Keywords
Last Name

Cheng Lin, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 638-6705
ORCID ORCID Icon0000-0003-3653-9633
Other Positions
TitleCenter Faculty Member
InstitutionBoston University School of Medicine
DepartmentMass Spectrometry

 Self-Described Keywords
  • Mass Spectrometry, Proteomics, Glycomics, PTM characterization
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pu Y, Ridgeway ME, Glaskin RS, Park MA, Costello CE, Lin C. Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2016 Apr 05; 88(7):3440-3. PMID: 26959868.
    View in: PubMed
  2. Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85. PMID: 26729453.
    View in: PubMed
  3. Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chem Sci. 2016 Feb 1; 7(2):1447-1456. PMID: 26900446.
    View in: PubMed
  4. Yu X, Sargaeva NP, Thompson CJ, Costello CE, Lin C. In-Source Decay Characterization of Isoaspartate and ß-Peptides. Int J Mass Spectrom. 2015 Nov 15; 390:101-109. PMID: 26644780.
    View in: PubMed
  5. Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic Study on Electronic Excitation Dissociation of the Cellobiose-Na(+) Complex. J Am Soc Mass Spectrom. 2016 Feb; 27(2):319-28. PMID: 26432580.
    View in: PubMed
  6. Ji Y, Liu M, Bachschmid MM, Costello CE, Lin C. Surfactant-Induced Artifacts during Proteomic Sample Preparation. Anal Chem. 2015 Jun 2; 87(11):5500-4. PMID: 25945600.
    View in: PubMed
  7. Huang Y, Mao Y, Zong C, Lin C, Boons GJ, Zaia J. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal Chem. 2015 Jan 6; 87(1):592-600. PMID: 25486437.
    View in: PubMed
  8. Hu H, Huang Y, Mao Y, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol Cell Proteomics. 2014 Sep; 13(9):2490-502. PMID: 24925905.
    View in: PubMed
  9. Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic study on electron capture dissociation of the oligosaccharide-Mg²? complex. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1451-60. PMID: 24845360.
    View in: PubMed
  10. Wu ZL, Robey MT, Tatge T, Lin C, Leymarie N, Zou Y, Zaia J. Detecting O-GlcNAc using in vitro sulfation. Glycobiology. 2014 Aug; 24(8):740-7. PMID: 24799377.
    View in: PubMed
  11. Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Direct detection of S-palmitoylation by mass spectrometry. Anal Chem. 2013 Dec 17; 85(24):11952-9. PMID: 24279456.
    View in: PubMed
  12. Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86. PMID: 24224699.
    View in: PubMed
  13. Yu X, Jiang Y, Chen Y, Huang Y, Costello CE, Lin C. Detailed glycan structural characterization by electronic excitation dissociation. Anal Chem. 2013 Nov 5; 85(21):10017-21. PMID: 24080071.
    View in: PubMed
  14. Qi Y, Li H, Wills RH, Perez-Hurtado P, Yu X, Kilgour DP, Barrow MP, Lin C, O'Connor PB. Absorption-mode Fourier transform mass spectrometry: the effects of apodization and phasing on modified protein spectra. J Am Soc Mass Spectrom. 2013 Jun; 24(6):828-34. PMID: 23568027.
    View in: PubMed
  15. Yu X, Huang Y, Lin C, Costello CE. Energy-dependent electron activated dissociation of metal-adducted permethylated oligosaccharides. Anal Chem. 2012 Sep 4; 84(17):7487-94. PMID: 22881449.
    View in: PubMed
  16. Li X, Yu X, Costello CE, Lin C, O'Connor PB. Top-down study of ß2-microglobulin deamidation. Anal Chem. 2012 Jul 17; 84(14):6150-7. PMID: 22746280.
    View in: PubMed
  17. Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41. PMID: 22085642.
    View in: PubMed
  18. Sargaeva NP, Lin C, O'Connor PB. Differentiating N-terminal aspartic and isoaspartic acid residues in peptides. Anal Chem. 2011 Sep 1; 83(17):6675-82. PMID: 21736361.
    View in: PubMed
  19. Li X, Huang Y, O'Connor PB, Lin C. Structural heterogeneity of doubly-charged peptide b-ions. J Am Soc Mass Spectrom. 2011 Feb; 22(2):245-54. PMID: 21472584.
    View in: PubMed
  20. Sargaeva NP, Lin C, O'Connor PB. Unusual fragmentation of ß-linked peptides by ExD tandem mass spectrometry. J Am Soc Mass Spectrom. 2011 Mar; 22(3):480-91. PMID: 21472566.
    View in: PubMed
  21. Li X, Lin C, O'Connor PB. Glutamine deamidation: differentiation of glutamic acid and gamma-glutamic acid in peptides by electron capture dissociation. Anal Chem. 2010 May 1; 82(9):3606-15. PMID: 20373761.
    View in: PubMed
  22. Li X, Lin C, Han L, Costello CE, O'Connor PB. Charge remote fragmentation in electron capture and electron transfer dissociation. J Am Soc Mass Spectrom. 2010 Apr; 21(4):646-56. PMID: 20171118.
    View in: PubMed
  23. Sargaeva NP, Lin C, O'Connor PB. Identification of aspartic and isoaspartic acid residues in amyloid beta peptides, including Abeta1-42, using electron-ion reactions. Anal Chem. 2009 Dec 1; 81(23):9778-86. PMID: 19873993.
    View in: PubMed
  24. Kong X, Lin C, Infusini G, Oh HB, Jiang H, Breuker K, Wu CC, Charkin OP, Chang HC, McLafferty FW. Numerous isomers of serine octamer ions characterized by infrared photodissociation spectroscopy. Chemphyschem. 2009 Oct 19; 10(15):2603-6. PMID: 19728345.
    View in: PubMed
  25. Li X, Cournoyer JJ, Lin C, O'Connor PB. The effect of fixed charge modifications on electron capture dissociation. J Am Soc Mass Spectrom. 2008 Oct; 19(10):1514-26. PMID: 18657441.
    View in: PubMed
  26. Li X, Cournoyer JJ, Lin C, O'Connor PB. Use of 18O labels to monitor deamidation during protein and peptide sample processing. J Am Soc Mass Spectrom. 2008 Jun; 19(6):855-64. PMID: 18394920.
    View in: PubMed
  27. Lin C, Cournoyer JJ, O'Connor PB. Probing the gas-phase folding kinetics of peptide ions by IR activated DR-ECD. J Am Soc Mass Spectrom. 2008 Jun; 19(6):780-9. PMID: 18400512.
    View in: PubMed
  28. Lin C, Mathur R, Aizikov K, O'Connor PB. First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer. J Am Soc Mass Spectrom. 2007 Dec; 18(12):2090-3. PMID: 17931882.
    View in: PubMed
  29. Cournoyer JJ, Lin C, Bowman MJ, O'Connor PB. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation. J Am Soc Mass Spectrom. 2007 Jan; 18(1):48-56. PMID: 16997569.
    View in: PubMed
  30. Lin C, Cournoyer JJ, O'Connor PB. Use of a double resonance electron capture dissociation experiment to probe fragment intermediate lifetimes. J Am Soc Mass Spectrom. 2006 Nov; 17(11):1605-15. PMID: 16904337.
    View in: PubMed
  31. Belyayev MA, Cournoyer JJ, Lin C, O'Connor PB. The effect of radical trap moieties on electron capture dissociation spectra of substance P. J Am Soc Mass Spectrom. 2006 Oct; 17(10):1428-36. PMID: 16875835.
    View in: PubMed
  32. O'Connor PB, Lin C, Cournoyer JJ, Pittman JL, Belyayev M, Budnik BA. Long-lived electron capture dissociation product ions experience radical migration via hydrogen abstraction. J Am Soc Mass Spectrom. 2006 Apr; 17(4):576-85. PMID: 16503151.
    View in: PubMed
  33. Cournoyer JJ, Lin C, O'Connor PB. Detecting deamidation products in proteins by electron capture dissociation. Anal Chem. 2006 Feb 15; 78(4):1264-71. PMID: 16478121.
    View in: PubMed
  34. Zabrouskov V, Han X, Welker E, Zhai H, Lin C, van Wijk KJ, Scheraga HA, McLafferty FW. Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry. Biochemistry. 2006 Jan 24; 45(3):987-92. PMID: 16411774.
    View in: PubMed
  35. O'connor PB, Pittman JL, Thomson BA, Budnik BA, Cournoyer JC, Jebanathirajah J, Lin C, Moyer S, Zhao C. A new hybrid electrospray Fourier transform mass spectrometer: design and performance characteristics. Rapid Commun Mass Spectrom. 2006; 20(2):259-66. PMID: 16353130.
    View in: PubMed
  36. Oh HB, Lin C, Hwang HY, Zhai H, Breuker K, Zabrouskov V, Carpenter BK, McLafferty FW. Infrared photodissociation spectroscopy of electrosprayed ions in a Fourier transform mass spectrometer. J Am Chem Soc. 2005 Mar 23; 127(11):4076-83. PMID: 15771545.
    View in: PubMed
  37. Breuker K, Oh H, Lin C, Carpenter BK, McLafferty FW. Nonergodic and conformational control of the electron capture dissociation of protein cations. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14011-6. PMID: 15381764.
    View in: PubMed
  38. Lin C, Witinski MF, Davis HF. Oxygen Atom Rydberg Time-of-Flight Spectroscopy. J Chem Phys. 2003; 119(1):251-255.
  39. Strazisar BR, Lin C, Davis HF. Vibrationally inelastic scattering of high- n Rydberg H atoms from N2 and O2. Phys Rev Lett. 2001 Apr 30; 86(18):3997-4000. PMID: 11328079.
    View in: PubMed
  40. Strazisar BR, Lin C, Davis HF. Mode-specific energy disposal in the four-atom reaction OH + D2 --> HOD + D. Science. 2000 Nov 3; 290(5493):958-61. PMID: 11062122.
    View in: PubMed
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