Tsuneya Ikezu, MD, PhD
Adjunct Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University
BS, University of Tokyo



My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Alzheimer Disease Genetic Architecture in African Americans
05/15/2020 - 04/30/2025 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-10

Targeting the miR-155 signaling pathway to induce beneficial disease associated microglia subtypes in Alzheimer's Disease
09/30/2021 - 09/29/2022 (Key Person / Mentor)
NIH/National Institute on Aging
1F31AG071106-01A1

Validating TTBK1 as a target for Alzheimer’s disease
07/01/2020 - 08/16/2022 (PI)
Alzheimer's Research UK


Abbvie-BU Collaborative Proposal
12/13/2016 - 12/31/2021 (PI)
AbbVie


Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 08/31/2021 (PI)
NIH/National Institute on Aging
1RF1AG054199-01

Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
08/01/2018 - 07/31/2021 (PI)
The Nancy Lurie Marks Family Foundation


TREM2-TYROBP coupling modulation for the reduction of Alzheimer's-mediated neuroinflammation: a novel pharmacologic therapy
05/01/2018 - 04/30/2021 (Key Person / Mentor)
NIH/National Institute on Aging
5F31AG057170-03

Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
08/15/2017 - 04/30/2021 (Multi-PI)
PI: Tsuneya Ikezu, MD, PhD
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG054672-04

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2021 (PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
NIH/National Institute on Aging
5R01AG048927-05

Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
02/01/2020 - 12/31/2020 (PI)
NIH/National Institute on Aging
1R01AG066429-01

Showing 10 of 30 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model 5R01AG072719-04
2024 Molecular characterization of extracellular vesicles for the spread of misfolded tau protein 5R01AG067763-04
2024 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 5R01AG066429-05
2023 Tumor susceptibility gene 101, a new microglial therapy candidate for Alzheimer’s disease to prevent cognitive decline 1RF1AG082704-01
2023 Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model 5R01AG072719-03
2023 Molecular characterization of extracellular vesicles for the spread of misfolded tau protein 5R01AG067763-03
2023 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 5R01AG066429-04
2022 Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model 5R01AG072719-02
2022 Molecular characterization of extracellular vesicles for the spread of misfolded tau protein 5R01AG067763-02
2022 Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease 5R01AG066429-03
Showing 10 of 43 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Di Florio DN, Beetler DJ, McCabe EJ, Sin J, Ikezu T, Fairweather D. Mitochondrial extracellular vesicles, autoimmunity and myocarditis. Front Immunol. 2024; 15:1374796. PMID: 38550582; PMCID: PMC10972887; DOI: 10.3389/fimmu.2024.1374796;
     
  2. Sandau US, Magaña SM, Costa J, Nolan JP, Ikezu T, Vella LJ, Jackson HK, Moreira LR, Palacio PL, Hill AF, Quinn JF, Van Keuren-Jensen KR, McFarland TJ, Palade J, Sribnick EA, Su H, Vekrellis K, Coyle B, Yang Y, Falcón-Perez JM, Nieuwland R, Saugstad JA. Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. J Extracell Vesicles. 2024 Jan; 13(1):e12397. PMID: 38158550; PMCID: PMC10756860; DOI: 10.1002/jev2.12397;
     
  3. Yukawa K, Yamamoto-Mcguire S, Cafaro L, Hong C, Kamme F, Ikezu T, Ikezu S. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta Neuropathol Commun. 2023 Oct 19; 11(1):166.View Related Profiles. PMID: 37853497; PMCID: PMC10585748; DOI: 10.1186/s40478-023-01661-3;
     
  4. Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFß-mediated checkpoints. Nat Immunol. 2023 Nov; 24(11):1839-1853. PMID: 37749326; PMCID: PMC10863749; DOI: 10.1038/s41590-023-01627-6;
     
  5. You Y, Zhang Z, Sultana N, Ericsson M, Martens YA, Sun M, Kanekiyo T, Ikezu S, Shaffer SA, Ikezu T. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Sci Adv. 2023 Sep 15; 9(37):eadi3647.View Related Profiles. PMID: 37713494; PMCID: PMC10881047; DOI: 10.1126/sciadv.adi3647;
     
  6. Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T. Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. J Extracell Vesicles. 2023 Aug; 12(8):e12358.View Related Profiles. PMID: 37563857; PMCID: PMC10415636; DOI: 10.1002/jev2.12358;
     
  7. Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. Identification of a protective microglial state mediated by miR-155 and interferon-? signaling in a mouse model of Alzheimer's disease. Nat Neurosci. 2023 Jul; 26(7):1196-1207. PMID: 37291336; PMCID: PMC10619638; DOI: 10.1038/s41593-023-01355-y;
     
  8. Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, Tomita T. INPP5D modulates TREM2 loss-of-function phenotypes in a ß-amyloidosis mouse model. iScience. 2023 Apr 21; 26(4):106375. PMID: 37035000; PMCID: PMC10074152; DOI: 10.1016/j.isci.2023.106375;
     
  9. Beetler DJ, Di Florio DN, Bruno KA, Ikezu T, March KL, Cooper LT, Wolfram J, Fairweather D. Extracellular vesicles as personalized medicine. Mol Aspects Med. 2023 Jun; 91:101155. PMID: 36456416; PMCID: PMC10073244; DOI: 10.1016/j.mam.2022.101155;
     
  10. Yeh H, Woodbury ME, Ingraham Dixie KL, Ikezu T, Ikezu S. Microglial WNT5A supports dendritic spines maturation and neuronal firing. Brain Behav Immun. 2023 Jan; 107:403-413.View Related Profiles. PMID: 36395958; PMCID: PMC10588768; DOI: 10.1016/j.bbi.2022.11.003;
     
Showing 10 of 134 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 134 publications over 31 distinct years, with a maximum of 11 publications in 2008

YearPublications
19922
19931
19941
19951
19961
19974
19983
19993
20021
20032
20044
20051
20064
20076
200811
20094
20105
20115
20125
20133
20143
20155
20164
20177
20184
20197
20209
202110
202210
20236
20242


2018 Boston University: Jack Spivack Excellence in Neurosciences Award

Available to Mentor as: (Review Mentor Role Definitions):
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Contact for Mentoring:

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Boston MA 02118
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