Keywords
Last Name

Jesus Fernando Garcia-Diaz, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4395
ORCID ORCID Icon0000-0002-1846-7712
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Research in my lab centers on the regulation of ion channel expression during neuronal differentiation and on the modulation of ion channel activity by certain neurotransmitters. We use cell culture techniques, electrophysiology and fluorescence microscopy to analyze the expression pattern and regulation of ion channels in cochlear ganglion (CG) neurons during development. Spiral or cochlear ganglion neurons are responsible for the faithful transmission of sound information from the hair cells in the organ of Corti (the sound transducing elements) to the cochlear nucleus in the brain and, thus, are endowed with a set of fast activating voltage-gated ion channels. We have analyzed the temporal pattern of expression of voltage-gated sodium, calcium and potassium channels in chick embryo CG neurons and found functionally relevant correlations between the development of membrane currents and the innervation pattern of the cochlea (Garcia-Diaz et al., 1998; Garcia-Diaz, 1999). We are also investigating whether certain members of the nerve growth factor family of proteins (neurotrophins), released by the target cells of neurons, regulate the expression of ion channels during embryonic development (Jimenez et al., 1997; Garcia-Diaz, 1999). On the other hand, efferent innervation acting through muscarinic and purinergic receptors modulates the firing response of CG neurons to sound information. We are presently investigating whether the activation of these receptors, and the ensuing signaling events, modulate a cloned non-inactivating potassium channel transfected in a heterologous system.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
1990 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-03 1
1989 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-02 1
1988 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 1R01DK039214-01A1 1


 Self-Described Keywords
  • Electrophysiology
  • Epithelial ion transport
  • Regulation of ion channels
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. García-Díaz JF. Development of a fast transient potassium current in chick cochlear ganglion neurons. Hear Res. 1999 Sep; 135(1-2):124-34.
    View in: PubMed
  2. Jiménez C, Giréldez F, Represa J, García-Díaz JF. Calcium currents in dissociated cochlear neurons from the chick embryo and their modification by neurotrophin-3. Neuroscience. 1997 Apr; 77(3):673-82.
    View in: PubMed
  3. Gaposchkin CG, Garcia-Diaz JF. Modulation of cultured brain, adrenal, and aortic endothelial cell glucose transport. Biochim Biophys Acta. 1996 Dec 4; 1285(2):255-66.
    View in: PubMed
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