Darrell Nelson Kotton, MD
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine

Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Boston University
Center for Regenerative Medicine

Boston University School of Medicine
Pathology & Laboratory Medicine

Framingham Heart Study

Boston University
Pulmonary Center

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2018 American Thoracic Society: Research Achievement Award
2018 Boston University, Graduate Medical Sciences: Educator of the Year Award
2017 Association of American Medical Colleges: Inaugural Research Resources Sharing Award
2016 David C. Seldin Endowed Professor of Medicine
2014 Boston Univ. Dept. of Medicine: Robert Dawes Evans Senior Research Mentor Award
2013 Alpha-1 Foundation: Researcher of the Year Award
2010 American Society of Clinical Investigation, Elected Member
2009 Co-Director, Boston University Center for Regenerative Medicine (CReM)
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar

Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro
12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB

NRSA Training Core
04/15/2020 - 03/31/2025 (PI)
NIH/National Center for Advancing Translational Sciences

Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs
12/15/2020 - 11/30/2024 (PI)
NIH/National Heart, Lung, and Blood Institute

Derivation of lung epithelia from iPS cells for advanced disease modeling
06/01/2019 - 05/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute

De-Novo Generation of Pulmonary ionocytes from Human Pluripotent Stem Cells
11/01/2020 - 10/31/2022 (Multi-PI)
PI: Darrell Nelson Kotton, MD
Cystic Fibrosis Foundation

National Biorepository for Lung Disease-Specific Induced Pluripotent Stem Cells
05/01/2020 - 04/30/2022 (PI)
NIH/National Heart, Lung, and Blood Institute

Development of DF-COV for the treatment and prevention of COVID-19 and associated immunopathologic respiratory complications
01/15/2021 - 01/14/2022 (Subcontract PI)
Dana-Farber Cancer Institute DOD Army Med Resrch

A new human iPSC in vitro system to model the inception of lung adenocarcinoma (2nd Year Renewal - WWDA)
12/01/2020 - 12/31/2021 (Multi-PI)
PI: Darrell Nelson Kotton, MD
Janssen Research & Development, LLC

In vitro differentiation of parathyroid cells from stem cells
01/01/2020 - 12/31/2021 (Subcontract PI)
Massachusetts General Hospital Univ of Pittsburgh

Celgene Corporation - Boston University SRA
04/09/2018 - 10/31/2021 (PI)
Celgene Corporation

Showing 10 of 54 results. Show All Results


Yr Title Project-Sub Proj Pubs
2021 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 1U01HL152976-01
2021 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-06 39
2021 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-06 10
2021 Thyroid Follicular Cell Signaling and Development in Humans 2R01DK105029-06 6
2021 NRSA Training Core 5TL1TR001410-06 9
2021 Derivation of lung epithelia from iPS cells for advanced disease modeling 5R01HL095993-12 16
2021 Biology of the Lung: A Multidisciplinary Program 2T32HL007035-46A1 121
2020 Generation of functional lung stem cells from human iPSCs 5U01HL148692-02 1
2020 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-05 39
2020 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-05 10
Showing 10 of 83 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sun YL, Hurley K, Villacorta-Martin C, Huang J, Hinds A, Gopalan K, Caballero IS, Russo SJ, Kitzmiller JA, Whitsett JA, Beers MF, Kotton DN. Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters. Am J Respir Cell Mol Biol. 2021 10; 65(4):442-460.View Related Profiles. PMID: 34101541
  2. Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.View Related Profiles. PMID: 34260266; PMCID: PMC8428404; DOI: 10.1128/JVI.00862-21;
  3. Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Pretto CD, Qiao Y, Zhang Y, Frum T, Kadambi NS, Amin AT, O'Meara TR, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Chinnaiyan AM, Sexton JZ. Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). PMID: 34413211
  4. Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 Aug 31; 36(9):109636.View Related Profiles. PMID: 34469722
  5. Suzuki S, Hawkins FJ, Barillà C, Beermann ML, Kotton DN, Davis BR. Differentiation of human pluripotent stem cells into functional airway basal stem cells. STAR Protoc. 2021 Sep 17; 2(3):100683.View Related Profiles. PMID: 34355203; PMCID: PMC8322461; DOI: 10.1016/j.xpro.2021.100683;
  6. Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey EE, Cohen NA, Weiss SR. SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). PMID: 33811184; PMCID: PMC8072330; DOI: 10.1073/pnas.2022643118;
  7. Posabella A, Alber AB, Undeutsch HJ, Droeser RA, Hollenberg AN, Ikonomou L, Kotton DN. Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Front Endocrinol (Lausanne). 2021; 12:666565.View Related Profiles. PMID: 33959101; PMCID: PMC8095374; DOI: 10.3389/fendo.2021.666565;
  8. Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 04 07; 6(58). PMID: 33827897; PMCID: PMC8139422; DOI: 10.1126/sciimmunol.abg0833;
  9. Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ. Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem Cell Reports. 2021 03 09; 16(3):505-518. PMID: 33636110; PMCID: PMC7881728; DOI: 10.1016/j.stemcr.2021.02.010;
  10. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;
Showing 10 of 117 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 117 publications over 20 distinct years, with a maximum of 20 publications in 2020


Recent (within 3 months)

MED’s Biology of the Lung Funded through Its 50th—Yes, 50th—Year

BU Today 9/23/2021

Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases

Genetic Engineering and Biotechnology News 9/1/2021


BU awarded T32 grant to mentor research trainees in lung biology and pulmonary sciences

News Medical 7/1/2021

How Coronavirus Damages Lung Cells within Mere Hours

BU Today 1/11/2021

$2.4M NIH Grant Supports Boston Team Creating Cell Model for IPF

Pulmonary Fibrosis News 12/22/2020

CF Foundation Awards Research Projects to Advance Therapies for All CF Patients

Cystic Fibrosis News Today 12/15/2020

How Coronavirus Kickstarts Deadly Lung Inflammation

Futurity 9/28/2020

Boston University Researchers Shed Light on How COVID Causes Fatal Lung Inflammation

RT Magazine 9/25/2020

In Deadly COVID-19 Lung Inflammation, BU Researchers Discover a Culprit in NFkB Pathway

BU Today 9/24/2020

BU researchers say they found what causes fatal lung inflammation in COVID-19 patients

Boston 25 9/21/2020

New organoids facilitate sooner examine of early lung most cancers, potential therapies

Home Health Choices 9/10/2020

What Sets Off Deadly Levels of Lung Inflammation in Some COVID-19 Patients?

BU Today 9/8/2020

'It's Quite Painful': Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

It’s Quite Painful’: Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

Machine Learning Gives Rise to Better Lung Disease Models from Stem Cells

BU Today 2/4/2020
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells

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