Vasan S. Ramachandran, MD
Adjunct Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Preventive Medicine & Epidemiology

MD, All India Institute of Medical Science (AIIMS)
MBBS, All India Institute of Medical Science (AIIMS)
DM, All India Institute of Medical Science (AIIMS)



Vasan S. Ramachandran, M.D., Principal Investigator and Director of the Framingham Heart Study (FHS), and Principal Investigator of the Risk Underlying Rural Areas Longitudinal Study (RURAL).

Dr. Ramachandran is an Adjunct Professor of Medicine and Epidemiology at BUSM/BUSPH, and Dean of the University of Texas School of Public Health San Antonio. He is a trained cardiologist with subspecialty training in echocardiography. He is a fellow of the AHA Councils on Epidemiology and Prevention and Functional Genomics and Translational Biology, and a fellow of the American College of Cardiology (ACC). Dr. Ramachandran has extensive experience in supervising trainees at many levels and has taught the foundational core course on Cardiovascular Epidemiology at BUSPH (EP751). He has several active R01 grants from the NHLBI/NIDDK/NIA, received two K24 Mid-Career Investigator mentoring grants from the NHLBI, and has mentored several K23 awardees. Overall, he has supervised over 75 trainees during the past 20 years (~40% women, 25% non-White); most are in key positions in academia. He received the Outstanding Mentor awards from the Department of Medicine, BUSM, and the AHA Council on Epidemiology and Prevention, the prestigious AHA Population Science Award in 2014 and the AHA Distinguished Scientist Award in 2021.

Importantly, Dr. Ramachandran’s own peer-reviewed funding spans thematic areas of genetics and genomics, cardiac and vascular remodeling, novel biomarkers, systems biology including proteomics and metabolomics, microbiome, and stem cell biology. He has a 25-year history in research in cardiovascular epidemiology, including the two years he trained as a FHS fellow (1993-1995). He established the first School of Public Health in Kerala, India, between 1996-1998, serving as its inaugural director and the coordinator of its MPH program. He is the founding member and leader of the international EchoGen consortium, and chairs the Steering Committee of the Chronic Kidney Disease Biomarker Consortium funded by the NIDDK (U01DK085689). He is recognized internationally for translational research in cardiovascular epidemiology and lectures regularly at the AHA early career session on “how to develop a career in translational research and epidemiology/genetics.” He is a Trained Mentor and has been been a past member of the NIH Cardiovascular and Sleep (CASE) SRG, and an active reviewer of grants for national and international funding agencies. He served for many years on the NHLBI panel for reviewing K23-K24-K25 career development grants. He served as an Associate Editor for Circulation, and the founding Editor-in-Chief of Circulation: Cardiovascular Genetics. He directs the Center for Integrative Transdisciplinary Epidemiology within BUSM, that hosts multiple epidemiological datasets, including from multiple cohort studies, national surveys (NHANES), administrative databases and electronic health records; this center will be a valuable data source for trainees.

For the last 25 years, Dr. Ramachandran has focused his research on A) the genetic and non-genetic epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; B) population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling, including but not limited to role of natriuretic peptides, insulin resistance, cardiac extracellular matrix markers, oxidative stress, inflammation, growth factors; genetics of LV remodeling, LA and aortic structure and gene-environment interactions; brachial artery endothelial function, its correlates and tonometric assessment of large artery function; C) genetic and non-genetic epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; large artery stiffness and function and role in systolic hypertension in the elderly; genetics of high blood pressure and large artery function; D) CVD risk estimation in the short, medium- and long-term, with novel biomarkers including genomic biomarkers; and E) rural health disparities via the RURAL cohort study.

Dean
University of Texas School of Public Health San Antonio




Multidisciplinary Training Program in Cardiovascular Epidemiology
04/01/2021 - 03/31/2026 (PI of Sub-Project / SP)
PI: Vanessa Xanthakis, PhD
NIH/National Heart, Lung, and Blood Institute
5T32HL125232-08

Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease
03/15/2021 - 02/28/2026 (Co-Investigator of Sub-Project / SP)
Beth Israel Deaconess Medical Center, Inc NIH NHLBI
5R01HL155717-02

Framingham Heart Study
04/01/2019 - 06/30/2025 (PI of Sub-Project / SP)
PI: Joanne M. Murabito, MD
NIH/National Heart, Lung, and Blood Institute
75N92019D00031

Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and Resilience in the Framingham Study
09/15/2020 - 05/31/2025 (Co-Investigator of Sub-Project / SP)
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG066524-03

Return of Genomic Results and Estimating Penetrance in Population-Based Cohorts
08/01/2019 - 06/30/2024 (Co-Investigator of Sub-Project / SP)
Broad Institute, Inc., The NIH NHLBI
1R01HL143295-04

Cardio-metabolic risk in Multi-ethnic Physical Activity and Sedentary Behavior Study
12/15/2016 - 11/30/2023 (Co-Investigator of Sub-Project / SP)
Albert Einstein College of Medicine NIH NHLBI
5R01HL136266-05

Mediators of Systemic Inflammation and Heart Failure Risk in the Community
04/01/2019 - 03/31/2023 (Co-Investigator of Sub-Project / SP)
Cedars-Sinai Medical Center NIH NHLBI
5R01HL143227-04

Neighborhoods and Cardiovascular Risk and Resilience in Rural Communities
04/01/2022 - 10/31/2022 (Subcontract PI)
University of California, Berkeley NIH NHLBI
1R01HL157820-01A1

Epidemiologic Determinants of Cardiac Structure and Function in Rural Residents: RURAL ECHO
02/21/2022 - 10/31/2022 (Subcontract PI)
Duke University NIH NHLBI
1R01HL157531-01A1

RURAL: Risk Underlying Rural Areas Longitudinal Cohort Study
04/01/2019 - 10/31/2022 (PI)
NIH/National Heart, Lung, and Blood Institute
5U01HL146382-04

Showing 10 of 57 results. Show All Results

Population-Based Reference Ranges for Estradiol and Estrone in Men
04/07/2012 - 07/31/2012 (Activity-level PI)
PI: Shalender Bhasin, MBBS
NIH-NIDDK
1R01 DK092938-01A1


Title


Yr Title Project-Sub Proj Pubs
2024 Epidemiology of blood pressure responses to perturbations: Correlates and prognosis for vascular risk, end-organ damage, cognitive aging and preclinical Alzheimer's disease 5R01AG075703-03
2023 Aortic stiffness, wave reflection, and cerebrovascular flow pulsatility: relations with brain small vessel disease and cognitive function in a middle-aged cohort 1RF1AG079390-01A1
2023 Development of a cloud-based analytical tool for polygenic risk score and its implication in heart failure research. 3R01HL160793-02S1
2023 Genetic Architecture of Cardiac Structure and Function and Its Impact on Heart Failure 5R01HL160793-02
2023 Epidemiology of blood pressure responses to perturbations: Correlates and prognosis for vascular risk, end-organ damage, cognitive aging and preclinical Alzheimer's disease 7R01AG075703-02
2023 Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and Resilience 5R01AG066524-04
2023 ASSIST - Address Self-Management Strategies to Improve and Sustain T2D outcomes for adults with comorbid chronic pain and type 2 diabetes in the South 3U01HL146382-06S1
2023 RURAL: Risk Underlying Rural Areas Longitudinal Cohort Study 7U01HL146382-05
2023 RURAL: Risk Underlying Rural Areas Longitudinal Cohort Study 5U01HL146382-06
2022 Genetic Architecture of Cardiac Structure and Function and Its Impact on Heart Failure 1R01HL160793-01A1
Showing 10 of 121 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Zhou JC, Zhao Y, Bello N, Benjamin EJ, Ramachandran VS, Levy D, Cheng S, Murabito JM, Ho JE, Lau ES. Infertility and Subclinical Antecedents of Heart Failure With Preserved Ejection Fraction in the Framingham Heart Study. J Card Fail. 2024 Mar; 30(3):513-515.View Related Profiles. PMID: 37979670
     
  2. Weber JE, Ahmadi M, Boldt LH, Eckardt KU, Edelmann F, Gerhardt H, Grittner U, Haubold K, Hübner N, Kollmus-Heege J, Landmesser U, Leistner DM, Mai K, Müller DN, Nolte CH, Pieske B, Piper SK, Rattan S, Rauch G, Schmidt S, Schmidt-Ott KM, Schönrath K, Schulz-Menger J, Schweizerhof O, Siegerink B, Spranger J, Ramachandran VS, Witzenrath M, Endres M, Pischon T. Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients. BMJ Open. 2023 Oct 31; 13(10):e076415. PMID: 37907297; PMCID: PMC10618970; DOI: 10.1136/bmjopen-2023-076415;
     
  3. Westerman KE, Walker ME, Gaynor SM, Wessel J, DiCorpo D, Ma J, Alonso A, Aslibekyan S, Baldridge AS, Bertoni AG, Biggs ML, Brody JA, Chen YI, Dupuis J, Goodarzi MO, Guo X, Hasbani NR, Heath A, Hidalgo B, Irvin MR, Johnson WC, Kalyani RR, Lange L, Lemaitre RN, Liu CT, Liu S, Moon JY, Nassir R, Pankow JS, Pettinger M, Raffield LM, Rasmussen-Torvik LJ, Selvin E, Senn MK, Shadyab AH, Smith AV, Smith NL, Steffen L, Talegakwar S, Taylor KD, de Vries PS, Wilson JG, Wood AC, Yanek LR, Yao J, Zheng Y, Boerwinkle E, Morrison AC, Fornage M, Russell TP, Psaty BM, Levy D, Heard-Costa NL, Ramachandran VS, Mathias RA, Arnett DK, Kaplan R, North KE, Correa A, Carson A, Rotter JI, Rich SS, Manson JE, Reiner AP, Kooperberg C, Florez JC, Meigs JB, Merino J, Tobias DK, Chen H, Manning AK. Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits. Diabetes. 2023 May 01; 72(5):653-665.View Related Profiles. PMID: 36791419; PMCID: PMC10130485; DOI: 10.2337/db22-0851;
     
  4. Satizabal CL, Himali JJ, Beiser AS, Ramachandran V, Melo van Lent D, Himali D, Aparicio HJ, Maillard P, DeCarli CS, Harris WS, Seshadri S. Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife: The Framingham Heart Study. Neurology. 2022 Dec 05; 99(23):e2572-e2582.View Related Profiles. PMID: 36198518; PMCID: PMC9754651; DOI: 10.1212/WNL.0000000000201296;
     
  5. Pirruccello JP, Lin H, Khurshid S, Nekoui M, Weng LC, Ramachandran VS, Isselbacher EM, Benjamin EJ, Lubitz SA, Lindsay ME, Ellinor PT. Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals. JAMA. 2022 11 15; 328(19):1935-1944.View Related Profiles. PMID: 36378208; PMCID: PMC9667326; DOI: 10.1001/jama.2022.19701;
     
  6. Cohen JB, Mitchell GF, Gill D, Burgess S, Rahman M, Hanff TC, Ramachandran VS, Mutalik KM, Townsend RR, Chirinos JA. Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank. Circ Res. 2022 Sep 02; 131(6):545-554. PMID: 35946401; PMCID: PMC7613487; DOI: 10.1161/CIRCRESAHA.122.320796;
     
  7. Schwartz B, Schou M, Barrillas Lara IM, Monahan K, Helm R, Køber L, Gislason GH, Ramachandran VS, Torp-Pedersen C, Andersson C. Prognostic importance of atrial fibrillation in heart failure according to time elapsed since diagnosis. Heart Rhythm O2. 2022 Aug; 3(4):430-432.View Related Profiles. PMID: 36097453; PMCID: PMC9463685; DOI: 10.1016/j.hroo.2022.04.008;
     
  8. Vasan RS, Enserro DM, Beiser AS, Xanthakis V. Lifetime Risk of Heart Failure Among Participants in the Framingham Study. J Am Coll Cardiol. 2022 01 25; 79(3):250-263.View Related Profiles. PMID: 35057911; PMCID: PMC8820638; DOI: 10.1016/j.jacc.2021.10.043;
     
  9. Lee AM, Hu J, Xu Y, Abraham AG, Xiao R, Coresh J, Rebholz C, Chen J, Rhee EP, Feldman HI, Ramachandran VS, Kimmel PL, Warady BA, Furth SL, Denburg MR. Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology. J Am Soc Nephrol. 2022 02; 33(2):375-386. PMID: 35017168; PMCID: PMC8819986; DOI: 10.1681/ASN.2021040538;
     
  10. Vasan RS, van den Heuvel E. Differences in estimates for 10-year risk of cardiovascular disease in Black versus White individuals with identical risk factor profiles using pooled cohort equations: an in silico cohort study. Lancet Digit Health. 2022 01; 4(1):e55-e63.View Related Profiles. PMID: 34952676; PMCID: PMC8715354; DOI: 10.1016/S2589-7500(21)00236-3;
     
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