Keywords
Last Name

Fuzhong Qin, MD, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8051
ORCID ORCID Icon0000-0002-9534-3617
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
I have a broad background in cardiovascular physiology, with specific training and expertise in the areas of reactive oxygen species and myocardial remodeling in pacing-induced heart failure, myocardial infarction-induced heart failure, pressure overload-induced myocardial hypertrophy and failure and transgenic mice with heart failure as well as reactive oxygen species in cultured cardiac myocytes. Particularly I have expertise (scientific) in a) oxidative stress, myocyte apoptosis, and apoptosis-related signal transduction pathways, b) oxidative stress, oxidative protein modifications of SERCA2, intracellular calcium transients and myocyte contractile function, c) oxidative stress, myocyte hypertrophy and myocardial diastolic dysfunction. I also have expertise (technical) in the animal models (mice, rats, rabbits and dogs) of myocardial ischemia / reperfusion, coronary artery ligation-induced myocardial infarction and failure, and ascending aortic constriction-induced myocardial hypertrophy and failure, conventional echocardiography, mitral inflow and tissue Doppler echocardiography, in vivo hemodynamics, ex vivo Langendorff isolated heart perfusion, measurements of intracellular calcium concentration and contractile function in isolated myocytes, myocyte culture, assessment of oxidative stress, histological measurements including hematoxylin and eosin staining, Masson trichrome staining, TUNEL staining and immunohistochemical and immunofluorescence staining, biochemical measurements including Western blot, immunoprecipitation, RT-PCR and etc.

 Self-Described Keywords
  • Apoptosis
  • Calcium
  • Diastolic function
  • Heart failure
  • Hypertrophy
  • Myocardial Contraction
  • Myocardial infarction
  • Oxidative stress
  • Posttranslational modification
  • Reactive Oxygen Species
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases
  • Signal transduction
  • Ventricular function
  • Ventricular remodeling
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Xu XJ, Babo E, Qin F, Croteau D, Colucci WS. Short-term caloric restriction in db/db mice improves myocardial function and increases high molecular weight (HMW) adiponectin. IJC Metab Endocr. 2016 Dec; 13:28-34. PMID: 27942464.
    View in: PubMed
  2. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1). PMID: 26755553.
    View in: PubMed
  3. Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1). PMID: 26722122.
    View in: PubMed
  4. Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Wilson S C, Edward J M. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83. PMID: 25497302.
    View in: PubMed
  5. Qin F, Siwik DA, Pimentel DR, Morgan RJ, Biolo A, Tu VH, Kang YJ, Cohen RA, Colucci WS. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. Am J Physiol Heart Circ Physiol. 2014 May 15; 306(10):H1453-63. PMID: 24633550.
    View in: PubMed
  6. Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184. PMID: 23963753.
    View in: PubMed
  7. Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 2012 Dec; 56(12):1812-24. PMID: 23097236.
    View in: PubMed
  8. Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation. 2012 Apr 10; 125(14):1757-64, S1-6. PMID: 22388319.
    View in: PubMed
  9. Mazzini M, Tadros T, Siwik D, Joseph L, Bristow M, Qin F, Cohen R, Monahan K, Klein M, Colucci W. Primary carnitine deficiency and sudden death: in vivo evidence of myocardial lipid peroxidation and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2. Cardiology. 2011; 120(1):52-8. PMID: 22116472.
    View in: PubMed
  10. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13. PMID: 21788586.
    View in: PubMed
  11. Lancel S, Qin F, Lennon SL, Zhang J, Tong X, Mazzini MJ, Kang YJ, Siwik DA, Cohen RA, Colucci WS. Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice. Circ Res. 2010 Jul 23; 107(2):228-32. PMID: 20508180.
    View in: PubMed
  12. Qin F, Lennon-Edwards S, Lancel S, Biolo A, Siwik DA, Pimentel DR, Dorn GW, Kang YJ, Colucci WS. Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice. Circ Heart Fail. 2010 Mar; 3(2):306-13. PMID: 20018955.
    View in: PubMed
  13. Sam F, Duhaney TA, Sato K, Wilson RM, Ohashi K, Sono-Romanelli S, Higuchi A, De Silva DS, Qin F, Walsh K, Ouchi N. Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. Endocrinology. 2010 Jan; 151(1):322-31. PMID: 19850745.
    View in: PubMed
  14. Biolo A, Greferath R, Siwik DA, Qin F, Valsky E, Fylaktakidou KC, Pothukanuri S, Duarte CD, Schwarz RP, Lehn JM, Nicolau C, Colucci WS. Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1926-9. PMID: 19204295.
    View in: PubMed
  15. Qin F, Simeone M, Patel R. Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radic Biol Med. 2007 Jul 15; 43(2):271-81. PMID: 17603936.
    View in: PubMed
  16. Qin F, Yan C, Patel R, Liu W, Dong E. Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction. Free Radic Biol Med. 2006 May 15; 40(10):1827-42. PMID: 16678021.
    View in: PubMed
  17. Qin F, Patel R, Yan C, Liu W. NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin. Free Radic Biol Med. 2006 Jan 15; 40(2):236-46. PMID: 16413406.
    View in: PubMed
  18. Mao W, Iwai C, Qin F, Liang CS. Norepinephrine induces endoplasmic reticulum stress and downregulation of norepinephrine transporter density in PC12 cells via oxidative stress. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2381-9. PMID: 15626688.
    View in: PubMed
  19. Qin F, Liang MC, Liang CS. Progressive left ventricular remodeling, myocyte apoptosis, and protein signaling cascades after myocardial infarction in rabbits. Biochim Biophys Acta. 2005 Jun 10; 1740(3):499-513. PMID: 15949720.
    View in: PubMed
  20. Kawai K, Qin F, Shite J, Mao W, Fukuoka S, Liang CS. Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy. Am J Physiol Heart Circ Physiol. 2004 Sep; 287(3):H1003-12. PMID: 15105169.
    View in: PubMed
  21. Mao W, Qin F, Iwai C, Vulapalli R, Keng PC, Liang CS. Extracellular norepinephrine reduces neuronal uptake of norepinephrine by oxidative stress in PC12 cells. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H29-39. PMID: 14962827.
    View in: PubMed
  22. Qin F, Shite J, Liang CS. Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAPK pathways. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H822-32. PMID: 12714335.
    View in: PubMed
  23. Qin F, Shite J, Mao W, Liang CS. Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: association with improvement of cardiac function. Eur J Pharmacol. 2003 Feb 14; 461(2-3):149-58. PMID: 12586210.
    View in: PubMed
  24. Qin F, Vulapalli RS, Stevens SY, Liang CS. Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H363-71. PMID: 11748083.
    View in: PubMed
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