Ann C. McKee, MD
Professor
Boston University School of Medicine
Dept of Neurology

MD, Case School of Medicine



Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences


VA Boston Healthcare System



2018 Time Magazine: 100 Most Influential People of 2018
2018 Alzheimer’s Association: Henry Wisniewski Lifetime Achievement Award


TAU PATHOLOGY IN CTE VS. ALZHEIMER'S DISEASE: MICROVASCULOPATHY AND NEUROINFLAMMATION
09/15/2017 - 06/30/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF REBECCA MATHIAS
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System

CTE AND POSTTRAUMATIC NEURODEGENERATION: NEUROPATHOLOGY AND EX VIVO IMAGING
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

BIOCHEMICAL AND GENETIC INVESTIGATION OF TAU IN CHRONIC ENCEPHALOPATHY
11/01/2015 - 10/31/2018 (PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF DAVID KWASNIK
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF BOBAK ABDOLMOHAMMADI
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF JASON MILLER
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF LANEY EVERS
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF SARAH SVIRSKY
07/01/2017 - 06/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF REBECCA MATHIAS
02/01/2015 - 06/30/2018 (PI)
VA Boston Healthcare System

Showing 10 of 23 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 CENC-VA TBI Brain Tissue Repository 5I01RX002170-03
2018 Tau Biomarkers following Blast mTBI in OEF/OIF Veterans 5I01RX000991-05
2018 Core D: Neuropathology Core 5P30AG013846-22-6897 428
2017 Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation 1RF1AG057902-01
2017 CENC-VA TBI Brain Tissue Repository 5I01RX002170-02
2017 CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging 5U01NS086659-04 15
2017 Core D: Neuropathology Core 2P30AG013846-21-6897 428
2016 CENC-VA TBI Brain Tissue Repository 1I01RX002170-01
2016 ShEEP Request for Advanced Multiphoton Laser Upgrade for Dissection of Neural Circuits 1IS1BX003544-01
2016 ShEEP Request for Zeiss LSM880 with Airyscan 1IS1BX003538-01
Showing 10 of 31 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1091-1100.View Related Profiles. PMID: 30299493.
     
  2. Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 Nov 04; 6(1):115.View Related Profiles. PMID: 30390709.
     
  3. Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2018 Oct 23; 692:204-209.View Related Profiles. PMID: 30366016.
     
  4. Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 Dec; 136(6):955-972.View Related Profiles. PMID: 30194648.
     
  5. Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768.View Related Profiles. PMID: 30053297.
     
  6. Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170.View Related Profiles. PMID: 30049650.
     
  7. Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901.View Related Profiles. PMID: 29710395.
     
  8. Mufson EJ, He B, Ginsberg SD, Carper BA, Bieler GS, Crawford F, Alvarez VE, Huber BR, Stein TD, McKee AC, Perez SE. Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma. 2018 Jun 01; 35(11):1260-1271.View Related Profiles. PMID: 29338612.
     
  9. Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 Feb 01; 141(2):422-458.View Related Profiles. PMID: 29360998; DOI: 10.1093/brain/awx350;.
     
  10. Kriegel J, Papadopoulos Z, McKee AC. Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation? Cold Spring Harb Perspect Med. 2018 02 01; 8(2). PMID: 28096246; DOI: 10.1101/cshperspect.a024059;.
     
Showing 10 of 141 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 141 publications over 28 distinct years, with a maximum of 18 publications in 2015

YearPublications
19881
19891
19903
19911
19921
19934
19941
19952
19981
19993
20002
20012
20021
20042
20052
20064
20071
20084
20093
20105
20119
201210
20136
201412
201518
201612
201715
201815
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Recent (within 3 months)

Doctors Said Hockey Enforcer Todd Ewen Did Not Have C.T.E. But He Did

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Yahoo Sports 10/23/2018

A Terrible Thing To Waste

The Boston Globe 10/18/2018

Ann Mckee Elected to the National Academy of Medicine

BU Today 10/15/2018

CTE researchers seek to study more female brains

The Washington Post 10/11/2018

Scientists seek veterans to help treat CTE

60 Minutes – CBS News 9/16/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

Older

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Baltimore Sun 9/5/2018

Researchers close in on CTE diagnosis in living, one brain at a time

USA Today 8/24/2018

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

Los Angeles Times 8/8/2018

Another CTE diagnosis in soccer adds to growing concern

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Oxygen 6/26/2018

Boynton joins NHL concussion lawsuit, pledges brain to science

TSN 6/21/2018

NHL Commissioner Bettman sidesteps question about concussions

Los Angeles Times 5/28/2018

Naperville Park District latest to add flag football as parents' fear of concussions grows

Chicago Tribune 5/5/2018

The Tragic Diagnosis They Already Knew: Their Brother Died With C.T.E.

The New York Times 5/3/2018

Former NHLer Parker had CTE when he died

TSN 5/3/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing football young may mean earlier cognitive, emotional problems

CNN Health 4/30/2018

TIME’s 100 Most influential People: BU’s Ann McKee

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Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so

Philly.com 4/19/2018

Experts say CTE ‘is associated with ice hockey play'

Daily News 4/12/2018

Family of Late Minnesota Hockey Star Waiting for Results from CTE Lab

KSTP 2/27/2018

Former Seahawks' brains shed light on NFL head injuries

King 5 News 2/21/2018

Intercepted Podcast Bonus: The NFL’s Violent Ballet

The Intercept 2/1/2018

Bob Costas will skip the Super Bowl because of the NFL’s connection to brain trauma

SB Nation 1/24/2018

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