Darrell Nelson Kotton, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine


Pronouns: he/him/his



Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Director
Boston University
Center for Regenerative Medicine


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro
12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB


Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)
08/01/2021 - 07/31/2026 (Multi-PI)
PI: Darrell Nelson Kotton, MD
Stanford University NIH NHLBI
1P01HL152953-01A1

Biology of the Lung: A Multidisciplinary Program
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Heart, Lung, and Blood Institute
2T32HL007035-46A1

NRSA Training Core
04/15/2020 - 03/31/2025 (PI)
NIH/National Center for Advancing Translational Sciences
5TL1TR001410-06

Engineering Branching Networks Through Synthetic Turing Morphogen Circuits
12/10/2021 - 12/09/2024 (Multi-PI)
PI: Darrell Nelson Kotton, MD
Allen Institute d/b/a The Paul G. Allen Frontiers Group


Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs
12/15/2020 - 11/30/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
5U01HL152976-02

Generation of human alveolar epithelial type I cells from pluripotent stem cells
06/01/2021 - 05/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
1F31HL158193-01

Characterization of iPSC-derived alveolar epithelial type II cells
12/21/2018 - 12/31/2023 (PI)
Novartis Institutes for BioMedical Research


Preparing human lung cells and organoids able to model human responses to respiratory infections and ready to predict effective therapeutics
11/01/2021 - 10/31/2023 (PI)
Good Ventures


IDEAL2.0: iPSC Disease Modeling and Drug Screening
01/01/2022 - 06/30/2023 (PI)
Bristol-Myers Squibb


Showing 10 of 69 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 5U01HL152976-02
2022 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-07
2022 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-07
2022 Thyroid Follicular Cell Signaling and Development in Humans 5R01DK105029-07
2022 NRSA Training Core 5TL1TR001410-07
2022 Derivation of lung epithelia from iPS cells for advanced disease modeling 5R01HL095993-13
2022 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-47
2021 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 1U01HL152976-01
2021 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-06 39
2021 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-06 10
Showing 10 of 89 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Werder RB, Liu T, Abo KM, Lindstrom-Vautrin J, Villacorta-Martin C, Huang J, Hinds A, Boyer N, Bullitt E, Liesa M, Silverman EK, Kotton DN, Cho MH, Zhou X, Wilson AA. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022 Jul 15; 8(28):eabo6566.View Related Profiles. PMID: 35857525; PMCID: PMC9278866; DOI: 10.1126/sciadv.abo6566;
     
  2. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Jun; 18(6):e1010659.View Related Profiles. PMID: 35749346; PMCID: PMC9231773; DOI: 10.1371/journal.ppat.1010659;
     
  3. Berical A, Beermann ML, Suzuki S, LeSuer J, Matte T, Davis B, Kotton D, Hawkins F. Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells. J Vis Exp. 2022 Jun 14; (184).View Related Profiles. PMID: 35781291
     
  4. Werder RB, Huang J, Abo KM, Hix OT, Minakin K, Alysandratos KD, Merritt C, Berthiaume K, Alber AB, Burgess CL, Kotton DN, Wilson AA. Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells. J Vis Exp. 2022 Apr 15; (182).View Related Profiles. PMID: 35499347
     
  5. Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature. 2022 Apr; 604(7904):120-126. PMID: 35355013; PMCID: PMC9297319; DOI: 10.1038/s41586-022-04552-0;
     
  6. Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight. 2022 Mar 22; 7(6).View Related Profiles. PMID: 35315362; PMCID: PMC8986076; DOI: 10.1172/jci.insight.155589;
     
  7. Gil CH, Chakraborty D, Vieira CP, Prasain N, Calzi SL, Fortmann SD, Hu P, Banno K, Jamal M, Huang C, Sielski MS, Lin Y, Huang X, Dupont MD, Floyd JL, Prasad R, Longhini ALF, McGill TJ, Chung HM, Murphy MP, Kotton DN, Boulton ME, Yoder MC, Grant MB. Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice. Sci Adv. 2022 Mar 04; 8(9):eabm5559. PMID: 35245116; PMCID: PMC8896785; DOI: 10.1126/sciadv.abm5559;
     
  8. Wang SW, Herriges MJ, Hurley K, Kotton DN, Klein AM. CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information. Nat Biotechnol. 2022 Jul; 40(7):1066-1074.View Related Profiles. PMID: 35190690
     
  9. Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563.View Related Profiles. PMID: 35137631; PMCID: PMC8957336; DOI: 10.1152/ajplung.00325.2021;
     
  10. Miorin L, Mire CE, Ranjbar S, Hume AJ, Huang J, Crossland NA, White KM, Laporte M, Kehrer T, Haridas V, Moreno E, Nambu A, Jangra S, Cupic A, Dejosez M, Abo KA, Tseng AE, Werder RB, Rathnasinghe R, Mutetwa T, Ramos I, de Aja JS, de Alba Rivas CG, Schotsaert M, Corley RB, Falvo JV, Fernandez-Sesma A, Kim C, Rossignol JF, Wilson AA, Zwaka T, Kotton DN, Mühlberger E, García-Sastre A, Goldfeld AE. The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters. bioRxiv. 2022 Feb 09.View Related Profiles. PMID: 35169796; PMCID: PMC8845418; DOI: 10.1101/2022.02.08.479634;
     
Showing 10 of 134 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 134 publications over 21 distinct years, with a maximum of 20 publications in 2020

YearPublications
20011
20033
20042
20054
20061
20072
20084
20095
20106
20118
201212
201310
20143
20157
20162
20179
20185
20193
202020
202113
202214


Ambitious Effort to Develop Lab-Grown Lungs Wins Paul G. Allen Frontiers Group Funding

BU Today 2/9/2022

MED’s Biology of the Lung Funded through Its 50th—Yes, 50th—Year

BU Today 9/23/2021

Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases

Genetic Engineering and Biotechnology News 9/1/2021

BU awarded T32 grant to mentor research trainees in lung biology and pulmonary sciences

News Medical 7/1/2021

How Coronavirus Damages Lung Cells within Mere Hours

BU Today 1/11/2021

$2.4M NIH Grant Supports Boston Team Creating Cell Model for IPF

Pulmonary Fibrosis News 12/22/2020

CF Foundation Awards Research Projects to Advance Therapies for All CF Patients

Cystic Fibrosis News Today 12/15/2020

How Coronavirus Kickstarts Deadly Lung Inflammation

Futurity 9/28/2020

Boston University Researchers Shed Light on How COVID Causes Fatal Lung Inflammation

RT Magazine 9/25/2020

In Deadly COVID-19 Lung Inflammation, BU Researchers Discover a Culprit in NFkB Pathway

BU Today 9/24/2020

BU researchers say they found what causes fatal lung inflammation in COVID-19 patients

Boston 25 9/21/2020

New organoids facilitate sooner examine of early lung most cancers, potential therapies

Home Health Choices 9/10/2020

What Sets Off Deadly Levels of Lung Inflammation in Some COVID-19 Patients?

BU Today 9/8/2020

'It's Quite Painful': Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

It’s Quite Painful’: Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

Machine Learning Gives Rise to Better Lung Disease Models from Stem Cells

BU Today 2/4/2020

2020 Association of American Physicians: AAP, Elected Member
2018 American Thoracic Society: Research Achievement Award
2018 Boston University, Graduate Medical Sciences: Educator of the Year Award
2017 Association of American Medical Colleges: Inaugural Research Resources Sharing Award
2016 David C. Seldin Endowed Professor of Medicine
2014 Boston Univ. Dept. of Medicine: Robert Dawes Evans Senior Research Mentor Award
2013 Alpha-1 Foundation: Researcher of the Year Award
2010 American Society of Clinical Investigation, Elected Member
2009 Co-Director, Boston University Center for Regenerative Medicine (CReM)
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

670 Albany St Biosquare III
Boston MA 02118
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