Darrell Nelson Kotton, MD
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine

Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Boston University School of Medicine
Center for Regenerative Medicine

Boston University School of Medicine
Pathology & Laboratory Medicine

Framingham Heart Study

Boston University
Pulmonary Center

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2018 American Thoracic Society: Research Achievement Award
2018 Boston University, Graduate Medical Sciences: Educator of the Year Award
2017 Association of American Medical Colleges: Inaugural Research Resources Sharing Award
2016 David C. Seldin Endowed Professor of Medicine
2014 Boston Univ. Dept. of Medicine: Robert Dawes Evans Senior Research Mentor Award
2013 Alpha-1 Foundation: Researcher of the Year Award
2010 American Society of Clinical Investigation, Elected Member
2009 Co-Director, Boston University Center for Regenerative Medicine (CReM)
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar

Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro
12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB

Derivation of lung epithelia from iPS cells for advanced disease modeling
06/01/2019 - 05/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute

Reconstructing regulatory networks from time series single cell data
08/01/2017 - 07/31/2021 (Subcontract PI)
Carnegie Mellon University NIH NIGMS

Generation of functional lung stem cells from human iPSCs
07/01/2019 - 06/30/2021 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Heart, Lung, and Blood Institute

A National iPS cell network with deep phenotyping for translational research
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Center for Advancing Translational Sciences

Celgene Corporation - Boston University SRA
04/09/2018 - 04/08/2021 (PI)
Celgene Corporation

MLSC Phase 2 Proposal 2014: The Lung Regeneration Initiative (LRI)
09/24/2015 - 09/23/2020 (PI)
Massachusetts Life Sciences Center

Generation of purified population of putative human iPSC-derived AEC2
07/01/2018 - 06/30/2020 (PI)
MedImmune, Inc.

Epigenenomic and transcriptomic networks in normal and defective lung development
09/15/2015 - 06/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute

Editing alveolar progenitor cells for correction of monogenic disease
09/23/2016 - 05/31/2020 (Subcontract PI)
Cincinnati Children's Hospital Medical Center NIH NHLBI

Showing 10 of 41 results. Show All Results


Yr Title Project-Sub Proj Pubs
2020 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-05 10
2020 NRSA Training Core 2TL1TR001410-05A1 9
2020 Derivation of lung epithelia from iPS cells for advanced disease modeling 5R01HL095993-11 16
2019 Generation of functional lung stem cells from human iPSCs 1U01HL148692-01 1
2019 Thyroid Follicular Cell Development in Mice and Humans 5R01DK105029-05 6
2019 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-04 39
2019 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-04 10
2019 A National iPS Cell Network with Deep Phenotyping for Translational Research 5U01TR001810-04 12
2019 Derivation of lung epithelia from iPS cells for advanced disease modeling 2R01HL095993-10 16
2018 Thyroid Follicular Cell Development in Mice and Humans 7R01DK105029-04 6
Showing 10 of 72 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell Stem Cell. 2020 Aug 22.View Related Profiles. PMID: 32891189
  2. Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR, Wilson AA, Connors LH, Kotton DN, Wiseman RL, Murphy GJ. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports. 2020 08 11; 15(2):515-528.View Related Profiles. PMID: 32735824
  3. Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 07 14; 15(1):242-255.View Related Profiles. PMID: 32619491
  4. Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles. PMID: 32637964
  5. Cohen Y, Shen J, Semu D, Leman DP, Liberti WA, Perkins LN, Liberti DC, Kotton DN, Gardner TJ. Hidden neural states underlie canary song syntax. Nature. 2020 Jun; 582(7813):539-544. PMID: 32555461
  6. Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Frum T, Kadambi NS, Amin AT, O'Meara TR, Pretto CD, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Sexton JZ. Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. bioRxiv. 2020 Jun 10. PMID: 32577649
  7. Abo KM, Ma L, Matte T, Huang J, Alysandratos KD, Werder RB, Mithal A, Beermann ML, Lindstrom-Vautrin J, Mostoslavsky G, Ikonomou L, Kotton DN, Hawkins F, Wilson A, Villacorta-Martin C. Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.View Related Profiles. PMID: 32577635
  8. Wang R, McCauley KB, Kotton DN, Hawkins F. Differentiation of human airway-organoids from induced pluripotent stem cells (iPSCs). Methods Cell Biol. 2020; 159:95-114.View Related Profiles. PMID: 32586451
  9. Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 Apr 02; 26(4):482-502.View Related Profiles. PMID: 32243808
  10. Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kandula MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun. 2020 01 31; 11(1):635.View Related Profiles. PMID: 32005814
Showing 10 of 99 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 99 publications over 19 distinct years, with a maximum of 12 publications in 2012 and 2020

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells

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