Wellington V. Cardoso, MD, PhD
Adjunct Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Universidade de Brasília
PhD, Universidade de São Paulo



My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine




Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
1 R01 HL105971 01A1

Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL105971-03

Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the Developing Lung
12/01/2013 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
1F32HL117529-01A1

Regulation of Airway Smooth Muscle Differentiation by Retinoic Acid in the Developing Lung
07/01/2013 - 06/30/2014 (PI)
American Lung Association


Determinants of Cell Fate and Differentiation in the Developing Lung
07/01/1998 - 01/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5P01HL047049-20

Retinoic Acid Regulation of Lung Development
03/01/2012 - 09/30/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL067129-10

Heparan Sulfate - Fgf 10 Interactions in Lung Morphogenesis
07/01/2005 - 06/30/2008 (Co-PI)
Parker B. Francis Foundation

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (Dept Sponsor)
PI: Felicia Chen, MD
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01

Basic Mechanism of Lung Development
09/15/1999 - 08/31/2001 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R13 HL62941 02



Title


Yr Title Project-Sub Proj Pubs
2024 Regulation of Progenitor Cell Plasticity in Lung Development and Disease-Repair 5R35HL166661-02
2024 Local translation and viral infection in the airway epithelium 5R01AI170904-02
2023 Regulation of Progenitor Cell Plasticity in Lung Development and Disease-Repair 1R35HL166661-01
2023 Local translation and viral infection in the airway epithelium 1R01AI170904-01A1
2023 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-07
2022 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-06
2021 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-05 10
2020 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 3R35HL135834-04S1 10
2020 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-04 10
2020 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 5R01HL103676-08 36
Showing 10 of 67 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Mori M, Cardoso WV. Can a Rat Breathe through a Mouse's Lung? Am J Respir Crit Care Med. 2024 Jul 15; 210(2):133-134. PMID: 38701370; PMCID: PMC11273309; DOI: 10.1164/rccm.202404-0706ED;
     
  2. Hannan A, Wang Q, Wu Y, Makrides N, Qu X, Mao J, Que J, Cardoso W, Zhang X. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv. 2024 Jul 01. PMID: 39005335; PMCID: PMC11244872; DOI: 10.1101/2024.06.27.601065;
     
  3. van Soldt BJ, Metscher BD, Richardson MK, Cardoso WV. Sox9 is associated with two distinct patterning events during snake lung morphogenesis. Dev Biol. 2024 Feb; 506:7-19. PMID: 37995917; PMCID: PMC10872300; DOI: 10.1016/j.ydbio.2023.11.006;
     
  4. Neptune ER, Cardoso WV. Unravelling the expanding role of FGF10 signalling in lung homeostasis and maintenance. Eur Respir J. 2023 Nov; 62(5). PMID: 37945046
     
  5. Liu H, Li H, Jiang Z, Jin S, Song R, Yang Y, Li J, Huang J, Zhang X, Dong X, Mori M, Fritzler MJ, He L, Cardoso WV, Lu J. A local translation program regulates centriole amplification in the airway epithelium. Sci Rep. 2023 May 01; 13(1):7090. PMID: 37127654; PMCID: PMC10151349; DOI: 10.1038/s41598-023-34365-8;
     
  6. Zhou Y, Yang Y, Guo L, Qian J, Ge J, Sinner D, Ding H, Califano A, Cardoso WV. Airway basal cells show regionally distinct potential to undergo metaplastic differentiation. Elife. 2022 Sep 30; 11. PMID: 36178196; PMCID: PMC9578702; DOI: 10.7554/eLife.80083;
     
  7. Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. Elife. 2022 Sep 21; 11. PMID: 36129169; PMCID: PMC9553211; DOI: 10.7554/eLife.78217;
     
  8. Serra CFH, Liu H, Qian J, Mori M, Lu J, Cardoso WV. Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium. iScience. 2022 Aug 19; 25(8):104751. PMID: 35942101; PMCID: PMC9356082; DOI: 10.1016/j.isci.2022.104751;
     
  9. Huang CY, Huang HC, Chen MH, Lai TT, Chou HC, Chen CY, Yen TA, Cardoso WV, Tsao PN. Intravitreal Bevacizumab Is Associated With Prolonged Ventilatory Support in Preterm Infants With Bronchopulmonary Dysplasia. Chest. 2022 Dec; 162(6):1328-1337. PMID: 35753385
     
  10. Cardoso WV. Maturation for regeneration. Cell Stem Cell. 2021 10 07; 28(10):1680-1682. PMID: 34624228; PMCID: PMC8637042; DOI: 10.1016/j.stem.2021.09.007;
     
Showing 10 of 108 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 107 publications over 33 distinct years, with a maximum of 7 publications in 2018

YearPublications
19873
19892
19911
19921
19933
19953
19962
19971
19982
19991
20004
20015
20034
20045
20051
20063
20073
20085
20095
20103
20114
20123
20132
20143
20153
20165
20173
20187
20196
20215
20224
20233
20242

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cell fate
growth factors
lung development
lung disease
morphogenesis
organogenesis
progenitor cell
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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