Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB
Derivation of lung epithelia from iPS cells for advanced disease modeling06/01/2019 - 05/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute2R01HL095993-10
Reconstructing regulatory networks from time series single cell data08/01/2017 - 07/31/2021 (Subcontract PI)
Carnegie Mellon University NIH NIGMS5R01GM122096-03
Generation of functional lung stem cells from human iPSCs07/01/2019 - 06/30/2021 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Heart, Lung, and Blood Institute1U01HL148692-01
A National iPS cell network with deep phenotyping for translational research09/15/2016 - 06/30/2021 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Center for Advancing Translational Sciences5U01TR001810-04
Celgene Corporation - Boston University SRA04/09/2018 - 04/08/2021 (PI)
Celgene Corporation
MLSC Phase 2 Proposal 2014: The Lung Regeneration Initiative (LRI)09/24/2015 - 09/23/2020 (PI)
Massachusetts Life Sciences Center
Generation of purified population of putative human iPSC-derived AEC207/01/2018 - 06/30/2020 (PI)
MedImmune, Inc.
Epigenenomic and transcriptomic networks in normal and defective lung development09/15/2015 - 06/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL128172-04
Editing alveolar progenitor cells for correction of monogenic disease09/23/2016 - 05/31/2020 (Subcontract PI)
Cincinnati Children's Hospital Medical Center NIH NHLBI5U01HL134745-04
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Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage09/21/2016 - 05/31/2020 (Subcontract PI)
The Regents of the University of California, San Francisco NIH NHLBI5U01HL134766-04
A National Resource for Lung disease-specific IPS cells08/15/2014 - 04/30/2020 (Multi-PI)
PI:
Darrell Nelson Kotton, MDNIH/National Heart, Lung, and Blood Institute5R24HL123828-05
The Boston University Clinical and Transitional Science Institute (All Components)08/13/2015 - 03/31/2020 (PI)
NIH/National Center for Advancing Translational Sciences5TL1TR001410-04
A new human iPSC in vitro system to model the inception of lung adenocarcinoma01/01/2019 - 12/31/2019 (PI)
Johnson & Johnson
Characterization of iPSC-derived alveolar epithelial type II cells12/21/2018 - 12/01/2019 (PI)
Novartis Institutes for BioMedical Research
Thyroid Follicular Cell Development in Mouse and Humans06/01/2018 - 11/30/2019 (Subcontract PI)
Weill Medical College of Cornell NIH NIDDK5R01DK105029-05
Thyroid Follicular Cell development in mouse and humans12/01/2015 - 11/30/2019 (Subcontract PI)
Beth Israel Deaconess Medical Center, Inc NIH NIDDK5R01DK105029-03
Contribution of Gain of Function Toxicity to AATD Lung Disease Pathogenesis10/01/2018 - 09/30/2019 (Co-PI)
PI:
Andrew A. Wilson, MDAlpha 1 Foundation
Molecular and Biological Function of Long Non-Coding RNA Transcripts Divergent to Lung Development Genes08/01/2017 - 06/30/2019 (Subcontract PI)
Thomas Jefferson University NIH NHLBI5R01HL127426-04
Modelling AATD Lung Disease Using Alveolar Epithelial Cells Derived from Gene-Edited iPSC07/01/2017 - 06/30/2019 (PI)
Alpha 1 Foundation
Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells06/01/2016 - 05/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-09
iPSC Modeling of the Role of NKX2-1 in Human Lung Development and Disease04/01/2014 - 02/28/2019 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL122442-04
Derivation of proximal airway basal stem cells for treatment of Cystic Fibrosis01/01/2016 - 12/31/2018 (Subcontract PI)
University of Texas Cystic Fibrosis Fdn
Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells08/01/2013 - 05/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-07
Directed differentiation of human induced pluripotent stem cells into pulp regenerating progenitors04/01/2014 - 03/31/2016 (PI)
American Association of Endodontists Foundation
Generation of Alpha-1 iPS Cells04/01/2013 - 09/30/2015 (PI)
Alpha 1 Foundation
NHLBI Progenitor Cell Biology Consortium Administrative Coordinating Center08/01/2013 - 07/31/2015 (Subcontract PI)
University of Maryland, Baltimore County NIH NHLBI5U01HL099997-06
Bioengineering of Transplantable Humanized Lungs from iPS Cells09/15/2011 - 05/31/2015 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL108678-04
Lung Repair and Regeneration Consortium Administrative (Project)01/01/2014 - 12/31/2014 (Subcontract PI)
Duke University NIH NHLBI5U01HL110967-03
Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the Developing Lung12/01/2013 - 11/30/2014 (Co-PI)
PI:
Wellington V. Cardoso, MD, PhDNIH/National Heart, Lung, and Blood Institute1F32HL117529-01A1
Reconstructing Lung Epithelium with Gene-corrected Disease-specific iPS cells07/01/2012 - 06/30/2014 (PI)
American Lung Association
Generation of Bioartificial lungs from gene corrected PiZZ iPS cells07/01/2011 - 12/31/2013 (PI)
Alpha 1 Foundation
Bioengineering New Lungs from Cadaveric Scaffolds09/17/2010 - 08/31/2013 (Subcontract PI)
University of Vermont & State Agricultural College NIH NHLBI1RC1HL106625-01
Mechanistic Study of an Inheritied Arrhythmia in a Complex Genetic Background using IPS Cell Derived Cardiomyoctes09/01/2010 - 08/31/2013 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NY Dept of Health
De-Cellularized Human Lungs for Ex-Vivo Lung Regeneration08/01/2012 - 07/31/2013 (Subcontract PI)
University of Vermont & State Agricultural College NIH5R21HL108689-02
Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells08/01/2009 - 07/31/2013 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL095993-04
Hemangioblast Transplantation for Reconstitution of Lung Endothelium04/01/2008 - 03/31/2010 (PI)
NIH/National Heart, Lung, and Blood Institute5 R21 HL86610 02
Cell-Specific Delivery of RNAi to Pulmonary Alveolar Macrophages In Vivo09/30/2006 - 07/31/2008 (PI)
NIH/National Heart, Lung, and Blood Institute5 R21 HL86414 02
Derivation of Lung Epithelium from Bone Marrow02/04/2003 - 01/31/2008 (PI)
NIH/National Heart, Lung, and Blood Institute5 K08 HL71640 05
Stem Cell-Based Therapy for Alpha-1 Antitrypsin Deficiency01/01/2006 - 12/31/2007 (PI)
American Thoracic Society/ LUNGevity Foundation
Marrow Stem Cells as Precursors of Alveolar Epithelium07/01/2001 - 06/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute1 F32 HL67578 01