Konstantinos Alysandratos, MD, PHD
Assistant Professor
Boston University School of Medicine
Dept of Medicine


Dr. Konstantinos D. Alysandratos, MD, PhD is an Assistant Professor in the Department of Medicine at Boston University School of Medicine and is part of the team at the Center for Regenerative Medicine at Boston University as part of Dr. Darrell N. Kotton’s lab. He received his Doctorate of Medicine from the University of Athens and embarked on his research journey after winning a competitive 3-year scholarship from the Hellenic State Scholarships Foundation. As part of his doctoral work under the mentorship of Dr. Theoharides at Tufts University, he studied the interplay between neuropeptides and cytokines in the pathogenesis of atopic dermatitis and their role on mast cell activation. He has also contributed to translational discoveries relating to mast cell activation in neurodevelopmental disorders such as autism spectrum disorders that may inform novel therapeutic approaches. Dr. Alysandratos completed his internal medicine training at UT Southwestern Medical Center, during which time he developed his passion for intensive and pulmonary care.

2018 American Lung Association (ALA): Basic Science Award – 1st Place, Massachusetts Pulmonary Section
2017 6th Annual CTSI Translational Science Symposium: Exceptional poster presentation – 3rd prize award
2017 Annual Meeting of the Massachusetts Pulmonary Section American Lung Association (ALA): Best Case Presentation Award
2017 American Thoracic Society National Meeting: ATS Fellows Track Symposium Award
2013 Alpha Omega Alpha
2009 Hellenic State Scholarships Foundation: Graduate Scholarship for Studies Abroad
2007 Hellenic State Scholarships Foundation: Academic Performance Award

Utilizing a pluripotent stem cell model system to unravel the pathogenesis of pulmonary fibrosis
07/01/2018 - 06/30/2020 (PI)
Pulmonary Fibrosis Foundation

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595.View Related Profiles. PMID: 29657097.
  2. Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893.View Related Profiles. PMID: 28947536.
  3. Alysandratos KD, Serra M, Mulugeta S, Beers MF, Kotton DN. Am J Respi Crit Care Med. Deriving alveolar type 2 cells from pluripotent stem cells to model surfactant protein C (SP-C) mutations in vitro. 2017; 195:A4317.
  4. Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr. 2017 Feb; 56(1):161-170. PMID: 26525562; DOI: 10.1007/s00394-015-1066-z;.
  5. Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 2013 Sep; 169(3):695-9. PMID: 24033157; DOI: 10.1111/bjd.12413;.
  6. Alysandratos KD, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, Critchfield A, Theoharides TC. Neurotensin and CRH interactions augment human mast cell activation. PLoS One. 2012; 7(11):e48934. PMID: 23155429; DOI: 10.1371/journal.pone.0048934;.
  7. Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012 Jul 02; 12:89. PMID: 22747567; DOI: 10.1186/1471-2431-12-89;.
  8. Vasiadi M, Therianou A, Alysandratos KD, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Papadavid E, Stavrianeas N, Antoniou C, Kalogeromitros D, Theoharides TC. Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells. Br J Dermatol. 2012 Jun; 166(6):1349-52. PMID: 22283733; DOI: 10.1111/j.1365-2133.2012.10843.x;.
  9. Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD, Angelidou A, Shirihai O, Theoharides TC. Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 2012; 159(1):23-32.View Related Profiles. PMID: 22555146; DOI: 10.1159/000335178;.
  10. Theoharides TC, Enakuaa S, Sismanopoulos N, Asadi S, Papadimas EC, Angelidou A, Alysandratos KD. Contribution of stress to asthma worsening through mast cell activation. Ann Allergy Asthma Immunol. 2012 Jul; 109(1):14-9. PMID: 22727152; DOI: 10.1016/j.anai.2012.03.003;.
Showing 10 of 28 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 28 publications over 7 distinct years, with a maximum of 11 publications in 2010

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Pathogenesis of familial interstitial lung diseases
Idiopathic Pulmonary Fibrosis
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