in later years

HealthWorld 4/3/2021

Exercise, Healthy Diet in Midlife May Prevent Serious Health Conditions in Senior Years

Pharmacy Times 4/2/2021

Exercise, healthy diet in midlife may help in senior years • Vanessa Xanthakis, PhD, medicine

Live Mint 4/1/2021

Research shows how midlife diet, exercise can help in older adulthood

AJC 4/1/2021

Healthy Living in Middle Age Really Pays Off in Senior Years

HealthDay 3/31/2021

Study: Plant-Based Diets Improve Cardiac Function, Cognitive Health

Pharmacy Times 3/5/2021

Plant-based diet high in certain foods protects brain and heart

Slash Gear 3/5/2021

MIND diet, a combination of Mediterranean and DASH diets, associated with cardiac and cognitive benefits

Cardiovascular Business 2/26/2021

Research Suggests This Pair Of Superfood Families May Support Improved Heart & Brain Health

Mind Body Green 2/26/2021

Increased Blood Pressure During Exercise Could Predict Risk of CVD, Death

MD Magazine 5/20/2020

Ideal CV Health Over the Long Term Linked With Better Survival, Less Disease

tctMD 3/15/2020

The Longer You Follow a Healthier Lifestyle in Middle-Age The Lower Your Risk of Death Later in Life

Yahoo News 3/12/2020
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomarkers
Biostatistics
Epidemiology
Heart Failure
Multilevel modeling
Risk prediction
Screening
Ventricular remodeling

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