Tsuneya Ikezu, MD, PhD
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University

My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Boston University School of Medicine

2018 Boston University: Jack Spivack Excellence in Neurosciences Award

Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
08/15/2017 - 04/30/2022 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA

Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 06/30/2021 (PI)
NIH/National Institute on Aging

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2020 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging

Eisai-Boston University Innovative Medicines for Alzheimer Disease and Dementia (EBiAD)
12/08/2017 - 12/07/2019 (PI)
Eisai, Inc

Therapeutic evaluation of novel tau kinase inhibitors in Alzheimer's disease
07/01/2017 - 06/30/2019 (PI)
Coins for Alzheimer's Research Trust

Novel TREM2 Reporter Platform for Drug Discovery
07/01/2016 - 06/30/2019 (PI)
Bright Focus Foundation

Development of cell-based shRNA screening platform for targeting exosome pathway
03/01/2017 - 02/28/2019 (PI)
Ono Pharmaceutical Co Ltd (Japan)

Abbvie-BU Collaborative Proposal
12/13/2016 - 12/12/2018 (PI)

Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
09/15/2017 - 08/31/2018 (PI)
University of California, San Diego NIH NIA

Evaluation of STX6 silencing on the novel AAV-based PSP model
09/01/2016 - 08/31/2018 (PI)

Showing 10 of 19 results. Show All Results

Yr Title Project-Sub Proj Pubs
2017 Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease 1R56AG057469-01
2017 Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer?s disease 1R01AG054672-01
2016 Exosome-mediated propagation of pathogenic tau protein 1RF1AG054199-01
2012 Cells and Tissue Core 5P01NS043985-10-9003 195
2011 Cells and Tissue Core 5P01NS043985-09-9003 195
2011 Cells and Tissue Core 5P01NS043985-09-9003 195
2010 In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis 7R01MH083523-03 6
2010 Anti-inflammatory regulation of beta-amyloidosis 7R21AG032600-03 11
2010 Anti-inflammatory regulation of beta-amyloidosis 5R21AG032600-02 11
2010 Cells and Tissue Core 5P01NS043985-08-9003 195
Showing 10 of 23 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 Jun; 13(2):254-264.View Related Profiles. PMID: 29516269.
  2. Clayton KA, Van Enoo AA, Ikezu T. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Front Neurosci. 2017; 11:680. PMID: 29311768.
  3. DeLeo AM, Ikezu T. Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy. J Neuroimmune Pharmacol. 2017 Nov 28. PMID: 29185187.
  4. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 Jan; 21(1):72-80.View Related Profiles. PMID: 29273772.
  5. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 Sep 19; 47(3):566-581.e9. PMID: 28930663.
  6. Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017 Jun 23; 292(25):10651-10663.View Related Profiles. PMID: 28490631.
  7. Fujioka S, Curry SE, Kennelly KD, Tacik P, Heckman MG, Tsuboi Y, Strongosky AJ, van Gerpen JA, Uitti RJ, Ross OA, Ikezu T, Wszolek ZK. Occurrence of Crohn's disease with Parkinson's disease. Parkinsonism Relat Disord. 2017 Apr; 37:116-117. PMID: 28215729; DOI: 10.1016/j.parkreldis.2017.01.013;.
  8. Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017 May; 133(5):785-807. PMID: 28070672; DOI: 10.1007/s00401-017-1668-z;.
  9. Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, ß-amyloidosis, and Learning Impairment of APP/PS1 Mice. Mol Ther. 2009 May; 17(5):803-809. PMID: 28189021; DOI: 10.1038/mt.2009.44;.
  10. Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591]. EBioMedicine. 2016 06; 8:349.View Related Profiles. PMID: 27428444; DOI: 10.1016/j.ebiom.2016.05.033;.
Showing 10 of 87 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 87 publications over 25 distinct years, with a maximum of 11 publications in 2008


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