Tsuneya Ikezu, MD, PhD
Adjunct Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University




My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Professor
Boston University School of Medicine
Neurology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Alzheimer Disease Genetic Architecture in African Americans
05/15/2020 - 04/30/2025 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-08

Targeting the miR-155 signaling pathway to induce beneficial disease associated microglia subtypes in Alzheimer's Disease
09/30/2021 - 09/29/2023 (Key Person / Mentor)
NIH/National Institute on Aging
1F31AG071106-01A1

Validating TTBK1 as a target for Alzheimer’s disease
07/01/2020 - 08/16/2022 (PI)
Alzheimer's Research UK


Abbvie-BU Collaborative Proposal
12/13/2016 - 12/31/2021 (PI)
AbbVie


Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 08/31/2021 (PI)
NIH/National Institute on Aging
1RF1AG054199-01

Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
08/01/2018 - 07/31/2021 (PI)
The Nancy Lurie Marks Family Foundation


TREM2-TYROBP coupling modulation for the reduction of Alzheimer's-mediated neuroinflammation: a novel pharmacologic therapy
05/01/2018 - 04/30/2021 (Key Person / Mentor)
NIH/National Institute on Aging
5F31AG057170-03

Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
08/15/2017 - 04/30/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG054672-04

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2021 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-05

Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
02/01/2020 - 12/31/2020 (PI)
NIH/National Institute on Aging
1R01AG066429-01

Showing 10 of 30 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model 5R01AG072719-02
2022 Molecular characterization of extracellular vesicles for the spread of misfolded tau protein 5R01AG067763-02
2022 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 5R01AG066429-03
2021 Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model 1R01AG072719-01
2021 Molecular characterization of extracellular vesicles for the spread of misfolded tau protein 1R01AG067763-01A1
2021 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 7R01AG066429-02
2021 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s disease 5R01AG054672-05 12
2021 APOE and microglia-mediated progression in tau pathology in AD 2RF1AG054199-02A1 10
2020 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 1R01AG066429-01
2020 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease 5R01AG054672-04 12
Showing 10 of 36 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 Jun 10. PMID: 35689138
     
  2. You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. 2022 Jun; 21(6):e13617.View Related Profiles. PMID: 35567427
     
  3. Ruan Z, Takamatsu-Yukawa K, Wang Y, Ushman ML, Labadorf AT, Ericsson M, Ikezu S, Ikezu T. Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia. Cell Rep. 2022 May 10; 39(6):110791.View Related Profiles. PMID: 35545052
     
  4. Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 Feb 09.View Related Profiles. PMID: 35142023
     
  5. You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022 01; 11(1):e12183.View Related Profiles. PMID: 35029059; PMCID: PMC8758831; DOI: 10.1002/jev2.12183;
     
  6. Hersh SW, You Y, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058592.View Related Profiles. PMID: 34971140; DOI: 10.1002/alz.058592;
     
  7. Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021 09 15; 13(611):eabe8455.View Related Profiles. PMID: 34524859; PMCID: PMC8763211; DOI: 10.1126/scitranslmed.abe8455;
     
  8. Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 10; 26(10):6054-6064.View Related Profiles. PMID: 34480088; PMCID: PMC8758485; DOI: 10.1038/s41380-021-01266-z;
     
  9. Muraoka S, DeLeo AM, Yang Z, Tatebe H, Yukawa-Takamatsu K, Ikezu S, Tokuda T, Issadore D, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Aging Dis. 2021 Sep; 12(6):1363-1375.View Related Profiles. PMID: 34527415; PMCID: PMC8407879; DOI: 10.14336/AD.2020.0908;
     
  10. Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging Dis. 2021 Sep; 12(6):1376-1388.View Related Profiles. PMID: 34527416; PMCID: PMC8407888; DOI: 10.14336/AD.2020.1007;
     
Showing 10 of 121 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 121 publications over 29 distinct years, with a maximum of 11 publications in 2008

YearPublications
19922
19931
19941
19951
19961
19974
19983
19993
20021
20032
20044
20051
20064
20076
200811
20094
20105
20115
20125
20133
20143
20155
20164
20177
20184
20197
20209
202110
20225


2018 Boston University: Jack Spivack Excellence in Neurosciences Award

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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