Keywords
Last Name

Gyorgy Baffy, MD, PhD

TitleAdjunct Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology
Address72 E. Concord St Building A
Boston MA
 Awards and Honors

Start-EndDescription
2014-2015US Fulbright Scholar Award
2010Geza Hetenyi Award
1994Rolf Madaus Prize
1991-1993NIH Fogarty Fellow
1990OMGE Young Investigator Scholarship
 Research Expertise & Professional Interests
Dr. Gyorgy Baffy is an Associate Professor of Medicine at Harvard Medical School, Adjunct Associate Professor of Medicine in Gastroenterology at Boston University, and Chief of Gastroenterology at the VA Boston Healthcare System. He is a graduate of the University Medical School of Debrecen in Hungary. In addition, he obtained his PhD from his studies on growth factor-mediated calcium signaling as an NIH Fogarty Fellow in the Department of Biochemistry and Biophysics at the University of Pennsylvania. He trained in gastroenterology at the University of Michigan and the Brigham and Women’s Hospital. His research interests focus on various aspects of nonalcoholic fatty liver disease such as outcomes prediction, biomarkers of lipotoxicity, metabolic reprogramming, cancer bioenergetics, and hepatocellular carcinoma. He has been involved in various clinical trials that pertain to colorectal cancer screening. He organized multiple workshops and symposia on his research topics at major US conferences. He published over 60 peer-reviewed papers and book chapters. He has participated in numerous scientific review panels and provides editorial work for several journals in gastroenterology and hepatology. In 2014, he received a Fulbright US Scholar award to teach for a semester about current issues of obesity and related disorders at the University of Debrecen. He is a Fellow of the American College of Physicians, American Gastroenterological Association, and the American Association for the Study of Liver Diseases. He is the recipient of the Madaus Prize from the Madaus Liver Foundation and the Hetényi Medal of the Hungarian Gastroenterological Association.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Karagozian R, Bhardwaj G, Wakefield DB, Baffy G. Obesity paradox in advanced liver disease: obesity is associated with lower mortality in hospitalized patients with cirrhosis. Liver Int. 2016 Oct; 36(10):1450-6. PMID: 27037497.
    View in: PubMed
  2. Tarnoki AD, Tarnoki DL, Littvay L, Garami Z, Molnar AA, Berczi V, Karlinger K, Baffy G. Environmental Factors Responsible for Variability of Hepatic Vein Flow: A Doppler Assessment in Healthy Twins. Chin J Physiol. 2016 Feb 29; 59(1):33-8. PMID: 26875560.
    View in: PubMed
  3. Baffy G. MicroRNAs in Nonalcoholic Fatty Liver Disease. J Clin Med. 2015; 4(12):1977-88. PMID: 26690233.
    View in: PubMed
  4. Imler TD, Morea J, Kahi C, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A, Smalley W, Imperiale TF. Corrigendum: Multi-Center Colonoscopy Quality Measurement Utilizing Natural Language Processing. Am J Gastroenterol. 2015 Dec; 110(12):1743. PMID: 26673514.
    View in: PubMed
  5. Rodriguez-Diaz E, Baffy G, Singh SK. Probe-based confocal laser endomicroscopy quantitative morphometric markers associated with portal hypertension in duodenal mucosa. Liver Int. 2016 Feb; 36(2):223-31. PMID: 26133980.
    View in: PubMed
  6. Baffy G. Decoding multifocal hepatocellular carcinoma: an opportune pursuit. Hepatobiliary Surg Nutr. 2015 Jun; 4(3):206-10. PMID: 26151061.
    View in: PubMed
  7. Imler TD, Morea J, Kahi C, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A, Smalley W, Imperiale TF. Multi-center colonoscopy quality measurement utilizing natural language processing. Am J Gastroenterol. 2015 Apr; 110(4):543-52. PMID: 25756240.
    View in: PubMed
  8. Tarnoki AD, Tarnoki DL, Baffy G. Response to the letter entitled "Bioimpedance analysis--the shortcomings". Obes Res Clin Pract. 2014 Sep-Oct; 8(5):e511-2. PMID: 25081810.
    View in: PubMed
  9. Tarnoki AD, Tarnoki DL, Medda E, Cotichini R, Stazi MA, Fagnani C, Nisticà L, Lucatelli P, Boatta E, Zini C, Fanelli F, Baracchini C, Meneghetti G, Schillaci G, Osztovits J, Jermendy G, Kiss RB, Prà da IN, Karlinger K, Lannert A, Metneki J, Molnar AA, Garami Z, Berczi V, Halasz I, Baffy G. Bioimpedance analysis of body composition in an international twin cohort. Obes Res Clin Pract. 2014 May-Jun; 8(3):e201-98. PMID: 24847671.
    View in: PubMed
  10. Baffy G, Loscalzo J. Complexity and network dynamics in physiological adaptation: an integrated view. Physiol Behav. 2014 May 28; 131:49-56. PMID: 24751342.
    View in: PubMed
  11. Karagozian R, Derdák Z, Baffy G. Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism. 2014 May; 63(5):607-17. PMID: 24629562.
    View in: PubMed
  12. Baffy G. Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention. J Clin Transl Hepatol. 2013 Dec; 1(2):131-7. PMID: 26355775.
    View in: PubMed
  13. Karagozian R, Baker E, Houranieh A, Leavitt D, Baffy G. Risk profile of hepatocellular carcinoma reveals dichotomy among US veterans. J Gastrointest Cancer. 2013 Sep; 44(3):318-24. PMID: 23609167.
    View in: PubMed
  14. Baffy G. The impact of network medicine in gastroenterology and hepatology. Clin Gastroenterol Hepatol. 2013 Oct; 11(10):1240-4. PMID: 23932906.
    View in: PubMed
  15. Tarnoki AD, Tarnoki DL, Bogl LH, Medda E, Fagnani C, Nisticò L, Stazi MA, Brescianini S, Lucatelli P, Boatta E, Zini C, Fanelli F, Baracchini C, Meneghetti G, Osztovits J, Jermendy G, Kiss RG, Preda I, Karlinger K, Lannert A, Molnar AA, Littvay L, Garami Z, Berczi V, Pucci G, Baffy G, Schillaci G, Pietiläinen KH. Association of body mass index with arterial stiffness and blood pressure components: a twin study. Atherosclerosis. 2013 Aug; 229(2):388-95. PMID: 23880193.
    View in: PubMed
  16. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology. 2013 Jan; 57(1):205-16. PMID: 22859060.
    View in: PubMed
  17. Baffy G. Allostasis in nonalcoholic fatty liver disease: implications for risk assessment. Dig Dis Sci. 2013 Feb; 58(2):302-8. PMID: 22886595.
    View in: PubMed
  18. Tarnoki AD, Tarnoki DL, Bata P, Littvay L, Osztovits J, Jermendy G, Karlinger K, Lannert A, Preda I, Kiss RG, Molnar AA, Garami Z, Baffy G, Berczi V. Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: a twin study. Liver Int. 2012 Sep; 32(8):1287-93. PMID: 22651705.
    View in: PubMed
  19. Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol. 2012 Jun; 56(6):1384-91. PMID: 22326465.
    View in: PubMed
  20. Baffy G. Editorial: hepatocellular carcinoma in type 2 diabetes: more than meets the eye. Am J Gastroenterol. 2012 Jan; 107(1):53-5. PMID: 22218030.
    View in: PubMed
  21. Baffy G, Derdak Z, Robson SC. Mitochondrial recoupling: a novel therapeutic strategy for cancer? Br J Cancer. 2011 Aug 9; 105(4):469-74. PMID: 21712825.
    View in: PubMed
  22. Baffy G. Negative outcomes for intraoperative blood transfusion in patients with advanced cirrhosis: post hoc ergo propter hoc? Clin Gastroenterol Hepatol. 2010 Nov; 8(11):996. PMID: 20541626.
    View in: PubMed
  23. Baffy G. Uncoupling protein-2 and cancer. Mitochondrion. 2010 Apr; 10(3):243-52. PMID: 20005987.
    View in: PubMed
  24. Okpara N, Aswad B, Baffy G. Eosinophilic colitis. World J Gastroenterol. 2009 Jun 28; 15(24):2975-9. PMID: 19554649.
    View in: PubMed
  25. Baffy G. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol. 2009 Jul; 51(1):212-23. PMID: 19447517.
    View in: PubMed
  26. Derdak Z, Garcia TA, Baffy G. Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis. Methods Mol Biol. 2009; 559:205-17. PMID: 19609759.
    View in: PubMed
  27. Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res. 2008 Apr 15; 68(8):2813-9. PMID: 18413749.
    View in: PubMed
  28. Sheets AR, Fülöp P, Derdák Z, Kassai A, Sabo E, Mark NM, Paragh G, Wands JR, Baffy G. Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1017-24. PMID: 18292186.
    View in: PubMed
  29. Fülöp P, Derdák Z, Sheets A, Sabo E, Berthiaume EP, Resnick MB, Wands JR, Paragh G, Baffy G. Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression. Hepatology. 2006 Sep; 44(3):592-601. PMID: 16941708.
    View in: PubMed
  30. Hyatt P, Resnick M, Habr F, Baffy G. Brunner's gland hamartoma. Clin Gastroenterol Hepatol. 2006 Jul; 4(7):A26. PMID: 16630774.
    View in: PubMed
  31. Derdák Z, Fülöp P, Sabo E, Tavares R, Berthiaume EP, Resnick MB, Paragh G, Wands JR, Baffy G. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis. 2006 May; 27(5):956-61. PMID: 16401637.
    View in: PubMed
  32. Baffy G. Uncoupling protein-2 and non-alcoholic fatty liver disease. Front Biosci. 2005; 10:2082-96. PMID: 15970480.
    View in: PubMed
  33. Horimoto M, Resnick MB, Konkin TA, Routhier J, Wands JR, Baffy G. Expression of uncoupling protein-2 in human colon cancer. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 1):6203-7. PMID: 15448008.
    View in: PubMed
  34. Horimoto M, Fülöp P, Derdák Z, Wands JR, Baffy G. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology. 2004 Feb; 39(2):386-92. PMID: 14767991.
    View in: PubMed
  35. Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology. 2002 Apr; 35(4):753-61. PMID: 11915020.
    View in: PubMed
  36. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15; 105(6):745-55. PMID: 11440717.
    View in: PubMed
  37. Jacobson BC, Strate L, Baffy G, Huang L, Mutinga M, Banks PA. The nature of after-hours telephone medical practice by GI fellows. Am J Gastroenterol. 2001 Feb; 96(2):570-3. PMID: 11232709.
    View in: PubMed
  38. Baffy G, Boyle JM. Association of Zollinger-Ellison syndrome with pancreatitis: report of five cases. Dig Dis Sci. 2000 Aug; 45(8):1531-4. PMID: 11007101.
    View in: PubMed
  39. Várvölgyi C, Balogh Z, Bodnár Z, Eke E, Baffy G. Small-unit colonoscopy and quality assurance. Endoscopy. 2000 Jun; 32(6):504. PMID: 10863925.
    View in: PubMed
  40. Baffy G, Strate LL, Krnsky ML. Image of the month. Adherent, yellow exudate speckled with black spots in the distal two thirds of the esophagus. Diagnosis: This distinctive endoscopic image shows an acute necrotizing esophagitis, also known as the black esophagus. Gastroenterology. 2000 Feb; 118(2):252, 453. PMID: 10691371.
    View in: PubMed
  41. Baffy G, Sharma K, Shi W, Ziyadeh FN, Williamson JR. Growth arrest of a murine mesangial cell line by transforming growth factor beta 1 is associated with inhibition of mitogen-induced Ca2+ mobilization. Biochem Biophys Res Commun. 1995 May 16; 210(2):378-83. PMID: 7755613.
    View in: PubMed
  42. Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem. 1994 Mar 18; 269(11):8483-7. PMID: 8132575.
    View in: PubMed
  43. Baffy G, Yang L, Wolf BA, Williamson JR. G-protein specificity in signaling pathways that mobilize calcium in insulin-secreting beta-TC3 cells. Diabetes. 1993 Dec; 42(12):1878-82. PMID: 8243834.
    View in: PubMed
  44. Baffy G, Miyashita T, Williamson JR, Reed JC. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J Biol Chem. 1993 Mar 25; 268(9):6511-9. PMID: 8454620.
    View in: PubMed
  45. Yang L, Camoratto AM, Baffy G, Raj S, Manning DR, Williamson JR. Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. J Biol Chem. 1993 Feb 15; 268(5):3739-46. PMID: 8429049.
    View in: PubMed
  46. Baffy G, Yang L, Michalopoulos GK, Williamson JR. Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocytes. J Cell Physiol. 1992 Nov; 153(2):332-9. PMID: 1429853.
    View in: PubMed
  47. Yang LJ, Baffy G, Rhee SG, Manning D, Hansen CA, Williamson JR. Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes. J Biol Chem. 1991 Nov 25; 266(33):22451-8. PMID: 1657996.
    View in: PubMed
  48. Reed JC, Talwar HS, Cuddy M, Baffy G, Williamson J, Rapp UR, Fisher GJ. Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. Exp Cell Res. 1991 Aug; 195(2):277-83. PMID: 2070813.
    View in: PubMed
  49. Baffy G, Varga Z, Fóris G, Leövey A. Disturbed intracellular calcium-related processes of hepatocytes and neutrophils in human alcoholic liver disease. Clin Biochem. 1990 Jun; 23(3):241-5. PMID: 2142639.
    View in: PubMed
  50. Baffy G, Várhelyi I, Halász I. [Suspected intestinal perforation during paracentesis of a giant ovarian dermoid cyst]. Orv Hetil. 1988 May 8; 129(19):1001-2. PMID: 3387089.
    View in: PubMed
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