Fuzhong Qin, MD, PhD
|Title||Research Associate Professor|
|Institution||Boston University School of Medicine|
|Address||650 Albany St Evans Biomed Research Ctr|
Boston MA 02118
|Institution||Boston Medical Center|
I have a broad background in cardiovascular physiology, with specific training and expertise in the areas of reactive oxygen species and myocardial remodeling in pacing-induced heart failure, myocardial infarction-induced heart failure, pressure overload-induced myocardial hypertrophy and failure and transgenic mice with heart failure as well as reactive oxygen species in cultured cardiac myocytes. Particularly I have expertise (scientific) in a) oxidative stress, myocyte apoptosis, and apoptosis-related signal transduction pathways, b) oxidative stress, oxidative protein modifications of SERCA2, intracellular calcium transients and myocyte contractile function, c) oxidative stress, myocyte hypertrophy and myocardial diastolic dysfunction. I also have expertise (technical) in the animal models (mice, rats, rabbits and dogs) of myocardial ischemia / reperfusion, coronary artery ligation-induced myocardial infarction and failure, and ascending aortic constriction-induced myocardial hypertrophy and failure, conventional echocardiography, mitral inflow and tissue Doppler echocardiography, in vivo hemodynamics, ex vivo Langendorff isolated heart perfusion, measurements of intracellular calcium concentration and contractile function in isolated myocytes, myocyte culture, assessment of oxidative stress, histological measurements including hematoxylin and eosin staining, Masson trichrome staining, TUNEL staining and immunohistochemical and immunofluorescence staining, biochemical measurements including Western blot, immunoprecipitation, RT-PCR and etc.
- Diastolic function
- Heart failure
- Myocardial Contraction
- Myocardial infarction
- Oxidative stress
- Posttranslational modification
- Reactive Oxygen Species
- Sarcoplasmic Reticulum Calcium-Transporting ATPases
- Signal transduction
- Ventricular function
- Ventricular remodeling
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