Keywords
Last Name

Jesus Fernando Garcia-Diaz, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4395
ORCID ORCID Icon0000-0002-1846-7712
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Research in my lab centers on the regulation of ion channel expression during neuronal differentiation and on the modulation of ion channel activity by certain neurotransmitters. We use cell culture techniques, electrophysiology and fluorescence microscopy to analyze the expression pattern and regulation of ion channels in cochlear ganglion (CG) neurons during development. Spiral or cochlear ganglion neurons are responsible for the faithful transmission of sound information from the hair cells in the organ of Corti (the sound transducing elements) to the cochlear nucleus in the brain and, thus, are endowed with a set of fast activating voltage-gated ion channels. We have analyzed the temporal pattern of expression of voltage-gated sodium, calcium and potassium channels in chick embryo CG neurons and found functionally relevant correlations between the development of membrane currents and the innervation pattern of the cochlea (Garcia-Diaz et al., 1998; Garcia-Diaz, 1999). We are also investigating whether certain members of the nerve growth factor family of proteins (neurotrophins), released by the target cells of neurons, regulate the expression of ion channels during embryonic development (Jimenez et al., 1997; Garcia-Diaz, 1999). On the other hand, efferent innervation acting through muscarinic and purinergic receptors modulates the firing response of CG neurons to sound information. We are presently investigating whether the activation of these receptors, and the ensuing signaling events, modulate a cloned non-inactivating potassium channel transfected in a heterologous system.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
1990 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-03 1
1989 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-02 1
1988 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 1R01DK039214-01A1 1


 Self-Described Keywords
  • Electrophysiology
  • Epithelial ion transport
  • Regulation of ion channels
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. García-Díaz JF. Development of a fast transient potassium current in chick cochlear ganglion neurons. Hear Res. 1999 Sep; 135(1-2):124-34. PMID: 10491961.
    View in: PubMed
  2. Jiménez C, Giréldez F, Represa J, García-Díaz JF. Calcium currents in dissociated cochlear neurons from the chick embryo and their modification by neurotrophin-3. Neuroscience. 1997 Apr; 77(3):673-82. PMID: 9070744.
    View in: PubMed
  3. Gaposchkin CG, Garcia-Diaz JF. Modulation of cultured brain, adrenal, and aortic endothelial cell glucose transport. Biochim Biophys Acta. 1996 Dec 4; 1285(2):255-66. PMID: 8972710.
    View in: PubMed
  4. Kim NN, Kim JJ, Hypolite J, García-Díaz JF, Broderick GA, Tornheim K, Daley JT, Levin R, Saenz de Tejada I. Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol. 1996 Feb; 155(2):772-8. PMID: 8558723.
    View in: PubMed
  5. García-Díaz JF. Whole-cell and single channel K+ and Cl- currents in epithelial cells of frog skin. J Gen Physiol. 1991 Jul; 98(1):131-61. PMID: 1719124.
    View in: PubMed
  6. Nagel W, García-Díaz JF, Essig A. Voltage dependence of cellular current and conductances in frog skin. J Membr Biol. 1988 Nov; 106(1):13-28. PMID: 3265730.
    View in: PubMed
  7. García-Díaz JF, Klemperer G, Baxendale LM, Essig A. Cell sodium activity and sodium pump function in frog skin. J Membr Biol. 1986; 92(1):37-46. PMID: 3489101.
    View in: PubMed
  8. Klemperer G, Garcia-Diaz JF, Nagel W, Essig A. Basolateral membrane potential and conductance in frog skin exposed to high serosal potassium. J Membr Biol. 1986; 90(1):89-96. PMID: 3486296.
    View in: PubMed
  9. Garcia-Diaz JF, Essig A. Capacitative transients in voltage-clamped epithelia. Biophys J. 1985 Sep; 48(3):519-23. PMID: 4041541.
    View in: PubMed
  10. Garcia-Diaz JF, Essig A. Time-dependent phenomena in voltage-clamped epithelia. J Membr Biol. 1985; 87(2):173-6. PMID: 4078885.
    View in: PubMed
  11. García-Díaz JF, Baxendale LM, Klemperer G, Essig A. Cell K activity in frog skin in the presence and absence of cell current. J Membr Biol. 1985; 85(2):143-58. PMID: 3874286.
    View in: PubMed
  12. Garcia-Diaz JF, Stump S, Armstrong WM. Electronic device for microelectrode recordings in epithelial cells. Am J Physiol. 1984 Mar; 246(3 Pt 1):C339-46. PMID: 6703048.
    View in: PubMed
  13. Nagel W, Garcia-Diaz JF, Essig A. Contribution of junctional conductance to the cellular voltage-divider ratio in frog skins. Pflugers Arch. 1983 Dec; 399(4):336-41. PMID: 6607457.
    View in: PubMed
  14. García-Díaz JF, Nagel W, Essig A. Voltage-dependent K conductance at the apical membrane of Necturus gallbladder. Biophys J. 1983 Sep; 43(3):269-78. PMID: 6313084.
    View in: PubMed
  15. Nagel W, Garcia-Diaz JF, Essig A. Cellular and paracellular conductance patterns in voltage-clamped frog skin. Prog Clin Biol Res. 1983; 126:221-31. PMID: 6889388.
    View in: PubMed
  16. Garcia-Diaz JF, Nagel W, Essig A. Voltage-dependent apical conductance in Necturus gallbladder. Prog Clin Biol Res. 1983; 126:209-19. PMID: 6412247.
    View in: PubMed
  17. Armstrong WM, Garcia-Diaz JF. Intracellular sodium activity and transcellular sodium transport in gallbladder. Prog Clin Biol Res. 1981; 73:1-12. PMID: 7323078.
    View in: PubMed
  18. Armstrong WM, Garcia-Diaz JF, Diez de los Rios A. Energetics of coupled sodium chloride entry in absorptive cells of leaky epithelia. Soc Gen Physiol Ser. 1981; 36:151-62. PMID: 7280742.
    View in: PubMed
  19. Nagel W, Garcia-Diaz JF, Armstrong WM. Intracellular ionic activities in frog skin. J Membr Biol. 1981; 61(2):127-34. PMID: 6974243.
    View in: PubMed
  20. Armstrong WM, Garcia-Diaz JF. Ion-selective microelectrodes: theory and technique. Fed Proc. 1980 Sep; 39(11):2851-9. PMID: 7409206.
    View in: PubMed
  21. Garcia-Diaz JF, Armstrong WM. The steady-state relationship between sodium and chloride transmembrane electrochemical potential differences in Necturus gallbladder. J Membr Biol. 1980 Aug 7; 55(3):213-22. PMID: 7411593.
    View in: PubMed
  22. Armstrong WM, Garcia-Diaz JF, O'Doherty J, O'Regan MG. Transmucosal Na+ electrochemical potential difference and solute accumulation in epithelial cells of the small intestine. Fed Proc. 1979 Dec; 38(13):2722-8. PMID: 510560.
    View in: PubMed
  23. O'Doherty J, Garcia-Diaz JF, Armstrong WM. Sodium-selective liquid ion-exchanger microelectrodes for intracellular measurements. Science. 1979 Mar 30; 203(4387):1349-51. PMID: 424756.
    View in: PubMed
  24. Armstrong WM, Bixenman WR, Frey KF, Garcia-Diaz JF, O'Regan MG, Owens JL. Energetics of coupled Na+ and Cl- entry into epithelial cells of bullfrog small intestine. Biochim Biophys Acta. 1979 Feb 20; 551(1):207-19. PMID: 311657.
    View in: PubMed
  25. Garcia-Diaz JF, Corcia A. Electrical changes in isolated rat jejunum induced by hypertonicity. Biochim Biophys Acta. 1977 Jul 14; 468(2):177-87. PMID: 884085.
    View in: PubMed
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