Darrell Nelson Kotton, MD
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine

Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Boston University School of Medicine
Center for Regenerative Medicine

Boston University School of Medicine
Pathology & Laboratory Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center
Pulmonary, Allergy, Sleep & Critical Care Medicine

2010 American Society of Clinical Investigation, Elected Member
2009 Co-Director, Boston University Center for Regenerative Medicine (CReM)
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar

Reconstructing regulatory networks from time series single cell data
08/01/2017 - 07/31/2021 (PI)
Carnegie Mellon University NIH NIGMS

A National iPS cell network with deep phenotyping for translational research
09/15/2016 - 06/30/2021 (PI)
NIH/National Center for Advancing Translational Sciences

Celgene Corporation - Boston University SRA
04/09/2018 - 04/08/2021 (PI)
Celgene Corporation

MLSC Phase 2 Proposal 2014: The Lung Regeneration Initiative (LRI)
09/24/2015 - 09/23/2020 (PI)
Massachusetts Life Sciences Center

Generation of purified population of putative human iPSC-derived AEC2
07/01/2018 - 06/30/2020 (PI)
MedImmune, Inc.

The Boston University Clinical and Transitional Science Institute (All Components)
08/13/2015 - 03/31/2020 (PI)
NIH/National Center for Advancing Translational Sciences

A new human iPSC in vitro system to model the inception of lung adenocarcinoma
01/01/2019 - 12/31/2019 (PI)
Johnson & Johnson

Thyroid Follicular Cell development in mouse and humans
12/01/2015 - 11/30/2019 (PI)
Beth Israel Deaconess Medical Center, Inc NIH NIDDK

Contribution of Gain of Function Toxicity to AATD Lung Disease Pathogenesis
10/01/2018 - 09/30/2019 (Co-PI)
PI: Andrew A. Wilson, MD
Alpha 1 Foundation

Molecular and Biological Function of Long Non-Coding RNA Transcripts Divergent to Lung Development Genes
08/01/2017 - 06/30/2019 (PI)
Thomas Jefferson University NIH NHLBI

Showing 10 of 38 results. Show All Results

Yr Title Project-Sub Proj Pubs
2019 Thyroid Follicular Cell Development in Mice and Humans 5R01DK105029-05 6
2018 Thyroid Follicular Cell Development in Mice and Humans 7R01DK105029-04 6
2018 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-03 24
2018 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-03 8
2018 A National iPS Cell Network with Deep Phenotyping for Translational Research 3U01TR001810-03S1 7
2018 A National iPS Cell Network with Deep Phenotyping for Translational Research 5U01TR001810-03 7
2018 Thyroid Follicular Cell Development in Mice and Humans 5R01DK105029-03 6
2018 Epigenenomic and transcriptomic networks in normal and defective lung development 5R01HL128172-04 6
2018 Boston University Clinical and Translational Science Institute 5TL1TR001410-04 8
2018 A National Resource for Lung disease-specific iPS cells 5R24HL123828-05 9
Showing 10 of 64 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Reeves EP, Dunlea DM, McQuillan K, O'Dwyer CA, Carroll TP, Saldova R, Akepati PR, Wormald MR, McElvaney OJ, Shutchaidat V, Henry M, Meleady P, Keenan J, Liberti DC, Kotton DN, Rudd PM, Wilson AA, McElvaney NG. Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity. J Immunol. 2019 Apr 15; 202(8):2240-2253.View Related Profiles. PMID: 30796179.
  2. Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG. Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations. Am J Respir Crit Care Med. 2018 Oct 15; 198(8):1099-1102.View Related Profiles. PMID: 30011228.
  3. Hawkins FJ, Kotton DN. Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis. Trends Pharmacol Sci. 2018 10; 39(10):852-854.View Related Profiles. PMID: 30213439.
  4. McCauley KB, Hawkins F, Kotton DN. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e51.View Related Profiles. PMID: 30040246.
  5. McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595.View Related Profiles. PMID: 29657097.
  6. Kotton DN. Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation. J Clin Invest. 2018 03 01; 128(3):903-905. PMID: 29400691.
  7. Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 05; 21(4):472-488.e10.View Related Profiles. PMID: 28965766.
  8. Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893.View Related Profiles. PMID: 28947536.
  9. Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials. 2017 Dec; 147:116-132. PMID: 28942128.
  10. Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles. PMID: 28368460; DOI: 10.1093/infdis/jix159;.
Showing 10 of 85 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 85 publications over 18 distinct years, with a maximum of 12 publications in 2012

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells

Available to Mentor as: (Review Mentor Role Definitions):
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Boston MA 02118
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