Felicia Chen, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Albany Medical College

Dr. Chen attends on the Pulmonary Consult service and in the Medical Intensive Care Units at Boston Medical Center and Sturdy Memorial Hospital. She is a member of Dr. Wellington V. Cardoso’s lab.

The abnormalities of the developing respiratory system associated with retinoic acid (RA)-deficiency have been known for decades. However, the cellular and molecular events controlled by RA during lung development remain unclear. Dr. Chen’s research focuses on the various RA-dependent signaling mechanisms involved in primary lung bud formation. By using a combination of pharmacologic, genetic, and organ culture approaches, she has demonstrated the critical role of RA in controlling at least three major pathways, Tgf-beta, Wnt, and Fgf, to allow proper formation of the early lung. Currently, she’s investigating the role of retinoic acid in the differentiation of bronchial and vascular smooth muscles during lung development.

Special interests include:
-Mechanisms of primary lung bud induction
-Lung progenitor biology
-Role of retinoic acid in early lung development
-Lung injury and repair

Courtesy Staff Privileges
Boston Medical Center

Regulation of airway smooth muscle phenotype by retinoic acid
04/20/2016 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Inst

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (PI)
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01

Role of Retinoic Acid Signaling in Initiation of Lung Morphogenesis
07/01/2005 - 09/30/2006 (PI)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50.View Related Profiles. PMID: 27524796; DOI: 10.1016/j.ajpath.2016.05.023;.
  2. Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9.View Related Profiles. PMID: 25245693; DOI: 10.1007/978-1-4939-1164-6_11;.
  3. Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8.View Related Profiles. PMID: 20484817; PMCID: PMC2877937; DOI: 10.1172/JCI40253;.
  4. Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63.View Related Profiles. PMID: 19934349; PMCID: PMC3266050; DOI: 10.1513/pats.200905-031RM;.
  5. Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44.View Related Profiles. PMID: 18694942; PMCID: PMC2570893; DOI: 10.1074/jbc.M801565200;.
  6. Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79.View Related Profiles. PMID: 17634193.
  7. Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24.View Related Profiles. PMID: 16427040.
  8. Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23.View Related Profiles. PMID: 16036130.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 2005 and 2006 and 2007 and 2008 and 2009 and 2010 and 2015 and 2016

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Embryonic lung development
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72 E. Concord St Housman (R)
Boston MA 02118
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