Ann McKee | Profiles RNS

Ann C. McKee, MD

Professor

Boston University School of Medicine

Dept of Neurology

MD, Case School of Medicine

Websites

	CTE Center Faculty
	Neurology Faculty

Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine

Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences

VA Boston Healthcare System

2018 Time Magazine: 100 Most Influential People of 2018

2018 Alzheimer’s Association: Henry Wisniewski Lifetime Achievement Award

BU Sponsored Research
NIH RePORTER Sponsored Research

TAU PATHOLOGY IN CTE VS. ALZHEIMER'S DISEASE: MICROVASCULOPATHY AND NEUROINFLAMMATION
09/15/2017 - 06/30/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF REBECCA MATHIAS
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System

CTE AND POSTTRAUMATIC NEURODEGENERATION: NEUROPATHOLOGY AND EX VIVO IMAGING
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

BIOCHEMICAL AND GENETIC INVESTIGATION OF TAU IN CHRONIC ENCEPHALOPATHY
11/01/2015 - 10/31/2018 (PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF DAVID KWASNIK
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF BOBAK ABDOLMOHAMMADI
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF JASON MILLER
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF LANEY EVERS
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF SARAH SVIRSKY
07/01/2017 - 06/30/2018 (PI)
VA Boston Healthcare System

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF REBECCA MATHIAS
02/01/2015 - 06/30/2018 (PI)
VA Boston Healthcare System

Showing 10 of 23 results. Show All Results

Yr	Title	Project-Sub Proj	Pubs
2018	CENC-VA TBI Brain Tissue Repository	5I01RX002170-03
2018	Tau Biomarkers following Blast mTBI in OEF/OIF Veterans	5I01RX000991-05
2018	Core D: Neuropathology Core	5P30AG013846-22-6897	428
2017	Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation	1RF1AG057902-01
2017	CENC-VA TBI Brain Tissue Repository	5I01RX002170-02
2017	CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging	5U01NS086659-04	15
2017	Core D: Neuropathology Core	2P30AG013846-21-6897	428
2016	CENC-VA TBI Brain Tissue Repository	1I01RX002170-01
2016	ShEEP Request for Advanced Multiphoton Laser Upgrade for Dissection of Neural Circuits	1IS1BX003544-01
2016	ShEEP Request for Zeiss LSM880 with Airyscan	1IS1BX003538-01

Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Oct 09.View Related Profiles.
McKee, Ann
Huber, Bertrand
Kowall, Neil
Stein, Thor
PMID: 30299493.
Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 Sep 07.View Related Profiles.
McKee, Ann
Stein, Thor
PMID: 30194648.
Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768.View Related Profiles.
McKee, Ann
Huber, Bertrand
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Aytan, Nurgul
Au, Rhoda
Stern, Robert
Stein, Thor
Tripodis, Yorghos
PMID: 30053297.
Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170.View Related Profiles.
McKee, Ann
Mez, Jesse
Alosco, Michael
Stern, Robert
Stein, Thor
Tripodis, Yorghos
PMID: 30049650.
Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901.View Related Profiles.
McKee, Ann
Huber, Bertrand
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Goldstein, Lee
Alosco, Michael
McClean, Michael
Kowall, Neil
Stern, Robert
Stein, Thor
Tripodis, Yorghos
PMID: 29710395.
Mufson EJ, He B, Ginsberg SD, Carper BA, Bieler GS, Crawford F, Alvarez VE, Huber BR, Stein TD, McKee AC, Perez SE. Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma. 2018 Jun 01; 35(11):1260-1271.View Related Profiles.
McKee, Ann
Huber, Bertrand
Stein, Thor
Alvarez, Victor
PMID: 29338612.
Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 Feb 01; 141(2):422-458.View Related Profiles.
McKee, Ann
Huber, Bertrand
Nowinski, Christopher
Hamilton, James
Moncaster, Juliet
Goldstein, Lee
Wojnarowicz, Mark
Kowall, Neil
Hua, Ning
Casey, Noel
Minaeva, Olga
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos
PMID: 29360998; DOI: 10.1093/brain/awx350;.
Kriegel J, Papadopoulos Z, McKee AC. Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation? Cold Spring Harb Perspect Med. 2018 Feb 01; 8(2). PMID: 28096246; DOI: 10.1101/cshperspect.a024059;.
Moszczynski AJ, Strong W, Xu K, McKee A, Brown A, Strong MJ. Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS. Neurology. 2018 Jan 30; 90(5):e380-e387. PMID: 29298849.
Cherry JD, Zeineddin A, Dammer EB, Webster JA, Duong D, Seyfried NT, Levey AI, Alvarez VE, Huber BR, Stein TD, Kiernan PT, McKee AC, Lah JJ, Hales CM. Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):40-49.View Related Profiles.
McKee, Ann
Huber, Bertrand
Stein, Thor
Alvarez, Victor
PMID: 29145658.

Showing 10 of 138 results. Show More

Kenney K, Iacono D, Edlow BL, Katz DI, Diaz-Arrastia R, Dams-O'Connor K, Daneshvar DH, Stevens A, Moreau AL, Tirrell LS, Varjabedian A, Yendiki A, van der Kouwe A, Mareyam A, McNab JA, Gordon WA, Fischl B, McKee AC, Perl DP. Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):50-63.View Related Profiles.
McKee, Ann
Daneshvar, Daniel
Katz, Douglas
PMID: 29155947.
Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360.View Related Profiles.
McKee, Ann
Mez, Jesse
Alosco, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Tripodis, Yorghos
PMID: 29843242; DOI: 10.3233/JAD-180017;.
McKee AC, Mez J, Abdolmohammadi B. Chronic Traumatic Encephalopathy in Football Players-Reply. JAMA. 2017 12 19; 318(23):2353.View Related Profiles.
McKee, Ann
Mez, Jesse
PMID: 29260223.
Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 Feb; 17(1).View Related Profiles.
McKee, Ann
Ryu, Hoon
Kowall, Neil
Alvarez, Victor
PMID: 29130578.
Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J, Rahimpour Y, Puzo C, Healy RC, Martin B, Chaisson CE, Cantu RC, Au R, McClean M, McKee AC, Lin AP, Shenton ME, Killiany RJ, Stern RA. White matter signal abnormalities in former National Football League players. Alzheimers Dement (Amst). 2018; 10:56-65.View Related Profiles.
McKee, Ann
Chaisson, Christine
Alosco, Michael
McClean, Michael
Au, Rhoda
Stern, Robert
Killiany, Ronald
Tripodis, Yorghos
PMID: 29201991; DOI: 10.1016/j.dadm.2017.10.003;.
Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC. CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. PLoS One. 2017; 12(9):e0185541.View Related Profiles.
McKee, Ann
Huber, Bertrand
Daneshvar, Daniel
Mez, Jesse
Alosco, Michael
Au, Rhoda
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos
PMID: 28950005; DOI: 10.1371/journal.pone.0185541;.
Alosco ML, Kasimis AB, Stamm JM, Chua AS, Baugh CM, Daneshvar DH, Robbins CA, Mariani M, Hayden J, Conneely S, Au R, Torres A, McClean MD, McKee AC, Cantu RC, Mez J, Nowinski CJ, Martin BM, Chaisson CE, Tripodis Y, Stern RA. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl Psychiatry. 2017 Sep 19; 7(9):e1236.View Related Profiles.
Torres, Alcy
McKee, Ann
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Mez, Jesse
Stamm, Julie
Alosco, Michael
McClean, Michael
Au, Rhoda
Stern, Robert
Tripodis, Yorghos
PMID: 28926003; DOI: 10.1038/tp.2017.197;.
Mahar I, Alosco ML, McKee AC. Psychiatric phenotypes in chronic traumatic encephalopathy. Neurosci Biobehav Rev. 2017 Dec; 83:622-630.View Related Profiles.
McKee, Ann
Alosco, Michael
PMID: 28888534.
Goldstein LE, McKee AC. Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers. JAMA Neurol. 2017 Sep 01; 74(9):1045-1047.View Related Profiles.
McKee, Ann
Goldstein, Lee
PMID: 28738117.
Sours C, Hinds SR, McKee AC, Perl DP, Leggieri MJ. Brain Banks and Tissue Repositories for Blast-Related Chronic Traumatic Encephalopathy Research. J Neurotrauma. 2017 Sep; 34(S1):S4-S5. PMID: 28937954.
Friedman MJ, Huber BR, Brady CB, Ursano RJ, Benedek DM, Kowall NW, McKee AC. VA's National PTSD Brain Bank: a National Resource for Research. Curr Psychiatry Rep. 2017 Aug 25; 19(10):73.View Related Profiles.
McKee, Ann
Huber, Bertrand
Brady, Christopher
Kowall, Neil
PMID: 28840457.
Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR, Alosco ML, Solomon TM, Nowinski CJ, McHale L, Cormier KA, Kubilus CA, Martin BM, Murphy L, Baugh CM, Montenigro PH, Chaisson CE, Tripodis Y, Kowall NW, Weuve J, McClean MD, Cantu RC, Goldstein LE, Katz DI, Stern RA, Stein TD, McKee AC. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017 Jul 25; 318(4):360-370.View Related Profiles.
McKee, Ann
Huber, Bertrand
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Weuve, Jennifer
Mez, Jesse
Goldstein, Lee
Alosco, Michael
McClean, Michael
Kowall, Neil
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos
PMID: 28742910; DOI: 10.1001/jama.2017.8334;.
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, et al. RarView Related Profiles.
Beiser, Alexa
DeStefano, Anita
McKee, Ann
Satizabal, Claudia
Jun, Gyungah
Lin, Honghuang
Himali, Jayandra
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha
PMID: 28714976.
Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 05 19; 49(5):e333.View Related Profiles.
McKee, Ann
Ryu, Hoon
Kowall, Neil
Stein, Thor
Alvarez, Victor
PMID: 28524178.
Gangolli M, Holleran L, Hee Kim J, Stein TD, Alvarez V, McKee AC, Brody DL. Quantitative validation of a nonlinear histology-MRI coregistration method using generalized Q-sampling imaging in complex human cortical white matter. Neuroimage. 2017 Jun; 153:152-167.View Related Profiles.
McKee, Ann
Stein, Thor
Alvarez, Victor
PMID: 28365421; DOI: 10.1016/j.neuroimage.2017.03.059;.
Alosco ML, Duskin J, Besser LM, Martin B, Chaisson CE, Gunstad J, Kowall NW, McKee AC, Stern RA, Tripodis Y. Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set. J Alzheimers Dis. 2017; 57(3):953-968.View Related Profiles.
McKee, Ann
Chaisson, Christine
Alosco, Michael
Kowall, Neil
Stern, Robert
Tripodis, Yorghos
PMID: 28304301; DOI: 10.3233/JAD-161205;.
Armstrong RA, McKee AC, Cairns NJ. Pathology of the Superior Colliculus in Chronic Traumatic Encephalopathy. Optom Vis Sci. 2017 Jan; 94(1):33-42. PMID: 27391531; DOI: 10.1097/OPX.0000000000000911;.
Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8187-E8196. PMID: 27911827.
Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, Mez J, Montenigro PH, Solomon TM, Alosco ML, Stern RA, McKee AC, Stein TD. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016 Oct 28; 4(1):112.View Related Profiles.
McKee, Ann
Huber, Bertrand
Daneshvar, Daniel
Mez, Jesse
Alosco, Michael
Montenigro, Philip
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos
PMID: 27793189.
Armstrong RA, McKee AC, Alvarez VE, Cairns NJ. Clustering of tau-immunoreactive pathology in chronic traumatic encephalopathy. J Neural Transm (Vienna). 2017 Feb; 124(2):185-192.View Related Profiles.
McKee, Ann
Alvarez, Victor
PMID: 27770214; DOI: 10.1007/s00702-016-1635-1;.
McKee AC, Alosco ML, Huber BR. Repetitive Head Impacts and Chronic Traumatic Encephalopathy. Neurosurg Clin N Am. 2016 Oct; 27(4):529-35.View Related Profiles.
McKee, Ann
Huber, Bertrand
Alosco, Michael
PMID: 27637402; DOI: 10.1016/j.nec.2016.05.009;.
Alosco ML, Mez J, Kowall NW, Stein TD, Goldstein LE, Cantu RC, Katz DI, Solomon TM, Kiernan PT, Murphy L, Abdolmohammadi B, Daneshvar D, Montenigro PH, Nowinski CJ, Stern RA, McKee AC. Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination. J Neuropsychiatry Clin Neurosci. 2017; 29(1):6-12.View Related Profiles.
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Montenigro, Philip
Stern, Robert
Stein, Thor
PMID: 27539377; DOI: 10.1176/appi.neuropsych.16030043;.
Besser LM, Alosco ML, Ramirez Gomez L, Zhou XH, McKee AC, Stern RA, Gunstad J, Schneider JA, Chui H, Kukull WA. Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol. 2016 Oct; 75(10):955-962.View Related Profiles.
McKee, Ann
Alosco, Michael
Stern, Robert
PMID: 27516116.
Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology. J Alzheimers Dis. 2016 07 06; 53(4):1553-62.View Related Profiles.
Beiser, Alexa
McKee, Ann
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
PMID: 27392855; DOI: 10.3233/JAD-160163;.
Montenigro PH, Alosco ML, Martin BM, Daneshvar DH, Mez J, Chaisson CE, Nowinski CJ, Au R, McKee AC, Cantu RC, McClean MD, Stern RA, Tripodis Y. Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma. 2017 Jan 15; 34(2):328-340.View Related Profiles.
McKee, Ann
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Mez, Jesse
Alosco, Michael
McClean, Michael
Montenigro, Philip
Au, Rhoda
Stern, Robert
Tripodis, Yorghos
PMID: 27029716; DOI: 10.1089/neu.2016.4413;.
Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. A quantitative study of tau pathology in 11 cases of chronic traumatic encephalopathy. Neuropathol Appl Neurobiol. 2017 Feb; 43(2):154-166.View Related Profiles.
McKee, Ann
Stein, Thor
Alvarez, Victor
PMID: 26998921; DOI: 10.1111/nan.12323;.
Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Inj. 2016; 30(12):1399-1413.View Related Profiles.
McKee, Ann
Alvarez, Victor
PMID: 27834536.
Mez J, Solomon TM, Daneshvar DH, Stein TD, McKee AC. Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player. JAMA Neurol. 2016 Mar; 73(3):353-5.View Related Profiles.
McKee, Ann
Daneshvar, Daniel
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Stein, Thor
PMID: 26747562; PMCID: PMC4792748; DOI: 10.1001/jamaneurol.2015.3998;.
Huber BR, Alosco ML, Stein TD, McKee AC. Potential Long-Term Consequences of Concussive and Subconcussive Injury. Phys Med Rehabil Clin N Am. 2016 May; 27(2):503-11.View Related Profiles.
McKee, Ann
Huber, Bertrand
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PMID: 27154859; DOI: 10.1016/j.pmr.2015.12.007;.
Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2016 Jan; 75(1):19-34.View Related Profiles.
McKee, Ann
Stein, Thor
Alvarez, Victor
PMID: 26671985; PMCID: PMC4891281.
McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Tripodis Y, Crary JF, Bieniek KF, Dams-O'Connor K, Alvarez VE, Gordon WA. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol. 2016 Jan; 131(1):75-86.View Related Profiles.
McKee, Ann
Mez, Jesse
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos
PMID: 26667418; PMCID: PMC4698281; DOI: 10.1007/s00401-015-1515-z;.
Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL, Wisniewski T, Woulfe JM, Yamada M, Dickson DW. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol. 2016 Jan; 131(1):87-102. PMID: 26659578; PMCID: PMC4879001; DOI: 10.1007/s00401-015-1509-x;.
Martinez-Ramirez S, Romero JR, Shoamanesh A, McKee AC, Van Etten E, Pontes-Neto O, Macklin EA, Ayres A, Auriel E, Himali JJ, Beiser AS, DeCarli C, Stein TD, Alvarez VE, Frosch MP, Rosand J, Greenberg SM, Gurol ME, Seshadri S, Viswanathan A. Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage. Alzheimers Dement. 2015 Dec; 11(12):1480-8.View Related Profiles.
Beiser, Alexa
McKee, Ann
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Stein, Thor
Alvarez, Victor
PMID: 26079413; PMCID: PMC4677060; DOI: 10.1016/j.jalz.2015.04.009;.
Bieniek KF, Ross OA, Cormier KA, Walton RL, Soto-Ortolaza A, Johnston AE, DeSaro P, Boylan KB, Graff-Radford NR, Wszolek ZK, Rademakers R, Boeve BF, McKee AC, Dickson DW. Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol. 2015 Dec; 130(6):877-89. PMID: 26518018; PMCID: PMC4655127; DOI: 10.1007/s00401-015-1502-4;.
Mez J, Solomon TM, Daneshvar DH, Murphy L, Kiernan PT, Montenigro PH, Kriegel J, Abdolmohammadi B, Fry B, Babcock KJ, Adams JW, Bourlas AP, Papadopoulos Z, McHale L, Ardaugh BM, Martin BR, Dixon D, Nowinski CJ, Chaisson C, Alvarez VE, Tripodis Y, Stein TD, Goldstein LE, Katz DI, Kowall NW, Cantu RC, Stern RA, McKee AC. Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study. Alzheimers Res Ther. 2015; 7(1):62.View Related Profiles.
McKee, Ann
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Babcock, Katharine
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Kowall, Neil
Montenigro, Philip
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos
PMID: 26455775; PMCID: PMC4601147; DOI: 10.1186/s13195-015-0148-8;.
Stein TD, Alvarez VE, McKee AC. Concussion in Chronic Traumatic Encephalopathy. Curr Pain Headache Rep. 2015 Oct; 19(10):47.View Related Profiles.
McKee, Ann
Stein, Thor
Alvarez, Victor
PMID: 26260277; PMCID: PMC4633042; DOI: 10.1007/s11916-015-0522-z;.
Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein LE, Pascual-Leone A, McKee AC, Meehan W, Zhou XZ, Lu KP. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015 Jul 23; 523(7561):431-6.View Related Profiles.
McKee, Ann
Moncaster, Juliet
Goldstein, Lee
PMID: 26176913; DOI: 10.1038/nature14658;.
Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 Jul; 130(1):21-34.View Related Profiles.
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Mez, Jesse
Babcock, Katharine
Kowall, Neil
Montenigro, Philip
Stern, Robert
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos
PMID: 25943889; PMCID: PMC4529056; DOI: 10.1007/s00401-015-1435-y;.
McKee AC, Stein TD, Kiernan PT, Alvarez VE. The neuropathology of chronic traumatic encephalopathy. Brain Pathol. 2015 May; 25(3):350-64.View Related Profiles.
McKee, Ann
Stein, Thor
Alvarez, Victor
PMID: 25904048; PMCID: PMC4526170; DOI: 10.1111/bpa.12248;.
Iglesias JE, Augustinack JC, Nguyen K, Player CM, Player A, Wright M, Roy N, Frosch MP, McKee AC, Wald LL, Fischl B, Van Leemput K. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI. Neuroimage. 2015 Jul 15; 115:117-37. PMID: 25936807; PMCID: PMC4461537; DOI: 10.1016/j.neuroimage.2015.04.042;.
Daneshvar DH, Goldstein LE, Kiernan PT, Stein TD, McKee AC. Post-traumatic neurodegeneration and chronic traumatic encephalopathy. Mol Cell Neurosci. 2015 May; 66(Pt B):81-90.View Related Profiles.
McKee, Ann
Daneshvar, Daniel
Goldstein, Lee
Stein, Thor
PMID: 25758552; DOI: 10.1016/j.mcn.2015.03.007;.
Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz DV, Giza CC, Greenwald RM, Herring SA, Hoshizaki TB, Hudziak JJ, Huston J, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead JR, Wiese-Bjornstal DM. Ice Hockey Summit II: zero tolerance for head hits and fighting. Curr Sports Med Rep. 2015 Mar-Apr; 14(2):135-44. PMID: 25757010; DOI: 10.1249/JSR.0000000000000132;.
Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz DV, Giza CC, Greenwald RM, Herring SA, Hoshizaki TB, Hudziak JJ, Huston J, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead JR, Wiese-Bjornstal DM. Ice hockey summit II: zero tolerance for head hits and fighting. PM R. 2015 Mar; 7(3):283-95. PMID: 25797614; DOI: 10.1016/j.pmrj.2015.02.002;.
Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz D, Giza CC, Greenwald RM, Herring S, Hoshizaki TB, Hudziak JJ, Huston J, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead J, Wiese-Bjornstal DM. Ice Hockey Summit II: zero tolerance for head hits and fighting. Clin J Sport Med. 2015 Mar; 25(2):78-87. PMID: 25866860; DOI: 10.1097/JSM.0000000000000195;.
Kiernan PT, Montenigro PH, Solomon TM, McKee AC. Chronic traumatic encephalopathy: a neurodegenerative consequence of repetitive traumatic brain injury. Semin Neurol. 2015 Feb; 35(1):20-8.View Related Profiles.
McKee, Ann
Montenigro, Philip
PMID: 25714864; DOI: 10.1055/s-0035-1545080;.
Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16.View Related Profiles.
McKee, Ann
Jun, Gyungah
Farrer, Lindsay
Kowall, Neil
Stern, Robert
PMID: 25531812; PMCID: PMC4324097; DOI: 10.1001/jamaneurol.2014.2157;.
Mckee AC, Daneshvar DH. The neuropathology of traumatic brain injury. Handb Clin Neurol. 2015; 127:45-66.View Related Profiles.
McKee, Ann
Daneshvar, Daniel
PMID: 25702209; PMCID: PMC4694720; DOI: 10.1016/B978-0-444-52892-6.00004-0;.
Baugh CM, Kiernan PT, Kroshus E, Daneshvar DH, Montenigro PH, McKee AC, Stern RA. Frequency of head-impact-related outcomes by position in NCAA division I collegiate football players. J Neurotrauma. 2015 Mar 1; 32(5):314-26.View Related Profiles.
McKee, Ann
Daneshvar, Daniel
Montenigro, Philip
Stern, Robert
PMID: 25155288; PMCID: PMC4628259; DOI: 10.1089/neu.2014.3582;.
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.View Related Profiles.
McKee, Ann
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Kowall, Neil
Stern, Robert
PMID: 25199842; PMCID: PMC4314944; DOI: 10.1001/jamaneurol.2014.1491;.
Goldstein LE, McKee AC, Stanton PK. Considerations for animal models of blast-related traumatic brain injury and chronic traumatic encephalopathy. Alzheimers Res Ther. 2014; 6(5):64.View Related Profiles.
McKee, Ann
Goldstein, Lee
PMID: 25478023; DOI: 10.1186/s13195-014-0064-3;.
Baugh CM, Robbins CA, Stern RA, McKee AC. Current understanding of chronic traumatic encephalopathy. Curr Treat Options Neurol. 2014 Sep; 16(9):306.View Related Profiles.
McKee, Ann
Baugh, Christine
Stern, Robert
PMID: 25023937; DOI: 10.1007/s11940-014-0306-5;.
Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LI. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimers Dement. 2015 Jan; 11(1):70-98. PMID: 25022540; PMCID: PMC4287457; DOI: 10.1016/j.jalz.2014.04.514;.
Kaur B, Himali JJ, Seshadri S, Beiser AS, Au R, McKee AC, Auerbach S, Wolf PA, DeCarli CS. Association between neuropathology and brain volume in the Framingham Heart Study. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):219-25.View Related Profiles.
Beiser, Alexa
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Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha
PMID: 24614264; PMCID: PMC4139422; DOI: 10.1097/WAD.0000000000000032;.
McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S242-53.View Related Profiles.
McKee, Ann
Robinson, Meghan
PMID: 24924675; PMCID: PMC4255273; DOI: 10.1016/j.jalz.2014.04.003;.
Robbins CA, Daneshvar DH, Picano JD, Gavett BE, Baugh CM, Riley DO, Nowinski CJ, McKee AC, Cantu RC, Stern RA. Self-reported concussion history: impact of providing a definition of concussion. Open Access J Sports Med. 2014; 5:99-103.View Related Profiles.
McKee, Ann
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
Stern, Robert
PMID: 24891816; DOI: 10.2147/OAJSM.S58005;.
McKee AC. Author's reply: To PMID 19535999. J Neuropathol Exp Neurol. 2014 Apr; 73(4):375. PMID: 24662934; DOI: 10.1097/01.jnen.0000445642.03138.6e;.
Stein TD, Alvarez VE, McKee AC. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimers Res Ther. 2014; 6(1):4.View Related Profiles.
McKee, Ann
Stein, Thor
Alvarez, Victor
PMID: 24423082; DOI: 10.1186/alzrt234;.
McKee AC, Daneshvar DH, Alvarez VE, Stein TD. The neuropathology of sport. Acta Neuropathol. 2014 Jan; 127(1):29-51.View Related Profiles.
McKee, Ann
Daneshvar, Daniel
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PMID: 24366527; DOI: 10.1007/s00401-013-1230-6;.
Saman S, Lee NC, Inoyo I, Jin J, Li Z, Doyle T, McKee AC, Hall GF. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease. J Alzheimers Dis. 2014; 40 Suppl 1:S47-70. PMID: 24718102; DOI: 10.3233/JAD-132135;.
Mez J, Stern RA, McKee AC. Chronic traumatic encephalopathy: where are we and where are we going? Curr Neurol Neurosci Rep. 2013 Dec; 13(12):407.View Related Profiles.
McKee, Ann
Mez, Jesse
Stern, Robert
PMID: 24136455; DOI: 10.1007/s11910-013-0407-7;.
Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain Res. 2013 Dec 6; 1541:115-27.View Related Profiles.
Dedeoglu, Alpaslan
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Carreras, Isabel
Kowall, Neil
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PMID: 24161403; PMCID: PMC3863610; DOI: 10.1016/j.brainres.2013.10.025;.
Brady CB, Trevor KT, Stein TD, Deykin EY, Perkins SD, Averill JG, Guilderson L, McKee AC, Renner SW, Kowall NW. The Department of Veterans Affairs Biorepository Brain Bank: a national resource for amyotrophic lateral sclerosis research. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec; 14(7-8):591-7.View Related Profiles.
McKee, Ann
Brady, Christopher
Kowall, Neil
Stein, Thor
PMID: 23971854; DOI: 10.3109/21678421.2013.822516;.
Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013 Sep 24; 81(13):1122-9.View Related Profiles.
Budson, Andrew
McKee, Ann
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
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Montenigro, Philip
Stern, Robert
Stein, Thor
Alvarez, Victor
PMID: 23966253; PMCID: PMC3795597; DOI: 10.1212/WNL.0b013e3182a55f7f;.
Seichepine DR, Stamm JM, Daneshvar DH, Riley DO, Baugh CM, Gavett BE, Tripodis Y, Martin B, Chaisson C, McKee AC, Cantu RC, Nowinski CJ, Stern RA. Profile of self-reported problems with executive functioning in college and professional football players. J Neurotrauma. 2013 Jul 15; 30(14):1299-304.View Related Profiles.
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Stamm, Julie
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Tripodis, Yorghos
PMID: 23421745; PMCID: PMC3713446; DOI: 10.1089/neu.2012.2690;.
Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12066-71.View Related Profiles.
McKee, Ann
Ryu, Hoon
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Kowall, Neil
PMID: 23818595; PMCID: PMC3718122; DOI: 10.1073/pnas.1300894110;.
McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64.View Related Profiles.
Budson, Andrew
McKee, Ann
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Daneshvar, Daniel
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Kowall, Neil
Stern, Robert
Stein, Thor
Ikezu, Tsuneya
Alvarez, Victor
PMID: 23208308; PMCID: PMC3624697; DOI: 10.1093/brain/aws307;.
Le MN, Kim W, Lee S, McKee AC, Hall GF. Multiple mechanisms of extracellular tau spreading in a non-transgenic tauopathy model. Am J Neurodegener Dis. 2012; 1(3):316-33. PMID: 23383401; PMCID: PMC3560471.
Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, St George-Hyslop P, Goldstein LE, Farrer LA. d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS One. 2012; 7(9):e43728.View Related Profiles.
McKee, Ann
Jun, Gyungah
Moncaster, Juliet
Goldstein, Lee
Farrer, Lindsay
Wolf, Philip
Seshadri, Sudha
PMID: 22984439; PMCID: PMC3439481; DOI: 10.1371/journal.pone.0043728;.
Augustinack JC, Huber KE, Stevens AA, Roy M, Frosch MP, van der Kouwe AJ, Wald LL, Van Leemput K, McKee AC, Fischl B. Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI. Neuroimage. 2013 Jan 01; 64:32-42. PMID: 22960087; PMCID: PMC3508349.
Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64.View Related Profiles.
McKee, Ann
Delalle, Ivana
Polgar, Peter
Seshadri, Sudha
PMID: 22710966; PMCID: PMC3398703; DOI: 10.1097/NEN.0b013e31825d06b7;.
Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee AC. The Framingham Brain Donation Program: neuropathology along the cognitive continuum. Curr Alzheimer Res. 2012 Jul; 9(6):673-86.View Related Profiles.
Beiser, Alexa
McKee, Ann
Cabral, Howard
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha
PMID: 22471865; PMCID: PMC3622706.
Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8.View Related Profiles.
McKee, Ann
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Kowall, Neil
Stern, Robert
PMID: 22722634; PMCID: PMC3398432; DOI: 10.1212/WNL.0b013e3182605801;.
Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, Nowinski CJ, Cantu RC, McKee AC, Stern RA. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012 Jun; 6(2):244-54.View Related Profiles.
McKee, Ann
Baugh, Christine
Nowinski, Christopher
Stamm, Julie
Stern, Robert
PMID: 22552850; DOI: 10.1007/s11682-012-9164-5;.
Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60.View Related Profiles.
Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Nowinski, Christopher
Blusztajn, Jan
Moncaster, Juliet
Goldstein, Lee
Wojnarowicz, Mark
Kowall, Neil
Casey, Noel
Minaeva, Olga
Stern, Robert
Stein, Thor
Ikezu, Tsuneya
PMID: 22593173; PMCID: PMC3739428; DOI: 10.1126/scitranslmed.3003716;.
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012 May; 71(5):362-81. PMID: 22487856; PMCID: PMC3560290; DOI: 10.1097/NEN.0b013e31825018f7;.
Gavett BE, Cantu RC, Shenton M, Lin AP, Nowinski CJ, McKee AC, Stern RA. Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions. Curr Opin Neurol. 2011 Dec; 24(6):525-31.View Related Profiles.
McKee, Ann
Nowinski, Christopher
Stern, Robert
PMID: 22045219; DOI: 10.1097/WCO.0b013e32834cd477;.
Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, Jackson B, McKee AC, Alvarez VE, Lee NC, Hall GF. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem. 2012 Feb 3; 287(6):3842-9.View Related Profiles.
McKee, Ann
Alvarez, Victor
PMID: 22057275; PMCID: PMC3281682; DOI: 10.1074/jbc.M111.277061;.
Sullivan CP, Berg EA, Elliott-Bryant R, Fishman JB, McKee AC, Morin PJ, Shia MA, Fine RE. Pyroglutamate-Aß 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aß 11 forming the central core. Neurosci Lett. 2011 Nov 14; 505(2):109-12.View Related Profiles.
McKee, Ann
Fine, Richard
PMID: 22001577; PMCID: PMC3253715; DOI: 10.1016/j.neulet.2011.09.071;.
Stern RA, Riley DO, Daneshvar DH, Nowinski CJ, Cantu RC, McKee AC. Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy. PM R. 2011 Oct; 3(10 Suppl 2):S460-7.View Related Profiles.
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Stern, Robert
PMID: 22035690; DOI: 10.1016/j.pmrj.2011.08.008;.
Daneshvar DH, Riley DO, Nowinski CJ, McKee AC, Stern RA, Cantu RC. Long-term consequences: effects on normal development profile after concussion. Phys Med Rehabil Clin N Am. 2011 Nov; 22(4):683-700, ix.View Related Profiles.
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Stern, Robert
PMID: 22050943; PMCID: PMC3208826; DOI: 10.1016/j.pmr.2011.08.009;.
Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41.View Related Profiles.
McKee, Ann
Baldwin, Clinton
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Kowall, Neil
Stern, Robert
PMID: 21460841; PMCID: PMC3090745; DOI: 10.1038/ng.801;.
Daneshvar DH, Nowinski CJ, McKee AC, Cantu RC. The epidemiology of sport-related concussion. Clin Sports Med. 2011 Jan; 30(1):1-17, vii.View Related Profiles.
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
PMID: 21074078; PMCID: PMC2987636; DOI: 10.1016/j.csm.2010.08.006;.
Daneshvar DH, Baugh CM, Nowinski CJ, McKee AC, Stern RA, Cantu RC. Helmets and mouth guards: the role of personal equipment in preventing sport-related concussions. Clin Sports Med. 2011 Jan; 30(1):145-63, x.View Related Profiles.
McKee, Ann
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
Stern, Robert
PMID: 21074089; PMCID: PMC2987604; DOI: 10.1016/j.csm.2010.09.006;.
Gavett BE, Stern RA, McKee AC. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clin Sports Med. 2011 Jan; 30(1):179-88, xi.View Related Profiles.
McKee, Ann
Stern, Robert
PMID: 21074091; PMCID: PMC2995699; DOI: 10.1016/j.csm.2010.09.007;.
Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta Neuropathol. 2011 Apr; 121(4):487-98.View Related Profiles.
McKee, Ann
Ryu, Hoon
Lee, Junghee
Kowall, Neil
PMID: 21161248; PMCID: PMC3151672; DOI: 10.1007/s00401-010-0788-5;.
Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010; 5(10):e13250.View Related Profiles.
McKee, Ann
Wolozin, Benjamin
Sherman, Michael
Zaarur, Nava
Vanderweyde, Tara
PMID: 20948999; PMCID: PMC2952586; DOI: 10.1371/journal.pone.0013250;.
McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010 Sep; 69(9):918-29.View Related Profiles.
Budson, Andrew
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Kowall, Neil
Stern, Robert
PMID: 20720505; PMCID: PMC2951281; DOI: 10.1097/NEN.0b013e3181ee7d85;.
Gavett BE, Stern RA, Cantu RC, Nowinski CJ, McKee AC. Mild traumatic brain injury: a risk factor for neurodegeneration. Alzheimers Res Ther. 2010; 2(3):18.View Related Profiles.
McKee, Ann
Gavett, Brandon
Nowinski, Christopher
Stern, Robert
PMID: 20587081; PMCID: PMC2919698; DOI: 10.1186/alzrt42;.
Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673; PMCID: PMC2828525; DOI: 10.1038/ng.536;.
Yamin R, Zhao C, O'Connor PB, McKee AC, Abraham CR. Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Mol Neurodegener. 2009; 4:33.View Related Profiles.
McKee, Ann
Abraham, Carmela
PMID: 19627603; PMCID: PMC2726140; DOI: 10.1186/1750-1326-4-33;.
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009 Jul; 68(7):709-35.View Related Profiles.
Budson, Andrew
McKee, Ann
Gavett, Brandon
Nowinski, Christopher
Stern, Robert
PMID: 19535999; PMCID: PMC2945234; DOI: 10.1097/NEN.0b013e3181a9d503;.
Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11):1501-9.View Related Profiles.
McKee, Ann
Hamilton, James
Decano, Julius
Ruiz-Opazo, Nelson
Herrera, Victoria
PMID: 19273719; PMCID: PMC2825876; DOI: 10.1161/CIRCULATIONAHA.108.833327;.
T Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol. 2008 Dec; 65(12):1640-8.View Related Profiles.
McKee, Ann
Baldwin, Clinton
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
PMID: 19064752; PMCID: PMC2719762; DOI: 10.1001/archneur.65.12.1640;.
Harper DG, Stopa EG, Kuo-Leblanc V, McKee AC, Asayama K, Volicer L, Kowall N, Satlin A. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain. 2008 Jun; 131(Pt 6):1609-17.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 18372313; PMCID: PMC3286014; DOI: 10.1093/brain/awn049;.
Hanlon EB, Perelman LT, Vitkin EI, Greco FA, McKee AC, Kowall NW. Scattering differentiates Alzheimer disease in vitro. Opt Lett. 2008 Mar 15; 33(6):624-6.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 18347731.
McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 1; 1207:225-36.View Related Profiles.
Dedeoglu, Alpaslan
McKee, Ann
Ryu, Hoon
Carreras, Isabel
Kowall, Neil
PMID: 18374906; PMCID: PMC2587244; DOI: 10.1016/j.brainres.2008.01.095;.
Tobin JE, Cui J, Wilk JB, Latourelle JC, Laramie JM, McKee AC, Guttman M, Karamohamed S, DeStefano AL, Myers RH. Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain Res. 2007 Mar 30; 1139:42-7.View Related Profiles.
DeStefano, Anita
McKee, Ann
Latourelle, Jeanne
Myers, Richard
PMID: 17270157; PMCID: PMC1868471.
McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Wolf PA. Visual association pathology in preclinical Alzheimer disease. J Neuropathol Exp Neurol. 2006 Jun; 65(6):621-30.View Related Profiles.
McKee, Ann
Cabral, Howard
Kowall, Neil
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
PMID: 16783172.
Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. J Neurosci Res. 2006 May 15; 83(7):1262-70.View Related Profiles.
McKee, Ann
Carreras, Isabel
Ullman, M.
Fine, Richard
PMID: 16511862.
Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet. 2006 May; 38(5):518-20.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 16604072.
Wolozin B, Manger J, Bryant R, Cordy J, Green RC, McKee A. Re-assessing the relationship between cholesterol, statins and Alzheimer's disease. Acta Neurol Scand Suppl. 2006; 185:63-70.View Related Profiles.
McKee, Ann
Wolozin, Benjamin
PMID: 16866913.
Yip AG, McKee AC, Green RC, Wells J, Young H, Cupples LA, Farrer LA. APOE, vascular pathology, and the AD brain. Neurology. 2005 Jul 26; 65(2):259-65.View Related Profiles.
McKee, Ann
Cupples, L
Farrer, Lindsay
PMID: 16043796.
Harper DG, Volicer L, Stopa EG, McKee AC, Nitta M, Satlin A. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry. 2005 May; 13(5):359-68. PMID: 15879584.
Conn KJ, Gao W, McKee A, Lan MS, Ullman MD, Eisenhauer PB, Fine RE, Wells JM. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain Res. 2004 Oct 1; 1022(1-2):164-72.View Related Profiles.
McKee, Ann
Ullman, M.
Fine, Richard
PMID: 15353226.
Harper DG, Stopa EG, McKee AC, Satlin A, Fish D, Volicer L. Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease. Neurobiol Aging. 2004 Jul; 25(6):771-81. PMID: 15165702.
Georgopoulos S, McKee A, Kan HY, Zannis VI. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry. 2002 Jul 30; 41(30):9293-301.View Related Profiles.
McKee, Ann
Zannis, Vassilis
PMID: 12135350.
Volicer L, McKee A, Hewitt S. Dementia. Neurol Clin. 2001 Nov; 19(4):867-85. PMID: 11854104.
Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R, Volicer L. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry. 2001 Apr; 58(4):353-60. PMID: 11296096.
Chung TF, Sipe JD, McKee A, Fine RE, Schreiber BM, Liang JS, Johnson RJ. Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane. Amyloid. 2000 Jun; 7(2):105-10.View Related Profiles.
McKee, Ann
Schreiber, Barbara
Fine, Richard
PMID: 10842712.
Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, Ferrante RJ. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport. 2000 Jan 17; 11(1):211-3.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 10683860.
Volicer L, Wells JM, McKee AC, Kowall NW. Enhanced inhibition of free radical-induced deoxyribose breakdown by Alzheimer brain homogenates. Neurosci Lett. 1999 Aug 6; 270(3):169-72.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 10462121.
Hanlon EB, Itzkan I, Dasari RR, Feld MS, Ferrante RJ, McKee AC, Lathi D, Kowall NW. Near-infrared fluorescence spectroscopy detects Alzheimer's disease in vitro. Photochem Photobiol. 1999 Aug; 70(2):236-42.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 10461462.
McKee AC. Brain banking: basic science methods. Alzheimer Dis Assoc Disord. 1999 Apr-Jun; 13 Suppl 1:S39-44. PMID: 10369517.
McKee AC, Kowall NW, Schumacher JS, Beal MF. The neurotoxicity of amyloid beta protein in aged primates. Amyloid. 1998 Mar; 5(1):1-9.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 9546999.
Farrer LA, Abraham CR, Volicer L, Foley EJ, Kowall NW, McKee AC, Wells JM. Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. Exp Neurol. 1995 Dec; 136(2):162-70.View Related Profiles.
McKee, Ann
Abraham, Carmela
Farrer, Lindsay
Kowall, Neil
PMID: 7498406.
Vonsattel JP, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M, Gusella JF, Landwehrmeyer GB, Bird ED, Richardson EP, et al. An improved approach to prepare human brains for research. J Neuropathol Exp Neurol. 1995 Jan; 54(1):42-56. PMID: 7815079.
Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, McKee AC, Beal MF, Graham BH, Wallace DC. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics. 1994 Sep 15; 23(2):471-6. PMID: 7835898.
Markesbery WR, Wang HZ, Kowall NW, Kosik KS, McKee AC. Morphometric image analysis of neuropil threads in Alzheimer's disease. Neurobiol Aging. 1993 Jul-Aug; 14(4):303-7.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 8367011.
Delaney GA, McKee AC. Inter- and intra-rater reliability of the pressure threshold meter in measurement of myofascial trigger point sensitivity. Am J Phys Med Rehabil. 1993 Jun; 72(3):136-9. PMID: 8512674.
Nihei K, McKee AC, Kowall NW. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol. 1993; 86(1):55-64.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 8396837.
Kowall NW, McKee AC. The histopathology of neuronal degeneration and plasticity in Alzheimer disease. Adv Neurol. 1993; 59:5-33.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 8420123.
Kowall NW, McKee AC, Yankner BA, Beal MF. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging. 1992 Sep-Oct; 13(5):537-42.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 1461341.
McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol. 1991 Aug; 30(2):156-65.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 1910274.
McKee AC, Levine DN, Kowall NW, Richardson EP. Peduncular hallucinosis associated with isolated infarction of the substantia nigra pars reticulata. Ann Neurol. 1990 May; 27(5):500-4.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 2360791.
Newman NJ, Bell IR, McKee AC. Paraneoplastic limbic encephalitis: neuropsychiatric presentation. Biol Psychiatry. 1990 Mar 1; 27(5):529-42. PMID: 2155672.
McKee AC, Kosik KS, Kennedy MB, Kowall NW. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase. J Neuropathol Exp Neurol. 1990 Jan; 49(1):49-63.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 2153760.
McKee AC, Kowall NW, Kosik KS. Microtubular reorganization and dendritic growth response in Alzheimer's disease. Ann Neurol. 1989 Nov; 26(5):652-9.View Related Profiles.
McKee, Ann
Kowall, Neil
PMID: 2817839.
McKee AC, Winkelman MD, Banker BQ. Central pontine myelinolysis in severely burned patients: relationship to serum hyperosmolality. Neurology. 1988 Aug; 38(8):1211-7. PMID: 3399069.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 138 publications over 28 distinct years, with a maximum of 18 publications in 2015

Bar chart showing 138 publications over 28 distinct years, with a maximum of 18 publications in 2015

Year	Publications
1988	1
1989	1
1990	3
1991	1
1992	1
1993	4
1994	1
1995	2
1998	1
1999	3
2000	2
2001	2
2002	1
2004	2
2005	2
2006	4
2007	1
2008	4
2009	3
2010	5
2011	9
2012	10
2013	6
2014	12
2015	18
2016	12
2017	15
2018	12

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

neuropathological alterations of neurodegenerative diseases
tau protein
axonal injury
trauma
vascular injury
neurodegeneration
pathological disease
neuroanatomical localization of clinical symptoms

Contact for Mentoring:

Media Mentions

Recent (within 3 months)

Ann Mckee Elected to the National Academy of Medicine

BU Today 10/15/2018

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The Washington Post 10/11/2018

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60 Minutes – CBS News 9/16/2018

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CBS News 9/16/2018

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Baltimore Sun 9/5/2018

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

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Yahoo Finance 8/7/2018

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Futurity 5/2/2018

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BU Today 4/30/2018

Playing football young may mean earlier cognitive, emotional problems

CNN Health 4/30/2018

TIME’s 100 Most influential People: BU’s Ann McKee

Time 4/19/2018

Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so

Philly.com 4/19/2018

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Daily News 4/12/2018

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SB Nation 1/24/2018

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