Dr. Deeney's research is designed to discern the nutrient-derived metabolic signals leading to glucose- and fatty acid (FA)-induced insulin exocytosis from the pancreatic ß-cell. FA acutely stimulates glucose-induced insulin secretion (GSIS) while chronic exposure to elevated FA and glucose can result in glucolipotoxicity (GLT) with basal hypersecretion and inhibition of GSIS. Despite the adverse effects of chronic exposure, FA is known to be required for normal exocytosis from the ß-cell. Deciphering the dual effects of FA on GSIS will lead to the possible development of therapies that would reduce the inhibitory effects while sparing the stimulatory effects of FA on the ß-cell. Studies in his laboratory are aimed at identifying the lipids or lipid classes involved in enhancing and suppressing GSIS and assessing their effects on lipid-modulated or modulating proteins.
Evans Center for Interdisciplinary Biomedical Research
Boston University Medical Center
Boston Nutrition Obesity Research Center
Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 60 results.
Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 07 07; 32(1):44-55.e6.View Related Profiles. PMID: 32402267; PMCID: PMC7217133; DOI: 10.1016/j.cmet.2020.04.015;
Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200.View Related Profiles. PMID: 31869355; PMCID: PMC6927614; DOI: 10.1371/journal.pone.0226200;
Petcherski A, Trudeau KM, Wolf DM, Segawa M, Lee J, Taddeo EP, Deeney JT, Liesa M. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 ß-cells. J Mol Biol. 2018 12 07; 430(24):4823-4833.View Related Profiles. PMID: 30389435; PMCID: PMC6290358; DOI: 10.1016/j.jmb.2018.10.020;
Jones Iv AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS One. 2017; 12(12):e0188474.View Related Profiles. PMID: 29206239; PMCID: PMC5714353; DOI: 10.1371/journal.pone.0188474;
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