Caroline M. Apovian, MD
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition

MD, University of Medicine and Dentistry of New Jersey

Dr. Apovian’s focus is on clinical research in obesity and diabetes. Her group investigates weight loss and its effects on endothelial cell function, adipose cell metabolism and inflammation, research in the bariatric surgery population and novel pharmacotherapeutic antiobesity agents. She has become an expert in the technique for subcutaneous adipose tissue aspirations, and has been performing these aspirations on research subjects at Boston University for over 5 years. Other research projects include dietary and physical activity interventions in underserved post-partum women and the investigation into the effects of increased dietary protein on lean body mass, maximal voluntary muscle strength and power in older men with mobility limitations.

Boston University School of Medicine
Diabetes & Endocrinology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center
Endocrinology, Diabetes & Nutrition

2000-2002 American Society of Clinic Nutrition: Physician Nutrition Specialist Award
1993-1996 Geisinger Medical Center: Clinician-Investigator Career Development Award

Inflammation in human obesity and type 2 diabetes
07/01/2016 - 03/31/2018 (Co-PI)
PI: Barbara S Nikolajczyk, PhD
NIH/National Diabetes & Digestive & Kidney Diseases

Pivotal Aspiration Therapy with Adjusted Lifestyle (PATHWAY) Study
01/29/2013 - 03/31/2018 (PI)
Aspire Bariatrics, Inc.

A multicenter, randomized, double-blind, placebo-controlled study assessing the occurrence of major adverse cardiovascular events (MACE) in overweight and obese subjects with cardiovascular risk facto
07/01/2012 - 06/30/2017 (PI)
Orexigen Therapeutics, Inc.

A Randomized Multi-center pivotal efficacy and safety study comparing the endobarrier gastrointestinal liner system vs. sham for glycemic improvement in inadequately controlled
05/15/2013 - 12/31/2016 (PI)
GI Dynamics, Inc.

A Multicenter, Randomized, Double Blind, Placebo Controlled Study Comparing the Safety and Efficacy of Naltrexone Sustained Release (S/R)/Bupropion Sustained Release (S/R) and Placebo in Obese S
12/19/2007 - 12/31/2012 (PI)
Orexigen Therapeutics, Inc.

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Examine the Efficacy and Safety of Pramlintide+Metreleptin in Obese Subjects Following a Low-Calorie Diet Lead-In
01/01/2011 - 06/30/2012 (PI)
Amylin Pharmaceuticals, Inc.

Inspire ME IAA C_00046: International Study of Prediction of Intra-Abdominal Adiposity and its Relationships with CardioMetabolic Risk/Intra-Abdominal Adiposity
01/02/2008 - 01/02/2011 (PI)
Sanofi-Aventis, U.S., LLC

A Phase IIB, Multi-Center, Dose-Parallel, Randomized, Double-Blind, Monotherapy and Placebo-Controled Safety and Efficacy Study of Zonisamid SR Alone and Zomisamide SR plus Bupropion SR Combinati
07/22/2008 - 07/22/2010 (PI)
Orexigen Therapeutics, Inc.

Improving Family Communication to Reduce Obesity Among Children in Framingham, MA
12/31/2005 - 12/30/2008 (Co-PI)
MetroWest Community Health Care Foundation

Self Monitoring of Blood Glucose with Finger Tip Sampling vs. Alternative Site Sampling: Sources of Variability and Effect on Long Term Glycemic Control
09/30/2002 - 09/21/2008 (PI)

Showing 10 of 23 results. Show All Results

02/27/2017 - 02/27/2019 (PI)
Gelesis, Srl.

(Prenotification) Inflammation in human obesity and type 2 diabetes
01/01/2018 - 03/31/2018 (PI)
University of Kentucky Research Foundation NIH-NIDDK

G-04/GEL3002: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing…
03/31/2016 - 03/31/2018 (PI)
Gelesis, Srl.

Inflammation in human obesity and type 2 diabetes
04/01/2016 - 09/30/2017 (PI)
Trustees of Boston University NIH-NIDDK

Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance
10/01/2014 - 07/31/2017 (PI)
Children's Hospital Nutrition Science In

Conversion of Human Muscle Cells to Brown Adipocytes: In Vitro Studies
01/01/2017 - 07/19/2017 (PI)
Energesis Pharmaceuticals Dept of Defense

Comparison of Surgical vs. Lifestyle Weight Treatment in Obese Older Adults
07/01/2016 - 06/30/2017 (PI)
Beth Israel Center for Nutrition

Dietary Patterns and Biomarkers of Liver and Kidney Injury
02/01/2016 - 01/31/2017 (PI)
Coherence Lab

Optimizing Protein Intake in Older Americans with Mobility Limitations
09/01/2013 - 05/31/2016 (PI)
Brigham & Women's NIH-NIA

Apovian - AMPK & Adipose Tissue Biology in Bariatric Surgery Patients
07/16/2012 - 06/30/2014 (PI)
1R24 DK094749-01

Showing 10 of 17 results. Show All Results

Yr Title Project-Sub Proj Pubs
2017 Inflammation in human obesity and type 2 diabetes 5R01DK108056-02 1
2016 Inflammation in human obesity and type 2 diabetes 1R01DK108056-01A1 1
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-05 1
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-05S1 1
2013 Optimizing Protein Intake in Older Americans with Mobility Limitations 7R01AG037547-04 1
2013 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-04S1 1
2012 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-03 1
2011 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-02 1
2010 Optimizing Protein Intake in Older Americans with Mobility Limitations 1R01AG037547-01 1
2010 Reducing Obesity in Underserved Postpartum African American Women 1R21HD061311-01A1 1
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Apovian CM. Editorial 2018 Current Opinion in Endocrinology. Curr Opin Endocrinol Diabetes Obes. 2018 Aug 01. PMID: 30074501.
  2. Joshi PP, Quintiliani LM, McCarthy AC, Gilmore A, Mahesri M, Sullivan LM, Apovian CM. A Randomized Controlled Feasibility Trial in Behavioral Weight Management for Underserved Postpartum African American Women: The RENEW Study. Prev Chronic Dis. 2018 Jun 14; 15:E77.View Related Profiles. PMID: 29908054.
  3. Srivastava G, Apovian C. Future Pharmacotherapy for Obesity: New Anti-obesity Drugs on the Horizon. Curr Obes Rep. 2018 Jun; 7(2):147-161.View Related Profiles. PMID: 29504049.
  4. Stockman MC, Thomas D, Burke J, Apovian CM. Intermittent Fasting: Is the Wait Worth the Weight? Curr Obes Rep. 2018 Jun; 7(2):172-185. PMID: 29700718.
  5. Srivastava G, Palmer KD, Ireland KA, McCarthy AC, Donovan KE, Manders AJ, McDougal J, Lenders CM, Apovian CM. Shape-Up and Eat Right Families Pilot Program: Feasibility of a Weight Management Shared Medical Appointment Model in African-Americans With Obesity at an Urban Academic Medical Center. Front Pediatr. 2018; 6:101.View Related Profiles. PMID: 29707530.
  6. Bhasin S, Apovian CM, Travison TG, Pencina K, Moore LL, Huang G, Campbell WW, Li Z, Howland AS, Chen R, Knapp PE, Singer MR, Shah M, Secinaro K, Eder RV, Hally K, Schram H, Bearup R, Beleva YM, McCarthy AC, Woodbury E, McKinnon J, Fleck G, Storer TW, Basaria S. Effect of Protein Intake on Lean Body Mass in Functionally Limited Older Men: A Randomized Clinical Trial. JAMA Intern Med. 2018 Apr 01; 178(4):530-541.View Related Profiles. PMID: 29532075.
  7. Jafarzadeh SR, Clancy M, Li JS, Apovian CM, Guermazi A, Eckstein F, Felson DT. Changes in the structural features of osteoarthritis in a year of weight loss. Osteoarthritis Cartilage. 2018 Jun; 26(6):775-782.View Related Profiles. PMID: 29567521.
  8. Stefanik JJ, Felson DT, Apovian CM, Niu J, Clancy MM, LaValley MP, Neogi T. Changes in Pain Sensitization after Bariatric Surgery. Arthritis Care Res (Hoboken). 2018 Jan 05.View Related Profiles. PMID: 29316386.
  9. Velazquez A, Apovian CM. Updates on obesity pharmacotherapy. Ann N Y Acad Sci. 2018 Jan; 1411(1):106-119. PMID: 29377198.
  10. Ryan DH, Parkin CG, Longley W, Dixon J, Apovian C, Bode B. Efficacy and safety of an oral device to reduce food intake and promote weight loss. Obes Sci Pract. 2018 Feb; 4(1):52-61. PMID: 29479465.
Showing 10 of 171 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 170 publications over 25 distinct years, with a maximum of 19 publications in 2013 and 2017

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adipose tissue
Weight loss and management
Racial disparities
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72 E. Concord St Robinson (B)
Boston MA 02118
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