Jude Deeney, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

PhD, Karolinska Institutet
MS, Virginia Polytechnic Institute and State University




Dr. Deeney's research is designed to discern the nutrient-derived metabolic signals leading to glucose- and fatty acid (FA)-induced insulin exocytosis from the pancreatic ß-cell. FA acutely stimulates glucose-induced insulin secretion (GSIS) while chronic exposure to elevated FA and glucose can result in glucolipotoxicity (GLT) with basal hypersecretion and inhibition of GSIS. Despite the adverse effects of chronic exposure, FA is known to be required for normal exocytosis from the ß-cell. Deciphering the dual effects of FA on GSIS will lead to the possible development of therapies that would reduce the inhibitory effects while sparing the stimulatory effects of FA on the ß-cell. Studies in his laboratory are aimed at identifying the lipids or lipid classes involved in enhancing and suppressing GSIS and assessing their effects on lipid-modulated or modulating proteins.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Associate Member
Boston University Medical Center
Boston Nutrition Obesity Research Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 Jul 07; 32(1):44-55.e6.View Related Profiles. PMID: 32402267
     
  2. Rumala CZ, Liu J, Locasale JW, Corkey BE, Deeney JT, Rameh LE. Exposure of Pancreatic ß-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration. iScience. 2020 Feb 21; 23(2):100858.View Related Profiles. PMID: 32058969
     
  3. Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200.View Related Profiles. PMID: 31869355
     
  4. Petcherski A, Trudeau KM, Wolf DM, Segawa M, Lee J, Taddeo EP, Deeney JT, Liesa M. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 ß-cells. J Mol Biol. 2018 12 07; 430(24):4823-4833.View Related Profiles. PMID: 30389435
     
  5. Andrieu GP, Shafran JS, Deeney JT, Bharadwaj KR, Rangarajan A, Denis GV. BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment. J Leukoc Biol. 2018 08; 104(2):265-274.View Related Profiles. PMID: 29493812
     
  6. Jones Iv AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS One. 2017; 12(12):e0188474.View Related Profiles. PMID: 29206239; DOI: 10.1371/journal.pone.0188474;
     
  7. Pizarro-Delgado J, Deeney JT, Corkey BE, Tamarit-Rodriguez J. Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets. PLoS One. 2016; 11(11):e0166111.View Related Profiles. PMID: 27851770; DOI: 10.1371/journal.pone.0166111;
     
  8. Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS One. 2016; 11(3):e0151329.View Related Profiles. PMID: 27008626; PMCID: PMC4805167; DOI: 10.1371/journal.pone.0151329;
     
  9. Berdan CA, Erion KA, Burritt NE, Corkey BE, Deeney JT. Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets. PLoS One. 2016; 11(2):e0149008.View Related Profiles. PMID: 26867016; PMCID: PMC4750965; DOI: 10.1371/journal.pone.0149008;
     
  10. Rameh LE, Deeney JT. Phosphoinositide signalling in type 2 diabetes: a ß-cell perspective. Biochem Soc Trans. 2016 Feb; 44(1):293-8.View Related Profiles. PMID: 26862218; DOI: 10.1042/BST20150229;
     
Showing 10 of 59 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 59 publications over 29 distinct years, with a maximum of 6 publications in 1996

YearPublications
19841
19851
19861
19871
19882
19892
19902
19913
19922
19942
19966
19971
19981
20004
20012
20021
20032
20051
20075
20082
20092
20121
20131
20152
20165
20171
20182
20191
20202

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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