M. Maria Glymour, SD
Chair and Professor
Boston University School of Public Health
Epidemiology

SD, Harvard School of Public Health
AB, University of Chicago



Research Interests
- Alzheimer's disease and related causes of cognitive aging and dementia
- Social determinants of health and health equity
- Social policies and health
- Causal inference in social epidemiology and dementia research

My research focuses on how social factors experienced across the lifecourse, from infancy to adulthood, influence cognitive function, dementia, stroke, and other health outcomes in old age. I am especially interested in education and other exposures amenable to policy interventions. The health of current cohorts of elderly individuals in the US reflect a lifetime of social exposures, including educational experiences shaped by major changes in schooling policies. Education is especially interesting because it is such a powerful predictor of health and historically, access to education has frequently been restricted based on race, gender, and other socially enforced criteria. One thread of my research examines how changes in schooling laws and school quality in the 20th century might have influenced the health and cognitive outcomes of current cohorts of elderly, including adults subject to race-based school segregation. Our results suggest that extra schooling has substantial benefits for memory function in the elderly. I have also worked on the influence of "place" on health, for example to understand the excess stroke burden for individuals who grew up in the US Stroke Belt. In a project with colleagues including Drs. Rachel Whitmer, Elizabeth Rose Mayeda, and Paola Gilsanz, we are continuing a unique multi-ethnic cohort of older adults in Northern California, with a wealth of lifecourse biological and social data to offer insight into the reasons for racial/ethnic differences in Alzheimer's and dementia risk (https://rachelwhitmer.ucdavis.edu/khandle).

A separate theme of my research focuses on overcoming methodological problems encountered in analyses of social determinants of health, Alzheimer's disease, and dementia. For many reasons, research focusing on lifecourse epidemiology as well as cognitive aging introduces substantial methodological challenges. Sometimes, these are conceptual challenges, and clear causal thinking can help! Many of these challenges are being addressed in the MELODEM (MEthods in LOngitudinal research on DEMentia) initiative, an international group of researchers focusing on analytic challenges in research on dementia and cognitive aging. MELODEM has working group phone calls on the first and third Thursdays of the month, open to all (https://sites.bu.edu/melodem/). My group works with numerous colleagues on methods to improve measurement, including crosswalking across data sets. For example, in work with Dr. Zeki Al Hazzouri, we are linking data sets with detailed information at different lifecourse periods -- e.g., childhood, early adulthood, and later adulthood -- to better evaluate long-term effects of exposures at specific sensitive ages. In work with Dr. Cathy Schaefer, Ron Krauss, and many others, we are fielding emulated trial designs in the large, diverse Kaiser Permanente Northern California cohort. This setting is exceptional for emulated trial designs because of the large size, long follow-up, and combination of high-quality clinical data plus social and genetic information for large groups of study participants.

I have advocated the use of causal directed acyclic graphs (DAGs) as a standard research tool to represent our causal hypotheses and help elucidate potential biases in proposed analyses. In other cases, the methodological problems require more analytical solutions that have been developed elsewhere in epidemiology or in other disciplines, but are rarely applied to these research questions. Instrumental variables analyses of natural or induced experiments are one promising example. Genetic variations have recently been advanced as possible instrumental variables to estimate the health effects of a wide range of phenotypes, an approach sometimes called “Mendelian Randomization.” Using genetic polymorphisms as instrumental variables could provide a very powerful tool for social epidemiology, but the inferences from such analyses rest on strong assumptions. Thus I am currently working with a team to explore approaches to evaluating the plausibility of those assumptions in applications for social epidemiology.

Students and post-doctoral fellows interested in research collaborations related to my work are welcome to send me an email directly or contact Robin Hyatt, rshyatt@bu.edu, who handles my calendar.


Study of Healthy Aging in African Americans
08/15/2023 - 05/31/2028 (Subcontract PI)
University of California, Davis NIH NIA
2R01AG050782-03

Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) -- Project 1 Dementia
06/01/2023 - 05/31/2028 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health NIH NIA
2P01AG041710-09

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old
07/01/2023 - 06/30/2027 (Subcontract PI)
University of California, Davis NIH NIA
5R01AG056519-04

Lifecourse health, cerebral pathology, and ethnic disparities in dementia
06/01/2023 - 05/31/2026 (Subcontract PI)
University of California, Davis NIH NIA
5R01AG052132-06

Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy
09/01/2023 - 08/31/2025 (Key Person / Mentor)
PI: Kendra D Sims, PhD
NIH/National Institute on Aging
K99AG083121-01

The confluence of extreme heat cold on the health and longevity of an Aging Population with Alzheimers and related Dementia
06/01/2023 - 05/31/2025 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School NIH NIA
1RF1AG074372-01A1

Novel Designs and Methods to Remove Hidden Confounding Bias in Health Sciences
06/01/2023 - 04/30/2025 (Subcontract PI)
The Trustees of the University of Pennsylvania NIH NIA
5R01AG065276-04

Evidence for Action National Program Office Operations
04/01/2024 - 03/31/2025 (Subcontract PI)
The Regents of the University of California, San Francisco Robert Wood Johnson


Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer’s Disease and Related Disorders
06/01/2023 - 03/31/2025 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA
5R01AG072681-04

Lifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep Disturbance
09/01/2023 - 08/31/2024 (Co-Investigator)
PI: Ruijia Chen, ScD
NIH/National Institute on Aging
7K00AG068431-05

Showing 10 of 14 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bennett EE, Liu C, Stapp EK, Gianattasio KZ, Zimmerman SC, Wei J, Griswold ME, Fitzpatrick AL, Gottesman RF, Launer LJ, Windham BG, Levine DA, Fohner AE, Glymour MM, Power MC. Target trial emulation using cohort studies: estimating the effect of antihypertensive medication initiation on incident dementia. Epidemiology. 2024 Oct 01. PMID: 39352756
     
  2. Komura T, Tsugawa Y, Mayeda ER, Glymour MM, Inoue K. Association of Cardiovascular Events With Spouse's Subsequent Dementia. JAMA Neurol. 2024 Oct 01; 81(10):1098-1099. PMID: 39186285; PMCID: PMC11348081; DOI: 10.1001/jamaneurol.2024.2612;
     
  3. Kim MH, Liu SY, Brenowitz WD, Murchland AR, Nguyen TT, Manly JJ, Howard VJ, Thomas MD, Hill-Jarrett T, Crowe M, Murchison CF, Glymour MM. State Schooling Policies and Cognitive Performance Trajectories: A Natural Experiment in a National US Cohort of Black and White Adults. Epidemiology. 2024 Sep 27.View Related Profiles. PMID: 39329415
     
  4. Khadka A, Pacca L, Glymour MM, Bibbins-Domingo K, White JS, Basu S, Jiang F, Vable AM. Impact of Vietnam-era G.I. Bill eligibility on later-life blood pressure distribution: evidence from the Vietnam draft lottery natural experiment. Am J Epidemiol. 2024 Sep 17.View Related Profiles. PMID: 39289172; DOI: 10.1093/aje/kwae357;
     
  5. Mobley TM, Hayes-Larson E, Wu Y, Peterson RL, George KM, Gilsanz P, Glymour MM, Thomas MD, Barnes LL, Whitmer RA, Mayeda ER. School racial/ethnic composition, effect modification by caring teacher/staff presence, and mid-/late-life depressive symptoms: findings from the Study of Healthy Aging in African Americans. Am J Epidemiol. 2024 Sep 03; 193(9):1253-1260. PMID: 38634611; PMCID: PMC11369217; DOI: 10.1093/aje/kwae050;
     
  6. Jawadekar N, Zimmerman S, Lu P, Riley AR, Glymour MM, Kezios K, Al Hazzouri AZ. A critique and examination of the polysocial risk score approach: predicting cognition in the Health and Retirement Study. Am J Epidemiol. 2024 Sep 03; 193(9):1296-1300. PMID: 38775285; PMCID: PMC11369218; DOI: 10.1093/aje/kwae074;
     
  7. Hayes-Larson E, Zhou Y, Rojas-Saunero LP, Shaw C, Seamans MJ, Glymour MM, Murchland AR, Westreich D, Mayeda ER. Methods for Extending Inferences From Observational Studies: Considering Causal Structures, Identification Assumptions, and Estimators. Epidemiology. 2024 Nov 01; 35(6):753-763.View Related Profiles. PMID: 39120938
     
  8. Khadka A, Hebert JL, Glymour MM, Jiang F, Irish A, Duchowny KA, Vable AM. Quantile regressions as a tool to evaluate how an exposure shifts and reshapes the outcome distribution: A primer for epidemiologists. Am J Epidemiol. 2024 Aug 03. PMID: 39098821
     
  9. Sims KD, Glymour MM, Ncube CN, Willis MD. Improving spatial exposure data for everyone - lifecourse social context and ascertaining residential history. Am J Epidemiol. 2024 Aug 03.View Related Profiles. PMID: 39098825
     
  10. Kim MH, Frøslev T, White JS, Glymour MM, Illango SD, Sørensen HT, Pedersen L, Hamad R. Kim et al. Respond to "Dispersal policies, neighborhood disadvantage, and refugee health in a Nordic context". Am J Epidemiol. 2024 Jul 30.View Related Profiles. PMID: 39086093
     
Showing 10 of 488 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 488 publications over 23 distinct years, with a maximum of 52 publications in 2022

YearPublications
19911
19921
20042
20052
20062
20077
200812
20096
20104
201118
201226
201318
201432
201524
201633
201730
201830
201934
202035
202147
202252
202341
202431

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Recent (within 3 months)

Can We Prevent Alzheimer’s Disease and Related Dementias?

The Brink 11/12/2024

Collaborative initiative seeks to uncover ways to reduce Alzheimer’s and dementia risk

News Medical 9/30/2024
Older

How HDL 'Good' Cholesterol Might Raise Dementia Risk

US News & World Report 10/5/2023

FDA Gives Full Approval for New Alzheimer's Drug, But Will It Help Black Patients?

BET 7/10/2023

SPH to Welcome Maria Glymour as Chair of the Department of Epidemiology

Boston University School of Public Health 12/2/2022

2018 American Journal of Epidemiology: American Journal of Epidemiology Reviewers of the Year Award
2017 University of California, San Francisco, Academic Senate: Mentoring Award - Associate Professor Level
2016 American Journal of Epidemiology: American Journal of Epidemiology Reviewers of the Year Award
2013 Columbia University, Mailman School of Public Health: Columbia University Psychiatric- Neurological Epidemiology Early Investigator Award
2012 Harvard School of Public Health: Mentoring Award
Contact for Mentoring:

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