Carlos S. Kase, MD
Emeritus Professor
Boston University School of Medicine
Dept of Neurology

MD, Pontificia Universidad Católica de Chile



Born in Buenos Aires, Argentina, Dr. Carlos Kase earned his MD degree in Santiago, Chile, from the Catholic University of Chile in May 1967. He pursued further training in Neurology and Vascular Neurology at Massachusetts General Hospital in Boston from 1972-1973, and 1977-1978. Dr. Kase is board-certified by the American Board of Psychiatry and Neurology in Neurology (1980) and also board-certified in the subspecialty of Vascular Neurology (2005).

Dr. Kase joined the Department of Neurology at Boston University School of Medicine in 1984, where he is currently Professor of Neurology and Neurologist-in-Chief, Boston Medical Center. Prior to this, he joined Dr. J.P. Mohr in forming the Neurology Department at the University of South Alabama in Mobile, Alabama in 1978.

Dr. Kase's professional and research interests are in cerebrovascular diseases, with a special interest in intracerebral hemorrhage, carotid artery disease and lacunar infarctions. He has been actively involved in performing clinical studies and clinico-pathologic correlations in intracerebral hemorrhage and cerebral infarction. His research activities have included participation in multicenter NIH-sponsored studies such as the Stroke Data Bank (NINCDS), the Warfarin Aspirin Recurrent Stroke Study (WARSS), the Warfarin vs. Aspirin for Symptomatic Intracranial Disease (WASID) Study, the Secondary Prevention of Small Subcortical Strokes (SPS3) study, and the Insulin Resistance Intervention after Stroke (IRIS) trial, as well as in a number of therapeutic clinical trials. In addition, Dr. Kase has participated in the Framingham Study since 1984, where he has led a number of important epidemiological studies on risk factors in stroke.

Dr. Kase has received numerous distinguished honors for his work in cerebrovascular disease, including Honorary Membership to the Spanish Society of Neurology and the Mexican Association of Cerebrovascular Disease. In 2001, he received the C. Miller Fisher Award for Excellence in Stroke, awarded by the American Stroke Association, Massachusetts Affiliate. In 2002 he was awarded the title of Doctor Honoris Causa from the Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

Dr. Kase was recognized as a "Top Doctor" in Neurology by Boston Magazine in 2009, 2010, 2011, 2012 and by U.S. News and World Report in 2011.

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Randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of desmoteplase in acute ischemic stroke
09/01/2009 - 12/31/2014 (PI)
Lundbeck, Inc.

A Phase 2, Randomized, Double Blind Placebo Controlled Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of PF-04360365 (Ponezumab)
10/21/2013 - 11/30/2014 (PI)
Pfizer, Inc.

Personnel Agreement for Research Services of Ethan Treglia
01/01/2011 - 09/30/2012 (PI)
VA Boston Healthcare System

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects with a History of Atherosclerotic D
05/01/2008 - 04/30/2012 (PI)
Schering-Plough Research Institute

SPS3
12/01/2009 - 01/31/2012 (PI)
University of British Columbia NIH NINDS

PREDICT (Predicting hEmatoma growth anD outcome in Intracerebral hemorrhage using contrast bolus CT) study
11/01/2009 - 10/30/2010 (PI)
University of Calgary

PRoFESS- Prevention Regimen for Effectively Avoiding Second Strokes: A Double-Blind, Active and Placebo Controlled Study of Aggrenox vs. Clopidogrel and Aspirin, With and Without Micardis
09/01/2003 - 08/31/2007 (PI)
Boehringer Ingelheim Pharmaceuticals

DIAS 2: Desmoteplase (INN) In Acute Ischemic Stroke: Phase III
05/17/2005 - 12/31/2006 (PI)
Forest Laboratories, Inc./Forest Research Institute

Management of Atherothrombosis with Clopidogrel in High Risk Patients with Recent Transient Ischemic of Ischemic Stroke
09/01/2001 - 08/31/2003 (PI)
Parexel Sanofi Synthelabo

Epidemiologic Study of Acute Ischemic Stroke (ESIS)
09/22/2000 - 07/31/2003 (PI)
Genentech, Inc.

Showing 10 of 12 results. Show All Results

NIH StrokeNet Clinical Coordinating Center Master Trial Agreement (MTA) - Satellites
09/30/2013 - 07/31/2018 (PI)
Univ of Cincinnati NIH-NINDS

New England Regional Coordinating Center for the NINDS Stroke Trials Network
09/30/2013 - 07/31/2017 (PI)
Mass General Hosp NIH-NINDS

MR WITNESS: A Phase IIa Safety Study of Intravenous Thrombolysis with Altephase in MRI-Selected P…
11/19/2014 - 12/31/2015 (PI)
Mass General Hosp Genentech

Insulin Resistance Intervention After Stroke Trial (IRIS)
09/15/2004 - 08/31/2015 (PI)
Yale University NIH-NINDS

Bumpus Project 4
02/01/2004 - 01/31/2014 (PI)
Bumpus Foundation

MR Rescue
06/01/2007 - 04/30/2013 (PI)
Univ of California, Los Angeles NIH-NINDS

MA Coverdell Stroke Registry Project
06/09/2005 - 06/30/2009 (PI)
DPH

A Randomized Trial of Unruptured Brain Arteriovenous (ARUBA)
01/13/2006 - 07/31/2008 (PI)
Columbia University NIH
U01 NS0514843-01

Bumpus Parkinson'S Project 1
02/01/2001 - 02/01/2006 (PI)
Bumpus Foundation

Bumpus Parkinson'S Project 2
02/01/2001 - 02/01/2005 (PI)
Bumpus Foundation

Showing 10 of 11 results. Show All Results


Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Aparicio HJ, Himali JJ, Beiser AS, Davis-Plourde KL, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. J Am Heart Assoc. 2017 Jun 24; 6(6).View Related Profiles. PMID: 28647687.
  2. Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS, D''Agostino RB, Wolf PA, Vasan RS, DeCarli C, O''Donnell CJ, Seshadri S. Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis. 2017 Jun 23.View Related Profiles. PMID: 28673480.
  3. Perloff MD, Patel NS, Kase CS, Oza AU, Voetsch B, Romero JR. Cerebellar stroke presenting with isolated dizziness: Brain MRI in 136 patients. Am J Emerg Med. 2017 Jun 22.View Related Profiles. PMID: 28687453.
  4. Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. Stroke. 2017 Jul; 48(7):1760-1765.View Related Profiles. PMID: 28596451.
  5. Dufouil C, Beiser A, McLure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan L, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, D''Agostino RB, Samieri C, Vasan RS, Chêne G, Howard G, Seshadri S. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. 2017 Mar 21; 135(12):1145-1159.View Related Profiles. PMID: 28159800; DOI: 10.1161/CIRCULATIONAHA.115.021275;.
  6. Romero JR, Preis SR, Beiser A, Himali JJ, Shoamanesh A, Wolf PA, Kase CS, Vasan RS, DeCarli C, Seshadri S. Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study. Stroke. 2017 Mar; 48(3):781-783.View Related Profiles. PMID: 28143923; DOI: 10.1161/STROKEAHA.116.015354;.
  7. Lubitz SA, Yin X, McManus DD, Weng LC, Aparicio HJ, Walkey AJ, Rafael Romero J, Kase CS, Ellinor PT, Wolf PA, Seshadri S, Benjamin EJ. Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study. Stroke. 2017 Feb; 48(2):490-492.View Related Profiles. PMID: 28082669; DOI: 10.1161/STROKEAHA.116.015071;.
  8. Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP, Rosenblum M, Thompson RE, Awad IA. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet. 2017 Feb 11; 389(10069):603-611. PMID: 28081952; DOI: 10.1016/S0140-6736(16)32410-2;.
  9. Hanley DF, Thompson RE, Muschelli J, Rosenblum M, McBee N, Lane K, Bistran-Hall AJ, Mayo SW, Keyl P, Gandhi D, Morgan TC, Ullman N, Mould WA, Carhuapoma JR, Kase C, Ziai W, Thompson CB, Yenokyan G, Huang E, Broaddus WC, Graham RS, Aldrich EF, Dodd R, Wijman C, Caron JL, Huang J, Camarata P, Mendelow AD, Gregson B, Janis S, Vespa P, Martin N, Awad I, Zuccarello M. Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial. Lancet Neurol. 2016 Nov; 15(12):1228-1237. PMID: 27751554; DOI: 10.1016/S1474-4422(16)30234-4;.
  10. Shoamanesh A, Preis SR, Beiser AS, Kase CS, Wolf PA, Vasan RS, Benjamin EJ, Seshadri S, Romero JR. Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study. Neurology. 2016 Sep 20; 87(12):1206-11.View Related Profiles. PMID: 27558379; DOI: 10.1212/WNL.0000000000003115;.
Showing 10 of 181 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 178 publications over 37 distinct years, with a maximum of 11 publications in 2013

YearPublications
19801
19812
19821
19833
19844
19854
19864
19874
19886
19892
19903
19914
19922
19934
19942
19953
19967
19972
19986
19998
20014
20023
20039
20044
20054
20066
20076
20083
20096
20106
20116
20125
201311
20148
20159
20168
20178
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