Vasan S. Ramachandran, MD
Boston University School of Medicine
Dept of Medicine
Preventive Medicine & Epidemiology

MD, All India Institute of Medical Science (AIIMS)
MBBS, All India Institute of Medical Science (AIIMS)
DM, All India Institute of Medical Science (AIIMS)

Vasan S. Ramachandran, M.D., Principal Investigator and Director of the FHS, and Director of the FHS fellowship program in cardiovascular epidemiology for the last 25 years.

Dr. Ramachandran is a Professor of Medicine and Epidemiology at BUSM/BUSPH, and Chief, Section of Preventive Medicine and Epidemiology, Department of Medicine, BUSM. He is the Jay & Louis Coffman Professor of Vascular Medicine at BUSM. Dr. Ramachandran is a trained cardiologist with subspecialty training in echocardiography. He is a fellow of the AHA Councils on Epidemiology and Prevention and Functional Genomics and Translational Biology, and a fellow of the American College of Cardiology (ACC). He has extensive experience in supervising trainees at many levels and has taught the foundational core course on Cardiovascular Epidemiology at BUSPH (EP751). He has several active R01 grants from the NHLBI/NIDDK and received two K24 Mid-Career Investigator mentoring grants from the NHLBI. He has mentored several K23 awardees, and is currently the Principal Investigator of a post-doctoral training program (T32) in cardiovascular epidemiology. Overall, he has supervised over 70 trainees during the past 20 years; most are in key positions in academia. He received the Outstanding Mentor awards from the Department of Medicine, BUSM, and the AHA Council on Epidemiology and Prevention, and the prestigious AHA Population Science Award in 2014.

Importantly, Dr. Ramachandran’s own peer-reviewed funding spans thematic areas of genetics and genomics, cardiac and vascular remodeling, novel biomarkers, systems biology including proteomics and metabolomics, and stem cell biology. He has a 25-year history in research in cardiovascular epidemiology, including the two years he trained as a FHS fellow (1993-1995). He established the first School of Public Health in India between 1996-1998, serving as its inaugural director and the coordinator of its MPH program. He is the founding member and leader of the international EchoGen consortium, and chairs the Steering Committee of the Chronic Kidney Disease Biomarker Consortium funded by the NIDDK (U01DK085689). He is recognized internationally for translational research in cardiovascular epidemiology and lectures regularly at the AHA early career session on “how to develop a career in translational research and epidemiology/genetics.” He is well equipped to mentor trainees about grant writing having been a member of the Cardiovascular and Sleep (CASE) SRG, and an active reviewer of grants for national and international funding agencies. He served for many years on the NHLBI panel for reviewing K23-K24-K25 career development grants. He is well qualified to mentor trainees in best publication practices and has served until recently as an Associate Editor for Circulation, and the Editor-in-Chief of Circulation: Cardiovascular Genetics. He works directs the Center for Integrative Transdisciplinary Epidemiology within BUSM, that hosts multiple epidemiological datasets, including from multiple cohort studies, national surveys (NHANES), administrative databases and electronic health records; this center will be a valuable data source for trainees.

For the last 20 years, Dr. Ramachandran has focused his research on A) the genetic and non-genetic epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; B) population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling, including but not limited to role of natriuretic peptides, insulin resistance, cardiac extracellular matrix markers, oxidative stress, inflammation, growth factors; genetics of LV remodeling, LA and aortic structure and gene-environment interactions; brachial artery endothelial function, its correlates and tonometric assessment of large artery function; C) genetic and non-genetic epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; large artery stiffness and function and role in systolic hypertension in the elderly; genetics of high blood pressure and large artery function; and D) CVD risk estimation in the short, medium- and long-term, with novel biomarkers including genomic biomarkers.

Jay & Louis Coffman Professor of Vascular Medicine
Boston University School of Medicine

Boston University School of Public Health

Section Chief
Boston University School of Medicine
Preventive Medicine & Epidemiology

Director, Echocardiography/Vascular Laboratory
Framingham Heart Study

Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences

The Gut Microbiome and Bone Microarchitecture
08/06/2018 - 06/30/2022 (PI)
Hebrew Rehabilitation Center For Aged, Inc. NIH NIAMS

Multidisciplinary Training Program in Cardiovascular Epidemiology
04/01/2016 - 03/31/2021 (PI)
NIH/National Heart, Lung, and Blood Institute

Cardio-metabolic risk in Multi-ethnic Physical Activity and Sedentary Behavior Study
12/15/2016 - 11/30/2020 (PI)
Albert Einstein College of Medicine NIH NHLBI

Clinical and genetic correlates of the gut microbiome, and relation to cardiometabolic risk
01/01/2016 - 12/31/2019 (PI)
Broad Institute, Inc., The NIH NHLBI

Vascular Stiffness as a Precursor of Hypertension in a Middle-aged Cohort
08/01/2015 - 06/30/2019 (PI)
NIH/National Heart, Lung, and Blood Institute

Proteomic pathway discovery in Cardiovascular Disease
07/01/2016 - 04/30/2019 (PI)
Beth Israel Deaconess Medical Center, Inc NIH NHLBI

Framingham Heart Study
09/25/2015 - 03/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute

Framingham Heart Study
05/07/2015 - 03/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute

Trans-Omics for Precision Medicine (TOPMed) Data Coordinating Center (DCC)
03/01/2018 - 12/31/2018 (PI)
University of Washington NIH NHLBI

Molecular and Genetic Epidimiology of Lipoprotein (a)-mediated Calcific Aortic Valve Disease
01/01/2017 - 12/31/2018 (PI)
McGill University Health Center NIH NHLBI

Showing 10 of 40 results. Show All Results

Yr Title Project-Sub Proj Pubs
2019 Ventricular-vascular coupling in the elderly: lifecourse determinants, trajectories and prognostic significance 1R01HL142983-01A1
2019 Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS) 5R01HL136266-03 9
2019 Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS) 6R01HL136266-04 9
2019 Proteomic Pathway Discovery in Cardiovascular Disease 5R01HL132320-04 6
2019 Multidisciplinary Training Program in Cardiovascular Epidemiology 5T32HL125232-04 13
2019 Comprehensive Metabolic Profiling of Exercise to Predict Cardiometabolic Risk 5R01HL131029-04 14
2019 Clinical, genetic and cardiometabolic risk correlates of the gut microbiome 5R01HL131015-04 1
2018 Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS) 5R01HL136266-02 9
2018 Proteomic Pathway Discovery in Cardiovascular Disease 5R01HL132320-03 6
2018 Multidisciplinary Training Program in Cardiovascular Epidemiology 5T32HL125232-03 13
Showing 10 of 81 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, Patchen BK, Schu M, Beydoun MA, Brusselle GG, Eiriksdottir G, Zhou X, Wood AC, Graff M, Harris TB, Ikram MA, Jacobs DR, Launer LJ, Lemaitre RN, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Rohde RR, Rich SS, Rotter JI, Seshadri S, Smith LJ, Tiemeier H, Tsai MY, Uitterlinden AG, Voruganti VS, Xu H, Zilhão NR, Fornage M, Zillikens MC, London SJ, Barr RG, Dupuis J, Gharib SA, Gudnason V, Lahousse L, North KE, Steffen LM, Cassano PA, Hancock DB. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2019 Mar 01; 199(5):631-642.View Related Profiles. PMID: 30199657.
  2. Harris WS, Tintle NL, Ramachandran VS. Erythrocyte n-6 Fatty Acids and Risk for Cardiovascular Outcomes and Total Mortality in the Framingham Heart Study. Nutrients. 2018 Dec 19; 10(12). PMID: 30572606.
  3. Zekavat SM, Ruotsalainen S, Handsaker RE, Alver M, Bloom J, Poterba T, Seed C, Ernst J, Chaffin M, Engreitz J, Peloso GM, Manichaikul A, Yang C, Ryan KA, Fu M, Johnson WC, Tsai M, Budoff M, Vasan RS, Cupples LA, Rotter JI, Rich SS, Post W, Mitchell BD, Correa A, Metspalu A, Wilson JG, Salomaa V, Kellis M, Daly MJ, Neale BM, McCarroll S, Surakka I, Esko T, Ganna A, Ripatti S, Kathiresan S, Natarajan P. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 07 04; 9(1):2606.View Related Profiles. PMID: 29973585.
  4. de Boer RA, Nayor M, deFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JAC, Bahrami H, van der Harst P, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Hillege HL, Bartz TM, Benjamin EJ, Chan C, Allison M, Gardin JM, Januzzi JL, Shah SJ, Levy D, Herrington DM, Larson MG, van Gilst WH, Gottdiener JS, Bertoni AG, Ho JE. Association of Cardiovascular Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction. JAMA Cardiol. 2018 Mar 01; 3(3):215-224.View Related Profiles. PMID: 29322198.
  5. Nayor M, Duncan MS, Musani SK, Xanthakis V, LaValley MP, Larson MG, Fox ER, Vasan RS. Incidence of cardiovascular disease in individuals affected by recent changes to US blood pressure treatment guidelines. J Hypertens. 2018 02; 36(2):436-443.View Related Profiles. PMID: 29084083.
  6. Jørgensen ME, Andersson C, Vasan RS, Køber L, Abdulla J. Characteristics and prognosis of heart failure with improved compared with persistently reduced ejection fraction: A systematic review and meta-analyses. Eur J Prev Cardiol. 2018 03; 25(4):366-376. PMID: 29313369; DOI: 10.1177/2047487317750437;.
  7. Weinstein G, Zelber-Sagi S, Preis SR, Beiser AS, DeCarli C, Speliotes EK, Satizabal CL, Vasan RS, Seshadri S. Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study. JAMA Neurol. 2018 Jan 01; 75(1):97-104.View Related Profiles. PMID: 29159396.
  8. Sarnowski C, Satizabal CL, DeCarli C, Pitsillides AN, Cupples LA, Vasan RS, Wilson JG, Bis JC, Fornage M, Beiser AS, DeStefano AL, Dupuis J, Seshadri S. Whole genome sequence analyses of brain imaging measures in the Framingham Study. Neurology. 2018 Jan 16; 90(3):e188-e196.View Related Profiles. PMID: 29282330.
  9. Zachariah JP, Rong J, Larson MG, Hamburg NM, Benjamin EJ, Vasan RS, Mitchell GF. Metabolic Predictors of Change in Vascular Function: Prospective Associations From a Community-Based Cohort. Hypertension. 2018 02; 71(2):237-242.View Related Profiles. PMID: 29279312.
  10. Benson MD, Yang Q, Ngo D, Zhu Y, Shen D, Farrell LA, Sinha S, Keyes MJ, Vasan RS, Larson MG, Smith JG, Wang TJ, Gerszten RE. Genetic Architecture of the Cardiovascular Risk Proteome. Circulation. 2018 03 13; 137(11):1158-1172.View Related Profiles. PMID: 29258991.
Showing 10 of 789 results. Show More