Raphael A. Zoeller Jr, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Texas A&M University
BS, University of Maine



My expertise is in the area of lipid biosynthesis and metabolism and how they relate to human disease. My laboratory uses molecular biology, lipid chemistry & analysis, protein chemistry and forward genetics (mutant isolation).
We have recently developed a cell-based, high-throughput protocol to screen small molecule libraries for inhibitors of animal cell phospholipid biosynthesis. We have identified several candidate compounds and are now characterizing their efficacy and mode(s) of action.

Research Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Biomedical Genetics

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Member
Boston University
Boston Nutrition Obesity Research Center




A High Throughput Screen for Inhibitors of Mammalian Glycerolipid Biosynthesis
04/01/2015 - 03/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM107675-03

Endothelial Cell Hypoxia Tolerance: Role of Plasmalogens
07/01/2003 - 06/30/2008 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL68232 04

Regulation of Plasmalogen Levels in Animal Cells
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate

Biosynthesis and Function of Animal Cell Plasmalogens
12/01/1993 - 06/30/2004 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM50571 08



Title


Yr Title Project-Sub Proj Pubs
2017 A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis 5R01GM107675-03 2
2016 A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis 5R01GM107675-02 2
2015 A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis 1R01GM107675-01A1 2
2001 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 5R01GM050571-08 12
2000 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 5R01GM050571-07 12
1999 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 5R01GM050571-06 12
1998 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 2R01GM050571-05A1 12
1997 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS 5R01GM050571-04 12
1996 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS 5R01GM050571-03 12
1995 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS 5R01GM050571-02 12
Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shakya S, Herr RA, Carlson HL, Zoeller RA, Albert CJ, Ford DA. Endothelial Cell Protein Targeting by Myeloperoxidase-Derived 2-Chlorofatty Aldehyde. Antioxidants (Basel). 2022 May 10; 11(5). PMID: 35624804; PMCID: PMC9138145; DOI: 10.3390/antiox11050940;
     
  2. Honsho M, Tanaka M, Zoeller RA, Fujiki Y. Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum. Front Cell Dev Biol. 2020; 8:855. PMID: 33042986; PMCID: PMC7517302; DOI: 10.3389/fcell.2020.00855;
     
  3. Werner ER, Keller MA, Sailer S, Lackner K, Koch J, Hermann M, Coassin S, Golderer G, Werner-Felmayer G, Zoeller RA, Hulo N, Berger J, Watschinger K. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7792-7798. PMID: 32209662; PMCID: PMC7149458; DOI: 10.1073/pnas.1917461117;
     
  4. Park H, Haller J, Smith F, Parkin N, Lythe T, Zoeller RA, Chakravorty S. Attenuation of Hemolysis Due to Glucose-6-Phosphate Isomerase Deficiency With Ketogenic Diet - A Case Report. Hemasphere. 2020 Feb; 4(1):e328. PMID: 32072144; PMCID: PMC7000473; DOI: 10.1097/HS9.0000000000000328;
     
  5. Zoeller RA, Geoghegan-Barek K. A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis. Biochem Biophys Rep. 2019 Jul; 18:100621. PMID: 30899803; PMCID: PMC6406593; DOI: 10.1016/j.bbrep.2019.100621;
     
  6. Jarugumilli GK, Choi JR, Chan P, Yu M, Sun Y, Chen B, Niu J, DeRan M, Zheng B, Zoeller R, Lin C, Wu X. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal. ACS Chem Biol. 2018 05 18; 13(5):1130-1136. PMID: 29608264; PMCID: PMC5959771; DOI: 10.1021/acschembio.7b01063;
     
  7. Werner ER, Keller MA, Sailer S, Seppi D, Golderer G, Werner-Felmayer G, Zoeller RA, Watschinger K. A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. J Lipid Res. 2018 05; 59(5):901-909. PMID: 29540573; PMCID: PMC5928432; DOI: 10.1194/jlr.D080283;
     
  8. Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell. 2012 May 25; 46(4):461-71. PMID: 22633490; DOI: 10.1016/j.molcel.2012.04.033;
     
  9. Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS One. 2012; 7(4):e34904.View Related Profiles. PMID: 22493722; PMCID: PMC3321042; DOI: 10.1371/journal.pone.0034904;
     
  10. Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402.View Related Profiles. PMID: 21787864; PMCID: PMC3185221; DOI: 10.1016/j.bbadis.2011.07.007;
     
Showing 10 of 42 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 28 distinct years, with a maximum of 3 publications in 1997 and 2020

YearPublications
19842
19851
19861
19871
19882
19891
19902
19911
19922
19931
19942
19951
19973
19981
19992
20001
20011
20021
20031
20052
20081
20092
20111
20122
20182
20191
20203
20221

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

glycerolipids
lipids
mutants
obesity
phospholipids
triglycerides
phospholipid biosynthesis
small molecule inhibitors
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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