Wellington V. Cardoso, MD, PhD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Universidade de Brasília
PhD, Universidade de São Paulo



My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine




Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
1 R01 HL105971 01A1

REGULATION OF AIRWAY PROGENITOR CELL FATE IN DEVELOPMENT AND REGENERATION
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL105971-03

RETINOIC ACID REGULATION OF AIRWAY SMOOTH MUSCLE DIFFERENTIATION IN THE DEVELOPING LUNG
12/01/2013 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
1F32HL117529-01A1

REGULATION OF AIRWAY SMOOTH MUSCLE DIFFERENTIATION BY RETINOIC ACID IN THE DEVELOPING LUNG
07/01/2013 - 06/30/2014 (PI)
American Lung Association

DETERMINANTS OF CELL FATE AND DIFFERENTIATION IN THE DEVELOPING LUNG
07/01/1998 - 01/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5P01HL047049-20

RETINOIC ACID REGULATION OF LUNG DEVELOPMENT
03/01/2012 - 09/30/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL067129-10

Heparan Sulfate - Fgf 10 Interactions in Lung Morphogenesis
07/01/2005 - 06/30/2008 (Co-PI)
Parker B. Francis Foundation

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (Dept Sponsor)
PI: Felicia Chen, MD
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01

Basic Mechanism of Lung Development
09/15/1999 - 08/31/2001 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R13 HL62941 02




Yr Title Project-Sub Proj Pubs
2018 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-02
2018 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 5R01HL131422-03
2018 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 5R01HL103676-06 12
2017 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 3R01HL103676-05S1 12
2017 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 1R35HL135834-01
2017 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 5R01HL131422-02
2017 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 2R01HL103676-05 12
2016 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 1R01HL131422-01
2016 REGULATION OF THE CILIATED CELL PROGRAM IN AIRWAY PROGENITORS 5R01HL119836-03 1
2015 RETINOIC ACID REGULATION OF LUNG DEVELOPMENT 5R01HL067129-12 10
Showing 10 of 56 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Oct 04; 23(4):516-529.e5. PMID: 30244870.
     
  2. de Barros Mendes Lopes T, Groth EE, Veras M, Furuya TK, de Souza Xavier Costa N, Ribeiro Júnior G, Lopes FD, de Almeida FM, Cardoso WV, Saldiva PHN, Chammas R, Mauad T. Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life. Environ Pollut. 2018 Oct; 241:511-520. PMID: 29883952; DOI: 10.1016/j.envpol.2018.05.055;.
     
  3. Yang Y, Cardoso WV. Stem Cells Sheltered from Air-Raids Repair Airways. Cell Stem Cell. 2018 May 03; 22(5):613-614. PMID: 29727674.
     
  4. Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, García-Sastre A, Xu J, Cardoso WV. Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways. Dev Cell. 2018 03 26; 44(6):752-761.e4. PMID: 29587145.
     
  5. Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E974-E981. PMID: 29339516.
     
  6. Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2017 Jul 04; 8:15857. PMID: 28675157.
     
  7. Stupnikov MR, Cardoso WV. Sensing oxygen inside and out. Elife. 2017 May 19; 6. PMID: 28525315.
     
  8. Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Rep. 2017 Apr 11; 19(2):246-254.View Related Profiles. PMID: 28402849; DOI: 10.1016/j.celrep.2017.03.051;.
     
  9. Marquez HA, Cardoso WV. Vitamin A-retinoid signaling in pulmonary development and disease. Mol Cell Pediatr. 2016 Dec; 3(1):28.View Related Profiles. PMID: 27480876; DOI: 10.1186/s40348-016-0054-6;.
     
  10. Wagner DE, Cardoso WV, Gilpin SE, Majka S, Ott H, Randell SH, Thébaud B, Waddell T, Weiss DJ. An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases. Ann Am Thorac Soc. 2016 Aug; 13(8):S259-78. PMID: 27509163; DOI: 10.1513/AnnalsATS.201606-466ST;.
     
Showing 10 of 86 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 85 publications over 28 distinct years, with a maximum of 5 publications in 2001 and 2004 and 2008 and 2009 and 2016 and 2018

YearPublications
19873
19892
19911
19921
19933
19953
19962
19971
19982
19991
20004
20015
20034
20045
20051
20063
20073
20085
20095
20103
20114
20123
20132
20143
20153
20165
20173
20185
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cell fate
growth factors
lung development
lung disease
morphogenesis
organogenesis
progenitor cell
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72 E. Concord St Housman (R)
Boston MA 02118
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