Identifying ADRD intervention targets by characterizing neurobiological mechanisms of social isolation, loneliness, and social environment dynamics using novel imaging, molecular markers, and...
09/15/2022 - 05/31/2027 (Subcontract PI)
New York University School of Medicine NIH NIA
1R01AG079282-01

Novel biomarkers to predict cognitive decline and dementia in persons with cerebrovascular disease
07/01/2020 - 06/30/2024 (PI)
American Academy of Neurology


Blood biomarkers for prediction of vascular cognitive impairment & dementia
07/01/2020 - 06/30/2023 (PI)
Alzheimer's Association

1. Kelly DM, Pinheiro AA, Koini M, Anderson CD, Aparicio H, Hofer E, Kern D, Blacker D, DeCarli C, Hwang SJ, Viswanathan A, Gonzales MM, Beiser AS, Seshadri S, Schmidt R, Demissie S, Romero JR. Impaired Kidney Function, Cerebral Small Vessel Disease and Cognitive Disorders: The Framingham Heart Study. Nephrol Dial Transplant. 2024 Apr 02.View Related Profiles.

   Beiser, Alexa
   Aparicio, Hugo
   Demissie, Serkalem
   Hwang, Shih-Jen
   Seshadri, Sudha
   

   PMID: 38565317
2. DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024 Mar 25.View Related Profiles.

   Beiser, Alexa
   Satizabal, Claudia
   Aparicio, Hugo
   Himali, Jayandra
   Seshadri, Sudha
   

   PMID: 38526486; PMCID: PMC10964161; DOI: 10.1001/jamaneurol.2024.0469;
3. Elmore A, Adhikari N, Hartley AE, Javier Aparicio H, Posner DC, Hemani G, Tilling K, Gaunt TR, Wilson P, Casas JP, Michael Gaziano J, Smith GD, Paternoster L, Cho K, Peloso GM. Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank. medRxiv. 2024 Feb 01.View Related Profiles.

   Peloso, Gina
   Aparicio, Hugo
   Gaziano, J. Michael
   

   PMID: 38352469; PMCID: PMC10863017; DOI: 10.1101/2024.01.31.24302111;
4. Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075.View Related Profiles.

   Beiser, Alexa
   Satizabal, Claudia
   Aparicio, Hugo
   Himali, Jayandra
   Yang, Qiong
   Seshadri, Sudha
   

   PMID: 38290090
5. Montoliu-Gaya L, Alosco ML, Yhang E, Tripodis Y, Sconzo D, Ally M, Grötschel L, Ashton NJ, Lantero-Rodriguez J, Sauer M, Gomes B, Nilsson J, Brinkmalm G, Sugarman MA, Aparicio HJ, Martin B, Palmisano JN, Steinberg EG, Simkin I, Turk KW, Budson AE, Au R, Farrer L, Jun GR, Kowall NW, Stern RA, Goldstein LE, Qiu WQ, Mez J, Huber BR, Alvarez VE, McKee AC, Zetterberg H, Gobom J, Stein TD, Blennow K. Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study. Acta Neuropathol. 2023 Dec 30; 147(1):5.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Huber, Bertrand
   Sconzo, Daniel
   Steinberg, Eric
   Jun, Gyungah
   Aparicio, Hugo
   Mez, Jesse
   Turk, Katherine
   Goldstein, Lee
   Farrer, Lindsay
   Alosco, Michael
   Kowall, Neil
   Au, Rhoda
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 38159140; PMCID: PMC10757700; DOI: 10.1007/s00401-023-02660-3;
6. Song RJ, Larson MG, Aparicio HJ, Gaziano JM, Wilson P, Cho K, Vasan RS, Fox MP, Djoussé L. Moderate alcohol consumption on the risk of stroke in the Million Veteran Program. BMC Public Health. 2023 Dec 12; 23(1):2485.View Related Profiles.

   Aparicio, Hugo
   Gaziano, J. Michael
   Larson, Martin
   Fox, Matthew
   

   PMID: 38087273; PMCID: PMC10714616; DOI: 10.1186/s12889-023-17377-x;
7. Sheehy S, Aparicio HJ, Palmer JR, Cozier Y, Lioutas VA, Shulman JG, Rosenberg L. Perceived Interpersonal Racism and Incident Stroke Among US Black Women. JAMA Netw Open. 2023 Nov 01; 6(11):e2343203.View Related Profiles.

   Aparicio, Hugo
   Palmer, Julie
   Shulman, Julie
   Sheehy, Shanshan
   Cozier, Yvette
   

   PMID: 37948073; PMCID: PMC10638652; DOI: 10.1001/jamanetworkopen.2023.43203;
8. Ally M, Sugarman MA, Zetterberg H, Blennow K, Ashton NJ, Karikari TK, Aparicio HJ, Frank B, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Farrer LA, Jun GR, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Kowall NW, Killiany R, Stern RA, Stein TD, McKee AC, Qiu WQ, Mez J, Alosco ML. Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease. Alzheimers Dement (Amst). 2023; 15(4):e12492.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Frank, Brandon
   Steinberg, Eric
   Jun, Gyungah
   Aparicio, Hugo
   Mez, Jesse
   Turk, Katherine
   Goldstein, Lee
   Farrer, Lindsay
   O'Connor, Maureen
   Alosco, Michael
   Kowall, Neil
   Au, Rhoda
   Stern, Robert
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 37885919; PMCID: PMC10599277; DOI: 10.1002/dad2.12492;
9. Petrea RE, Pinheiro A, Demissie S, Ekenze O, Aparicio HJ, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S, Lioutas VA, Rafael Romero J. Hypertension Trends and White Matter Brain Injury in the Offspring Framingham Heart Study Cohort. Hypertension. 2024 Jan; 81(1):87-95.View Related Profiles.

   Beiser, Alexa
   Satizabal, Claudia
   Aparicio, Hugo
   Petrea, Rodica
   Demissie, Serkalem
   Seshadri, Sudha
   

   PMID: 37855140; PMCID: PMC10896002; DOI: 10.1161/HYPERTENSIONAHA.123.21264;
10. Vered S, Beiser AS, Sulimani L, Sznitman S, Gonzales MM, Aparicio HJ, DeCarli C, Scott MR, Ghosh S, Lewitus GM, Meiri D, Seshadri S, Weinstein G. The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury. Alzheimers Res Ther. 2023 Sep 12; 15(1):154.View Related Profiles.

    Beiser, Alexa
    Weinstein, Galit
    Aparicio, Hugo
    Seshadri, Sudha
    

    PMID: 37700370; PMCID: PMC10496329; DOI: 10.1186/s13195-023-01301-x;

Showing 10 of 79 results. Show More

High Blood Pressure Triples Stroke Risk for Black Women Under 35, Study Finds

Stroke risk increased 3-fold by hypertension before age 35 in Black women

Risk for stroke tripled among young Black women with high blood pressure

High Blood Pressure in Young Black Women Sends Stroke Risks Soaring

Black women with high blood pressure before age 35 have triple the risk of a stroke

Hypertension Before 35 Tied to Triple Stroke Risk in Midlife

Black women under 35 with high blood pressure may have triple the risk of stroke, study says

High Blood Pressure in Young Black Women Sends Stroke Risks Soaring

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Indigenous populations may have higher stroke risk

Seven BU Latinx Researchers Making a Difference

Race Matters in Stroke Survival, Study Finds

The Severity Of Depressive Symptoms Over Time May Help Predict Stroke Risk

Blood Pressure Trajectories in Early Adulthood Associated with Cerebral Lesions and Brain Structure in Midlife

Low blood pressure linked to increased death risk following stroke

Can Low Blood Pressure Lead to Stroke? Read on to Find Out More

Low Blood Pressure Linked to Increased Death Risk Following Stroke

Seizures Tied to a Doubling of Dementia Risk in Young Survivors

AHA News: Blood Test That Measures Alcohol Use May Predict Risk for Bleeding Strokes

Surviving a Stroke, Caroline's Story

Long-term Decline in Stroke Greater in Older Adults: Study

Longitudinal cohort studies could be a good alternative for early career investigators

2018–2019 Career Development Awards Honor Eight Junior Faculty