Massachusetts Center for Alzheimer and dEmeNtia behaVIoral reSearch In minOrity agiNg (Mass-ENVISION) - Community Liaison and Recruitment Core (CLRC)
09/01/2023 - 06/30/2028 (Subcontract PI)
Massachusetts General Hospital NIH NIA
1P30AG083196-01

Identifying ADRD intervention targets by characterizing neurobiological mechanisms of social isolation, loneliness, and social environment dynamics using novel imaging, molecular markers, and...
09/15/2022 - 05/31/2027 (Subcontract PI)
New York University, dba NYU Grossman School of Medicine NIH NIA
5R01AG079282-03

Novel biomarkers to predict cognitive decline and dementia in persons with cerebrovascular disease
07/01/2020 - 06/30/2025 (PI)
American Academy of Neurology


Precursors of Stroke Incidence and Prognosis
09/09/2023 - 09/10/2023 (Multi-PI)
PI: Hugo J. Aparicio, MD, MPH
NIH/National Institute of Neurological Disorders & Stroke
2R01NS017950-38A1

Blood biomarkers for prediction of vascular cognitive impairment & dementia
07/01/2020 - 06/30/2023 (PI)
Alzheimer's Association

1. Yau WW, Scott MR, Petrea RE, Buckley RF, Kojis D, Sperling RA, Chhatwal JP, Maillard P, Aparicio HJ, Romero JR, DeCarli CS, Beiser AS, Seshadri S. Sex-Specific Vulnerabilities to Subclinical Vascular Brain Injury in Early Late-Life: The Framingham Heart Study. Ann Neurol. 2024 Nov 14.View Related Profiles.

   Beiser, Alexa
   Aparicio, Hugo
   Romero, Jose
   Petrea, Rodica
   Seshadri, Sudha
   

   PMID: 39540324
2. Kelly DM, Pinheiro AA, Koini M, Anderson CD, Aparicio H, Hofer E, Kern D, Blacker D, DeCarli C, Hwang SJ, Viswanathan A, Gonzales MM, Beiser AS, Seshadri S, Schmidt R, Demissie S, Romero JR. Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study. Nephrol Dial Transplant. 2024 Oct 30; 39(11):1911-1922.View Related Profiles.

   Beiser, Alexa
   Aparicio, Hugo
   Demissie, Serkalem
   Hwang, Shih-Jen
   Seshadri, Sudha
   

   PMID: 38565317
3. Springer MV, Chen B, Whitney RT, Briceño EM, Gross AL, Aparicio HJ, Beiser AS, Burke JF, Giordani B, Gottesman RF, Hayward RA, Howard VJ, Koton S, Lazar RM, Sussman JB, Ye W, Levine DA. Age differences in the change in cognition after stroke. J Stroke Cerebrovasc Dis. 2024 Oct 12; 33(12):108087.View Related Profiles.

   Beiser, Alexa
   Aparicio, Hugo
   

   PMID: 39401577
4. Elmore AR, Adhikari N, Hartley AE, Aparicio HJ, Posner DC, Hemani G, Tilling K, Gaunt TR, Wilson PWF, Casas JP, Gaziano JM, Davey Smith G, Paternoster L, Cho K, Peloso GM. Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank. Stroke. 2024 Aug; 55(8):2045-2054.View Related Profiles.

   Peloso, Gina
   Aparicio, Hugo
   Gaziano, J. Michael
   

   PMID: 39038097; PMCID: PMC11259242; DOI: 10.1161/STROKEAHA.124.047103;
5. Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S, Chen J, Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M. SMIM1 absence is associated with reduced energy expenditure and excess weight. Med. 2024 Sep 13; 5(9):1083-1095.e6. PMID: 38906141
6. Joynt Maddox KE, Elkind MSV, Aparicio HJ, Commodore-Mensah Y, de Ferranti SD, Dowd WN, Hernandez AF, Khavjou O, Michos ED, Palaniappan L, Penko J, Poudel R, Roger VL, Kazi DS. Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050-Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association. Circulation. 2024 Jul 23; 150(4):e65-e88. PMID: 38832505
7. Levine DA, Whitney RT, Ye W, Briceño EM, Gross AL, Giordani BJ, Sussman JB, Lazar RM, Howard VJ, Aparicio HJ, Beiser AS, Elkind MSV, Gottesman RF, Koton S, Pendlebury ST, Kollipara AS, Springer MV, Seshadri S, Romero JR, Fitzpatrick AL, Longstreth WT, Hayward RA. Associations Between Stroke Type, Ischemic Stroke Subtypes, and Post-Stroke Cognitive Trajectories. medRxiv. 2024 May 01.View Related Profiles.

   Beiser, Alexa
   Aparicio, Hugo
   Seshadri, Sudha
   

   PMID: 38903102; PMCID: PMC11188123; DOI: 10.1101/2024.04.29.24306600;
8. DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024 May 01; 81(5):471-480.View Related Profiles.

   Beiser, Alexa
   Satizabal, Claudia
   Aparicio, Hugo
   Himali, Jayandra
   Seshadri, Sudha
   

   PMID: 38526486; PMCID: PMC10964161; DOI: 10.1001/jamaneurol.2024.0469;
9. Elmore A, Adhikari N, Hartley AE, Javier Aparicio H, Posner DC, Hemani G, Tilling K, Gaunt TR, Wilson P, Casas JP, Michael Gaziano J, Smith GD, Paternoster L, Cho K, Peloso GM. Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank. medRxiv. 2024 Feb 01.View Related Profiles.

   Peloso, Gina
   Aparicio, Hugo
   Gaziano, J. Michael
   

   PMID: 38352469; PMCID: PMC10863017; DOI: 10.1101/2024.01.31.24302111;
10. Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075.View Related Profiles.

    Beiser, Alexa
    Satizabal, Claudia
    Aparicio, Hugo
    Himali, Jayandra
    Yang, Qiong
    Seshadri, Sudha
    

    PMID: 38290090; PMCID: PMC11383876; DOI: 10.1212/WNL.0000000000208075;

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