Darrell Nelson Kotton, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Washington University School of Medicine
BA, University of Pennsylvania

Pronouns: he/him/his



Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.

Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Diversity, Equity, Inclusion and Accessibility

I moved to the United States as an immigrant at age 10 years, an experience that continues to inspire a personal appreciation for the importance of fostering inclusivity. My medical training has further instilled in me a desire to help augment diversity, equity, and inclusion (DEI) in every aspect of academic medicine, particularly amongst the trainees and mentors who will serve as role models for current and future generations of scientists, physicians, and physician-scientists. In caring for patients, I have witnessed first-hand the detrimental impacts on health that arise when historically marginalized populations are not given equal access to care.

In my role as an educator and Center Director I am fully committed to fostering a training environment and campus that prioritizes diversity, equity, and inclusion (DEI). I serve as a Principal Investigator (PI) or co-PI of 3 training grants at Boston University: our Pulmonary Biology T32, our TL1 Regenerative Medicine Training Program, and an R38 training program focused on Promoting Research in Internal Medicine Residency (PRIMER), and each of these programs has an outstanding track record of high enrollment of trainees from historically under-represented groups (URGs) in biomedical research. I thus consider it a major priority to train a diverse research investigator workforce that will become our future scientists and physicians. For example, 50% of graduate students currently enrolled in our TL1 Regenerative Medicine Training Program are from groups traditionally under-represented in academic medicine. In addition, this past year we significantly augmented high touch interactions with potential candidates for campus training programs, by increasing social media presence and contacts with outside pre-doctoral student candidates at national meetings attended by those interested in seeking graduate school training. For example, our TL1 leaders participated in initiatives for engagement with students at virtual meetings for the Annual Biomedical Research Conference for Minority Students (ABRCMS) and Society for Advancement of Chicanos/Hispanics and Native Americans in Science—Diversity in STEM (SACNAS). I have also worked hard to raise funds to support trainees from URGs who enroll in Boston University’s PREP program, a year-long preparatory program for recent bachelor’s degree recipients who are from URGs and seek entry into competitive PhD training programs. Our Center for Regenerative Medicine today represents a warm, welcoming environment to all, and our Center features an “anti-racism” committee and a small library of books focused on fostering DEI and combatting racism, a topic frequently discussed at our faculty meetings as well as at our weekly lab meetings.

In summary I am committed to fostering diversity, equity, and inclusion in my personal and professional life.

Director
Boston University
Center for Regenerative Medicine


Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine


Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis
01/01/2023 - 12/31/2027 (Key Person / Mentor)
PI: Konstantinos Alysandratos, MD, PHD
NIH/National Heart, Lung, and Blood Institute
1K08HL163494-01A1

Modeling Chronic obstructive pulmonary disease (COPD) using human iPSC in vitro
12/16/2019 - 12/16/2026 (PI)
AstraZeneca AB


Pluripotent stem cell-derived cell therapy for lung disease
07/01/2023 - 06/30/2026 (Key Person / Mentor)
PI: Michael J. Herriges, PhD
Parker B. Francis Fellowship Program


Biology of the Lung: A Multidisciplinary Program
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-48

Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2025 (Co-Investigator)
PI: Elke Muhlberger, PhD
Bill and Melinda Gates Foundation


Thyroid Follicular Cell Signaling and Development in Humans
05/01/2023 - 04/30/2025 (Multi-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Diabetes & Digestive & Kidney Diseases
7R01DK105029-08

NRSA Training Core
04/15/2020 - 03/31/2025 (PI)
NIH/National Center for Advancing Translational Sciences
5TL1TR001410-08

Role of epigenetic modifier EZH2 on alveolar regeneration after adult lung injury
01/01/2023 - 12/31/2024 (Key Person / Mentor)
PI: Jessie Huang, PhD
American Heart Association


Engineering Branching Networks Through Synthetic Turing Morphogen Circuits
12/10/2021 - 12/09/2024 (Multi-PI)
PI: Darrell Nelson Kotton, MD
Allen Institute d/b/a The Paul G. Allen Frontiers Group


Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs
12/15/2020 - 11/30/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
5U01HL152976-03

Showing 10 of 76 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 5U01HL152976-04
2023 Thyroid Follicular Cell Signaling and Development in Humans 7R01DK105029-08
2023 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 5U01HL152976-03
2023 NRSA Training Core 5TL1TR001410-08
2023 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-48
2022 Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs 5U01HL152976-02
2022 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 5U01HL134745-07
2022 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-07
2022 Thyroid Follicular Cell Signaling and Development in Humans 5R01DK105029-07
2022 NRSA Training Core 5TL1TR001410-07
Showing 10 of 94 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Montesi SB, Gomez CR, Beers M, Brown R, Chattopadhyay I, Flaherty KR, Garcia CK, Gomperts B, Hariri LP, Hogaboam CM, Jenkins RG, Kaminski N, Kim GHJ, Königshoff M, Kolb M, Kotton DN, Kropski JA, Lasky J, Magin CM, Maher TM, McCormick M, Moore BB, Nickerson-Nutter C, Oldham J, Podolanczuk AJ, Raghu G, Rosas I, Rowe SM, Schmidt WT, Schwartz D, Shore JE, Spino C, Craig JM, Martinez FJ. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. Am J Respir Crit Care Med. 2024 Feb 15; 209(4):362-373. PMID: 38113442
     
  2. Sun YL, Hennessey EE, Heins H, Yang P, Villacorta-Martin C, Kwan J, Gopalan K, James M, Emili A, Cole FS, Wambach JA, Kotton DN. Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations. J Clin Invest. 2024 Jan 16; 134(2).View Related Profiles. PMID: 38226623; PMCID: PMC10786693; DOI: 10.1172/JCI164274;
     
  3. Hume AJ, Olejnik J, White MR, Huang J, Turcinovic J, Heiden B, Bawa PS, Williams CJ, Gorham NG, Alekseyev YO, Connor JH, Kotton DN, Mühlberger E. Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality. Pathogens. 2024 Jan 09; 13(1).View Related Profiles. PMID: 38251369; PMCID: PMC10818917; DOI: 10.3390/pathogens13010062;
     
  4. Yampolskaya M, Herriges MJ, Ikonomou L, Kotton DN, Mehta P. scTOP: physics-inspired order parameters for cellular identification and visualization. Development. 2023 Nov 01; 150(21).View Related Profiles. PMID: 37756586; PMCID: PMC10629677; DOI: 10.1242/dev.201873;
     
  5. Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Am J Hum Genet. 2023 Oct 05; 110(10):1735-1749.View Related Profiles. PMID: 37734371; PMCID: PMC10577075; DOI: 10.1016/j.ajhg.2023.08.017;
     
  6. Herriges MJ, Yampolskaya M, Thapa BR, Lindstrom-Vautrin J, Wang F, Huang J, Na CL, Ma L, Montminy MM, Bawa P, Villacorta-Martin C, Mehta P, Kotton DN. Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice. Cell Stem Cell. 2023 Sep 07; 30(9):1217-1234.e7.View Related Profiles. PMID: 37625412; PMCID: PMC10529386; DOI: 10.1016/j.stem.2023.07.016;
     
  7. Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Berical A, Beermann ML, Wang F, Bawa PS, Kohn A, Ysasi AB, Kiyokawa H, Matte TM, Randell SH, Varelas X, Hawkins FJ, Kotton DN. Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell. 2023 Sep 07; 30(9):1199-1216.e7.View Related Profiles. PMID: 37625411; PMCID: PMC10528754; DOI: 10.1016/j.stem.2023.07.014;
     
  8. Hoffman ET, Uriarte JJ, Uhl FE, Eckstrom K, Tanneberger AE, Becker C, Moulin C, Asarian L, Ikonomou L, Kotton DN, Weiss DJ. Human alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells. Sci Rep. 2023 Jul 25; 13(1):12057. PMID: 37491483; PMCID: PMC10368739; DOI: 10.1038/s41598-023-37685-x;
     
  9. Alber AB, Marquez HA, Ma L, Kwong G, Thapa BR, Villacorta-Martin C, Lindstrom-Vautrin J, Bawa P, Wang F, Luo Y, Ikonomou L, Shi W, Kotton DN. Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme. Nat Commun. 2023 Jun 13; 14(1):3488.View Related Profiles. PMID: 37311756; PMCID: PMC10264380; DOI: 10.1038/s41467-023-39099-9;
     
  10. Wang R, Simone-Roach C, Lindstrom-Vautrin J, Wang F, Rollins S, Bawa PS, Lu J, Tang Y, Beermann ML, Schlaeger T, Mahoney J, Rowe SM, Hawkins FJ, Kotton DN. De Novo Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells. Am J Respir Crit Care Med. 2023 May 01; 207(9):1249-1253.View Related Profiles. PMID: 36857488; PMCID: PMC10161739; DOI: 10.1164/rccm.202205-1010LE;
     
Showing 10 of 155 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 155 publications over 23 distinct years, with a maximum of 20 publications in 2020

YearPublications
20011
20033
20042
20054
20061
20072
20084
20095
20106
20118
201212
201310
20143
20157
20162
20179
20185
20193
202020
202113
202217
202315
20243


Stem Cells Breathe New Life into Lungs

The Scientist 10/30/2023

Engineered stem cells could regenerate damaged tissue in PF

Pulmonary Fibrosis News 9/8/2023

BU Researchers See Future Where Lung Disease Is Treatable, and Damaged Lungs Are Regenerated

BU Today 8/31/2023

Green and glowing mouse lung cells made to model PF in the lab

Pulmonary Fibrosis News 6/25/2023

New Model of Lung Mesenchymal Cells Created

Technology Networks 6/14/2023

iPSC-Based Model System Helps Study Lung-Specific Mesenchyme

AZO Life Sciences 6/14/2023

Researchers create new model of lung mesenchymal cells

Medical Xpress 6/13/2023

Ambitious Effort to Develop Lab-Grown Lungs Wins Paul G. Allen Frontiers Group Funding

BU Today 2/9/2022

MED’s Biology of the Lung Funded through Its 50th—Yes, 50th—Year

BU Today 9/23/2021

Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases

Genetic Engineering and Biotechnology News 9/1/2021

BU awarded T32 grant to mentor research trainees in lung biology and pulmonary sciences

News Medical 7/1/2021

How Coronavirus Damages Lung Cells within Mere Hours

BU Today 1/11/2021

$2.4M NIH Grant Supports Boston Team Creating Cell Model for IPF

Pulmonary Fibrosis News 12/22/2020

CF Foundation Awards Research Projects to Advance Therapies for All CF Patients

Cystic Fibrosis News Today 12/15/2020

How Coronavirus Kickstarts Deadly Lung Inflammation

Futurity 9/28/2020

Boston University Researchers Shed Light on How COVID Causes Fatal Lung Inflammation

RT Magazine 9/25/2020

In Deadly COVID-19 Lung Inflammation, BU Researchers Discover a Culprit in NFkB Pathway

BU Today 9/24/2020

BU researchers say they found what causes fatal lung inflammation in COVID-19 patients

Boston 25 9/21/2020

New organoids facilitate sooner examine of early lung most cancers, potential therapies

Home Health Choices 9/10/2020

What Sets Off Deadly Levels of Lung Inflammation in Some COVID-19 Patients?

BU Today 9/8/2020

'It's Quite Painful': Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

It’s Quite Painful’: Research Labs Shut Down Non-Coronavirus Work Amid Outbreak

WBUR 3/17/2020

Machine Learning Gives Rise to Better Lung Disease Models from Stem Cells

BU Today 2/4/2020

2020 Association of American Physicians: AAP, Elected Member
2018 American Thoracic Society: Research Achievement Award
2018 Boston University, Graduate Medical Sciences: Educator of the Year Award
2017 Association of American Medical Colleges: Inaugural Research Resources Sharing Award
2016 David C. Seldin Endowed Professor of Medicine (Inaugural)
2014 Boston Univ. Dept. of Medicine: Robert Dawes Evans Senior Research Mentor Award
2013 Alpha-1 Foundation: Researcher of the Year Award
2010 American Society of Clinical Investigation, Elected Member
2009 Founding Director, Center for Regenerative Medicine (CReM) of Boston University and BMC
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells
Regenerative Medicine
Lung Injury and Repair

I have experience and success mentoring and preparing trainees for careers as independently funded basic science researchers. I serve as the founding Director of the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, and my laboratory has worked since 2004 in the field of pulmonary stem cell biology, regenerative medicine, and gene therapy. Fostering the careers of the next generation of academic medicine researchers and leaders is a top priority for me, and a mission I care about deeply: I have been the PI of a TL1 Training grant in Regenerative Medicine and I became the Co-PI of our campus's T32 Training grant in Lung Biology. I am also Co-PI of our campus’s R38 training program for medical residents interested in research training (PRIMER). I am myself a graduate of our T32 pulmonary training program and a product of the NHLBI’s K08 award program. Thus, I am personally familiar with the NIH’s training mechanisms, both as a trainee, mentor, and now program leader.

Available to Mentor as: (Review Mentor Role Definitions):
  • Career Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

670 Albany St Biosquare III
Boston MA 02118
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