Darrell Nelson Kotton, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine
BA, University of Pennsylvania

Pronouns: he/him/his



Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.

Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Director
Boston University
Center for Regenerative Medicine


Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine


Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




PRIMER: Promoting Research In MEdical Residency
07/01/2024 - 06/30/2029 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Heart, Lung, and Blood Institute
2R38HL143584-05

Developing Pluripotent Stem Cells to Model and Treat Lung Disease
03/01/2024 - 02/28/2029 (PI)
NIH/National Heart, Lung, and Blood Institute
1P01HL170952-01

Alveolar Epithelial Cell Dysfunction in Pulmonary Fibrosis: Leveraging SFTPC Mutations for Discovery of Molecular and Cellular Targets
07/15/2024 - 06/30/2028 (Subcontract PI)
The Trustees of the University of Pennsylvania NIH NHLBI
2R01HL145408-05A1

Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis
01/01/2023 - 12/31/2027 (Key Person / Mentor)
PI: Konstantinos Alysandratos, MD, PHD
NIH/National Heart, Lung, and Blood Institute
5K08HL163494-03

GSK_CReM_Collaboration: human iPSC model systems and drug development for pulmonary fibrosis and interstitial lung disease modeling. Workplan #:1 Sender/receiver assessment and target validation.
10/01/2024 - 09/30/2027 (PI)
GlaxoSmithKline LLC


GSK_CReM_Collaboration: human iPSC model systems and drug development for pulmonary fibrosis and interstitial lung disease modeling. Workplan #:2 Genetics and genomics analysis
10/01/2024 - 09/30/2027 (PI)
GlaxoSmithKline LLC


Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro
12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB


Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)
08/21/2023 - 07/31/2026 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health NIH NHLBI
5P01HL152953-04

Regeneration of lung epithelial stem cell compartments in a novel Z-AAT mouse model (Kiyokawa, Hirofumi)
07/01/2024 - 06/30/2026 (Key Person / Mentor)
PI: Hirofumi Kiyokawa, M.D., Ph.D.
Alpha-1 Foundation


Human iPSC -derived alveolar type 1 cells for understanding viral infections
07/01/2024 - 06/30/2026 (PI)
American Lung Association


Showing 10 of 86 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2025 Engraftment of PSC-Derived Lung Lineages to Reconstitute in vivo Airway and Alveolar Stem Cell Function 5P01HL170952-02-7287
2025 Adminstrative Core 5P01HL170952-02-7285
2025 Developing Pluripotent Stem Cells to Model and Treat Lung Disease 5P01HL170952-02
2025 Derivation of lung epithelia from iPS cells for advanced disease modeling 2R01HL095993-14
2024 Cell-cell and cell-matrix interactions driving progressive fibrosis in interstitial lung diseases 1U01HL175451-01
2024 Developing Pluripotent Stem Cells to Model and Treat Lung Disease 1P01HL170952-01
2024 Adminstrative Core 1P01HL170952-01-7285
2024 Engraftment of PSC-Derived Lung Lineages to Reconstitute in vivo Airway and Alveolar Stem Cell Function 1P01HL170952-01-7287
2024 Thyroid Follicular Cell Signaling and Development in Humans 5R01DK105029-09
2024 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 5U01HL152976-04
Showing 10 of 106 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Burgess CL, Ayers LJ, Minakin K, Alysandratos KD, Varelas X, Kotton DN. Protocol for the differentiation of human alveolar epithelial type I cells from pluripotent stem cell-derived type II-like cells. STAR Protoc. 2025 Mar 05; 6(1):103667.View Related Profiles. PMID: 40048418; DOI: 10.1016/j.xpro.2025.103667;
     
  2. Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, Kirchdoerfer RN, Saeed M, Baker SC. Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2419620122. PMID: 40035769; PMCID: PMC11912388; DOI: 10.1073/pnas.2419620122;
     
  3. Berical AC, Kiyokawa H, Beermann ML, Wallman D, Cherfane G, Dunphy V, Pan J, Tilston-Lunel A, Varelas X, Horani A, Brody SL, Kotton DN, Hawkins FJ. Reply to Huang et al.: Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes. Am J Respir Crit Care Med. 2025 Feb 25.View Related Profiles. PMID: 39999444; DOI: 10.1164/rccm.202412-2535LE;
     
  4. Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Ahmed DW, Spencer RC, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. Stem Cell Reports. 2025 Jan 14; 20(1):102376. PMID: 39672155; PMCID: PMC11784465; DOI: 10.1016/j.stemcr.2024.11.006;
     
  5. Kohn A, Herriges MJ, Basak P, Ma L, Thapa BR, Kotton DN, Hawkins FJ. Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract. bioRxiv. 2024 Nov 13.View Related Profiles. PMID: 39605510; PMCID: PMC11601482; DOI: 10.1101/2024.11.12.622518;
     
  6. Berical AC, Kiyokawa H, Beermann ML, Wallman D, Cherfane G, Dunphy V, Pan J, Tilston-Lunel A, Varelas X, Horani A, Brody SL, Kotton DN, Hawkins FJ. Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation. Am J Respir Crit Care Med. 2024 Nov 08; 211(1):131-4.View Related Profiles. PMID: 39514838; PMCID: PMC11755362; DOI: 10.1164/rccm.202406-1110RL;
     
  7. Undeutsch HJ, Posabella A, Alber AB, Bawa PS, Villacorta-Martin C, Wang F, Ikonomou L, Kotton DN, Hollenberg AN. Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells. Stem Cell Reports. 2024 Dec 10; 19(12):1690-1705.View Related Profiles. PMID: 39515316; PMCID: PMC11751801; DOI: 10.1016/j.stemcr.2024.10.004;
     
  8. Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Wang F, Bawa PS, Varelas X, Hawkins FJ, Kotton DN. Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells. Nat Protoc. 2025 Mar; 20(3):810-842.View Related Profiles. PMID: 39501108
     
  9. Tang X, Wei W, Sun Y, Weaver TE, Nakayasu ES, Clair G, Snowball JM, Na CL, Apsley KS, Martin EP, Kotton DN, Alysandratos KD, Huo J, Molkentin JD, Gower WA, Lin X, Whitsett JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. J Clin Invest. 2024 Oct 15; 134(23). PMID: 39405113; PMCID: PMC11601914; DOI: 10.1172/JCI173861;
     
  10. Gagnon KA, Huang J, Hix OT, Hui VW, Hinds A, Bullitt E, Eyckmans J, Kotton DN, Chen CS. Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma. APL Bioeng. 2024 Jun; 8(2):026126.View Related Profiles. PMID: 38911024; PMCID: PMC11191334; DOI: 10.1063/5.0207228;
     
Showing 10 of 171 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 171 publications over 24 distinct years, with a maximum of 20 publications in 2020

YearPublications
20011
20033
20042
20054
20061
20072
20084
20095
20106
20118
201212
201310
20143
20157
20162
20179
20185
20193
202020
202113
202217
202315
202416
20253


Researchers are one step closer to developing cell-based therapy for hypothyroidism

MSN 11/7/2024

Researchers will team up to develop pulmonary fibrosis stem cell models

Pulmonary Fibrosis News 10/25/2024

Global Biopharma Giant GSK and BU Announce Collaboration to Pioneer New Lung Disease Treatments

The Brink 10/17/2024

Stem Cells Breathe New Life into Lungs

The Scientist 10/30/2023

Engineered stem cells could regenerate damaged tissue in PF

Pulmonary Fibrosis News 9/8/2023

BU Researchers See Future Where Lung Disease Is Treatable, and Damaged Lungs Are Regenerated

BU Today 8/31/2023

Green and glowing mouse lung cells made to model PF in the lab

Pulmonary Fibrosis News 6/25/2023

New Model of Lung Mesenchymal Cells Created

Technology Networks 6/14/2023

iPSC-Based Model System Helps Study Lung-Specific Mesenchyme

AZO Life Sciences 6/14/2023

Researchers create new model of lung mesenchymal cells

Medical Xpress 6/13/2023

Ambitious Effort to Develop Lab-Grown Lungs Wins Paul G. Allen Frontiers Group Funding

BU Today 2/9/2022

MED’s Biology of the Lung Funded through Its 50th—Yes, 50th—Year

BU Today 9/23/2021

Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases

Genetic Engineering and Biotechnology News 9/1/2021

BU awarded T32 grant to mentor research trainees in lung biology and pulmonary sciences

News Medical 7/1/2021

How Coronavirus Damages Lung Cells within Mere Hours

BU Today 1/11/2021

$2.4M NIH Grant Supports Boston Team Creating Cell Model for IPF

Pulmonary Fibrosis News 12/22/2020

CF Foundation Awards Research Projects to Advance Therapies for All CF Patients

Cystic Fibrosis News Today 12/15/2020

How Coronavirus Kickstarts Deadly Lung Inflammation

Futurity 9/28/2020

Boston University Researchers Shed Light on How COVID Causes Fatal Lung Inflammation

RT Magazine 9/25/2020

In Deadly COVID-19 Lung Inflammation, BU Researchers Discover a Culprit in NFkB Pathway

BU Today 9/24/2020

BU researchers say they found what causes fatal lung inflammation in COVID-19 patients

Boston 25 9/21/2020

New organoids facilitate sooner examine of early lung most cancers, potential therapies

Home Health Choices 9/10/2020

What Sets Off Deadly Levels of Lung Inflammation in Some COVID-19 Patients?

BU Today 9/8/2020

'It's Quite Painful': Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

It’s Quite Painful’: Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

Machine Learning Gives Rise to Better Lung Disease Models from Stem Cells

BU Today 2/4/2020

2020 Association of American Physicians: AAP, Elected Member
2018 American Thoracic Society: Research Achievement Award
2018 Boston University, Graduate Medical Sciences: Educator of the Year Award
2017 Association of American Medical Colleges: Inaugural Research Resources Sharing Award
2016 David C. Seldin Endowed Professor of Medicine (Inaugural)
2014 Boston Univ. Dept. of Medicine: Robert Dawes Evans Senior Research Mentor Award
2013 Alpha-1 Foundation: Researcher of the Year Award
2010 American Society of Clinical Investigation, Elected Member
2009 Founding Director, Center for Regenerative Medicine (CReM) of Boston University and BMC
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells
Regenerative Medicine
Lung Injury and Repair

I have experience and success mentoring and preparing trainees for careers as independently funded basic science researchers. I serve as the founding Director of the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, and my laboratory has worked since 2004 in the field of pulmonary stem cell biology, regenerative medicine, and gene therapy. Fostering the careers of the next generation of academic medicine researchers and leaders is a top priority for me, and a mission I care about deeply: I have been the PI of a TL1 Training grant in Regenerative Medicine and I became the Co-PI of our campus's T32 Training grant in Lung Biology. I am also Co-PI of our campus’s R38 training program for medical residents interested in research training (PRIMER). I am myself a graduate of our T32 pulmonary training program and a product of the NHLBI’s K08 award program. Thus, I am personally familiar with the NIH’s training mechanisms, both as a trainee, mentor, and now program leader.

Available to Mentor as: (Review Mentor Role Definitions):
  • Career Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

670 Albany St Biosquare III
Boston MA 02118
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