Jesus Fernando Garcia-Diaz, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Universidad de Málaga
MS, Indiana University Bloomington
BS, Universidad de Zaragoza



Research in my lab centers on the regulation of ion channel expression during neuronal differentiation and on the modulation of ion channel activity by certain neurotransmitters. We use cell culture techniques, electrophysiology and fluorescence microscopy to analyze the expression pattern and regulation of ion channels in cochlear ganglion (CG) neurons during development. Spiral or cochlear ganglion neurons are responsible for the faithful transmission of sound information from the hair cells in the organ of Corti (the sound transducing elements) to the cochlear nucleus in the brain and, thus, are endowed with a set of fast activating voltage-gated ion channels. We have analyzed the temporal pattern of expression of voltage-gated sodium, calcium and potassium channels in chick embryo CG neurons and found functionally relevant correlations between the development of membrane currents and the innervation pattern of the cochlea (Garcia-Diaz et al., 1998; Garcia-Diaz, 1999). We are also investigating whether certain members of the nerve growth factor family of proteins (neurotrophins), released by the target cells of neurons, regulate the expression of ion channels during embryonic development (Jimenez et al., 1997; Garcia-Diaz, 1999). On the other hand, efferent innervation acting through muscarinic and purinergic receptors modulates the firing response of CG neurons to sound information. We are presently investigating whether the activation of these receptors, and the ensuing signaling events, modulate a cloned non-inactivating potassium channel transfected in a heterologous system.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences






Title


Yr Title Project-Sub Proj Pubs
1990 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-03 1
1989 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-02 1
1988 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 1R01DK039214-01A1 1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. García-Díaz JF. Development of a fast transient potassium current in chick cochlear ganglion neurons. Hear Res. 1999 Sep; 135(1-2):124-34. PMID: 10491961
     
  2. Jiménez C, Giréldez F, Represa J, García-Díaz JF. Calcium currents in dissociated cochlear neurons from the chick embryo and their modification by neurotrophin-3. Neuroscience. 1997 Apr; 77(3):673-82. PMID: 9070744
     
  3. Gaposchkin CG, Garcia-Diaz JF. Modulation of cultured brain, adrenal, and aortic endothelial cell glucose transport. Biochim Biophys Acta. 1996 Dec 4; 1285(2):255-66. PMID: 8972710
     
  4. Kim NN, Kim JJ, Hypolite J, García-Díaz JF, Broderick GA, Tornheim K, Daley JT, Levin R, Saenz de Tejada I. Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol. 1996 Feb; 155(2):772-8.View Related Profiles. PMID: 8558723
     
  5. García-Díaz JF. Whole-cell and single channel K+ and Cl- currents in epithelial cells of frog skin. J Gen Physiol. 1991 Jul; 98(1):131-61. PMID: 1719124; PMCID: PMC2229038
     
  6. Nagel W, García-Díaz JF, Essig A. Voltage dependence of cellular current and conductances in frog skin. J Membr Biol. 1988 Nov; 106(1):13-28.View Related Profiles. PMID: 3265730
     
  7. Klemperer G, Garcia-Diaz JF, Nagel W, Essig A. Basolateral membrane potential and conductance in frog skin exposed to high serosal potassium. J Membr Biol. 1986; 90(1):89-96. PMID: 3486296
     
  8. García-Díaz JF, Klemperer G, Baxendale LM, Essig A. Cell sodium activity and sodium pump function in frog skin. J Membr Biol. 1986; 92(1):37-46. PMID: 3489101
     
  9. Garcia-Diaz JF, Essig A. Capacitative transients in voltage-clamped epithelia. Biophys J. 1985 Sep; 48(3):519-23. PMID: 4041541; PMCID: PMC1329365; DOI: 10.1016/S0006-3495(85)83807-8;
     
  10. García-Díaz JF, Baxendale LM, Klemperer G, Essig A. Cell K activity in frog skin in the presence and absence of cell current. J Membr Biol. 1985; 85(2):143-58. PMID: 3874286
     
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 21 publications over 11 distinct years, with a maximum of 4 publications in 1983

YearPublications
19802
19813
19834
19841
19853
19862
19881
19911
19962
19971
19991

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Electrophysiology
Epithelial ion transport
Regulation of ion channels
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700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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617.358.8477
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