Tsuneya Ikezu, MD, PhD
Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University




My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Professor
Boston University School of Medicine
Neurology



2018 Boston University: Jack Spivack Excellence in Neurosciences Award


Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
08/15/2017 - 04/30/2022 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG054672-02

Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 06/30/2021 (PI)
NIH/National Institute on Aging
1RF1AG054199-01

Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
08/01/2018 - 07/31/2020 (PI)
The Nancy Lurie Marks Family Foundation


Identification of exosome signature in serum from ALS patients
07/01/2018 - 06/30/2020 (PI)
The Brigham and Women's Hospital, Inc. NIH NINDS
1R21NS104609-01A1

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2020 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
3R01AG048927-04S1

Eisai-Boston University Innovative Medicines for Alzheimer Disease and Dementia (EBiAD)
12/08/2017 - 12/07/2019 (PI)
Eisai, Inc


Evaluation of the effect of cell type-specific deletion of ESCRT genes on the spread of tau pathology
12/01/2018 - 11/30/2019 (PI)
Cure Alzheimer's Fund


Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
09/15/2017 - 08/31/2019 (PI)
University of California, San Diego NIH NIA
1R56AG057469-01

Therapeutic evaluation of novel tau kinase inhibitors in Alzheimer's disease
07/01/2017 - 06/30/2019 (PI)
Coins for Alzheimer's Research Trust


Novel TREM2 Reporter Platform for Drug Discovery
07/01/2016 - 06/30/2019 (PI)
Bright Focus Foundation


Showing 10 of 22 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 Identification of exosome signature in serum from ALS patients 1R21NS104609-01A1
2018 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer?s disease 5R01AG054672-02 5
2017 Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease 1R56AG057469-01 1
2017 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer?s disease 1R01AG054672-01 5
2016 Exosome-mediated propagation of pathogenic tau protein 1RF1AG054199-01 6
2012 Cells and Tissue Core 5P01NS043985-10-9003 242
2011 Cells and Tissue Core 5P01NS043985-09-9003 242
2011 Cells and Tissue Core 5P01NS043985-09-9003 242
2010 In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis 7R01MH083523-03 7
2010 Anti-inflammatory regulation of beta-amyloidosis 7R21AG032600-03 13
Showing 10 of 25 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Luengo E, Buendia I, Fernández-Mendívil C, Trigo-Alonso P, Negredo P, Michalska P, Hernández-García B, Sánchez-Ramos C, Bernal JA, Ikezu T, León R, López MG. Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux. J Pineal Res. 2019 Apr 03; e12578. PMID: 30943316.
     
  2. Delpech JC, Herron S, Botros MB, Ikezu T. Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease. Trends Neurosci. 2019 May; 42(5):361-372. PMID: 30926143.
     
  3. Yeh H, Ikezu T. Transcriptional and Epigenetic Regulation of Microglia in Health and Disease. Trends Mol Med. 2019 Feb; 25(2):96-111. PMID: 30578089.
     
  4. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, et al. Minimal informView Related Profiles. PMID: 30637094.
     
  5. Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol. 2019 Feb; 137(2):259-277.View Related Profiles. PMID: 30465259.
     
  6. Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 Jun; 13(2):254-264.View Related Profiles. PMID: 29516269.
     
  7. Clayton KA, Van Enoo AA, Ikezu T. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Front Neurosci. 2017; 11:680. PMID: 29311768.
     
  8. DeLeo AM, Ikezu T. Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy. J Neuroimmune Pharmacol. 2018 Sep; 13(3):292-308. PMID: 29185187.
     
  9. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 01; 21(1):72-80.View Related Profiles. PMID: 29273772.
     
  10. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 Sep 19; 47(3):566-581.e9. PMID: 28930663.
     
Showing 10 of 92 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 92 publications over 26 distinct years, with a maximum of 11 publications in 2008

YearPublications
19922
19931
19941
19951
19961
19974
19983
19993
20021
20032
20044
20051
20064
20076
200811
20094
20105
20115
20125
20133
20143
20155
20164
20177
20184
20192

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Boston MA 02118
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