Gustavo Mostoslavsky, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology

MD, Universidad Nacional de Tucumán
PhD, The Hebrew University of Jerusalem




Expertise includes: Stem cells; Induced Pluripotent Stem cells (iPSC); Gene transfer and Gene editing; Lentiviruses; Disease modeling; Intestinal organoids; Neural differentiation; Immune relevant cell differentiation.

Associate Professor
Boston University School of Medicine
Microbiology


Member
Boston University
Pulmonary Center


Co-Director
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Member
Boston University
Genome Science Institute


Boston Medical Center



2019 CJD Foundation: CJD Foundation Research Awardee
2019 ASRM: Ky Cha Award in Stem Cell Technologies
2019 DOM BUSM: Evans Outstanding Citizenship Award
2017 Boston University: Innovator of the Year
2015-2020 World Learning The Fulbright Specialist Program: Fulbright Senior Specialist Scholar
2009 NIH RC2 Challenge Award: Role Co-PI
2002-2004 Postdoctoral Award from the Lady Tata Memorial Trust
2000 Travel Allowance Fellowship from Boehringer Ingelheim Fonds
1999-2000 Hebrew University: The Excellency Award as Teaching Assistant at the Department of Microbiology, Faculty of Medicine
1995-1996 The Hebrew University of Jerusalem: Golda Meir Award
1994 Ministry of Science and the Arts of Israel: Ph.D. Fellowship


Modeling prion diseases using human iPSC-derived neurons
03/15/2019 - 02/28/2021 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111499-01

A National Resource for Lung disease-specific IPS cells
08/15/2014 - 04/30/2020 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
5R24HL123828-05

Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
06/30/2016 - 05/31/2019 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI126457-02

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Co-PI)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01


Modeling Prion Diseases Using Human iPSC-derived Neurons
03/15/2019 - 02/28/2021 (PI)
Trustees of Boston University NIH-NINDS

Distinct Functional Outcomes or BCR/TLR7 and BCR/TLR9 Co-engagement
03/12/2015 - 02/29/2020 (PI)
UMASS Worcester NIH-NIAMS

Modeling Creutzfeldt-Jakob Disease Using Human iPSC-derived Neurons
01/15/2019 - 01/14/2020 (PI)
Creutzfeldt-Jakob Disease Foundation, Inc.

Engineering a 3D human neurovascular unit for investigating and countering neuroinflamatory mechanis
09/30/2017 - 08/31/2019 (PI)
Trustees of Boston University NIH-NINDS

Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
06/30/2016 - 05/31/2019 (PI)
Trustees of Boston University NIH-NIAID

Targeting Sequencing and Functional Evaluation of Mutations in Schizophrenia
05/01/2014 - 02/28/2019 (PI)
Northshore University Health System NIH-NIMH
5R01MH100915-04

The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis
01/01/2014 - 12/31/2018 (PI)
Mass General Hosp NIH-NCI

iPSC-derived Repair Fibroblasts to Heal Refractory Venous Ulcers
08/01/2012 - 07/31/2013 (PI)
Tufts University NIH-NIDDK

Characterization of human blood and lung progenitors derived from iPS cells free of reprogramming tr
09/30/2009 - 08/31/2011 (PI)
Trustees of Boston University NIH-NHLBI

Study of Rag 1 hypomorphic mice and their rescue by lentiviral gene transfer
09/30/2008 - 08/31/2011 (PI)
NIH-NICHD
5R21 HD060308-02


Title


Yr Title Project-Sub Proj Pubs
2019 Modeling prion diseases using human iPSC-derived neurons 1R21NS111499-01
2018 A National Resource for Lung disease-specific iPS cells 5R24HL123828-05 12
2018 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis 5R01CA175727-05 20
2018 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis 3R01CA175727-05S1 20
2017 Antiviral responses in iPSC-derived human primary cells to Ebola virus infection 5R21AI126457-02 4
2017 A National Resource for Lung disease-specific iPS cells 5R24HL123828-04 12
2017 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis 5R01CA175727-04 20
2017 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis 3R01CA175727-04S1 20
2016 Antiviral responses in iPSC-derived human primary cells to Ebola virus infection 1R21AI126457-01 4
2016 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis 3R01CA175727-03S1 20
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Abo KM, Ma L, Matte T, Huang J, Alysandratos KD, Werder RB, Mithal A, Beermann ML, Lindstrom-Vautrin J, Mostoslavsky G, Ikonomou L, Kotton DN, Hawkins F, Wilson A, Villacorta-Martin C. Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.View Related Profiles. PMID: 32577635
     
  2. Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Res. 2020 07; 46:101803.View Related Profiles. PMID: 32442913
     
  3. Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. 2020 Apr 02; 26(4):593-608.e8.View Related Profiles. PMID: 32004478
     
  4. Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020 01 10; 11(1):215.View Related Profiles. PMID: 31924806
     
  5. Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4).View Related Profiles. PMID: 31581513
     
  6. Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D'Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F. Challenges in IBD Research: Novel Technologies. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S24-S30. PMID: 31095703
     
  7. Sommer CA, Capilla A, Molina-Estevez FJ, Gianotti-Sommer A, Skvir N, Caballero I, Chowdhury S, Mostoslavsky G. Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells. PLoS One. 2018; 13(7):e0200657.View Related Profiles. PMID: 30024920
     
  8. Park S, Mostoslavsky G. Generation of Human Induced Pluripotent Stem Cells Using a Defined, Feeder-Free Reprogramming System. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e48. PMID: 30040234
     
  9. Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018 03 01; 32(5-6):373-388. PMID: 29555651
     
  10. Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC. Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nat Commun. 2017 10 10; 8(1):765.View Related Profiles. PMID: 29018244
     
Showing 10 of 77 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 77 publications over 21 distinct years, with a maximum of 8 publications in 2010

YearPublications
19981
19991
20011
20021
20042
20052
20065
20075
20081
20093
20108
20116
20126
20137
20144
20154
20164
20177
20183
20192
20204
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

stem cells, iPSC, disease modeling

Available to Mentor as: (Review Mentor Role Definitions):
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

670 Albany St Biosquare III
Boston MA 02118
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