Alzheimer Disease Genetic Architecture in African Americans05/15/2020 - 04/30/2025 (PI of Sub-Project / SP)
PI:
Lindsay Farrer, PhDNIH/National Institute on Aging5R01AG048927-10
Targeting the miR-155 signaling pathway to induce beneficial disease associated microglia subtypes in Alzheimer's Disease09/30/2021 - 09/29/2022 (Key Person / Mentor)
NIH/National Institute on Aging1F31AG071106-01A1
Validating TTBK1 as a target for Alzheimer’s disease07/01/2020 - 08/16/2022 (PI)
Alzheimer's Research UK
Abbvie-BU Collaborative Proposal12/13/2016 - 12/31/2021 (PI)
AbbVie
Exosome-mediated propagation of pathogenic tau protein09/30/2016 - 08/31/2021 (PI)
NIH/National Institute on Aging1RF1AG054199-01
Characterization of Microglial Signaling in Maternal Immune Activation-related Autism08/01/2018 - 07/31/2021 (PI)
The Nancy Lurie Marks Family Foundation
TREM2-TYROBP coupling modulation for the reduction of Alzheimer's-mediated neuroinflammation: a novel pharmacologic therapy05/01/2018 - 04/30/2021 (Key Person / Mentor)
NIH/National Institute on Aging5F31AG057170-03
Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease08/15/2017 - 04/30/2021 (Multi-PI)
PI:
Tsuneya Ikezu, MD, PhDThe Brigham and Women's Hospital, Inc. NIH NIA5R01AG054672-04
Alzheimer Disease Genetic Architecture in African Americans02/15/2015 - 01/31/2021 (PI of Sub-Project / SP)
PI:
Lindsay Farrer, PhDNIH/National Institute on Aging5R01AG048927-05
Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease02/01/2020 - 12/31/2020 (PI)
NIH/National Institute on Aging1R01AG066429-01
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Evaluation of the effect of cell type-specific deletion of ESCRT genes on the spread of tau pathology12/01/2018 - 12/31/2020 (PI)
Cure Alzheimer's Fund
Identification of exosome signature in serum from ALS patients07/01/2018 - 12/31/2020 (Multi-PI)
PI:
Tsuneya Ikezu, MD, PhDThe Brigham and Women's Hospital, Inc. NIH NINDS5R21NS104609-02
Eisai-Boston University Innovative Medicines for Alzheimer Disease and Dementia (EBiAD)12/08/2017 - 12/07/2020 (PI)
Eisai, Inc.
Characterization of Microglial Signaling in Maternal Immune Activation-related Autism08/01/2018 - 07/31/2020 (PI)
Landreth Family Foundation
Novel TREM2 Reporter Platform for Drug Discovery07/01/2016 - 06/30/2020 (PI)
Bright Focus Foundation
Characterization of Human AD Brain-Derived Exosomes on Tau Propagation10/01/2016 - 09/30/2019 (Key Person / Mentor)
Alzheimer's Association
Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease09/15/2017 - 08/31/2019 (Multi-PI)
PI:
Tsuneya Ikezu, MD, PhDUniversity of California, San Diego NIH NIA1R56AG057469-01
Development of cell-based shRNA screening platform for targeting exosome pathway03/01/2017 - 08/31/2019 (PI)
Ono Pharmaceutical Co Ltd (Japan)
Therapeutic evaluation of novel tau kinase inhibitors in Alzheimer's disease07/01/2017 - 06/30/2019 (PI)
Coins for Alzheimer's Research Trust
Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism04/01/2015 - 03/31/2019 (PI)
Landreth Family Foundation
Evaluation of STX6 silencing on the novel AAV-based PSP model09/01/2016 - 02/28/2019 (PI)
CurePSP
Proteomic and RNA profiling of Exosomes in CTE biospecimens08/01/2016 - 07/31/2018 (PI)
Aethlon Medical, Inc.
Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism04/01/2015 - 03/31/2018 (PI)
The Nancy Lurie Marks Family Foundation
Exosome Pathway as a Novel Therapeutic Target of Tauopathy10/01/2014 - 09/30/2017 (PI)
Alzheimer's Association
miRNA/STAT3 axis as a novel therapeutic target of Down Syndrome12/01/2014 - 11/30/2016 (PI)
Jerome Lejeune Foundation
Target validation and development of drug discovery platform for TREM2/TYROBP signaling pathway modular11/01/2014 - 10/31/2016 (PI)
Massachusetts Neuroscience Consortium
Development of New PSP Mouse Model06/01/2016 - 08/31/2016 (Key Person / Mentor)
CurePSP
Microglia and exosome-mediated tau spreading mechanism in Alzheimer's disease brain07/01/2014 - 06/30/2016 (PI)
Coins for Alzheimer's Research Trust
LRRK2 in the Immune System Program12/01/2012 - 11/30/2014 (PI)
Michael J. Fox Foundation for Parkinson's Research
Exosome-mediated Dissemination of Tau Aggregation in Alzheimer's Disease07/01/2013 - 06/30/2014 (PI)
Alzheimer's Art Quilt Initiative