Tsuneya Ikezu | Profiles RNS

Tsuneya Ikezu, MD, PhD

Adjunct Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University
BS, University of Tokyo

Websites

	Pharmacology & Experimental Therapeutics Faculty
	ResearchGate
	Public Relations - BU Experts

ORCID : 0000-0002-3979-8596

My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Alzheimer Disease Genetic Architecture in African Americans
05/15/2020 - 04/30/2025 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-09

Targeting the miR-155 signaling pathway to induce beneficial disease associated microglia subtypes in Alzheimer's Disease
09/30/2021 - 09/29/2022 (Key Person / Mentor)
NIH/National Institute on Aging
1F31AG071106-01A1

Validating TTBK1 as a target for Alzheimer’s disease
07/01/2020 - 08/16/2022 (PI)
Alzheimer's Research UK

Abbvie-BU Collaborative Proposal
12/13/2016 - 12/31/2021 (PI)
AbbVie

Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 08/31/2021 (PI)
NIH/National Institute on Aging
1RF1AG054199-01

Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
08/01/2018 - 07/31/2021 (PI)
The Nancy Lurie Marks Family Foundation

TREM2-TYROBP coupling modulation for the reduction of Alzheimer's-mediated neuroinflammation: a novel pharmacologic therapy
05/01/2018 - 04/30/2021 (Key Person / Mentor)
NIH/National Institute on Aging
5F31AG057170-03

Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
08/15/2017 - 04/30/2021 (Multi-PI)
PI: Tsuneya Ikezu, MD, PhD
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG054672-04

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2021 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-05

Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
02/01/2020 - 12/31/2020 (PI)
NIH/National Institute on Aging
1R01AG066429-01

Showing 10 of 30 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease	5R01AG066429-05
2023	Tumor susceptibility gene 101, a new microglial therapy candidate for Alzheimer’s disease to prevent cognitive decline	1RF1AG082704-01
2023	Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model	5R01AG072719-03
2023	Molecular characterization of extracellular vesicles for the spread of misfolded tau protein	5R01AG067763-03
2023	Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease	5R01AG066429-04
2022	Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model	5R01AG072719-02
2022	Molecular characterization of extracellular vesicles for the spread of misfolded tau protein	5R01AG067763-02
2022	Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease	5R01AG066429-03
2021	Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model	1R01AG072719-01
2021	Molecular characterization of extracellular vesicles for the spread of misfolded tau protein	1R01AG067763-01A1

Showing 10 of 41 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Di Florio DN, Beetler DJ, McCabe EJ, Sin J, Ikezu T, Fairweather D. Mitochondrial extracellular vesicles, autoimmunity and myocarditis. Front Immunol. 2024; 15:1374796. PMID: 38550582; PMCID: PMC10972887; DOI: 10.3389/fimmu.2024.1374796;

Sandau US, Magaña SM, Costa J, Nolan JP, Ikezu T, Vella LJ, Jackson HK, Moreira LR, Palacio PL, Hill AF, Quinn JF, Van Keuren-Jensen KR, McFarland TJ, Palade J, Sribnick EA, Su H, Vekrellis K, Coyle B, Yang Y, Falcón-Perez JM, Nieuwland R, Saugstad JA. Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. J Extracell Vesicles. 2024 Jan; 13(1):e12397. PMID: 38158550; PMCID: PMC10756860; DOI: 10.1002/jev2.12397;

Yukawa K, Yamamoto-Mcguire S, Cafaro L, Hong C, Kamme F, Ikezu T, Ikezu S. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta Neuropathol Commun. 2023 Oct 19; 11(1):166.View Related Profiles.

Yamamoto-McGuire, Satomi
Ikezu, Tsuneya

PMID: 37853497; PMCID: PMC10585748; DOI: 10.1186/s40478-023-01661-3;

Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFß-mediated checkpoints. Nat Immunol. 2023 Nov; 24(11):1839-1853. PMID: 37749326; PMCID: PMC10863749; DOI: 10.1038/s41590-023-01627-6;

You Y, Zhang Z, Sultana N, Ericsson M, Martens YA, Sun M, Kanekiyo T, Ikezu S, Shaffer SA, Ikezu T. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Sci Adv. 2023 Sep 15; 9(37):eadi3647.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 37713494; PMCID: PMC10881047; DOI: 10.1126/sciadv.adi3647;

Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T. Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. J Extracell Vesicles. 2023 Aug; 12(8):e12358.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 37563857; PMCID: PMC10415636; DOI: 10.1002/jev2.12358;

Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. Identification of a protective microglial state mediated by miR-155 and interferon-? signaling in a mouse model of Alzheimer's disease. Nat Neurosci. 2023 Jul; 26(7):1196-1207. PMID: 37291336; PMCID: PMC10619638; DOI: 10.1038/s41593-023-01355-y;

Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, Tomita T. INPP5D modulates TREM2 loss-of-function phenotypes in a ß-amyloidosis mouse model. iScience. 2023 Apr 21; 26(4):106375. PMID: 37035000; PMCID: PMC10074152; DOI: 10.1016/j.isci.2023.106375;

Beetler DJ, Di Florio DN, Bruno KA, Ikezu T, March KL, Cooper LT, Wolfram J, Fairweather D. Extracellular vesicles as personalized medicine. Mol Aspects Med. 2023 Jun; 91:101155. PMID: 36456416; PMCID: PMC10073244; DOI: 10.1016/j.mam.2022.101155;

Yeh H, Woodbury ME, Ingraham Dixie KL, Ikezu T, Ikezu S. Microglial WNT5A supports dendritic spines maturation and neuronal firing. Brain Behav Immun. 2023 Jan; 107:403-413.View Related Profiles.

Woodbury, Maya
Ikezu, Tsuneya

PMID: 36395958; PMCID: PMC10588768; DOI: 10.1016/j.bbi.2022.11.003;

Showing 10 of 134 results. Show More

Herron S, Delpech JC, Madore C, Ikezu T. Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity. STAR Protoc. 2022 Dec 16; 3(4):101670. PMID: 36107747; PMCID: PMC9485281; DOI: 10.1016/j.xpro.2022.101670;

Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn J, Davis MR, Wilson JW, Margeta MA, Pitts KM, Herron S, Ikezu S, Ikezu T, Graham SL, Gupta VK, Black KL, Mirzaei M, Butovsky O, Koronyo-Hamaoui M. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia. Acta Neuropathol Commun. 2022 Sep 08; 10(1):136. PMID: 36076283; PMCID: PMC9461176; DOI: 10.1186/s40478-022-01439-z;

Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Publisher Correction: Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 Sep; 27(5):479-483. PMID: 35831741; PMCID: PMC9485317; DOI: 10.1007/s12192-022-01285-x;

Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 Sep; 27(5):461-478. PMID: 35689138; PMCID: PMC9485360; DOI: 10.1007/s12192-022-01279-9;

You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. 2022 Jun; 21(6):e13617.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Ikezu, Tsuneya
You, Yang

PMID: 35567427; PMCID: PMC9197405; DOI: 10.1111/acel.13617;

Ruan Z, Takamatsu-Yukawa K, Wang Y, Ushman ML, Labadorf AT, Ericsson M, Ikezu S, Ikezu T. Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia. Cell Rep. 2022 May 10; 39(6):110791.View Related Profiles.

Labadorf, Adam
Ikezu, Tsuneya
Ruan, Zhi

PMID: 35545052; PMCID: PMC9133589; DOI: 10.1016/j.celrep.2022.110791;

Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 Nov; 18(11):2042-2054.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Au, Rhoda
Stein, Thor
Ikezu, Tsuneya
Xia, Weiming

PMID: 35142023; PMCID: PMC9360190; DOI: 10.1002/alz.12607;

You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022 01; 11(1):e12183.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 35029059; PMCID: PMC8758831; DOI: 10.1002/jev2.12183;

Hersh SW, You Y, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058592.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Ikezu, Tsuneya
You, Yang

PMID: 34971140; DOI: 10.1002/alz.058592;

Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021 09 15; 13(611):eabe8455.View Related Profiles.

Luebke, Jennifer
Medalla, Maria
Ikezu, Seiko
Ikezu, Tsuneya
Johnson, William

PMID: 34524859; PMCID: PMC8763211; DOI: 10.1126/scitranslmed.abe8455;

Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 10; 26(10):6054-6064.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Hu, Jun
Lunetta, Kathryn
Farrer, Lindsay
Au, Rhoda
Stein, Thor
Ikezu, Tsuneya
Xia, Weiming

PMID: 34480088; PMCID: PMC8758485; DOI: 10.1038/s41380-021-01266-z;

Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging Dis. 2021 Sep; 12(6):1376-1388.View Related Profiles.

Emili, Andrew
Ikezu, Seiko
Ikezu, Tsuneya
Lin, Weiwei

PMID: 34527416; PMCID: PMC8407888; DOI: 10.14336/AD.2020.1007;

Muraoka S, DeLeo AM, Yang Z, Tatebe H, Yukawa-Takamatsu K, Ikezu S, Tokuda T, Issadore D, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Aging Dis. 2021 Sep; 12(6):1363-1375.View Related Profiles.

Stern, Robert
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 34527415; PMCID: PMC8407879; DOI: 10.14336/AD.2020.0908;

Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056. PMID: 34056454; PMCID: PMC8158845; DOI: 10.1021/acsomega.1c00660;

Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 Apr 14; 16(1):24.View Related Profiles.

Iwahara, Naotoshi
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 33853665; PMCID: PMC8048194; DOI: 10.1186/s13024-021-00447-2;

Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 03 22; 16(1):18.View Related Profiles.

Iwahara, Naotoshi
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 33752701; PMCID: PMC7986521; DOI: 10.1186/s13024-021-00440-9;

Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain. 2021 02 12; 144(1):288-309.View Related Profiles.

Luebke, Jennifer
Ikezu, Seiko
Ikezu, Tsuneya
Ruan, Zhi

PMID: 33246331; PMCID: PMC7880668; DOI: 10.1093/brain/awaa376;

Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res. 2021 03 05; 20(3):1733-1743.View Related Profiles.

Iwahara, Naotoshi
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 33534581; PMCID: PMC7944570; DOI: 10.1021/acs.jproteome.0c00934;

Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 Jun; 19(6):1017-1034. PMID: 33451707

Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. 2020 08 25; 9(9).View Related Profiles.

Ikezu, Seiko
Ikezu, Tsuneya

PMID: 32854315; PMCID: PMC7565882; DOI: 10.3390/cells9091959;

Ruan Z, Delpech JC, Venkatesan Kalavai S, Van Enoo AA, Hu J, Ikezu S, Ikezu T. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020 08 18; 15(1):47.View Related Profiles.

Ikezu, Seiko
Ikezu, Tsuneya
Ruan, Zhi

PMID: 32811520; PMCID: PMC7436984; DOI: 10.1186/s13024-020-00396-2;

Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles.

Zaia, Joseph
Sethi, Manveen
Medalla, Maria
Ikezu, Seiko
Ikezu, Tsuneya
Xia, Weiming
You, Yang
Ruan, Zhi

PMID: 32301581; PMCID: PMC7293582; DOI: 10.1002/alz.12089;

Ikezu T, Koro L, Wolozin B, Farraye FA, Strongosky AJ, Wszolek ZK. Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo. J Neuroimmune Pharmacol. 2020 12; 15(4):794-800.View Related Profiles.

Wolozin, Benjamin
Farraye, Francis
Ikezu, Tsuneya

PMID: 32180132; PMCID: PMC7718203; DOI: 10.1007/s11481-020-09909-8;

Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2021 06; 26(6):1808-1831.View Related Profiles.

Luebke, Jennifer
Medalla, Maria
Woodbury, Maya
Ikezu, Seiko
Ikezu, Tsuneya
Johnson, William
You, Yang
Ruan, Zhi

PMID: 32071385; PMCID: PMC7431382; DOI: 10.1038/s41380-020-0671-2;

Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49.View Related Profiles.

Emili, Andrew
Ikezu, Tsuneya
Xia, Weiming
Lin, Weiwei

PMID: 32035230; PMCID: PMC7667497; DOI: 10.1016/j.ymeth.2020.02.002;

Ikezu S, Ingraham Dixie KL, Koro L, Watanabe T, Kaibuchi K, Ikezu T. Tau-tubulin kinase 1 and amyloid-ß peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta Neuropathol Commun. 2020 02 04; 8(1):12.View Related Profiles.

Ikezu, Seiko
Ikezu, Tsuneya

PMID: 32019603; PMCID: PMC7001309; DOI: 10.1186/s40478-020-0890-4;

You Y, Borgmann K, Edara VV, Stacy S, Ghorpade A, Ikezu T. Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing. J Extracell Vesicles. 2020; 9(1):1706801.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 32002171; PMCID: PMC6968484; DOI: 10.1080/20013078.2019.1706801;

You Y, Botros MB, Enoo AAV, Bockmiller A, Herron S, Delpech JC, Ikezu T. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. 2019 12 01; 422:65-74.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 31689387; PMCID: PMC6898791; DOI: 10.1016/j.neuroscience.2019.10.001;

Muraoka S, Jedrychowski MP, Tatebe H, DeLeo AM, Ikezu S, Tokuda T, Gygi SP, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Front Neurosci. 2019; 13:1059.View Related Profiles.

Stern, Robert
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 31649498; PMCID: PMC6794346; DOI: 10.3389/fnins.2019.01059;

You Y, Ikezu T. Emerging roles of extracellular vesicles in neurodegenerative disorders. Neurobiol Dis. 2019 10; 130:104512.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 31229685; PMCID: PMC6689424; DOI: 10.1016/j.nbd.2019.104512;

Luengo E, Buendia I, Fernández-Mendívil C, Trigo-Alonso P, Negredo P, Michalska P, Hernández-García B, Sánchez-Ramos C, Bernal JA, Ikezu T, León R, López MG. Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux. J Pineal Res. 2019 Aug; 67(1):e12578. PMID: 30943316

Delpech JC, Herron S, Botros MB, Ikezu T. Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease. Trends Neurosci. 2019 05; 42(5):361-372. PMID: 30926143; PMCID: PMC6486849; DOI: 10.1016/j.tins.2019.02.007;

Ruan Z, Ikezu T. Tau Secretion. Adv Exp Med Biol. 2019; 1184:123-134.View Related Profiles.

Ikezu, Tsuneya
Ruan, Zhi

PMID: 32096034

Yeh H, Ikezu T. Transcriptional and Epigenetic Regulation of Microglia in Health and Disease. Trends Mol Med. 2019 02; 25(2):96-111. PMID: 30578089; PMCID: PMC6377292; DOI: 10.1016/j.molmed.2018.11.004;

Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, et al. Minimal informView Related Profiles.

Saa, Paula
Ikezu, Tsuneya

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Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol. 2019 02; 137(2):259-277.View Related Profiles.

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PMID: 30465259; PMCID: PMC6377165; DOI: 10.1007/s00401-018-1937-5;

Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 06; 13(2):254-264.View Related Profiles.

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Zeldich, Ella
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PMID: 29516269; PMCID: PMC5928172; DOI: 10.1007/s11481-018-9781-x;

Clayton KA, Van Enoo AA, Ikezu T. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Front Neurosci. 2017; 11:680. PMID: 29311768; PMCID: PMC5733046; DOI: 10.3389/fnins.2017.00680;

DeLeo AM, Ikezu T. Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy. J Neuroimmune Pharmacol. 2018 09; 13(3):292-308. PMID: 29185187; PMCID: PMC5972041; DOI: 10.1007/s11481-017-9768-z;

Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 01; 21(1):72-80.View Related Profiles.

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Bryant, Camron
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Luebke, Jennifer
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Ash, Peter
Cottone, Pietro
Ikezu, Tsuneya
Tripodis, Yorghos

PMID: 29273772; PMCID: PMC5745051; DOI: 10.1038/s41593-017-0022-z;

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 Sep 19; 47(3):566-581.e9. PMID: 28930663; PMCID: PMC5719893; DOI: 10.1016/j.immuni.2017.08.008;

Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017 Jun 23; 292(25):10651-10663.View Related Profiles.

Varnum, Megan
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 28490631; PMCID: PMC5481570; DOI: 10.1074/jbc.M116.759159;

Fujioka S, Curry SE, Kennelly KD, Tacik P, Heckman MG, Tsuboi Y, Strongosky AJ, van Gerpen JA, Uitti RJ, Ross OA, Ikezu T, Wszolek ZK. Occurrence of Crohn's disease with Parkinson's disease. Parkinsonism Relat Disord. 2017 Apr; 37:116-117. PMID: 28215729; PMCID: PMC7976661; DOI: 10.1016/j.parkreldis.2017.01.013;

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017 May; 133(5):785-807. PMID: 28070672; PMCID: PMC5391267; DOI: 10.1007/s00401-017-1668-z;

Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, ß-amyloidosis, and Learning Impairment of APP/PS1 Mice. Mol Ther. 2009 May; 17(5):803-809. PMID: 28189021; DOI: 10.1038/mt.2009.44;

Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591]. EBioMedicine. 2016 06; 8:349.View Related Profiles.

Wolozin, Benjamin
Ikezu, Tsuneya

PMID: 27428444; PMCID: PMC4919567; DOI: 10.1016/j.ebiom.2016.05.033;

Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332.View Related Profiles.

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Asai, Hirohide
Kirber, Michael
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Ikezu, Tsuneya
Bolotina, Victoria

PMID: 26755131; PMCID: PMC4729940; DOI: 10.1038/ncomms10332;

Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2016; 51(4):1099-109.View Related Profiles.

Chaisson, Christine
Stern, Robert
Cantu, Robert
Ikezu, Tsuneya
Tripodis, Yorghos

PMID: 26890775; PMCID: PMC4833534; DOI: 10.3233/JAD-151028;

Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia. J Pharmacol Exp Ther. 2016 Mar; 356(3):702-11. PMID: 26675679; PMCID: PMC4767398; DOI: 10.1124/jpet.115.230391;

Wolozin B, Ikezu T. Syk and Yea Shall Find. EBioMedicine. 2015 Nov; 2(11):1590-1.View Related Profiles.

Wolozin, Benjamin
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PMID: 26870779; PMCID: PMC4740329; DOI: 10.1016/j.ebiom.2015.11.012;

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles.

Wolozin, Benjamin
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Haydar, Tarik
Ikezu, Tsuneya

PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;

Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease. Neurobiol Aging. 2015 Nov; 36(11):2995-3007.View Related Profiles.

Varnum, Megan
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 26315370; PMCID: PMC4772879; DOI: 10.1016/j.neurobiolaging.2015.07.027;

Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu T. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J Neurosci. 2015 Jul 1; 35(26):9764-81.View Related Profiles.

Asai, Hirohide
Woodbury, Maya
Freilich, Robert
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 26134658; PMCID: PMC4571507; DOI: 10.1523/JNEUROSCI.4790-14.2015;

Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92.View Related Profiles.

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Chen, Ci-Di
Zeldich, Ella
Jun, Gyungah
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Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Ikezu, Tsuneya

PMID: 25043464; PMCID: PMC4830273; DOI: 10.1002/ana.24219;

Ikezu S, Ikezu T. Tau-tubulin kinase. Front Mol Neurosci. 2014; 7:33.View Related Profiles.

Ikezu, Seiko
Ikezu, Tsuneya

PMID: 24808823; PMCID: PMC4009424; DOI: 10.3389/fnmol.2014.00033;

Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. Am J Pathol. 2014 Mar; 184(3):808-18.View Related Profiles.

Asai, Hirohide
Woodbury, Maya
Ikezu, Seiko
Ikezu, Tsuneya

PMID: 24418258; PMCID: PMC3936332; DOI: 10.1016/j.ajpath.2013.11.026;

Freilich RW, Woodbury ME, Ikezu T. Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. PLoS One. 2013; 8(11):e79416.View Related Profiles.

Woodbury, Maya
Freilich, Robert
Ikezu, Tsuneya

PMID: 24244499; PMCID: PMC3823621; DOI: 10.1371/journal.pone.0079416;

Woodbury ME, Ikezu T. Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. J Neuroimmune Pharmacol. 2014 Mar; 9(2):92-101.View Related Profiles.

Woodbury, Maya
Ikezu, Tsuneya

PMID: 24057103; PMCID: PMC4109802; DOI: 10.1007/s11481-013-9501-5;

Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948; PMCID: PMC3730768; DOI: 10.1016/j.ajpath.2013.05.005;

McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Abraham, Carmela
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Daneshvar, Daniel
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Kowall, Neil
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya
Alvarez, Victor

PMID: 23208308; PMCID: PMC3624697; DOI: 10.1093/brain/aws307;

Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz). 2012 Aug; 60(4):251-66.View Related Profiles.

Varnum, Megan
Ikezu, Tsuneya

PMID: 22710659; PMCID: PMC4429536; DOI: 10.1007/s00005-012-0181-2;

Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci. 2012 Jun 13; 32(24):8270-83.View Related Profiles.

Wolozin, Benjamin
Varnum, Megan
Vanderweyde, Tara
Ikezu, Tsuneya

PMID: 22699908; PMCID: PMC3402380; DOI: 10.1523/JNEUROSCI.1592-12.2012;

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Nowinski, Christopher
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Kowall, Neil
Casey, Noel
Minaeva, Olga
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya

PMID: 22593173; PMCID: PMC3739428; DOI: 10.1126/scitranslmed.3003716;

Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease? J Alzheimers Dis. 2012; 29(2):329-40.View Related Profiles.

Wolozin, Benjamin
Zhu, Haihao
Ikezu, Tsuneya
Qiu, Wendy

PMID: 22232014; PMCID: PMC3784270; DOI: 10.3233/JAD-2011-111472;

Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49):E1339-48. PMID: 22042871; PMCID: PMC3241747; DOI: 10.1073/pnas.1102349108;

Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T. AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice. Gene Ther. 2012 Jul; 19(7):724-33. PMID: 21918553; PMCID: PMC3241853; DOI: 10.1038/gt.2011.126;

Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer's disease animal model. J Neuroimmune Pharmacol. 2012 Jun; 7(2):412-23. PMID: 21826404; PMCID: PMC3223330; DOI: 10.1007/s11481-011-9304-5;

Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J Immunol. 2011 Jun 15; 186(12):6925-32. PMID: 21551363; PMCID: PMC3110566; DOI: 10.4049/jimmunol.1100211;

Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T. Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. J Neurochem. 2011 Jan; 116(2):192-204. PMID: 20492361; PMCID: PMC2957558; DOI: 10.1111/j.1471-4159.2010.06824.x;

Freilich RW, Ikezu T. Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum. J Neuroimmune Pharmacol. 2011 Mar; 6(1):41-56.View Related Profiles.

Freilich, Robert
Ikezu, Tsuneya

PMID: 21103946; PMCID: PMC3101078; DOI: 10.1007/s11481-010-9250-7;

Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as ß-amyloid binding ligands and free radical scavengers. J Med Chem. 2010 Nov 25; 53(22):7992-9. PMID: 21038854; PMCID: PMC3057505; DOI: 10.1021/jm1006929;

Tokuraku K, Okuyama S, Matsushima K, Ikezu T, Kotani S. Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain. Neurosci Lett. 2010 Oct 29; 484(2):143-7. PMID: 20727942; DOI: 10.1016/j.neulet.2010.08.038;

Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J. 2010 Aug; 24(8):3093-102. PMID: 20371618; PMCID: PMC2909296; DOI: 10.1096/fj.10-155317;

Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB J. 2010 Aug; 24(8):2904-15. PMID: 20354135; DOI: 10.1096/fj.09-150144;

Tokuraku K, Marquardt M, Ikezu T. Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes. PLoS One. 2009; 4(12):e8492. PMID: 20041162; PMCID: PMC2794548; DOI: 10.1371/journal.pone.0008492;

Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. PLoS One. 2009; 4(7):e6197. PMID: 19593388; PMCID: PMC2703798; DOI: 10.1371/journal.pone.0006197;

Ikezu T. The aging of human-immunodeficiency-virus-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2009 Jun; 4(2):161-2. PMID: 19415503; DOI: 10.1007/s11481-009-9155-5;

Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Mol Ther. 2009 May; 17(5):803-9. PMID: 19277012; PMCID: PMC2709991; DOI: 10.1038/mt.2009.44;

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J Neurosci. 2008 Dec 31; 28(53):14511-21. PMID: 19118186; PMCID: PMC6671237; DOI: 10.1523/JNEUROSCI.3417-08.2008;

Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. J Neuroimmune Pharmacol. 2009 Mar; 4(1):116-28. PMID: 19034669; PMCID: PMC2644346; DOI: 10.1007/s11481-008-9140-4;

Buescher JL, Martinez LB, Sato S, Okuyama S, Ikezu T. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. J Neuroimmune Pharmacol. 2009 Mar; 4(1):103-15. PMID: 19034670; PMCID: PMC2680142; DOI: 10.1007/s11481-008-9139-x;

Xu J, Ikezu T. The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era. J Neuroimmune Pharmacol. 2009 Jun; 4(2):200-12. PMID: 19016329; PMCID: PMC2682636; DOI: 10.1007/s11481-008-9136-0;

Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. J Immunol. 2008 Sep 15; 181(6):3877-86. PMID: 18768842; PMCID: PMC2603577; DOI: 10.4049/jimmunol.181.6.3877;

Buescher JL, Duan F, Sun J, Price RW, Ikezu T. OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients. J Neuroimmune Pharmacol. 2008 Dec; 3(4):230-5. PMID: 18773297; PMCID: PMC2581637; DOI: 10.1007/s11481-008-9125-3;

Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol. 2008 Feb; 172(2):521-33. PMID: 18187566; PMCID: PMC2312373; DOI: 10.2353/ajpath.2008.070076;

Ikezu T, Gendelman HE. Neurobiology and Neural Systems. Neuroimmune Pharmacology. Springer. New York, NY. 2008.
Gendelman S, Gendelman HE, Ikezu T. Huntington’s Disease. Neuroimmune Pharmacology. Springer. New York, NY. 2008.
Ikezu T. Alzheimer’s Disease. Neuroimmune Pharmacology. Springer. New York, NY. 2008.
Ikezu T. Glial regulation of beta-amyloid deposition in transgenic animal models of Alzheimer's disease. New Immunology Research Developments (G. V. Müller Ed.). Nova Science Publishers, Inc. Hauppauge, NY. 2008.

Gorantla S, Liu J, Sneller H, Dou H, Holguin A, Smith L, Ikezu T, Volsky DJ, Poluektova L, Gendelman HE. Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis. J Immunol. 2007 Oct 1; 179(7):4345-56. PMID: 17878329

Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. J Med Chem. 2007 Oct 4; 50(20):4986-92. PMID: 17845017

Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol. 2007 Feb; 170(2):680-92. PMID: 17255335; PMCID: PMC1851864; DOI: 10.2353/ajpath.2007.060378;

Buescher JB, Gross S, Gendelman HE, Ikezu T. Neuropathogenesis of HIV. Handbook of Clinical Neurology (J. R. Berger Ed.). Elsevier Science Pub Co. 2007.

Buescher JL, Gross S, Gendelman HE, Ikezu T. The neuropathogenesis of HIV-1 infection. Handb Clin Neurol. 2007; 85:45-67. PMID: 18808975; DOI: 10.1016/S0072-9752(07)85004-4;

Horiba M, Martinez LB, Buescher JL, Sato S, Limoges J, Jiang Y, Jones C, Ikezu T. OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions. J Gen Virol. 2007 Jan; 88(Pt 1):236-41. PMID: 17170456; PMCID: PMC3229096; DOI: 10.1099/vir.0.82066-0;

Yamamoto M, Kiyota T, Walsh SM, Ikezu T. Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice. J Neuroimmune Pharmacol. 2007 Jun; 2(2):213-21. PMID: 18040846

Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep; 98(5):1573-84. PMID: 16923168

Huang Y, Erdmann N, Peng H, Herek S, Davis JS, Luo X, Ikezu T, Zheng J. TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. J Immunol. 2006 Aug 15; 177(4):2304-13. PMID: 16887991; PMCID: PMC1892167; DOI: 10.4049/jimmunol.177.4.2304;

Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 2006 Jun 15; 107(12):4770-80. PMID: 16478881; PMCID: PMC1895810; DOI: 10.1182/blood-2005-11-4721;

Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. Am J Pathol. 2005 May; 166(5):1475-85. PMID: 15855647; PMCID: PMC1606401; DOI: 10.1016/s0002-9440(10)62364-4;

Xiong H, McCabe L, Costello J, Anderson E, Weber G, Ikezu T. Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease. Neurobiol Aging. 2004 Aug; 25(7):905-11. PMID: 15212844

Carlson KA, Limoges J, Pohlman GD, Poluektova LY, Langford D, Masliah E, Ikezu T, Gendelman HE. OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. J Neuroimmunol. 2004 May; 150(1-2):186-98. PMID: 15081264

Li X, Ikezu T, Hexum TD. Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation. Peptides. 2004 Feb; 25(2):267-74. PMID: 15063008

Carlson KA, Leisman G, Limoges J, Pohlman GD, Horiba M, Buescher J, Gendelman HE, Ikezu T. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. J Immunol. 2004 Jan 1; 172(1):381-91. PMID: 14688346

Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL, Ghorpade A, Zheng J, Xiong H. Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity. J Neurochem. 2003 May; 85(4):925-34. PMID: 12716424

Luo X, Weber GA, Zheng J, Gendelman HE, Ikezu T. C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease. J Neuroimmunol. 2003 Feb; 135(1-2):62-71. PMID: 12576225

Li X, Drakulich DA, Zhang P, Shen M, Weber GA, Ikezu T, Hexum TD. Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP. J Neurosci Methods. 2002 Dec 31; 122(1):91-6. PMID: 12535768

Parolini I, Sargiacomo M, Galbiati F, Rizzo G, Grignani F, Engelman JA, Okamoto T, Ikezu T, Scherer PE, Mora R, Rodriguez-Boulan E, Peschle C, Lisanti MP. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J Biol Chem. 1999 Sep 3; 274(36):25718-25. PMID: 10464309

Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA. A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury. Am J Physiol. 1999 Aug; 277(2 Pt 1):E316-24. PMID: 10444428

Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. J Neurosci. 1999 Aug 1; 19(15):6538-48. PMID: 10414982

Ikezu T, Ueda H, Trapp BD, Nishiyama K, Sha JF, Volonte D, Galbiati F, Byrd AL, Bassell G, Serizawa H, Lane WS, Lisanti MP, Okamoto T. Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Res. 1998 Sep 7; 804(2):177-92. PMID: 9841091

Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett. 1998 May 29; 428(3):205-11. PMID: 9654135

Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. J Biol Chem. 1998 Apr 24; 273(17):10485-95. PMID: 9553108

Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA. Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem. 1997 Oct 3; 272(40):25289-95. PMID: 9312146

Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I. G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 1997 Aug 15; 16(16):4897-907. PMID: 9305632; PMCID: PMC1170125

Giambarella U, Murayama Y, Ikezu T, Fujita T, Nishimoto I. Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation. FEBS Lett. 1997 Jul 21; 412(1):97-101. PMID: 9257698

Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. 1997 Mar 7; 272(10):6525-33. PMID: 9045678

Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Martyn JA, Nishimoto I. Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP. EMBO J. 1996 May 15; 15(10):2468-75. PMID: 8665854; PMCID: PMC450179

Ikezu T, Okamoto T, Giambarella U, Yokota T, Nishimoto I. In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor. J Biol Chem. 1995 Dec 8; 270(49):29224-8. PMID: 7493951

Ikezu T, Okamoto T, Murayama Y, Okamoto T, Homma Y, Ogata E, Nishimoto I. Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product. J Biol Chem. 1994 Dec 16; 269(50):31955-61. PMID: 7989371

Takahashi K, Murayama Y, Okamoto T, Yokota T, Ikezu T, Takahashi S, Giambarella U, Ogata E, Nishimoto I. Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11772-6. PMID: 8265625; PMCID: PMC48066

Ikezu T, Okamoto T, Ogata E, Nishimoto I. Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif. FEBS Lett. 1992 Oct 12; 311(1):29-32. PMID: 1327875

Okamoto T, Ikezu T, Murayama Y, Ogata E, Nishimoto I. Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies. FEBS Lett. 1992 Jun 29; 305(2):125-8. PMID: 1618340

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 134 publications over 31 distinct years, with a maximum of 11 publications in 2008

Bar chart showing 134 publications over 31 distinct years, with a maximum of 11 publications in 2008

Year	Publications
1992	2
1993	1
1994	1
1995	1
1996	1
1997	4
1998	3
1999	3
2002	1
2003	2
2004	4
2005	1
2006	4
2007	6
2008	11
2009	4
2010	5
2011	5
2012	5
2013	3
2014	3
2015	5
2016	4
2017	7
2018	4
2019	7
2020	9
2021	10
2022	10
2023	6
2024	2