Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
09/15/2021 - 08/31/2024 (Multi-PI)
PI: Ann C. McKee, MD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS122854-01

Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes
09/30/2019 - 07/31/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U54NS115266-03

An integrated biobanking platform for frontotemporal dementia research
12/01/2021 - 11/30/2023 (PI)
Rainwater Charitable Foundation


The Contribution of Age-Related Tauopathies to Alzheimer's Disease
09/30/2018 - 05/31/2023 (PI)
NIH/National Institute on Aging
5R01AG062348-04

Tau Pathology in Motor Regions and Parkinsonism in Chronic Traumatic Encephalopathy: A Comparison to Progressive Supranuclear Palsy and Corticobasal Degeneration
05/01/2022 - 04/30/2023 (Key Person / Mentor)
NIH/National Institute of Neurological Disorders & Stroke
1F31NS127449-01

Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
09/15/2017 - 08/31/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

Updating the Neuropathological Criteria for PSP
12/01/2020 - 07/31/2021 (Subcontract PI)
The Regents of the University of California, San Francisco Rainwater Char. Fdn


Personnel Agreement for Research Services of Rebecca Mathias
10/01/2019 - 04/30/2020 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Rebecca Mathias
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System


CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

Showing 10 of 30 results. Show All Results

1. Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096.View Related Profiles.

   Labadorf, Adam
   McKee, Ann
   Huber, Bertrand
   Brady, Christopher
   Mez, Jesse
   Alosco, Michael
   Kowall, Neil
   Aytan, Nurgul
   Stein, Thor
   Alvarez, Victor
   

   PMID: 35663558; PMCID: PMC9160996; DOI: 10.3389/fnins.2022.855096;
2. Colvin LE, Foster ZW, Stein TD, Thakore-James M, Salajegheh MK, Carr K, Spencer KR, Abdul Rauf N, Adams L, Averill JG, Walker SE, Robey I, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB. Utility of the ALSFRS-R for predicting ALS and comorbid disease neuropathology: The Veterans Affairs Biorepository Brain Bank. Muscle Nerve. 2022 May 18.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Brady, Christopher
   Thakore-James, Manisha
   Kowall, Neil
   Stein, Thor
   Alvarez, Victor
   

   PMID: 35585776
3. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 May 13.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Steinberg, Eric
   Jun, Gyungah
   Aparicio, Hugo
   Mez, Jesse
   Turk, Katherine
   Goldstein, Lee
   Alosco, Michael
   Kowall, Neil
   Au, Rhoda
   Stern, Robert
   Killiany, Ronald
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 35554506; DOI: 10.1093/brain/awac175;
4. Yang J, Chang S, Chen IA, Kura S, Rosen GA, Saltiel NA, Huber BR, Varadarajan D, Balbastre Y, Magnain C, Chen SC, Fischl B, Mckee AC, Boas D, Wang H. Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography. IEEE Trans Biomed Eng. 2022 May 13; PP.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Boas, David
   

   PMID: 35560084
5. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Jun 14; 98(24):e2454-e2464.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Steinberg, Eric
   Mez, Jesse
   Turk, Katherine
   Goldstein, Lee
   O'Connor, Maureen
   Alosco, Michael
   Kowall, Neil
   Au, Rhoda
   Stern, Robert
   Killiany, Ronald
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 35444054; PMCID: PMC9231841; DOI: 10.1212/WNL.0000000000200304;
6. LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Selection Bias Analysis Supports Dose-Response Relationship between Level of American Football Play and Chronic Traumatic Encephalopathy Diagnosis. Am J Epidemiol. 2022 Apr 16.View Related Profiles.

   McKee, Ann
   Nowinski, Christopher
   Weuve, Jennifer
   Mez, Jesse
   Fox, Matthew
   Alosco, Michael
   Tripodis, Yorghos
   

   PMID: 35434739; DOI: 10.1093/aje/kwac075;
7. Babcock KJ, Abdolmohammadi B, Kiernan PT, Mahar I, Cherry JD, Alvarez VE, Goldstein LE, Stein TD, McKee AC, Huber BR. Interface astrogliosis in contact sport head impacts and military blast exposure. Acta Neuropathol Commun. 2022 Apr 13; 10(1):52.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Mahar, Ian
   Cherry, Jonathan
   Babcock, Katharine
   Goldstein, Lee
   Stein, Thor
   Alvarez, Victor
   

   PMID: 35418116; PMCID: PMC9009003; DOI: 10.1186/s40478-022-01358-z;
8. Glass JD, Hammers JL, Omalu BL, Bieniek KF, Crary JF, Dickson DW, Stein TD, Mez J, Alosco ME, McKee AC. Erratum to Letters to the Editor regarding: The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol 2021;80(3):210-9. J Neuropathol Exp Neurol. 2022 Feb 24; 81(3):249.View Related Profiles.

   McKee, Ann
   Mez, Jesse
   Stein, Thor
   

   PMID: 35098301
9. Moncaster JA, Moir RD, Burton MA, Chadwick O, Minaeva O, Alvarez VE, Ericsson M, Clark JI, McKee AC, Tanzi RE, Goldstein LE. Alzheimer's disease amyloid-ß pathology in the lens of the eye. Exp Eye Res. 2022 Feb 21; 108974.View Related Profiles.

   McKee, Ann
   Moncaster, Juliet
   Goldstein, Lee
   Minaeva, Olga
   Alvarez, Victor
   

   PMID: 35202705
10. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles.

    Budson, Andrew
    McKee, Ann
    Huber, Bertrand
    Dwyer, Brigid
    Katz, Douglas
    Mez, Jesse
    Cherry, Jonathan
    Turk, Katherine
    Goldstein, Lee
    Alosco, Michael
    Kowall, Neil
    Stern, Robert
    Stein, Thor
    Alvarez, Victor
    Xia, Weiming
    Tripodis, Yorghos
    

    PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;

Showing 10 of 205 results. Show More

A degenerative disease: Doctor says not only concussions, but cumulative ‘sub-concussive’ blows to the head lead to CTE

What happened to Taylor?: Friends, family look back at the college football player who suffered from chronic traumatic encephalopathy

Brain Disorder Found in Some NFL Players Appears Rare in Combat Veterans, Study Finds

Family of late 49er Greg Clark shares story of his battle with CTE

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Brain exam confirms late college football star Colt Brennan suffered from CTE

‘It's the Continuous Hits’: Colt Brennan’s Family Learns CTE Played Role in His Death

Cialis and Brain Blood Flow; Sleep and Media Use; Can Tarantulas Solve Chronic Pain?

Former Canadiens star Backstrom had CTE, researcher says

Can COVID-19 alter your personality? Here's what brain research shows.

Everyday people fear they have CTE. A dubious market has sprung up to treat them

‘We thought it was just concussions’ – CTE and the death of Vincent Jackson

Former NFL wide receiver Vincent Jackson diagnosed with stage 2 CTE

Vincent Jackson, former NFL star found dead in hotel room in February, had stage 2 CTE, family says

NFL players are 4 times more likely to develop ALS, a new study shows

Dangers of CTE in former athletes

Former NFL star Vincent Jackson had stage 2 CTE when he died: family

Family of Former NFL WR Vincent Jackson Says Researchers Diagnosed Him With CTE

Widow of former NFL star Vincent Jackson speaks out for 1st time since his death, reveals CTE diagnosis

A new revelation unfolds in the death of former NFL receiver Vincent Jackson

A former NFL player who killed 6 had 'unusually severe' stage 2 CTE that can change behavior, expert says

NFL players are four times more likely to die of ALS, study finds

Morning Express With Robin Meade

New Day With John Berman and Brianna Keilar

Ex-NFL player Phillip Adams had same 'unusually severe' CTE as Aaron Hernandez when he killed six innocent neighbors and himself in April: Doctors blame league for IGNORING him when he begged for help

Ex-NFL player Phillip Adams had CTE at time of rampage that killed 6, doctors sa

Docs Reveal Ex-NFL Player Had Severe Brain Injury When He Killed 6

Boston University doctors say ex-NFL player Phillip Adams had CTE when he killed six people and himself

Former NFL player Phillip Adams had CTE when he allegedly gunned down 6 people: BU CTE Center

Autopsy: Severe brain trauma in ex-NFL player who shot 6

Ex-Patriot who killed six in murderous rampage suffered ‘unusually severe’ CTE, doc says

Phillip Adams suffered from extensive CTE

Former NFL player accused of killing six people was suffering from severe CTE

Autopsy finds severe brain trauma in ex-NFL player who shot 6 people

Former NFL Player Who Shot And Killed 6 Had 'Severe' CTE, Doctors Say

An ex-NFL player who killed 6 people and then himself had CTE, doctors say

Coroner: Ex-NFL player who killed six had severe CTE

Medical examiner says ex-NFL player Phillip Adams had CTE during S.C. shooting

Autopsy Of NFL Player Accused Of 6 Killings Reveals 'Unusually Severe' CTE

Former NFL player who killed six people had stage 2 CTE, autopsy finds

A former NFL player who killed 6 had 'unusually severe' stage 2 CTE that can change behavior, expert says

Former NFL player Phillip Adams, who shot to death six people and killed himself, suffered from CTE

NPR Investigates: CTE, Desperate Patients, And The Hope For A Cure (Pt 1)

Former Stanford player Zach Hoffpauir, who died accidentally, diagnosed with ‘startling’ CTE levels

Former Stanford football player Zach Hoffpauir posthumously diagnosed with CTE at 26

“He had no memories of it whatsoever’: How Chuck Crist’s family discovered he had CTE

Olympic Bobsledder Who Killed Himself Likely Had C.T.E.

Doctors provide consensus symptoms of CTE among living, a major step for researchers

More football leads to worse CTE, scientists say. Consider NFL great Willie Wood

Vincent Jackson's brain will be donated for CTE research

Super Bowl 2021: Dark side of the NFL including murder cases, suicides, & the horror brain disease found in dead players

How a Damaged Drainage System May Lead to More Severe Concussions

The Good Kind of Brain Drain

A new way of looking at concussions

Dr Ann McKee: Rugby is ready to explode. Children should not be playing it

The NFL and Nickelodeon made football kid-friendly. In light of concussions, is that wise?

Steve Thompson in group of ex-rugby union internationals to sue for brain damage

Steve Thompson in group of ex-rugby union internationals to sue for brain damage

Team Canada's Erin Ambrose donating brain for concussion research

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

Ministry Of Sport Brain Health Week Kicks Off With Dr. Ann McKee

Disease Caused by Concussions Led to Football Player’s Suicide: ‘He Wanted Us to Tell His Story’

Tackle Football in Childhood: Does Age Matter?

Researchers at BU hoping results from recent CTE study will help lead to development of treatments

L.A. firefighter fights against time in battle with ALS

We Know Repeated Head Hits Contribute to CTE—But What About Alzheimer’s Disease?

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

Helmets protect athletes’ skulls. Will the NFL use neuroscience to protect their brains?

In brains of dead athletes, researchers seek clues to head trauma

CTE doctor Bennet Omalu claims NFL behind Washington Post hit piece

Exactly How Dangerous Is Football?

What a lifetime of playing football can do to the human brain

Does Football Bear Responsibility for a Chiefs Legend’s 1980 Murder-Suicide?

What Does Football Do to the Brain?

The Perfect ’72 Dolphins and Football’s Ultimate Toll

From Scientist to Salesman

Experts rip doctor-turned-evangelist Bennet Omalu for CTE claims

Aaron Hernandez: Netflix documentary investigates CTE injury

Aaron Hernandez” 5 Bombshell Details We Learned From Netflix’s Docu-Series

How Netflix’s Aaron Hernandez documentary could bring attention back to the hidden epidemic in American’s national sport

Aaron Hernandez Netflix documentary: 10 questions still unanswered in ‘Killer Inside’

Netflix’s Aaron Hernandez Doc Examines the Full Story of the NFL Star Turned Convicted Murderer

CTE Rears its Ugly Head Again with New Aaron Hernandez Documentary

Netflix’s New Docuseries ‘Killer Inside’ Examines The Fall of Aaron Hernandez

'We NEED more studies': Neurologists demand urgent research into whether contact sports cause motor neurone disease after rugby star Rob Burrow is diagnosed aged 37

A Troubled Ex-USC Football Star Died at 31. His Family Hoped That Studying His Brain for CTE Would Help Others

Pro Soccer Players More Likely to Develop Dementia: Study

Pro Soccer Players More Likely to Develop Dementia: Study

Study reveals concussions in high school sports have dropped 40% since 2013 - but football head trauma that causes CTE is still on rise

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Watch: PSA Claims ‘Tackle Football Is Like Smoking’

More Years of Football, Higher Odds for Brain Disease Later

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

More Years of Football, Higher Odds for Brain Disease Later

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

CTE Risk Goes Up 30% For Each Year Of Playing Football

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

CTE Risk More Than Doubles after Just Three Years of Playing Football

CTE Risk, Severity Increases With Years Playing Football, Study Shows

The Transformers

Study Shows Hockey Great Stan Mikita Suffered from CTE

Why Women’s Soccer Players are Worried About Their Brains

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

Dementia Tied to White Matter Rarefaction in Football Players With CTE

Patriots Legend Nick Buoniconti Dies

Aaron Hernandez's estate reaches secret settlement with the families of two men the deceased ex-Patriots star was acquitted of killing during a night club altercation in 2012

Do Brain Injuries Affect Women Differently Than Men?

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Ann McKee Urges MED Graduates to Speak Up for the Voiceless

Exploring the real science behind tackle football's risks

For Patients With Memory Loss, Working Towards Better Diagnosis

Widow Of Hockey Enforcer Todd Ewen Blames NHL For CTE, His Death

The Tragic Post-Hockey Life of an NHL ‘Enforcer’

Four BU Professors Receive University’s Highest Faculty Honor

Gronk’s retirement becomes a flashpoint in CTE debate

Gronk Retires. Were Concussions and CTE a Factor?

Before CTE Diagnosis, Tommy Nobis’ Family Was Troubled By His Behavior

A somber Super Bowl reminder in ‘Mr. Falcon’ CTE diagnosis

Subconcussive Head Impacts Alter Oculomotor Responses

Tim Green’s ALS: Is it fair to blame football?

Why We Still Don’t Know How Many NFL Players Have CTE

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

Ex-Patriot Kevin Turner’s children are battling the nurse who became his wife and heir

Doctors Said Hockey Enforcer Todd Ewen Did Not Have C.T.E. But He Did

Gene Variation May Explain Most Severe CTE

VA researchers named most influential people in health care by TIME magazine

T 100 2018

Why Some People Develop More Severe CTE Symptoms than Others

NHL Won't Admit Liability, Will Pay Around $19 Million In Concussion Lawsuit Settlement

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

Specific Gene Variant Linked To Severe Symptoms Of CTE

Why Some People’s CTE Symptoms Are More Severe Than Others

Analysis shows 147 college football programs had at least one player diagnosed with CTE

In football, CTE skeptics like Merril Hoge challenge brain-damage conclusions, but Doug Baldwin cites ‘common sense’

Merril Hoge, co-author of new book are way off target in discussing football, CTE

10 key points from Gladiator: Aaron Hernandez and Football Inc.

How one flawed study and irresponsible reporting launched a wave of CTE hysteria

A Terrible Thing To Waste

Ann Mckee Elected to the National Academy of Medicine

CTE researchers seek to study more female brains

Scientists seek veterans to help treat CTE

Combat veterans coming home with CTE

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Researchers close in on CTE diagnosis in living, one brain at a time

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

Another CTE diagnosis in soccer adds to growing concern

Athletes Who May Have Suffered From CTE — And The Tragic Outcomes

Boynton joins NHL concussion lawsuit, pledges brain to science

NHL Commissioner Bettman sidesteps question about concussions

Naperville Park District latest to add flag football as parents' fear of concussions grows

The Tragic Diagnosis They Already Knew: Their Brother Died With C.T.E.

Former NHLer Parker had CTE when he died

Starting tackle football early sets kids up for brain problems

MED Researchers: Youth Football Linked to Earlier Brain Problems

Playing football young may mean earlier cognitive, emotional problems

TIME’s 100 Most influential People: BU’s Ann McKee

Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so

Experts say CTE ‘is associated with ice hockey play'

Family of Late Minnesota Hockey Star Waiting for Results from CTE Lab

Former Seahawks' brains shed light on NFL head injuries

Intercepted Podcast Bonus: The NFL’s Violent Ballet

Bob Costas will skip the Super Bowl because of the NFL’s connection to brain trauma

Kevin Turner’s rugged road