Caroline M. Apovian, MD
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

MD, University of Medicine and Dentistry of New Jersey

Dr. Apovian’s focus is on clinical research in obesity and diabetes. Her group investigates weight loss and its effects on endothelial cell function, adipose cell metabolism and inflammation, research in the bariatric surgery population and novel pharmacotherapeutic antiobesity agents. She has become an expert in the technique for subcutaneous adipose tissue aspirations, and has been performing these aspirations on research subjects at Boston University for over 5 years. Other research projects include dietary and physical activity interventions in underserved post-partum women and the investigation into the effects of increased dietary protein on lean body mass, maximal voluntary muscle strength and power in older men with mobility limitations.

Boston University School of Medicine
Diabetes & Endocrinology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center
Endocrinology, Diabetes, Nutrition & Weight Management

2000-2002 American Society of Clinic Nutrition: Physician Nutrition Specialist Award
1993-1996 Geisinger Medical Center: Clinician-Investigator Career Development Award

Inflammation in human obesity and type 2 diabetes
07/01/2016 - 03/31/2018 (Co-PI)
PI: Barbara S Nikolajczyk, PhD
NIH/National Diabetes & Digestive & Kidney Diseases

Pivotal Aspiration Therapy with Adjusted Lifestyle (PATHWAY) Study
01/29/2013 - 03/31/2018 (PI)
Aspire Bariatrics, Inc.

A multicenter, randomized, double-blind, placebo-controlled study assessing the occurrence of major adverse cardiovascular events (MACE) in overweight and obese subjects with cardiovascular risk facto
07/01/2012 - 06/30/2017 (PI)
Orexigen Therapeutics, Inc.

A Randomized Multi-center pivotal efficacy and safety study comparing the endobarrier gastrointestinal liner system vs. sham for glycemic improvement in inadequately controlled
05/15/2013 - 12/31/2016 (PI)
GI Dynamics, Inc.

A Multicenter, Randomized, Double Blind, Placebo Controlled Study Comparing the Safety and Efficacy of Naltrexone Sustained Release (S/R)/Bupropion Sustained Release (S/R) and Placebo in Obese S
12/19/2007 - 12/31/2012 (PI)
Orexigen Therapeutics, Inc.

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Examine the Efficacy and Safety of Pramlintide+Metreleptin in Obese Subjects Following a Low-Calorie Diet Lead-In
01/01/2011 - 06/30/2012 (PI)
Amylin Pharmaceuticals, Inc.

Inspire ME IAA C_00046: International Study of Prediction of Intra-Abdominal Adiposity and its Relationships with CardioMetabolic Risk/Intra-Abdominal Adiposity
01/02/2008 - 01/02/2011 (PI)
Sanofi-Aventis, U.S., LLC

A Phase IIB, Multi-Center, Dose-Parallel, Randomized, Double-Blind, Monotherapy and Placebo-Controled Safety and Efficacy Study of Zonisamid SR Alone and Zomisamide SR plus Bupropion SR Combinati
07/22/2008 - 07/22/2010 (PI)
Orexigen Therapeutics, Inc.

Improving Family Communication to Reduce Obesity Among Children in Framingham, MA
12/31/2005 - 12/30/2008 (Co-PI)
MetroWest Community Health Care Foundation

Self Monitoring of Blood Glucose with Finger Tip Sampling vs. Alternative Site Sampling: Sources of Variability and Effect on Long Term Glycemic Control
09/30/2002 - 09/21/2008 (PI)

Showing 10 of 23 results. Show All Results

SELECT - EX9536-4388 - Semaglutide effects on cardiovascular outcomes in people with overweight…
11/02/2018 - 11/02/2021 (PI)
Novo Nordisk

Assessing Food Intake with the Automatic Ingestion Monitor
07/01/2017 - 06/30/2019 (PI)
Trustees of Boston University NIH-NIDDK

G-04/GEL3002: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing…
03/31/2016 - 03/31/2019 (PI)
Gelesis, Srl.

02/27/2017 - 02/27/2019 (PI)
Gelesis, Srl.

Inflammation in human obesity and type 2 diabetes
10/01/2017 - 03/31/2018 (PI)
University of Kentucky Research Foundation NIH-NIDDK

Inflammation in human obesity and type 2 diabetes
04/01/2016 - 09/30/2017 (PI)
Trustees of Boston University NIH-NIDDK

Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance
10/01/2014 - 07/31/2017 (PI)
Children's Hospital Nutrition Science In

Conversion of Human Muscle Cells to Brown Adipocytes: In Vitro Studies
01/01/2017 - 07/19/2017 (PI)
Energesis Pharmaceuticals Dept of Defense

Comparison of Surgical vs. Lifestyle Weight Treatment in Obese Older Adults
07/01/2016 - 06/30/2017 (PI)
Beth Israel Center for Nutrition

Dietary Patterns and Biomarkers of Liver and Kidney Injury
02/01/2016 - 01/31/2017 (PI)
Coherence Lab

Showing 10 of 19 results. Show All Results

Yr Title Project-Sub Proj Pubs
2019 Boston Nutrition Obesity Research Center 5P30DK046200-27 906
2019 Boston Nutrition Obesity Research Center 3P30DK046200-27S1 906
2019 ConProject-001 3P30DK046200-27S1-6469 906
2019 ConProject-002 3P30DK046200-27S1-6470 906
2019 ConProject-003 3P30DK046200-27S1-6471 906
2019 ConProject-004 3P30DK046200-27S1-6472 906
2017 Inflammation in human obesity and type 2 diabetes 5R01DK108056-02 4
2016 Inflammation in human obesity and type 2 diabetes 1R01DK108056-01A1 4
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-05 2
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-05S1 2
Showing 10 of 22 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Greenway FL, Aronne LJ, Raben A, Astrup A, Apovian CM, Hill JO, Kaplan LM, Fujioka K, Matejkova E, Svacina S, Luzi L, Gnessi L, Navas-Carretero S, Martinez JA, Still CD, Sannino A, Saponaro C, Demitri C, Urban LE, Leider H, Chiquette E, Ron ES, Zohar Y, Heshmati HM. Erratum: A Randomized, Double-Blind, Placebo-Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss. Obesity (Silver Spring). 2019 Jul; 27(7):1210. PMID: 31231960.
  2. Wee CC, Fleishman A, McCarthy AC, Hess DT, Apovian C, Jones DB. Decision Regret up to 4 Years After Gastric Bypass and Gastric Banding. Obes Surg. 2019 May; 29(5):1624-1631. PMID: 30796614.
  3. Gopal DM, Ayalon N, Wang YC, Siwik D, Sverdlov A, Donohue C, Perez A, Downing J, Apovian C, Silva V, Panagia M, Kolachalama V, Ho JE, Liang CS, Gokce N, Colucci WS. Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients. J Am Heart Assoc. 2019 Apr 02; 8(7):e011100.View Related Profiles. PMID: 30929550.
  4. Fujioka K, Malhotra M, Perdomo C, Apovian CM. Effect of lorcaserin in different age groups: a post hoc analysis of patients from the BLOOM, BLOSSOM and BLOOM-DM studies. Obes Sci Pract. 2019 Apr; 5(2):120-129. PMID: 31019729.
  5. Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S. Obesity and Fat Metabolism in HIV-infected Individuals: Immunopathogenic Mechanisms and Clinical Implications. J Infect Dis. 2019 Mar 20. PMID: 30893434.
  6. Tsai AG, Apovian C, Kaplan L. Weight Loss Interventions in Adults. JAMA. 2019 03 05; 321(9):900. PMID: 30835301.
  7. Srivastava G, Fox CK, Kelly AS, Jastreboff AM, Browne AF, Browne NT, Pratt JSA, Bolling C, Michalsky MP, Cook S, Lenders CM, Apovian CM. Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity. Obesity (Silver Spring). 2019 Feb; 27(2):190-204.View Related Profiles. PMID: 30677262.
  8. Pi-Sunyer X, Apovian CM, McElroy SL, Dunayevich E, Acevedo LM, Greenway FL. Psychiatric adverse events and effects on mood with prolonged-release naltrexone/bupropion combination therapy: a pooled analysis. Int J Obes (Lond). 2019 Jan 21. PMID: 30664661.
  9. Rizo IM, Apovian CM. Diabetic Ketoacidosis Post Bariatric Surgery. Front Endocrinol (Lausanne). 2018; 9:812.View Related Profiles. PMID: 30697192.
  10. Apovian CM, Okemah J, O'Neil PM. Body Weight Considerations in the Management of Type 2 Diabetes. Adv Ther. 2019 Jan; 36(1):44-58. PMID: 30465123.
Showing 10 of 184 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 184 publications over 26 distinct years, with a maximum of 19 publications in 2013 and 2017

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adipose tissue
Weight loss and management
Racial disparities
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