Felicia Chen, MD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Albany Medical College
BA, Johns Hopkins University



Dr. Chen's laboratory projects focus on retinoic acid biology in healthy and diseased lungs. She uses a multifaceted approach to knock down retinoic acid signals in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modifications. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) lung microbiome, 3) embryonic airway epithelial specification, and 4) matrix fibroblast activation.

Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung homeostasis
-Lung injury and repair
-Fibrotic lung diseases
-Asthma

Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Courtesy Staff Privileges
Boston Medical Center
Medicine




Regulation of airway smooth muscle phenotype by retinoic acid
04/20/2016 - 03/31/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL130287-04

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (PI)
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01


Role of Retinoic Acid Signaling in Initiation of Lung Morphogenesis
07/01/2005 - 09/30/2006 (PI)
GlaxoSmithKline


Title


Yr Title Project-Sub Proj Pubs
2019 Regulation of airway smooth muscle phenotype by retinoic acid 5R01HL130287-04 3
2018 Regulation of airway smooth muscle phenotype by retinoic acid 5R01HL130287-03 3
2017 Regulation of airway smooth muscle phenotype by retinoic acid 5R01HL130287-02 3
2016 Regulation of airway smooth muscle phenotype by retinoic acid 1R01HL130287-01A1 3
2005 Retinoic Acid Signaling in Lung Morphogenesis Initiation 1F32HL080846-01 1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Marquez HA, Chen F. Retinoic Acid Signaling and Development of the Respiratory System. Subcell Biochem. 2020; 95:151-174.View Related Profiles. PMID: 32297299
     
  2. Norman TA, Gower AC, Chen F, Fine A. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019; 14(5):e0216795.View Related Profiles. PMID: 31083674; PMCID: PMC6513083; DOI: 10.1371/journal.pone.0216795;
     
  3. Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 08 23; 3(16).View Related Profiles. PMID: 30135301; PMCID: PMC6141181; DOI: 10.1172/jci.insight.120398;
     
  4. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925; PMCID: PMC5617666; DOI: 10.1172/JCI94639;
     
  5. Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50.View Related Profiles. PMID: 27524796; PMCID: PMC5222968; DOI: 10.1016/j.ajpath.2016.05.023;
     
  6. Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9.View Related Profiles. PMID: 25245693; DOI: 10.1007/978-1-4939-1164-6_11;
     
  7. Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11.View Related Profiles. PMID: 24401276; PMCID: PMC3904614; DOI: 10.1172/JCI70291;
     
  8. Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8.View Related Profiles. PMID: 20484817; PMCID: PMC2877937; DOI: 10.1172/JCI40253;
     
  9. Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63.View Related Profiles. PMID: 19934349; PMCID: PMC3266050; DOI: 10.1513/pats.200905-031RM;
     
  10. Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44.View Related Profiles. PMID: 18694942; PMCID: PMC2570893; DOI: 10.1074/jbc.M801565200;
     
Showing 10 of 13 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 13 publications over 13 distinct years, with a maximum of 1 publications in 2005 and 2006 and 2007 and 2008 and 2009 and 2010 and 2014 and 2015 and 2016 and 2017 and 2018 and 2019 and 2020

YearPublications
20051
20061
20071
20081
20091
20101
20141
20151
20161
20171
20181
20191
20201

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Embryonic lung development
Lung homeostasis
Lung injury and repair
Retinoid biology
Asthma
Fibrotic lung diseases
Lung regeneration

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  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Housman (R)
Boston MA 02118
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617.358.1197
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