Ann C. McKee, MD
William Fairfield Warren Distinguished Professor
Boston University School of Medicine
Dept of Neurology

MD, Case School of Medicine

Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Boston University School of Medicine
Pathology & Laboratory Medicine

Framingham Heart Study

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

VA Boston Healthcare System

2018 Time Magazine: 100 Most Influential People of 2018
2018 Alzheimer’s Association: Henry Wisniewski Lifetime Achievement Award

Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes
09/30/2019 - 07/31/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke

The Contribution of Age-Related Tauopathies to Alzheimer's Disease
09/30/2018 - 05/31/2023 (PI)
NIH/National Institute on Aging

Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
09/15/2017 - 03/31/2022 (PI)
NIH/National Institute on Aging

Updating the Neuropathological Criteria for PSP
12/01/2020 - 07/31/2021 (Subcontract PI)
The Regents of the University of California, San Francisco Rainwater Char. Fdn

Personnel Agreement for Research Services of Rebecca Mathias
10/01/2019 - 04/30/2020 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Rebecca Mathias
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System

CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Biochemical and Genetic Investigation of Tau in Chronic Encephalopathy
11/01/2015 - 10/31/2018 (Subcontract PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch

Personnel Agreement for Research Services of David Kwasnik
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Bobak Abdolmohammadi
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Showing 10 of 27 results. Show All Results

Boston University Alzheimer's Disease Core Center
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
CENC-VA TBI Brain Tissue Repository
Molecular and Genetic Investigation of Tau in Chronic Traumatic Encephalopathy (CTE)

Yr Title Project-Sub Proj Pubs
2021 Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms 1RF1NS122854-01
2021 Core D: Neuropathology Core 1P30AG072978-01-9744
2021 Neuropath Core 5U19AG068753-02-8038
2021 CTBI:CBI Tauopathy in Mice and Human: Neurodegeneration after Repetitive Neurotrauma: Mechanisms and Biomarker Discovery 5I01BX004613-02
2021 Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes 5U54NS115266-03
2021 Admin Core 5U54NS115266-03-6597
2021 Brain Bank Core 5U54NS115266-03-6599
2021 The Contribution of Age-Related Tauopathies to Alzheimer's Disease 5R01AG062348-04 6
2021 VA Biorepository Brain Bank 5I01BX002466-08 8
2020 Neuropath Core 1U19AG068753-01-8038
Showing 10 of 55 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI. Tau seeding in chronic traumatic encephalopathy parallels disease severity. Acta Neuropathol. 2021 Oct 09.View Related Profiles. PMID: 34626223
  2. Cherry JD, Agus F, Dixon E, Huber B, Alvarez VE, Mez J, McKee AC, Labadorf A, Stein TD. Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free Neuropathol. 2021; 2.View Related Profiles. PMID: 34485990; PMCID: PMC8415801; DOI: 10.17879/freeneuropathology-2021-3453;
  3. Alosco ML, Mariani ML, Adler CH, Balcer LJ, Bernick C, Au R, Banks SJ, Barr WB, Bouix S, Cantu RC, Coleman MJ, Dodick DW, Farrer LA, Geda YE, Katz DI, Koerte IK, Kowall NW, Lin AP, Marcus DS, Marek KL, McClean MD, McKee AC, Mez J, Palmisano JN, Peskind ER, Tripodis Y, Turner RW, Wethe JV, Cummings JL, Reiman EM, Shenton ME, Stern RA. Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project. Alzheimers Res Ther. 2021 08 12; 13(1):136.View Related Profiles. PMID: 34384490; PMCID: PMC8357968; DOI: 10.1186/s13195-021-00872-x;
  4. Mez J, Alosco ML, Nowinski CJ, McKee AC, Tripodis Y. Reader Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players. Neurology. 2021 08 10; 97(6):297-298.View Related Profiles. PMID: 34373356; DOI: 10.1212/WNL.0000000000012381;
  5. Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, Dickson DW, McKee AC, Stein TD, Trojanowski JQ, Woltjer RL, Kovacs GG, Kofler JK, Kaye J, White CL, Crary JF. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathol Commun. 2021 08 05; 9(1):134.View Related Profiles. PMID: 34353357; PMCID: PMC8340493; DOI: 10.1186/s40478-021-01233-3;
  6. Gutierrez-Quiceno L, Dammer EB, Johnson AG, Webster JA, Shah R, Duong D, Yin L, Seyfried NT, Alvarez VE, Stein TD, McKee AC, Hales CM. A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy. Mol Neurodegener. 2021 06 25; 16(1):40.View Related Profiles. PMID: 34172091; PMCID: PMC8235576; DOI: 10.1186/s13024-021-00462-3;
  7. Chancellor KB, Chancellor SE, Duke-Cohan JE, Huber BR, Stein TD, Alvarez VE, Okaty BW, Dymecki SM, McKee AC. Altered oligodendroglia and astroglia in chronic traumatic encephalopathy. Acta Neuropathol. 2021 08; 142(2):295-321.View Related Profiles. PMID: 34019156; PMCID: PMC8270845; DOI: 10.1007/s00401-021-02322-2;
  8. Cherry JD, Esnault CD, Baucom ZH, Tripodis Y, Huber BR, Alvarez VE, Stein TD, Dickson DW, McKee AC. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta Neuropathol Commun. 2021 05 12; 9(1):86.View Related Profiles. PMID: 33980303; PMCID: PMC8114683; DOI: 10.1186/s40478-021-01189-4;
  9. Mez J, Alosco ML, Daneshvar DH, Saltiel N, Baucom Z, Abdolmohammadi B, Uretsky M, Nicks R, Martin BM, Palmisano JN, Nowinski CJ, Montenigro P, Solomon TM, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Goldstein LE, Katz DI, Cantu RC, Kowall NW, Tripodis Y, Huber BR, Stein TD, Stern RA, McKee AC. Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology. Alzheimers Dement. 2021 Apr 07.View Related Profiles. PMID: 33826224
  10. Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O'Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley ÉM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome. Neurology. 2021 05 04; 96(18):848-863.View Related Profiles. PMID: 33722990; PMCID: PMC8166432; DOI: 10.1212/WNL.0000000000011850;
Showing 10 of 187 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 187 publications over 31 distinct years, with a maximum of 18 publications in 2015


Recent (within 3 months)

Former Stanford player Zach Hoffpauir, who died accidentally, diagnosed with ‘startling’ CTE levels

The Mercury News 8/24/2021

Former Stanford football player Zach Hoffpauir posthumously diagnosed with CTE at 26

SFGate 8/24/2021


“He had no memories of it whatsoever’: How Chuck Crist’s family discovered he had CTE

Buffalo News 7/11/2021

Olympic Bobsledder Who Killed Himself Likely Had C.T.E.

New York Times 4/8/2021

Doctors provide consensus symptoms of CTE among living, a major step for researchers

The Washington Post 3/15/2021

More football leads to worse CTE, scientists say. Consider NFL great Willie Wood

The Washington Post 3/12/2021

Vincent Jackson's brain will be donated for CTE research

USA Today 2/18/2021

Super Bowl 2021: Dark side of the NFL including murder cases, suicides, & the horror brain disease found in dead players

The Sun 2/7/2021

How a Damaged Drainage System May Lead to More Severe Concussions

Smithsonian Magazine 2/1/2021

The Good Kind of Brain Drain

The Atlantic 1/23/2021

A new way of looking at concussions

Knowable Magazine 1/20/2021

Dr Ann McKee: Rugby is ready to explode. Children should not be playing it

The Times 1/13/2021

The NFL and Nickelodeon made football kid-friendly. In light of concussions, is that wise?

Yahoo 1/13/2021

Steve Thompson in group of ex-rugby union internationals to sue for brain damage

BBC 12/8/2020

Steve Thompson in group of ex-rugby union internationals to sue for brain damage

BBC 12/8/2020

Team Canada's Erin Ambrose donating brain for concussion research

The Sudbury Star 12/1/2020

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

League of Fans 10/29/2020

Ministry Of Sport Brain Health Week Kicks Off With Dr. Ann McKee

Ministry of Sport 9/13/2020

Disease Caused by Concussions Led to Football Player’s Suicide: ‘He Wanted Us to Tell His Story’

People Magazine 9/10/2020

Tackle Football in Childhood: Does Age Matter?

Medpage Today 9/10/2020

Researchers at BU hoping results from recent CTE study will help lead to development of treatments

WHDH-TV 8/11/2020

L.A. firefighter fights against time in battle with ALS

The Los Angeles Times 5/22/2020

We Know Repeated Head Hits Contribute to CTE—But What About Alzheimer’s Disease?

BU Today 4/29/2020

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

People 3/14/2020

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

People Magazine 3/14/2020

Helmets protect athletes’ skulls. Will the NFL use neuroscience to protect their brains?

Salon 3/9/2020

In brains of dead athletes, researchers seek clues to head trauma

Reuters 2/20/2020

In Brains of Dead Athletes, Researchers Seek Clues to Head Trauma

Reuters 2/20/2020

CTE doctor Bennet Omalu claims NFL behind Washington Post hit piece

New York Post 2/10/2020

Exactly How Dangerous Is Football?

The New Yorker 2/1/2020

What a lifetime of playing football can do to the human brain

VOX 2/1/2020

Does Football Bear Responsibility for a Chiefs Legend’s 1980 Murder-Suicide?

Slate 1/31/2020

What Does Football Do to the Brain?

BU Today 1/30/2020

The Perfect ’72 Dolphins and Football’s Ultimate Toll

The New York Times 1/30/2020

From Scientist to Salesman

The Washington Post 1/22/2020

Experts rip doctor-turned-evangelist Bennet Omalu for CTE claims

The New York Post 1/22/2020

Aaron Hernandez: Netflix documentary investigates CTE injury

Fox Sports Australia 1/20/2020

Aaron Hernandez” 5 Bombshell Details We Learned From Netflix’s Docu-Series

BET 1/17/2020

How Netflix’s Aaron Hernandez documentary could bring attention back to the hidden epidemic in American’s national sport

The Independent 1/16/2020

Aaron Hernandez Netflix documentary: 10 questions still unanswered in ‘Killer Inside’

Mass Live 1/15/2020

Netflix’s Aaron Hernandez Doc Examines the Full Story of the NFL Star Turned Convicted Murderer

Esquire 1/15/2020

CTE Rears its Ugly Head Again with New Aaron Hernandez Documentary

LA Times 1/15/2020

Netflix’s New Docuseries ‘Killer Inside’ Examines The Fall of Aaron Hernandez

Oxygen 1/8/2020

'We NEED more studies': Neurologists demand urgent research into whether contact sports cause motor neurone disease after rugby star Rob Burrow is diagnosed aged 37

Daily Mail 12/20/2019

A Troubled Ex-USC Football Star Died at 31. His Family Hoped That Studying His Brain for CTE Would Help Others

LA Times 12/3/2019

Pro Soccer Players More Likely to Develop Dementia: Study

U.S. News & World Report 10/21/2019

Pro Soccer Players More Likely to Develop Dementia: Study

HealthDay 10/21/2019

Study reveals concussions in high school sports have dropped 40% since 2013 - but football head trauma that causes CTE is still on rise

The Daily Mail 10/15/2019

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Sporting News 10/14/2019

Watch: PSA Claims ‘Tackle Football Is Like Smoking’

Breitbart 10/14/2019

More Years of Football, Higher Odds for Brain Disease Later

HealthDay 10/10/2019

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

ZME Science 10/9/2019

More Years of Football, Higher Odds for Brain Disease Later

U.S. News & World Report 10/9/2019

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

Daily Mail 10/8/2019

CTE Risk Goes Up 30% For Each Year Of Playing Football

Futurity 10/8/2019

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Daily Mail 10/8/2019

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

The Daily Wire 10/8/2019

CTE Risk More Than Doubles after Just Three Years of Playing Football

BU Today 10/7/2019

CTE Risk, Severity Increases With Years Playing Football, Study Shows

Boston Herald 10/7/2019

The Transformers

BU Today 9/20/2019

Study Shows Hockey Great Stan Mikita Suffered from CTE

AP 9/13/2019

Why Women’s Soccer Players are Worried About Their Brains

Bleacher Report 9/10/2019

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

Forbes 9/2/2019

Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Patriots Legend Nick Buoniconti Dies

BU Today 8/1/2019

Aaron Hernandez's estate reaches secret settlement with the families of two men the deceased ex-Patriots star was acquitted of killing during a night club altercation in 2012

Daily Mail 7/26/2019

Do Brain Injuries Affect Women Differently Than Men?

New York Times Magazine 6/26/2019

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Genetic Literacy Project 6/13/2019

Ann McKee Urges MED Graduates to Speak Up for the Voiceless

BU Today 5/28/2019

Exploring the real science behind tackle football's risks

WPVI-TV 5/28/2019

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

Widow Of Hockey Enforcer Todd Ewen Blames NHL For CTE, His Death

NBC News 5/6/2019

The Tragic Post-Hockey Life of an NHL ‘Enforcer’

The Atlantic 4/25/2019

Four BU Professors Receive University’s Highest Faculty Honor

BU Today 4/20/2019

Gronk’s retirement becomes a flashpoint in CTE debate

NBC Sports 3/30/2019

Gronk Retires. Were Concussions and CTE a Factor?

BU Today 3/27/2019

Before CTE Diagnosis, Tommy Nobis’ Family Was Troubled By His Behavior

Atlanta Journal Constitution 1/30/2019

A somber Super Bowl reminder in ‘Mr. Falcon’ CTE diagnosis

Associated Press 1/29/2019

Subconcussive Head Impacts Alter Oculomotor Responses

Reuters Health 12/26/2018

Tim Green’s ALS: Is it fair to blame football?

Syracuse 12/17/2018

Why We Still Don’t Know How Many NFL Players Have CTE

Five Thirty Eight 12/17/2018

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Ex-Patriot Kevin Turner’s children are battling the nurse who became his wife and heir

The Boston Globe 12/7/2018

Doctors Said Hockey Enforcer Todd Ewen Did Not Have C.T.E. But He Did

The New York Times 11/30/2018

Gene Variation May Explain Most Severe CTE

Futurity 11/29/2018

VA researchers named most influential people in health care by TIME magazine

Military Times 11/28/2018

T 100 2018

Time 11/28/2018

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

NHL Won't Admit Liability, Will Pay Around $19 Million In Concussion Lawsuit Settlement

Deadspin 11/13/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

CBS News 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Analysis shows 147 college football programs had at least one player diagnosed with CTE

USA Today 11/2/2018

In football, CTE skeptics like Merril Hoge challenge brain-damage conclusions, but Doug Baldwin cites ‘common sense’

The Seattle Times 10/26/2018

Merril Hoge, co-author of new book are way off target in discussing football, CTE

USA Today 10/24/2018

10 key points from Gladiator: Aaron Hernandez and Football Inc.

The Boston Globe 10/23/2018

How one flawed study and irresponsible reporting launched a wave of CTE hysteria

Yahoo Sports 10/23/2018

A Terrible Thing To Waste

The Boston Globe 10/18/2018

Ann Mckee Elected to the National Academy of Medicine

BU Today 10/15/2018

CTE researchers seek to study more female brains

The Washington Post 10/11/2018

Scientists seek veterans to help treat CTE

60 Minutes – CBS News 9/16/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Baltimore Sun 9/5/2018

Researchers close in on CTE diagnosis in living, one brain at a time

USA Today 8/24/2018

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

Los Angeles Times 8/8/2018

Another CTE diagnosis in soccer adds to growing concern

Yahoo Finance 8/7/2018

Athletes Who May Have Suffered From CTE — And The Tragic Outcomes

Oxygen 6/26/2018

Boynton joins NHL concussion lawsuit, pledges brain to science

TSN 6/21/2018

NHL Commissioner Bettman sidesteps question about concussions

Los Angeles Times 5/28/2018

Naperville Park District latest to add flag football as parents' fear of concussions grows

Chicago Tribune 5/5/2018

The Tragic Diagnosis They Already Knew: Their Brother Died With C.T.E.

The New York Times 5/3/2018

Former NHLer Parker had CTE when he died

TSN 5/3/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing football young may mean earlier cognitive, emotional problems

CNN Health 4/30/2018

TIME’s 100 Most influential People: BU’s Ann McKee

Time 4/19/2018

Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so 4/19/2018

Experts say CTE ‘is associated with ice hockey play'

Daily News 4/12/2018

Family of Late Minnesota Hockey Star Waiting for Results from CTE Lab

KSTP 2/27/2018

Former Seahawks' brains shed light on NFL head injuries

King 5 News 2/21/2018

Intercepted Podcast Bonus: The NFL’s Violent Ballet

The Intercept 2/1/2018

Bob Costas will skip the Super Bowl because of the NFL’s connection to brain trauma

SB Nation 1/24/2018

Kevin Turner’s rugged road

ESPN 3/16/2011
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