Darrell Nelson Kotton, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine




Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Director
Boston University
Center for Regenerative Medicine


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2018 American Thoracic Society: Research Achievement Award
2018 Boston University, Graduate Medical Sciences: Educator of the Year Award
2017 Association of American Medical Colleges: Inaugural Research Resources Sharing Award
2016 David C. Seldin Endowed Professor of Medicine
2014 Boston Univ. Dept. of Medicine: Robert Dawes Evans Senior Research Mentor Award
2013 Alpha-1 Foundation: Researcher of the Year Award
2010 American Society of Clinical Investigation, Elected Member
2009 Co-Director, Boston University Center for Regenerative Medicine (CReM)
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar


Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro
12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB


NRSA Training Core
04/15/2020 - 03/31/2025 (PI)
NIH/National Center for Advancing Translational Sciences
2TL1TR001410-05A1

Derivation of lung epithelia from iPS cells for advanced disease modeling
06/01/2019 - 05/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
3R01HL095993-11S1

In vitro differentiation of parathyroid cells from stem cells
01/01/2020 - 12/31/2021 (Subcontract PI)
Massachusetts General Hospital Univ of Pittsburgh


Reconstructing regulatory networks from time series single cell data
08/01/2017 - 07/31/2021 (Subcontract PI)
Carnegie Mellon University NIH NIGMS
5R01GM122096-04

Generation of functional lung stem cells from human iPSCs
07/01/2019 - 06/30/2021 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Heart, Lung, and Blood Institute
5U01HL148692-02

Characterization of iPSC-derived alveolar epithelial type II cells
12/21/2018 - 06/30/2021 (PI)
Novartis Institutes for BioMedical Research


A National iPS cell network with deep phenotyping for translational research
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Center for Advancing Translational Sciences
5U01TR001810-05

A new human iPSC in vitro system to model the inception of lung adenocarcinoma (2nd Year Renewal - WWDA)
12/01/2020 - 05/31/2021 (PI)
Janssen Research & Development, LLC


PCTC Administrative Coordinating Center
12/01/2019 - 05/31/2021 (Subcontract PI)
University of Maryland d.b.a. University of Maryland Baltimore Campus NIH NHLBI
5U24HL134763-04

Showing 10 of 49 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 1U01HL152976-01
2020 Generation of functional lung stem cells from human iPSCs 5U01HL148692-02 1
2020 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-05 39
2020 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-05 10
2020 A National iPS Cell Network with Deep Phenotyping for Translational Research 5U01TR001810-05 12
2020 NRSA Training Core 2TL1TR001410-05A1 9
2020 Derivation of lung epithelia from iPS cells for advanced disease modeling 5R01HL095993-11 16
2020 Derivation of lung epithelia from iPS cells for advanced disease modeling 3R01HL095993-11S1 16
2019 Generation of functional lung stem cells from human iPSCs 1U01HL148692-01 1
2019 Thyroid Follicular Cell Development in Mice and Humans 5R01DK105029-05 6
Showing 10 of 77 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey EE, Cohen NA, Weiss SR. SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). PMID: 33811184
     
  2. Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 04 07; 6(58). PMID: 33827897
     
  3. Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ. Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem Cell Reports. 2021 03 09; 16(3):505-518. PMID: 33636110
     
  4. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854
     
  5. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; DOI: 10.1016/j.molcel.2020.11.028;
     
  6. Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles. PMID: 33140044
     
  7. Hawkins FJ, Suzuki S, Beermann ML, Barillà C, Wang R, Villacorta-Martin C, Berical A, Jean JC, Le Suer J, Matte T, Simone-Roach C, Tang Y, Schlaeger TM, Crane AM, Matthias N, Huang SXL, Randell SH, Wu J, Spence JR, Carraro G, Stripp BR, Rab A, Sorsher EJ, Horani A, Brody SL, Davis BR, Kotton DN. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2021 Jan 07; 28(1):79-95.e8.View Related Profiles. PMID: 33098807
     
  8. Alysandratos KD, Herriges MJ, Kotton DN. Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annu Rev Physiol. 2021 02 10; 83:529-550.View Related Profiles. PMID: 33074772
     
  9. Ding J, Lugo-Martinez J, Yuan Y, Kotton DN, Bar-Joseph Z. Reconstructing SARS-CoV-2 response signaling and regulatory networks. bioRxiv. 2020 Oct 13. PMID: 33083801
     
  10. Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey E, Cohen NA, Weiss SR. SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes. bioRxiv. 2020 Sep 25. PMID: 32995797
     
Showing 10 of 111 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 111 publications over 20 distinct years, with a maximum of 20 publications in 2020

YearPublications
20011
20033
20042
20054
20061
20072
20084
20095
20106
20118
201212
201310
20143
20157
20162
20179
20185
20193
202020
20214
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

670 Albany St Biosquare III
Boston MA 02118
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