Pluripotent stem cell-derived cell therapy for lung disease07/01/2023 - 06/30/2026 (Key Person / Mentor)
PI:
Michael J. Herriges, PhDParker B. Francis Fellowship Program
Biology of the Lung: A Multidisciplinary Program07/01/2021 - 06/30/2026 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Heart, Lung, and Blood Institute5T32HL007035-48
Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs12/15/2020 - 11/30/2025 (PI)
NIH/National Heart, Lung, and Blood Institute5U01HL152976-04
Evaluation of the expression and functional impact of HBoV1-GFP and HBoV1-ABCA3 transduction in iPSC-derived alveolar type 2 cells and in iPSC-derived basal epithelial cells10/04/2023 - 10/03/2025 (PI)
Carbon Biosciences, Inc.
Reverse genetic tools and novel models of henipavirus infection10/28/2022 - 09/30/2025 (Co-Investigator)
PI:
Elke Muhlberger, PhDBill and Melinda Gates Foundation
Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementation08/01/2024 - 07/31/2025 (Subcontract PI)
The University of Iowa NIH NCATS1R03TR004814-01A1
Mechanisms of epithelial repair and remodeling in pulmonary fibrosis07/15/2020 - 06/30/2025 (Subcontract PI)
Vanderbilt University NIH NHLBI5R01HL153246-05
Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage09/21/2016 - 05/31/2025 (Multi-PI)
PI:
Darrell Nelson Kotton, MDThe Regents of the University of California, San Francisco NIH NHLBI5U01HL134766-08
NRSA Training Core04/15/2020 - 05/01/2025 (PI)
NIH/National Center for Advancing Translational Sciences5TL1TR001410-09
Thyroid Follicular Cell Signaling and Development in Humans05/01/2023 - 04/30/2025 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Diabetes & Digestive & Kidney Diseases5R01DK105029-09
National Biorepository for Lung Disease-Specific Induced Pluripotent Stem Cells05/01/2020 - 04/30/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
Development of DF-COV for the treatment and prevention of COVID-19 and associated immunopathologic respiratory complications01/15/2021 - 01/14/2025 (Subcontract PI)
Dana-Farber Cancer Institute DOD Army Med Resrch
Engineering Branching Networks Through Synthetic Turing Morphogen Circuits12/10/2021 - 12/09/2024 (Multi-PI)
PI:
Darrell Nelson Kotton, MDAllen Institute d/b/a The Paul G. Allen Frontiers Group
Preparing human lung cells and organoids able to model human responses to respiratory infections and ready to predict effective therapeutics11/01/2021 - 10/31/2024 (PI)
Good Ventures
PRIMER: Promoting Research In MEdical Residency07/01/2020 - 06/30/2024 (Key Person)
PI:
Vanessa Xanthakis, PhDNIH/National Heart, Lung, and Blood Institute5R38HL143584-04
PCTC Administrative Coordinating Center06/01/2022 - 05/31/2024 (Key Person / Mentor)
University of Maryland, Baltimore NIH NHLBI5U24HL134763-07
Derivation of lung epithelia from iPS cells for advanced disease modeling06/01/2019 - 05/31/2024 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-13
Editing alveolar progenitor cells for correction of monogenic disease09/23/2016 - 05/31/2024 (Multi-PI)
PI:
Darrell Nelson Kotton, MDChildren's Hospital Medical Center NIH NHLBI5U01HL134745-07
Role of epigenetic modifier EZH2 on alveolar regeneration after adult lung injury01/01/2023 - 02/01/2024 (Key Person / Mentor)
PI:
Jessie Huang, PhDAmerican Heart Association
iPSC-airway to assess CF intrinsic epithelial response to SARS-CoV-201/01/2021 - 12/31/2023 (Subcontract PI)
The Children's Hospital Corporation Cystic Fibrosis Fdn
Characterization of iPSC-derived alveolar epithelial type II cells12/21/2018 - 12/31/2023 (PI)
Novartis Institutes for BioMedical Research
IDEAL2.0: iPSC Disease Modeling and Drug Screening01/01/2022 - 06/30/2023 (PI)
Bristol-Myers Squibb
Generation of human alveolar epithelial type I cells from pluripotent stem cells06/01/2021 - 05/31/2023 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute5F31HL158193-02
Spirovant SRA: LV-mediated ABCA3 gene expression for correction of the ABCA3 deficiency phenotype05/18/2022 - 05/17/2023 (PI)
Spirovant Sciences, Inc.
Thyroid Follicular Cell Development in Mice and Humans07/01/2021 - 04/30/2023 (Multi-PI)
PI:
Darrell Nelson Kotton, MDWeill Medical College of Cornell University NIH NIDDK5R01DK105029-07
Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)08/01/2021 - 01/13/2023 (Multi-PI)
PI:
Darrell Nelson Kotton, MDStanford University NIH NHLBI5P01HL152953-02
De-Novo Generation of Pulmonary ionocytes from Human Pluripotent Stem Cells11/01/2020 - 10/31/2022 (Multi-PI)
PI:
Darrell Nelson Kotton, MDCystic Fibrosis Foundation
Modeling childhood interstitial lung disease with patient-specific pluripotent stem cells carrying ABCA3 mutations09/12/2018 - 07/31/2022 (Key Person / Mentor)
PI:
Yuliang SunNIH/National Heart, Lung, and Blood Institute5F30HL142169-04
Reconstructing regulatory networks from time series single cell data08/01/2017 - 07/31/2022 (Subcontract PI)
Carnegie Mellon University NIH NIGMS5R01GM122096-04
Generation of functional lung stem cells from human iPSCs07/01/2019 - 06/30/2022 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Heart, Lung, and Blood Institute5U01HL148692-02
A National iPS cell network with deep phenotyping for translational research09/15/2016 - 06/30/2022 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Center for Advancing Translational Sciences5U01TR001810-05
Development of a mouse model of syngeneic airway stem cell transplantation06/01/2021 - 05/31/2022 (Key Person / Mentor)
University of Maryland College Park NIH NHLBI5U24HL134763-06
PCTC Administrative Coordinating Center12/01/2019 - 05/31/2022 (Subcontract PI)
University of Maryland, Baltimore NIH NHLBI5U24HL134763-04
PCTC Admin coordinating center: scRNA-Seq to define the heterogeneity of iPSC-derived lung progenitors12/01/2019 - 05/31/2022 (Subcontract PI)
University of Maryland College Park NIH NHLBI55U24HL134763-04-04
A new human iPSC in vitro system to model the inception of lung adenocarcinoma (2nd Year Renewal - WWDA)12/01/2020 - 12/31/2021 (Multi-PI)
PI:
Darrell Nelson Kotton, MDJanssen Research & Development, LLC
In vitro differentiation of parathyroid cells from stem
cells01/01/2020 - 12/31/2021 (Subcontract PI)
Massachusetts General Hospital Univ of Pittsburgh
Celgene Corporation - Boston University SRA04/09/2018 - 10/31/2021 (PI)
Celgene Corporation
Effective treatments for SARS-CoV-2 based on modeling lung single cell response data09/01/2020 - 08/31/2021 (Subcontract PI)
Carnegie Mellon University C3DTI.ai
PCTC Administrative Coordinating Center06/01/2020 - 05/31/2021 (Key Person / Mentor)
University of Maryland, Baltimore NIH NHLBI5U24HL134763
Human iPSC-derived lung organoids for modeling COVID-19 infection05/01/2020 - 04/30/2021 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School China Evergrande Gr
A new human iPSC in vitro system to model the inception of
lung adenocarcinoma06/01/2020 - 11/30/2020 (Multi-PI)
PI:
Darrell Nelson Kotton, MDJohnson & Johnson Enterprise Innovation, Inc.
PCTC Administrative Coordinating Center12/01/2019 - 11/30/2020 (Key Person / Mentor)
University of Maryland, Baltimore NIH NHLBI5U24HL134763-04
Thyroid Follicular Cell development in mouse and humans06/01/2018 - 11/30/2020 (Multi-PI)
PI:
Darrell Nelson Kotton, MDWeill Medical College of Cornell NIH NIDDK5R01DK105029-05
MLSC Phase 2 Proposal 2014: The Lung Regeneration Initiative (LRI)09/24/2015 - 09/23/2020 (PI)
Massachusetts Life Sciences Center
Generation of purified population of putative human iPSC-derived AEC207/01/2018 - 06/30/2020 (PI)
MedImmune, Inc.
Epigenenomic and transcriptomic networks in normal and defective lung development09/15/2015 - 06/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL128172-04
A National Resource for Lung disease-specific IPS cells08/15/2014 - 04/30/2020 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Heart, Lung, and Blood Institute5R24HL123828-05
The Boston University Clinical and Transitional Science Institute (All Components)08/13/2015 - 04/14/2020 (PI)
NIH/National Center for Advancing Translational Sciences5TL1TR001410-04
A new human iPSC in vitro system to model the inception of lung adenocarcinoma01/01/2019 - 12/31/2019 (PI)
Johnson & Johnson
Thyroid Follicular Cell development in mouse and humans12/01/2015 - 11/30/2019 (Multi-PI)
PI:
Darrell Nelson Kotton, MDBeth Israel Deaconess Medical Center, Inc. NIH NIDDK5R01DK105029-03
Contribution of Gain of Function Toxicity to AATD Lung Disease Pathogenesis10/01/2018 - 09/30/2019 (Co-Investigator)
PI:
Andrew A. Wilson, MDAlpha-1 Foundation
Molecular and Biological Function of Long Non-Coding RNA Transcripts Divergent to Lung Development Genes08/01/2017 - 06/30/2019 (Subcontract PI)
Thomas Jefferson University NIH NHLBI5R01HL127426-04
Modelling AATD Lung Disease Using Alveolar Epithelial Cells Derived from Gene-Edited iPSC07/01/2017 - 06/30/2019 (PI)
Alpha-1 Foundation
PCTC Administrative Coordinating Center01/01/2019 - 05/31/2019 (Key Person / Mentor)
University of Maryland, Baltimore NIH NHLBI5U24HL134763-02
Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells06/01/2016 - 05/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-09
iPSC Modeling of the Role of NKX2-1 in Human Lung Development and Disease04/01/2014 - 02/28/2019 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL122442-04
Derivation of proximal airway basal stem cells for treatment of Cystic Fibrosis01/01/2016 - 12/31/2018 (Subcontract PI)
University of Texas Cystic Fibrosis Fdn
Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells08/01/2013 - 05/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-07
Directed differentiation of human induced pluripotent stem cells into pulp regenerating progenitors04/01/2014 - 03/31/2016 (PI)
American Association of Endodontists Foundation
Defining the genetic program of primordial lung progenitors12/21/2011 - 11/30/2015 (Key Person)
PI:
Laertis Ikonomou, PhDNIH/National Heart, Lung, and Blood Institute5R01HL111574-04
Generation of Alpha-1 iPS Cells04/01/2013 - 09/30/2015 (PI)
Alpha-1 Foundation
NHLBI Progenitor Cell Biology Consortium Administrative Coordinating Center08/01/2013 - 07/31/2015 (Subcontract PI)
University of Maryland, Baltimore County NIH NHLBI5U01HL099997-06
Bioengineering of Transplantable Humanized Lungs from iPS Cells09/15/2011 - 05/31/2015 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Heart, Lung, and Blood Institute5R01HL108678-04
Lung Repair and Regeneration Consortium Administrative (Project)01/01/2014 - 12/31/2014 (Subcontract PI)
Duke University NIH NHLBI5U01HL110967-03
Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the Developing Lung12/01/2013 - 11/30/2014 (Co-Investigator)
PI:
Wellington V. Cardoso, MD, PhDNIH/National Heart, Lung, and Blood Institute1F32HL117529-01A1
Reconstructing Lung Epithelium with Gene-corrected Disease-specific iPS cells07/01/2012 - 06/30/2014 (PI)
American Lung Association
Generation of Bioartificial lungs from gene corrected PiZZ iPS cells07/01/2011 - 12/31/2013 (PI)
Alpha-1 Foundation
Bioengineering New Lungs from Cadaveric Scaffolds09/17/2010 - 08/31/2013 (Subcontract PI)
University of Vermont & State Agricultural College NIH NHLBI1RC1HL106625-01
Mechanistic Study of an Inheritied Arrhythmia in a Complex Genetic Background using IPS Cell Derived Cardiomyoctes09/01/2010 - 08/31/2013 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NY Dept of Health
De-Cellularized Human Lungs for Ex-Vivo Lung Regeneration08/01/2012 - 07/31/2013 (Subcontract PI)
University of Vermont & State Agricultural College NIH5R21HL108689-02
Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells08/01/2009 - 07/31/2013 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-04
Hemangioblast Transplantation for Reconstitution of Lung Endothelium04/01/2008 - 03/31/2010 (PI)
NIH/National Heart, Lung, and Blood Institute5 R21 HL86610 02
Cell-Specific Delivery of RNAi to Pulmonary Alveolar Macrophages In Vivo09/30/2006 - 07/31/2008 (PI)
NIH/National Heart, Lung, and Blood Institute5 R21 HL86414 02
Derivation of Lung Epithelium from Bone Marrow02/04/2003 - 01/31/2008 (PI)
NIH/National Heart, Lung, and Blood Institute5 K08 HL71640 05
Stem Cell-Based Therapy for Alpha-1 Antitrypsin Deficiency01/01/2006 - 12/31/2007 (PI)
American Thoracic Society/ LUNGevity Foundation
Marrow Stem Cells as Precursors of Alveolar Epithelium07/01/2001 - 06/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute1 F32 HL67578 01