Wellington V. Cardoso, MD, PhD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Universidade de Brasília
PhD, Universidade de São Paulo




My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine




Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
1 R01 HL105971 01A1

Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL105971-03

Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the Developing Lung
12/01/2013 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
1F32HL117529-01A1

Regulation of Airway Smooth Muscle Differentiation by Retinoic Acid in the Developing Lung
07/01/2013 - 06/30/2014 (PI)
American Lung Association


Determinants of Cell Fate and Differentiation in the Developing Lung
07/01/1998 - 01/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5P01HL047049-20

Retinoic Acid Regulation of Lung Development
03/01/2012 - 09/30/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL067129-10

Heparan Sulfate - Fgf 10 Interactions in Lung Morphogenesis
07/01/2005 - 06/30/2008 (Co-PI)
Parker B. Francis Foundation

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (Dept Sponsor)
PI: Felicia Chen, MD
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01

Basic Mechanism of Lung Development
09/15/1999 - 08/31/2001 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R13 HL62941 02



Title


Yr Title Project-Sub Proj Pubs
2021 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-05 10
2020 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-04 10
2020 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 3R35HL135834-04S1 10
2020 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 5R01HL103676-08 36
2019 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-03 10
2019 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 5R01HL131422-04 2
2019 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 5R01HL103676-07 36
2018 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 5R35HL135834-02 10
2018 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 5R01HL131422-03 2
2018 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 5R01HL103676-06 36
Showing 10 of 64 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Cardoso WV. Maturation for regeneration. Cell Stem Cell. 2021 Oct 07; 28(10):1680-1682. PMID: 34624228
     
  2. Hazan R, Mori M, Danielian PS, Guen VJ, Rubin SM, Cardoso WV, Lees JA. E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. Mol Biol Cell. 2021 10 01; 32(20):ar1. PMID: 34260288
     
  3. Shui JE, Wang W, Liu H, Stepanova A, Liao G, Qian J, Ai X, Ten V, Lu J, Cardoso WV. Prematurity alters the progenitor cell program of the upper respiratory tract of neonates. Sci Rep. 2021 05 24; 11(1):10799.View Related Profiles. PMID: 34031475; PMCID: PMC8144386; DOI: 10.1038/s41598-021-90093-x;
     
  4. Suzuki M, Wang T, Garretto D, Isasi CR, Cardoso WV, Greally JM, Quadro L. Disproportionate Vitamin A Deficiency in Women of Specific Ethnicities Linked to Differences in Allele Frequencies of Vitamin A-Related Polymorphisms. Nutrients. 2021 May 21; 13(6). PMID: 34063790; PMCID: PMC8223783; DOI: 10.3390/nu13061743;
     
  5. Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 Apr 20; 35(3):109011.View Related Profiles. PMID: 33882306; PMCID: PMC8140387; DOI: 10.1016/j.celrep.2021.109011;
     
  6. van Soldt BJ, Cardoso WV. Hippo-Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior. Wiley Interdiscip Rev Dev Biol. 2020 05; 9(3):e371. PMID: 31828974
     
  7. Bailey DD, Zhang Y, van Soldt BJ, Jiang M, Suresh S, Nakagawa H, Rustgi AK, Aceves SS, Cardoso WV, Que J. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. Development. 2019 12 04; 146(23). PMID: 31748205; PMCID: PMC6918786; DOI: 10.1242/dev.178855;
     
  8. Mori M, Furuhashi K, Danielsson JA, Hirata Y, Kakiuchi M, Lin CS, Ohta M, Riccio P, Takahashi Y, Xu X, Emala CW, Lu C, Nakauchi H, Cardoso WV. Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells. Nat Med. 2019 11; 25(11):1691-1698. PMID: 31700187
     
  9. Stupnikov MR, Yang Y, Mori M, Lu J, Cardoso WV. Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation. Elife. 2019 10 21; 8. PMID: 31631837; PMCID: PMC6887486; DOI: 10.7554/eLife.50487;
     
  10. Lee S, Ahad A, Luu M, Moon S, Caesar J, Cardoso WV, Grant MB, Chaqour B. CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis. Mol Cell Biol. 2019 09 15; 39(18). PMID: 31262999; PMCID: PMC6712939; DOI: 10.1128/MCB.00107-19;
     
Showing 10 of 99 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 98 publications over 30 distinct years, with a maximum of 7 publications in 2018

YearPublications
19873
19892
19911
19921
19933
19953
19962
19971
19982
19991
20004
20015
20034
20045
20051
20063
20073
20085
20095
20103
20114
20123
20132
20143
20153
20165
20173
20187
20196
20215

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cell fate
growth factors
lung development
lung disease
morphogenesis
organogenesis
progenitor cell
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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