Konstantinos Alysandratos, MD, PHD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Athens
PhD, University of Athens



Konstantinos Alysandratos, MD, PhD is an Assistant Professor in the Pulmonary, Allergy, Sleep & Critical Care Medicine Section at Boston University Chobanian & Avedisian School of Medicine and serves as Co-Director of the Interstitial Lung Disease (ILD) Clinic at Boston Medical Center, where he specializes in the treatment of complex lung diseases. He is also a Principal Investigator at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, leading an NIH-funded research program aimed at advancing the understanding of pulmonary fibrosis pathogenesis and identifying druggable targets, particularly within the alveolar epithelium, using pluripotent stem cell model systems. Dr. Alysandratos earned his MD and PhD degrees from the University of Athens in Greece, completed his internal medicine residency at the University of Texas Southwestern Medical Center, and completed fellowships in Sleep Medicine and Pulmonary/Critical Care Medicine at Boston University.

Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis
01/01/2023 - 12/31/2027 (PI)
NIH/National Heart, Lung, and Blood Institute
5K08HL163494-03

Modeling pulmonary fibrosis using patient-specific iPSCs carrying telomerase mutations
10/01/2025 - 09/30/2027 (Key Person / Mentor)
Pulmonary Fibrosis Foundation


Utilizing a pluripotent stem cell model system to unravel the pathogenesis of pulmonary fibrosis
07/01/2018 - 06/30/2020 (PI)
Pulmonary Fibrosis Foundation




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Hoffman ET, Shah A, Barboza WR, Rodriguez LR, Dherwani R, Dooley PE, Minakin K, Tomer Y, Ayers LJ, Jones D, Murthy A, Bennett A, Lange AN, Bawa PS, Wang F, Babu A, Chavez K, Nakamoto RS, Cooper CH, Basil MC, Raredon MSB, Kotton DN, Alysandratos KD, Katzen J. Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models. Nat Commun. 2025 Sep 30; 16(1):8710.View Related Profiles. PMID: 41027873; PMCID: PMC12484947; DOI: 10.1038/s41467-025-63735-1;
     
  2. Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight. 2025 Aug 08; 10(15).View Related Profiles. PMID: 40591409; PMCID: PMC12333953; DOI: 10.1172/jci.insight.182578;
     
  3. Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122.View Related Profiles. PMID: 40504150; PMCID: PMC12184426; DOI: 10.1073/pnas.2426528122;
     
  4. Burgess CL, Ayers LJ, Minakin K, Alysandratos KD, Varelas X, Kotton DN. Protocol for the differentiation of human alveolar epithelial type I cells from pluripotent stem cell-derived type II-like cells. STAR Protoc. 2025 Mar 21; 6(1):103667.View Related Profiles. PMID: 40048418; PMCID: PMC11928952; DOI: 10.1016/j.xpro.2025.103667;
     
  5. Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, Kirchdoerfer RN, Saeed M, Baker SC. Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2419620122.View Related Profiles. PMID: 40035769; PMCID: PMC11912388; DOI: 10.1073/pnas.2419620122;
     
  6. Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Ahmed DW, Spencer RC, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. Stem Cell Reports. 2025 Jan 14; 20(1):102376.View Related Profiles. PMID: 39672155; PMCID: PMC11784465; DOI: 10.1016/j.stemcr.2024.11.006;
     
  7. Tang X, Wei W, Sun Y, Weaver TE, Nakayasu ES, Clair G, Snowball JM, Na CL, Apsley KS, Martin EP, Kotton DN, Alysandratos KD, Huo J, Molkentin JD, Gower WA, Lin X, Whitsett JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. J Clin Invest. 2024 Oct 15; 134(23).View Related Profiles. PMID: 39405113; PMCID: PMC11601914; DOI: 10.1172/JCI173861;
     
  8. Hurley K, Ozaki M, Philippot Q, Galvin L, Crosby D, Kirwan M, Gill DR, Alysandratos KD, Jenkins G, Griese M, Nathan N, Borie R. A roadmap to precision treatments for familial pulmonary fibrosis. EBioMedicine. 2024 Jun; 104:105135. PMID: 38718684; PMCID: PMC11096859; DOI: 10.1016/j.ebiom.2024.105135;
     
  9. Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN. Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell. 2024 May 02; 31(5):657-675.e8.View Related Profiles. PMID: 38642558; PMCID: PMC11147407; DOI: 10.1016/j.stem.2024.03.017;
     
  10. Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. bioRxiv. 2024 Mar 19.View Related Profiles. PMID: 38562781; PMCID: PMC10983987; DOI: 10.1101/2024.03.19.585720;
     
Showing 10 of 65 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 65 publications over 14 distinct years, with a maximum of 11 publications in 2010

YearPublications
201011
20115
20127
20131
20151
20172
20181
20191
20207
20217
20226
20234
20247
20255


Global Biopharma Giant GSK and BU Announce Collaboration to Pioneer New Lung Disease Treatments

The Brink 10/17/2024

Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases

Genetic Engineering and Biotechnology News 9/1/2021

2018 American Lung Association (ALA): Basic Science Award – 1st Place, Massachusetts Pulmonary Section
2017 6th Annual CTSI Translational Science Symposium: Exceptional poster presentation – 3rd prize award
2017 Annual Meeting of the Massachusetts Pulmonary Section American Lung Association (ALA): Best Case Presentation Award
2017 American Thoracic Society National Meeting: ATS Fellows Track Symposium Award
2013 Alpha Omega Alpha
2009 Hellenic State Scholarships Foundation: Graduate Scholarship for Studies Abroad
2007 Hellenic State Scholarships Foundation: Academic Performance Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Idiopathic Pulmonary Fibrosis
Stem Cells
Regenerative Medicine
Interstitial Lung Disease

Available to Mentor as: (Review Mentor Role Definitions):
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

670 Albany Street
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