Felicia Chen, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Albany Medical College



Dr. Chen attends in the Intensive Care Unit at Boston Medical Center. She also provides pulmonary and critical care consultative services at Sturdy Memorial Hospital and an affiliated rehabilitation hospital.

Dr. Chen's laboratory projects focus on the role of retinoic acid, the natural active metabolite of vitamin A, in embryonic lung development and postnatal lung health. Dr. Chen uses a multifaceted approach to achieve retinoic acid deficiency in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modification. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) pulmonary vascular smooth muscle phenotypes, 3) embryonic airway epithelial specification, and 4) pulmonary lymphatic endothelial development.

Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung homeostasis
-Lung injury and repair
-Fibrotic lung diseases
-Asthma

Courtesy Staff Privileges
Boston Medical Center
Medicine




REGULATION OF AIRWAY SMOOTH MUSCLE PHENOTYPE BY RETINOIC ACID
04/20/2016 - 03/31/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL130287-03

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (PI)
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01


Role of Retinoic Acid Signaling in Initiation of Lung Morphogenesis
07/01/2005 - 09/30/2006 (PI)
GlaxoSmithKline


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 Aug 23; 3(16).View Related Profiles. PMID: 30135301.
     
  2. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925.
     
  3. Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50.View Related Profiles. PMID: 27524796; DOI: 10.1016/j.ajpath.2016.05.023;.
     
  4. Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9.View Related Profiles. PMID: 25245693; DOI: 10.1007/978-1-4939-1164-6_11;.
     
  5. Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11.View Related Profiles. PMID: 24401276; PMCID: PMC3904614; DOI: 10.1172/JCI70291;.
     
  6. Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8.View Related Profiles. PMID: 20484817; PMCID: PMC2877937; DOI: 10.1172/JCI40253;.
     
  7. Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63.View Related Profiles. PMID: 19934349; PMCID: PMC3266050; DOI: 10.1513/pats.200905-031RM;.
     
  8. Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44.View Related Profiles. PMID: 18694942; PMCID: PMC2570893; DOI: 10.1074/jbc.M801565200;.
     
  9. Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79.View Related Profiles. PMID: 17634193.
     
  10. Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24.View Related Profiles. PMID: 16427040.
     
Showing 10 of 11 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 11 publications over 11 distinct years, with a maximum of 1 publications in 2005 and 2006 and 2007 and 2008 and 2009 and 2010 and 2014 and 2015 and 2016 and 2017 and 2018

YearPublications
20051
20061
20071
20081
20091
20101
20141
20151
20161
20171
20181
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Embryonic lung development
Lung homeostasis
Lung injury and repair
Retinoid biology
Asthma
Fibrotic lung diseases
Lung regeneration

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')


72 E. Concord St Housman (R)
Boston MA 02118
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