Tsuneya Ikezu, MD, PhD
Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University




My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Professor
Boston University School of Medicine
Neurology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2018 Boston University: Jack Spivack Excellence in Neurosciences Award


Alzheimer Disease Genetic Architecture in African Americans
05/15/2020 - 04/30/2025 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
2R01AG048927-06

Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
02/01/2020 - 12/31/2024 (PI)
NIH/National Institute on Aging
1R01AG066429-01

Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
08/15/2017 - 04/30/2022 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG054672-04

Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
08/01/2018 - 07/31/2021 (PI)
The Nancy Lurie Marks Family Foundation


Validating TTBK1 as a target for Alzheimer’s disease
07/01/2020 - 06/30/2021 (PI)
Alzheimer's Research UK


Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 03/31/2021 (PI)
NIH/National Institute on Aging
1RF1AG054199-01

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2021 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-05

Identification of exosome signature in serum from ALS patients
07/01/2018 - 12/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NINDS
5R21NS104609-02

Eisai-Boston University Innovative Medicines for Alzheimer Disease and Dementia (EBiAD)
12/08/2017 - 12/07/2020 (PI)
Eisai, Inc


Evaluation of the effect of cell type-specific deletion of ESCRT genes on the spread of tau pathology
12/01/2018 - 11/30/2020 (PI)
Cure Alzheimer's Fund


Showing 10 of 26 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 1R01AG066429-01
2020 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s disease 5R01AG054672-04 12
2019 Identification of exosome signature in serum from ALS patients 5R21NS104609-02 3
2019 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer?s disease 5R01AG054672-03 12
2018 Identification of exosome signature in serum from ALS patients 1R21NS104609-01A1 3
2018 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer?s disease 5R01AG054672-02 12
2017 Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease 1R56AG057469-01 9
2017 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer?s disease 1R01AG054672-01 12
2016 Exosome-mediated propagation of pathogenic tau protein 1RF1AG054199-01 10
2012 Cells and Tissue Core 5P01NS043985-10-9003 250
Showing 10 of 29 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. 2020 Aug 25; 9(9).View Related Profiles. PMID: 32854315
     
  2. Ruan Z, Delpech JC, Venkatesan Kalavai S, Van Enoo AA, Hu J, Ikezu S, Ikezu T. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020 08 18; 15(1):47.View Related Profiles. PMID: 32811520
     
  3. Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles. PMID: 32301581
     
  4. Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. PMID: 32295833
     
  5. Ikezu T, Koro L, Wolozin B, Farraye FA, Strongosky AJ, Wszolek ZK. Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo. J Neuroimmune Pharmacol. 2020 Mar 16.View Related Profiles. PMID: 32180132
     
  6. Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2020 Feb 18.View Related Profiles. PMID: 32071385
     
  7. Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49.View Related Profiles. PMID: 32035230
     
  8. Ikezu S, Ingraham Dixie KL, Koro L, Watanabe T, Kaibuchi K, Ikezu T. Tau-tubulin kinase 1 and amyloid-ß peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta Neuropathol Commun. 2020 02 04; 8(1):12.View Related Profiles. PMID: 32019603
     
  9. You Y, Borgmann K, Edara VV, Stacy S, Ghorpade A, Ikezu T. Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing. J Extracell Vesicles. 2020; 9(1):1706801.View Related Profiles. PMID: 32002171
     
  10. You Y, Botros MB, Enoo AAV, Bockmiller A, Herron S, Delpech JC, Ikezu T. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. 2019 12 01; 422:65-74.View Related Profiles. PMID: 31689387
     
Showing 10 of 105 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 105 publications over 27 distinct years, with a maximum of 11 publications in 2008

YearPublications
19922
19931
19941
19951
19961
19974
19983
19993
20021
20032
20044
20051
20064
20076
200811
20094
20105
20115
20125
20133
20143
20155
20164
20177
20184
20197
20208


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