Keywords
Last Name

Raphael A. Zoeller Jr, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-4010
ORCID ORCID Icon0000-0002-6560-0993
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionBiomedical Genetics

 Research Expertise & Professional Interests
My expertise is in the area of lipid biosynthesis and metabolism and how they relate to human disease. My laboratory uses molecular biology, lipid chemistry & analysis, protein chemistry and forward genetics (mutant isolation).

 Self-Described Keywords
  • glycerolipids
  • lipids
  • mutants
  • obesity
  • phospholipids
  • triglycerides
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell. 2012 May 25; 46(4):461-71.
    View in: PubMed
  2. Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS One. 2012; 7(4):e34904.
    View in: PubMed
  3. Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402.
    View in: PubMed
  4. Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL, Ford DA. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. J Lipid Res. 2010 May; 51(5):1085-92.
    View in: PubMed
  5. Haller JF, Smith C, Liu D, Zheng H, Tornheim K, Han GS, Carman GM, Zoeller RA. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase. J Biol Chem. 2010 Jan 8; 285(2):866-77.
    View in: PubMed
  6. Gaposchkin DP, Farber HW, Zoeller RA. On the importance of plasmalogen status in stimulated arachidonic acid release in the macrophage cell line RAW 264.7. Biochim Biophys Acta. 2008 Apr; 1781(4):213-9.
    View in: PubMed
  7. Zheng H, Duclos RI, Smith CC, Farber HW, Zoeller RA. Synthesis and biological properties of the fluorescent ether lipid precursor 1-O-[9'-(1''-pyrenyl)]nonyl-sn-glycerol. J Lipid Res. 2006 Mar; 47(3):633-42.
    View in: PubMed
  8. Liu D, Nagan N, Just WW, Rodemer C, Thai TP, Zoeller RA. Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. J Lipid Res. 2005 Apr; 46(4):727-35.
    View in: PubMed
  9. Munn NJ, Arnio E, Liu D, Zoeller RA, Liscum L. Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport. J Lipid Res. 2003 Jan; 44(1):182-92.
    View in: PubMed
  10. Zoeller RA, Grazia TJ, LaCamera P, Park J, Gaposchkin DP, Farber HW. Increasing plasmalogen levels protects human endothelial cells during hypoxia. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H671-9.
    View in: PubMed
  11. Nagan N, Zoeller RA. Plasmalogens: biosynthesis and functions. Prog Lipid Res. 2001 May; 40(3):199-229.
    View in: PubMed
  12. Gaposchkin DP, Zoeller RA, Broitman SA. Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. Lipids. 2000 Feb; 35(2):181-6.
    View in: PubMed
  13. Zoeller RA, Lake AC, Nagan N, Gaposchkin DP, Legner MA, Lieberthal W. Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether. Biochem J. 1999 Mar 15; 338 ( Pt 3):769-76.
    View in: PubMed
  14. Gaposchkin DP, Zoeller RA. Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. J Lipid Res. 1999 Mar; 40(3):495-503.
    View in: PubMed
  15. Nagan N, Hajra AK, Larkins LK, Lazarow P, Purdue PE, Rizzo WB, Zoeller RA. Isolation of a Chinese hamster fibroblast variant defective in dihydroxyacetonephosphate acyltransferase activity and plasmalogen biosynthesis: use of a novel two-step selection protocol. Biochem J. 1998 May 15; 332 ( Pt 1):273-9.
    View in: PubMed
  16. James PF, Lake AC, Hajra AK, Larkins LK, Robinson M, Buchanan FG, Zoeller RA. An animal cell mutant with a deficiency in acyl/alkyl-dihydroxyacetone-phosphate reductase activity. Effects on the biosynthesis of ether-linked and diacyl glycerolipids. J Biol Chem. 1997 Sep 19; 272(38):23540-6.
    View in: PubMed
  17. James PF, Zoeller RA. Isolation of animal cell mutants defective in long-chain fatty aldehyde dehydrogenase. Sensitivity to fatty aldehydes and Schiff's base modification of phospholipids: implications for Sj-ogren-Larsson syndrome. J Biol Chem. 1997 Sep 19; 272(38):23532-9.
    View in: PubMed
  18. Nagan N, Hajra AK, Das AK, Moser HW, Moser A, Lazarow P, Purdue PE, Zoeller RA. A fibroblast cell line defective in alkyl-dihydroxyacetone phosphate synthase: a novel defect in plasmalogen biosynthesis. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4475-80.
    View in: PubMed
  19. Zoeller RA, Layne MD, Modest EJ. Animal cell mutants unable to take up biologically active glycerophospholipids. J Lipid Res. 1995 Sep; 36(9):1866-75.
    View in: PubMed
  20. Rangaswamy S, Zoeller RA. Fatty acid desaturation in an animal cell mutant defective in plasmanylethanolamine desaturase. Biochim Biophys Acta. 1994 Feb 10; 1211(1):79-84.
    View in: PubMed
  21. Singh N, Zoeller RA, Tykocinski ML, Lazarow PB, Tartakoff AM. Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors. Mol Cell Biol. 1994 Jan; 14(1):21-31.
    View in: PubMed
  22. Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA. Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem. 1993 Oct 15; 268(29):22055-9.
    View in: PubMed
  23. Zoeller RA, Rangaswamy S, Herscovitz H, Rizzo WB, Hajra AK, Das AK, Moser HW, Moser A, Lazarow PB, Santos MJ. Mutants in a macrophage-like cell line are defective in plasmalogen biosynthesis, but contain functional peroxisomes. J Biol Chem. 1992 Apr 25; 267(12):8299-306.
    View in: PubMed
  24. Zoeller RA, Raetz CR. Strategies for isolating somatic cell mutants defective in lipid biosynthesis. Methods Enzymol. 1992; 209:34-51.
    View in: PubMed
  25. Gordon JA, Zoeller RA, Spector AA. Hydroxyeicosatetraenoic acid oxidation in Chinese hamster ovary cells: a peroxisomal metabolic pathway. Biochim Biophys Acta. 1991 Aug 20; 1085(1):21-8.
    View in: PubMed
  26. James PF, Rizzo WB, Lee J, Zoeller RA. Isolation and characterization of a Chinese hamster ovary cell line deficient in fatty alcohol:NAD+ oxidoreductase activity. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6102-6.
    View in: PubMed
  27. Morand OH, Allen LA, Zoeller RA, Raetz CR. A rapid selection for animal cell mutants with defective peroxisomes. Biochim Biophys Acta. 1990 May 16; 1034(2):132-41.
    View in: PubMed
  28. Zoeller RA, Allen LA, Santos MJ, Lazarow PB, Hashimoto T, Tartakoff AM, Raetz CR. Chinese hamster ovary cell mutants defective in peroxisome biogenesis. Comparison to Zellweger syndrome. J Biol Chem. 1989 Dec 25; 264(36):21872-8.
    View in: PubMed
  29. Zoeller RA, Morand OH, Raetz CR. A possible role for plasmalogens in protecting animal cells against photosensitized killing. J Biol Chem. 1988 Aug 15; 263(23):11590-6.
    View in: PubMed
  30. Morand OH, Zoeller RA, Raetz CR. Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation. J Biol Chem. 1988 Aug 15; 263(23):11597-606.
    View in: PubMed
  31. Zoeller RA, Wightman PD, Anderson MS, Raetz CR. Accumulation of lysophosphatidylinositol in RAW 264.7 macrophage tumor cells stimulated by lipid A precursors. J Biol Chem. 1987 Dec 15; 262(35):17212-20.
    View in: PubMed
  32. Zoeller RA, Raetz CR. Isolation of animal cell mutants deficient in plasmalogen biosynthesis and peroxisome assembly. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5170-4.
    View in: PubMed
  33. Zoeller RA, Wood R. The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. Biochim Biophys Acta. 1985 Jun 30; 845(3):380-8.
    View in: PubMed
  34. Zoeller RA, Wood R. Effects of cyclopropene fatty acids on the lipid composition of the Morris hepatoma 7288C. Lipids. 1984 Jul; 19(7):529-38.
    View in: PubMed
  35. Zoeller RA, Wood R. Analysis of the stearoyl-CoA desaturase system in the Morris hepatoma 7288C and 7288CTC. Lipids. 1984 Jul; 19(7):488-91.
    View in: PubMed
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