Cheng Lin | Profiles RNS

Cheng Lin, PhD

Research Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Cornell University
MSc, Cornell University
BSc, Beijing University

Websites

	Biochemistry Faculty
	Center for Biomedical Mass Spectrometry Faculty

ORCID : 0000-0003-3653-9633

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

High-Throughput De Novo Glycan Sequencing
09/01/2019 - 08/31/2024 (PI)
NIH/National Institute of General Medical Sciences
5R01GM132675-04

Characterization of glycan isomers by trapped ion mobility spectometry-electron activated dissociation tandem mass spectrometry
09/01/2016 - 08/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R21GM122635-02

Development of new approaches to FT-ICR mass spectometry
07/15/2016 - 07/14/2017 (Subcontract PI)
MassTech Inc. NIH NIGMS
1R43GM121139-01

Defining the Isoaspartome
06/01/2007 - 05/31/2012 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM78293 04

Defining the Isoaspartome
06/01/2007 - 05/31/2012 (PI)
NIH/National Institute of General Medical Sciences
5R01GM078293-05

Title

Yr	Title	Project-Sub Proj	Pubs
2022	High-Throughput De Novo Glycan Sequencing	5R01GM132675-04
2021	High-Throughput De Novo Glycan Sequencing	5R01GM132675-03
2020	High-Throughput De Novo Glycan Sequencing	5R01GM132675-02
2020	High-Throughput De Novo Glycan Sequencing	3R01GM132675-01S1
2019	High-Throughput De Novo Glycan Sequencing	1R01GM132675-01
2017	Characterization of glycan isomers by trapped ion mobility spectrometry-electron activated dissociation tandem mass spectrometry	5R21GM122635-02	5
2016	Characterization of glycan isomers by trapped ion mobility spectrometry-electron activated dissociation tandem mass spectrometry	1R21GM122635-01	5
2011	Defining the IsoAspartome	5R01GM078293-05	36
2010	Defining the IsoAspartome	5R01GM078293-04	36
2009	Defining the IsoAspartome	5R01GM078293-03	36

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Pu Y, Ridgeway ME, Glaskin RS, Park MA, Costello CE, Lin C. Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2016 Apr 05; 88(7):3440-3.View Related Profiles.

Costello, Catherine
Lin, Cheng
Glaskin, Rebecca

PMID: 26959868; PMCID: PMC4821751; DOI: 10.1021/acs.analchem.6b00041;

Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85.View Related Profiles.

Costello, Catherine
Lin, Cheng
Bachschmid, Markus
Ji, Yuhuan

PMID: 26729453; PMCID: PMC4794353; DOI: 10.1007/s13361-015-1319-3;

Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chem Sci. 2016 Feb 01; 7(2):1447-1456.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang

PMID: 26900446; PMCID: PMC4755500; DOI: 10.1039/c5sc03798k;

Yu X, Sargaeva NP, Thompson CJ, Costello CE, Lin C. In-Source Decay Characterization of Isoaspartate and ß-Peptides. Int J Mass Spectrom. 2015 Nov 15; 390:101-109.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 26644780; PMCID: PMC4669973; DOI: 10.1016/j.ijms.2015.07.013;

Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic Study on Electronic Excitation Dissociation of the Cellobiose-Na(+) Complex. J Am Soc Mass Spectrom. 2016 Feb; 27(2):319-28.View Related Profiles.

Costello, Catherine
Lin, Cheng
Huang, Yiqun

PMID: 26432580; PMCID: PMC4724539; DOI: 10.1007/s13361-015-1277-9;

Ji Y, Liu M, Bachschmid MM, Costello CE, Lin C. Surfactant-Induced Artifacts during Proteomic Sample Preparation. Anal Chem. 2015 Jun 2; 87(11):5500-4.View Related Profiles.

Costello, Catherine
Lin, Cheng
Bachschmid, Markus

PMID: 25945600; PMCID: PMC4574305; DOI: 10.1021/acs.analchem.5b00249;

Huang Y, Mao Y, Zong C, Lin C, Boons GJ, Zaia J. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal Chem. 2015 Jan 6; 87(1):592-600.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 25486437; PMCID: PMC4287833; DOI: 10.1021/ac503248k;

Hu H, Huang Y, Mao Y, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol Cell Proteomics. 2014 Sep; 13(9):2490-502.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 24925905; PMCID: PMC4159664; DOI: 10.1074/mcp.M114.039560;

Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic study on electron capture dissociation of the oligosaccharide-Mg²? complex. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1451-60.View Related Profiles.

Costello, Catherine
Lin, Cheng
Huang, Yiqun

PMID: 24845360; PMCID: PMC4108535; DOI: 10.1007/s13361-014-0921-0;

Wu ZL, Robey MT, Tatge T, Lin C, Leymarie N, Zou Y, Zaia J. Detecting O-GlcNAc using in vitro sulfation. Glycobiology. 2014 Aug; 24(8):740-7.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Leymarie, Nancy

PMID: 24799377; PMCID: PMC4070980; DOI: 10.1093/glycob/cwu037;

Showing 10 of 40 results. Show More

Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Direct detection of S-palmitoylation by mass spectrometry. Anal Chem. 2013 Dec 17; 85(24):11952-9.View Related Profiles.

Costello, Catherine
Lin, Cheng
Haeussler, Dagmar
Bachschmid, Markus
Leymarie, Nancy
Ji, Yuhuan

PMID: 24279456; PMCID: PMC3912867; DOI: 10.1021/ac402850s;

Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86.View Related Profiles.

Costello, Catherine
Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 24224699; PMCID: PMC3912864; DOI: 10.1021/ac402931j;

Yu X, Jiang Y, Chen Y, Huang Y, Costello CE, Lin C. Detailed glycan structural characterization by electronic excitation dissociation. Anal Chem. 2013 Nov 5; 85(21):10017-21.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 24080071; PMCID: PMC3851312; DOI: 10.1021/ac402886q;

Qi Y, Li H, Wills RH, Perez-Hurtado P, Yu X, Kilgour DP, Barrow MP, Lin C, O'Connor PB. Absorption-mode Fourier transform mass spectrometry: the effects of apodization and phasing on modified protein spectra. J Am Soc Mass Spectrom. 2013 Jun; 24(6):828-34. PMID: 23568027; PMCID: PMC4024093; DOI: 10.1007/s13361-013-0600-6;

Yu X, Huang Y, Lin C, Costello CE. Energy-dependent electron activated dissociation of metal-adducted permethylated oligosaccharides. Anal Chem. 2012 Sep 4; 84(17):7487-94.View Related Profiles.

Costello, Catherine
Lin, Cheng
Huang, Yiqun

PMID: 22881449; PMCID: PMC3568493; DOI: 10.1021/ac301589z;

Li X, Yu X, Costello CE, Lin C, O'Connor PB. Top-down study of ß2-microglobulin deamidation. Anal Chem. 2012 Jul 17; 84(14):6150-7.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 22746280; PMCID: PMC4170183; DOI: 10.1021/ac3009324;

Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41.View Related Profiles.

Costello, Catherine
Lin, Cheng
Haeussler, Dagmar
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Kumar, Vikas

PMID: 22085642; PMCID: PMC3290434; DOI: 10.1096/fj.11-189415;

Sargaeva NP, Lin C, O'Connor PB. Differentiating N-terminal aspartic and isoaspartic acid residues in peptides. Anal Chem. 2011 Sep 1; 83(17):6675-82. PMID: 21736361; PMCID: PMC3165085; DOI: 10.1021/ac201223d;

Sargaeva NP, Lin C, O'Connor PB. Unusual fragmentation of ß-linked peptides by ExD tandem mass spectrometry. J Am Soc Mass Spectrom. 2011 Mar; 22(3):480-91. PMID: 21472566; PMCID: PMC4361814; DOI: 10.1007/s13361-010-0049-9;

Li X, Huang Y, O'Connor PB, Lin C. Structural heterogeneity of doubly-charged peptide b-ions. J Am Soc Mass Spectrom. 2011 Feb; 22(2):245-54. PMID: 21472584; PMCID: PMC3305756; DOI: 10.1007/s13361-010-0036-1;

Li X, Lin C, O'Connor PB. Glutamine deamidation: differentiation of glutamic acid and gamma-glutamic acid in peptides by electron capture dissociation. Anal Chem. 2010 May 1; 82(9):3606-15. PMID: 20373761; PMCID: PMC2872026; DOI: 10.1021/ac9028467;

Li X, Lin C, Han L, Costello CE, O'Connor PB. Charge remote fragmentation in electron capture and electron transfer dissociation. J Am Soc Mass Spectrom. 2010 Apr; 21(4):646-56.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 20171118; PMCID: PMC2882803; DOI: 10.1016/j.jasms.2010.01.001;

Sargaeva NP, Lin C, O'Connor PB. Identification of aspartic and isoaspartic acid residues in amyloid beta peptides, including Abeta1-42, using electron-ion reactions. Anal Chem. 2009 Dec 1; 81(23):9778-86. PMID: 19873993; PMCID: PMC3114306; DOI: 10.1021/ac901677t;

Kong X, Lin C, Infusini G, Oh HB, Jiang H, Breuker K, Wu CC, Charkin OP, Chang HC, McLafferty FW. Numerous isomers of serine octamer ions characterized by infrared photodissociation spectroscopy. Chemphyschem. 2009 Oct 19; 10(15):2603-6. PMID: 19728345; PMCID: PMC2784886; DOI: 10.1002/cphc.200900564;

Li X, Cournoyer JJ, Lin C, O'Connor PB. The effect of fixed charge modifications on electron capture dissociation. J Am Soc Mass Spectrom. 2008 Oct; 19(10):1514-26. PMID: 18657441; PMCID: PMC3116146; DOI: 10.1016/j.jasms.2008.06.014;

Li X, Cournoyer JJ, Lin C, O'Connor PB. Use of 18O labels to monitor deamidation during protein and peptide sample processing. J Am Soc Mass Spectrom. 2008 Jun; 19(6):855-64. PMID: 18394920; PMCID: PMC3105245; DOI: 10.1016/j.jasms.2008.02.011;

Lin C, Cournoyer JJ, O'Connor PB. Probing the gas-phase folding kinetics of peptide ions by IR activated DR-ECD. J Am Soc Mass Spectrom. 2008 Jun; 19(6):780-9. PMID: 18400512; PMCID: PMC3117249; DOI: 10.1016/j.jasms.2008.01.001;

Lin C, Mathur R, Aizikov K, O'Connor PB. First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer. J Am Soc Mass Spectrom. 2007 Dec; 18(12):2090-3. PMID: 17931882; PMCID: PMC2872035; DOI: 10.1016/j.jasms.2007.09.004;

Cournoyer JJ, Lin C, Bowman MJ, O'Connor PB. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation. J Am Soc Mass Spectrom. 2007 Jan; 18(1):48-56. PMID: 16997569; DOI: 10.1016/j.jasms.2006.08.008;

Lin C, Cournoyer JJ, O'Connor PB. Use of a double resonance electron capture dissociation experiment to probe fragment intermediate lifetimes. J Am Soc Mass Spectrom. 2006 Nov; 17(11):1605-15. PMID: 16904337; DOI: 10.1016/j.jasms.2006.07.007;

Belyayev MA, Cournoyer JJ, Lin C, O'Connor PB. The effect of radical trap moieties on electron capture dissociation spectra of substance P. J Am Soc Mass Spectrom. 2006 Oct; 17(10):1428-36. PMID: 16875835; DOI: 10.1016/j.jasms.2006.06.008;

O'Connor PB, Lin C, Cournoyer JJ, Pittman JL, Belyayev M, Budnik BA. Long-lived electron capture dissociation product ions experience radical migration via hydrogen abstraction. J Am Soc Mass Spectrom. 2006 Apr; 17(4):576-85. PMID: 16503151; DOI: 10.1016/j.jasms.2005.12.015;

Cournoyer JJ, Lin C, O'Connor PB. Detecting deamidation products in proteins by electron capture dissociation. Anal Chem. 2006 Feb 15; 78(4):1264-71. PMID: 16478121; DOI: 10.1021/ac051691q;

Zabrouskov V, Han X, Welker E, Zhai H, Lin C, van Wijk KJ, Scheraga HA, McLafferty FW. Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry. Biochemistry. 2006 Jan 24; 45(3):987-92. PMID: 16411774; PMCID: PMC2515934; DOI: 10.1021/bi0517584;

O'connor PB, Pittman JL, Thomson BA, Budnik BA, Cournoyer JC, Jebanathirajah J, Lin C, Moyer S, Zhao C. A new hybrid electrospray Fourier transform mass spectrometer: design and performance characteristics. Rapid Commun Mass Spectrom. 2006; 20(2):259-66. PMID: 16353130; DOI: 10.1002/rcm.2307;

Oh HB, Lin C, Hwang HY, Zhai H, Breuker K, Zabrouskov V, Carpenter BK, McLafferty FW. Infrared photodissociation spectroscopy of electrosprayed ions in a Fourier transform mass spectrometer. J Am Chem Soc. 2005 Mar 23; 127(11):4076-83. PMID: 15771545; DOI: 10.1021/ja040136n;

Breuker K, Oh H, Lin C, Carpenter BK, McLafferty FW. Nonergodic and conformational control of the electron capture dissociation of protein cations. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14011-6. PMID: 15381764; PMCID: PMC521113; DOI: 10.1073/pnas.0406095101;

Lin C, Witinski MF, Davis HF. Oxygen Atom Rydberg Time-of-Flight Spectroscopy. J Chem Phys. 2003; 119(1):251-255.

Strazisar BR, Lin C, Davis HF. Vibrationally inelastic scattering of high- n Rydberg H atoms from N2 and O2. Phys Rev Lett. 2001 Apr 30; 86(18):3997-4000. PMID: 11328079; DOI: 10.1103/PhysRevLett.86.3997;

Strazisar BR, Lin C, Davis HF. Mode-specific energy disposal in the four-atom reaction OH + D2 --> HOD + D. Science. 2000 Nov 3; 290(5493):958-61. PMID: 11062122

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 16 distinct years, with a maximum of 7 publications in 2006

Bar chart showing 40 publications over 16 distinct years, with a maximum of 7 publications in 2006

Year	Publications
2000	1
2001	1
2003	1
2004	1
2005	1
2006	7
2007	1
2008	3
2009	2
2010	2
2011	4
2012	2
2013	4
2014	4
2015	4
2016	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Mass Spectrometry, Proteomics, Glycomics, PTM characterization

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Boston MA 02118
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