Gustavo Mostoslavsky, MD, PhD Hear my name
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Gastroenterology

MD, Universidad Nacional de Tucumán
PhD, The Hebrew University of Jerusalem



Expertise includes: Stem cells; Induced Pluripotent Stem cells (iPSC); Gene transfer and Gene editing; Lentiviruses; Disease modeling; Intestinal organoids; Neural differentiation; Immune relevant cell differentiation.

Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology


Member
Boston University
Pulmonary Center


Co-Director
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Member
Boston University
Genome Science Institute


Boston Medical Center
Gastroenterology




An iPSC-derived human organoid based model of intestinal filovirus infection
03/01/2024 - 02/28/2025 (Key Person / Mentor)
NIH/National Institute of Allergy & Infectious Diseases
1F31AI183803-01

Functional T cells from iPSCs Using Chimeric Antigen Receptors
06/01/2019 - 05/31/2021 (Key Person / Mentor)
PI: Dar M. Heinze, PhD
NIH/National Heart, Lung, and Blood Institute
5F32HL149605-02

Modeling prion diseases using human iPSC-derived neurons
03/15/2019 - 02/28/2021 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111499-01

A National Resource for Lung disease-specific IPS cells
08/15/2014 - 04/30/2020 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
5R24HL123828-05

Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
06/30/2016 - 05/31/2019 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI126457-02

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01


Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2025 (PI)
Trustees of Boston University, BUMC Bill & Melinda Gates

Synergistic Mechanisms of Inflammasome Activation in Microglia by Opiates and Chronic HIV infection
07/15/2020 - 04/30/2025 (PI)
Trustees of Boston University, BUMC National Institute o

Uncovering the RNA regulatory mechanisms driving pathogenicity of mass-casualty viruses: Merging the technologies of RNA biology and enhanced biosafety to create the next generation of broad spectrum, RNA-based antiviral therapies
10/01/2022 - 09/30/2024 (PI)
Howard Hughes Medical Institute

Pre notification Epigenetic Scars: Understanding DSB repair from pathway choice to long term effects and their consequences.
07/01/2023 - 06/30/2024 (PI)
Ben Gurion University of the Negev Euro Research Coun

Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids
07/05/2022 - 06/30/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R21AI167369-01A1

T cell function by targeting HER2 positive cancer cells in vitro
01/01/2021 - 12/31/2023 (PI)
Clade Therapeutics

Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids
07/05/2022 - 07/04/2023 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R21AI167369-01A1

Modeling Prion Diseases Using Human iPSC-derived Neurons
03/15/2020 - 02/28/2021 (PI)
Trustees of Boston University, BUMC National Institute o

Modeling Creutzfeldt-Jakob Disease Using Human iPSC-derived Neurons
01/15/2020 - 01/14/2021 (PI)
Creutzfeldt-Jakob Disease Foundation, Inc.

Distinct Functional Outcomes or BCR/TLR7 and BCR/TLR9 Co-engagement
03/12/2015 - 02/29/2020 (PI)
UMASS Worcester NIH-NIAMS

Showing 10 of 17 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2024 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 5R01DA051889-05
2023 Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids 5R21AI167369-02
2023 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 5R01DA051889-04
2022 Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids 1R21AI167369-01A1
2022 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 5R01DA051889-03
2021 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 5R01DA051889-02
2020 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 1R01DA051889-01
2019 Modeling prion diseases using human iPSC-derived neurons 1R21NS111499-01
2018 A National Resource for Lung disease-specific iPS cells 5R24HL123828-05 12
2018 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis 5R01CA175727-05 20
Showing 10 of 32 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912.View Related Profiles. PMID: 37729429; PMCID: PMC10685174; DOI: 10.1182/bloodadvances.2022008347;
     
  2. Heinze D, Park S, McCracken A, Haratianfar M, Lindstrom J, Villacorta-Martin C, Mithal A, Wang F, Yang MW, Murphy G, Mostoslavsky G. Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs. Stem Cell Reports. 2022 Dec 13; 17(12):2610-2628.View Related Profiles. PMID: 36332629; PMCID: PMC9768581; DOI: 10.1016/j.stemcr.2022.10.007;
     
  3. Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Oct 11; 17(10):2286-2302.View Related Profiles. PMID: 36084636; PMCID: PMC9561183; DOI: 10.1016/j.stemcr.2022.08.003;
     
  4. Berical A, Lee RE, Lu J, Beermann ML, Le Suer JA, Mithal A, Thomas D, Ranallo N, Peasley M, Stuffer A, Bukis K, Seymour R, Harrington J, Coote K, Valley H, Hurley K, McNally P, Mostoslavsky G, Mahoney J, Randell SH, Hawkins FJ. A multimodal iPSC platform for cystic fibrosis drug testing. Nat Commun. 2022 Jul 29; 13(1):4270.View Related Profiles. PMID: 35906215; PMCID: PMC9338271; DOI: 10.1038/s41467-022-31854-8;
     
  5. Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles. PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;
     
  6. Wang Q, Feng L, Zhang H, Gao J, Mao C, Landesman-Bollag E, Mostoslavsky G, Lunderberg JM, Zheng W, Hao S, Gao W. Longitudinal waning of mRNA vaccine-induced neutralizing antibodies against SARS-CoV-2 detected by an LFIA rapid test. Antib Ther. 2022 Jan; 5(1):55-62. PMID: 35146332; PMCID: PMC8807222; DOI: 10.1093/abt/tbac004;
     
  7. Casalia ML, Casabona JC, García C, Cavaliere Candedo V, Quintá HR, Farías MI, Gonzalez J, Gonzalez Morón D, Córdoba M, Consalvo D, Mostoslavsky G, Urbano FJ, Pasquini J, Murer MG, Rela L, Kauffman MA, Pitossi FJ. A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels. Stem Cell Res Ther. 2021 11 25; 12(1):590. PMID: 34823607; PMCID: PMC8620942; DOI: 10.1186/s13287-021-02658-2;
     
  8. Chahla RE, Tomas-Grau RH, Cazorla SI, Ploper D, Vera Pingitore E, López MA, Aznar P, Alcorta ME, Vélez EMDM, Stagnetto A, Ávila CL, Maldonado-Galdeano C, Socias SB, Heinze D, Navarro SA, Llapur CJ, Costa D, Flores I, Edelstein A, Kowdle S, Perandones C, Lee B, Apfelbaum G, Mostoslavsky R, Mostoslavsky G, Perdigón G, Chehín RN. Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina. Lancet Reg Health Am. 2022 Feb; 6:100123. PMID: 34841388; PMCID: PMC8604626; DOI: 10.1016/j.lana.2021.100123;
     
  9. Tomas-Grau RH, Ploper D, Ávila CL, Vera Pingitore E, Maldonado Galdeano C, Chaves S, Socias SB, Stagnetto A, Navarro SA, Chahla RE, Aguilar López M, Llapur CJ, Aznar P, Alcorta ME, Costas D, Flores I, Heinze D, Apfelbaum G, Mostoslavsky R, Mostoslavsky G, Cazorla SI, Perdigón GDV, Chehín R. Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD "In-House" ELISA. Front Med (Lausanne). 2021; 8:720988. PMID: 34722566; PMCID: PMC8551828; DOI: 10.3389/fmed.2021.720988;
     
  10. Mithal A, Hume AJ, Lindstrom-Vautrin J, Villacorta-Martin C, Olejnik J, Bullitt E, Hinds A, Mühlberger E, Mostoslavsky G. Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response. Stem Cell Reports. 2021 04 13; 16(4):940-953.View Related Profiles. PMID: 33852884; PMCID: PMC8042780; DOI: 10.1016/j.stemcr.2021.02.019;
     
Showing 10 of 91 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 91 publications over 24 distinct years, with a maximum of 8 publications in 2010

YearPublications
19981
19991
20011
20021
20042
20052
20065
20075
20081
20093
20108
20116
20126
20137
20144
20154
20164
20177
20183
20192
20206
20216
20225
20231

2019 CJD Foundation: CJD Foundation Research Awardee
2019 ASRM: Ky Cha Award in Stem Cell Technologies
2019 DOM BUSM: Evans Outstanding Citizenship Award
2017 Boston University: Innovator of the Year
2015-2020 World Learning The Fulbright Specialist Program: Fulbright Senior Specialist Scholar
2009 NIH RC2 Challenge Award: Role Co-PI
2002-2004 Postdoctoral Award from the Lady Tata Memorial Trust
2000 Travel Allowance Fellowship from Boehringer Ingelheim Fonds
1999-2000 Hebrew University: The Excellency Award as Teaching Assistant at the Department of Microbiology, Faculty of Medicine
1995-1996 The Hebrew University of Jerusalem: Golda Meir Award
1994 Ministry of Science and the Arts of Israel: Ph.D. Fellowship
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

stem cells, iPSC, disease modeling

Available to Mentor as: (Review Mentor Role Definitions):
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

670 Albany St Biosquare III
Boston MA 02118
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