Ann C. McKee, MD
William Fairfield Warren Distinguished Professor
Boston University School of Medicine
Dept of Neurology

MD, Case School of Medicine




Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


VA Boston Healthcare System



2018 Time Magazine: 100 Most Influential People of 2018
2018 Alzheimer’s Association: Henry Wisniewski Lifetime Achievement Award


Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes
09/30/2019 - 07/31/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1U54NS115266-01

The Contribution of Age-Related Tauopathies to Alzheimer's Disease
09/30/2018 - 05/31/2023 (PI)
NIH/National Institute on Aging
5R01AG062348-02

Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
09/15/2017 - 03/31/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

Personnel Agreement for Research Services of Rebecca Mathias
10/01/2019 - 04/30/2020 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Rebecca Mathias
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System


CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

Biochemical and Genetic Investigation of Tau in Chronic Encephalopathy
11/01/2015 - 10/31/2018 (Subcontract PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch


Personnel Agreement for Research Services of David Kwasnik
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Bobak Abdolmohammadi
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Jason Miller
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Showing 10 of 26 results. Show All Results


Title
Boston University Alzheimer's Disease Core Center
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
CENC-VA TBI Brain Tissue Repository
Molecular and Genetic Investigation of Tau in Chronic Traumatic Encephalopathy (CTE)


Yr Title Project-Sub Proj Pubs
2020 CTBI:CBI Tauopathy in Mice and Human: Neurodegeneration after Repetitive Neurotrauma: Mechanisms and Biomarker Discovery 1I01BX004613-01
2019 Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes 1U54NS115266-01
2019 ShEEP Request for Nikon N-Storm Super-resolution microscope 1IS1BX004787-01
2019 The Contribution of Age-Related Tauopathies to Alzheimer's Disease 5R01AG062348-02 6
2019 CENC-VA TBI Brain Tissue Repository 5I01RX002170-04 2
2019 Core D: Neuropathology Core 5P30AG013846-23-6897 874
2019 Admin Core 1U54NS115266-01-6597
2019 Brain Bank Core 1U54NS115266-01-6599
2018 The Contribution of Age-Related Tauopathies to Alzheimer's Disease 1R01AG062348-01 6
2018 CENC-VA TBI Brain Tissue Repository 5I01RX002170-03 2
Showing 10 of 41 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Adams JW, Alosco ML, Mez J, Alvarez VE, Huber BR, Tripodis Y, Adler CH, Kubilius C, Cormier KA, Mathais R, Nicks R, Kelley HJ, Saltiel N, Uretsky M, Nair E, Aytan N, Cherry JD, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy. Acta Neuropathol. 2020 Sep 17.View Related Profiles. PMID: 32939646
     
  2. Mez J, Stern RA, McKee AC. Chronic Traumatic Encephalopathy. Semin Neurol. 2020 Aug; 40(4):351-352.View Related Profiles. PMID: 32906179
     
  3. Warling A, Uchida R, Shin H, Dodelson C, Garcia ME, Shea-Shumsky NB, Svirsky S, Pothast M, Kelley H, Schumann CM, Brzezinski C, Bauman MD, Alexander A, McKee AC, Stein TD, Schall M, Jacobs B. Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration. J Comp Neurol. 2020 Sep 01.View Related Profiles. PMID: 32869318
     
  4. Alosco ML, Cherry JD, Huber BR, Tripodis Y, Baucom Z, Kowall NW, Saltiel N, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Palmisano JN, Martin B, Cantu RC, Stern RA, Alvarez VE, Mez J, Stein TD, McKee AC. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme. Acta Neuropathol. 2020 Oct; 140(4):495-512.View Related Profiles. PMID: 32778942
     
  5. Mez J, Daneshvar DH, Alosco ML, Alvarez VE, Huber BR, Stein TD, McKee AC. Reply to "Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy". Ann Neurol. 2020 Aug 04.View Related Profiles. PMID: 32754941
     
  6. McKee AC, Stein TD, Crary JF, Bieniek KF, Cantu RC, Kovacs GG. Practical Considerations in the Diagnosis of Mild Chronic Traumatic Encephalopathy and Distinction From Age-Related Tau Astrogliopathy. J Neuropathol Exp Neurol. 2020 Aug 01; 79(8):921-924.View Related Profiles. PMID: 32688381
     
  7. McKee AC. The Neuropathology of Chronic Traumatic Encephalopathy: The Status of the Literature. Semin Neurol. 2020 Aug; 40(4):359-369. PMID: 32712946
     
  8. Spencer KR, Foster ZW, Rauf NA, Guilderson L, Collins D, Averill JG, Walker SE, Robey I, Cherry JD, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB, Stein TD. Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans. Brain Pathol. 2020 Jul 07.View Related Profiles. PMID: 32633852
     
  9. Cherry JD, Kim SH, Stein TD, Pothast MJ, Nicks R, Meng G, Huber BR, Mez J, Alosco ML, Tripodis Y, Farrell K, Alvarez VE, McKee AC, Crary JF. Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain Pathol. 2020 Sep; 30(5):913-925.View Related Profiles. PMID: 32500646; DOI: 10.1111/bpa.12867;
     
  10. Alosco ML, Tripodis Y, Baucom ZH, Mez J, Stein TD, Martin B, Haller O, Conneely S, McClean M, Nosheny R, Mackin S, McKee AC, Weiner MW, Stern RA. Late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology. 2020 Aug 18; 95(7):e793-e804.View Related Profiles. PMID: 32591472; DOI: 10.1212/WNL.0000000000010040;
     
Showing 10 of 172 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 172 publications over 30 distinct years, with a maximum of 18 publications in 2015

YearPublications
19882
19891
19903
19911
19921
19934
19941
19952
19981
19993
20002
20012
20021
20042
20052
20064
20071
20084
20093
20105
20119
201210
20136
201412
201518
201612
201715
201816
201916
202013


Recent (within 3 months)

Ministry Of Sport Brain Health Week Kicks Off With Dr. Ann McKee

Ministry of Sport 9/13/2020

Disease Caused by Concussions Led to Football Player’s Suicide: ‘He Wanted Us to Tell His Story’

People Magazine 9/10/2020

Tackle Football in Childhood: Does Age Matter?

Medpage Today 9/10/2020

Researchers at BU hoping results from recent CTE study will help lead to development of treatments

WHDH-TV 8/11/2020

Older

L.A. firefighter fights against time in battle with ALS

The Los Angeles Times 5/22/2020

We Know Repeated Head Hits Contribute to CTE—But What About Alzheimer’s Disease?

BU Today 4/29/2020

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

People 3/14/2020

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

People Magazine 3/14/2020

Helmets protect athletes’ skulls. Will the NFL use neuroscience to protect their brains?

Salon 3/9/2020

In brains of dead athletes, researchers seek clues to head trauma

Reuters 2/20/2020

In Brains of Dead Athletes, Researchers Seek Clues to Head Trauma

Reuters 2/20/2020

CTE doctor Bennet Omalu claims NFL behind Washington Post hit piece

New York Post 2/10/2020

Exactly How Dangerous Is Football?

The New Yorker 2/1/2020

What a lifetime of playing football can do to the human brain

VOX 2/1/2020

Does Football Bear Responsibility for a Chiefs Legend’s 1980 Murder-Suicide?

Slate 1/31/2020

What Does Football Do to the Brain?

BU Today 1/30/2020

The Perfect ’72 Dolphins and Football’s Ultimate Toll

The New York Times 1/30/2020

From Scientist to Salesman

The Washington Post 1/22/2020

Experts rip doctor-turned-evangelist Bennet Omalu for CTE claims

The New York Post 1/22/2020

Aaron Hernandez: Netflix documentary investigates CTE injury

Fox Sports Australia 1/20/2020

Aaron Hernandez” 5 Bombshell Details We Learned From Netflix’s Docu-Series

BET 1/17/2020

How Netflix’s Aaron Hernandez documentary could bring attention back to the hidden epidemic in American’s national sport

The Independent 1/16/2020

Aaron Hernandez Netflix documentary: 10 questions still unanswered in ‘Killer Inside’

Mass Live 1/15/2020

Netflix’s Aaron Hernandez Doc Examines the Full Story of the NFL Star Turned Convicted Murderer

Esquire 1/15/2020

CTE Rears its Ugly Head Again with New Aaron Hernandez Documentary

LA Times 1/15/2020

Netflix’s New Docuseries ‘Killer Inside’ Examines The Fall of Aaron Hernandez

Oxygen 1/8/2020

'We NEED more studies': Neurologists demand urgent research into whether contact sports cause motor neurone disease after rugby star Rob Burrow is diagnosed aged 37

Daily Mail 12/20/2019

A Troubled Ex-USC Football Star Died at 31. His Family Hoped That Studying His Brain for CTE Would Help Others

LA Times 12/3/2019

Pro Soccer Players More Likely to Develop Dementia: Study

U.S. News & World Report 10/21/2019

Pro Soccer Players More Likely to Develop Dementia: Study

HealthDay 10/21/2019

Study reveals concussions in high school sports have dropped 40% since 2013 - but football head trauma that causes CTE is still on rise

The Daily Mail 10/15/2019

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Sporting News 10/14/2019

Watch: PSA Claims ‘Tackle Football Is Like Smoking’

Breitbart 10/14/2019

More Years of Football, Higher Odds for Brain Disease Later

HealthDay 10/10/2019

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

ZME Science 10/9/2019

More Years of Football, Higher Odds for Brain Disease Later

U.S. News & World Report 10/9/2019

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

Daily Mail 10/8/2019

CTE Risk Goes Up 30% For Each Year Of Playing Football

Futurity 10/8/2019

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Daily Mail 10/8/2019

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

The Daily Wire 10/8/2019

CTE Risk More Than Doubles after Just Three Years of Playing Football

BU Today 10/7/2019

CTE Risk, Severity Increases With Years Playing Football, Study Shows

Boston Herald 10/7/2019

The Transformers

BU Today 9/20/2019

Study Shows Hockey Great Stan Mikita Suffered from CTE

AP 9/13/2019

Why Women’s Soccer Players are Worried About Their Brains

Bleacher Report 9/10/2019

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

Forbes 9/2/2019

Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Patriots Legend Nick Buoniconti Dies

BU Today 8/1/2019

Aaron Hernandez's estate reaches secret settlement with the families of two men the deceased ex-Patriots star was acquitted of killing during a night club altercation in 2012

Daily Mail 7/26/2019

Do Brain Injuries Affect Women Differently Than Men?

New York Times Magazine 6/26/2019

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Genetic Literacy Project 6/13/2019

Ann McKee Urges MED Graduates to Speak Up for the Voiceless

BU Today 5/28/2019

Exploring the real science behind tackle football's risks

WPVI-TV 5/28/2019

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

Widow Of Hockey Enforcer Todd Ewen Blames NHL For CTE, His Death

NBC News 5/6/2019

The Tragic Post-Hockey Life of an NHL ‘Enforcer’

The Atlantic 4/25/2019

Four BU Professors Receive University’s Highest Faculty Honor

BU Today 4/20/2019

Gronk’s retirement becomes a flashpoint in CTE debate

NBC Sports 3/30/2019

Gronk Retires. Were Concussions and CTE a Factor?

BU Today 3/27/2019

Before CTE Diagnosis, Tommy Nobis’ Family Was Troubled By His Behavior

Atlanta Journal Constitution 1/30/2019

A somber Super Bowl reminder in ‘Mr. Falcon’ CTE diagnosis

Associated Press 1/29/2019

Subconcussive Head Impacts Alter Oculomotor Responses

Reuters Health 12/26/2018

Tim Green’s ALS: Is it fair to blame football?

Syracuse 12/17/2018

Why We Still Don’t Know How Many NFL Players Have CTE

Five Thirty Eight 12/17/2018

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Ex-Patriot Kevin Turner’s children are battling the nurse who became his wife and heir

The Boston Globe 12/7/2018

Doctors Said Hockey Enforcer Todd Ewen Did Not Have C.T.E. But He Did

The New York Times 11/30/2018

Gene Variation May Explain Most Severe CTE

Futurity 11/29/2018

VA researchers named most influential people in health care by TIME magazine

Military Times 11/28/2018

T 100 2018

Time 11/28/2018

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

NHL Won't Admit Liability, Will Pay Around $19 Million In Concussion Lawsuit Settlement

Deadspin 11/13/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

CBS News 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Analysis shows 147 college football programs had at least one player diagnosed with CTE

USA Today 11/2/2018

In football, CTE skeptics like Merril Hoge challenge brain-damage conclusions, but Doug Baldwin cites ‘common sense’

The Seattle Times 10/26/2018

Merril Hoge, co-author of new book are way off target in discussing football, CTE

USA Today 10/24/2018

10 key points from Gladiator: Aaron Hernandez and Football Inc.

The Boston Globe 10/23/2018

How one flawed study and irresponsible reporting launched a wave of CTE hysteria

Yahoo Sports 10/23/2018

A Terrible Thing To Waste

The Boston Globe 10/18/2018

Ann Mckee Elected to the National Academy of Medicine

BU Today 10/15/2018

CTE researchers seek to study more female brains

The Washington Post 10/11/2018

Scientists seek veterans to help treat CTE

60 Minutes – CBS News 9/16/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Baltimore Sun 9/5/2018

Researchers close in on CTE diagnosis in living, one brain at a time

USA Today 8/24/2018

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

Los Angeles Times 8/8/2018

Another CTE diagnosis in soccer adds to growing concern

Yahoo Finance 8/7/2018

Athletes Who May Have Suffered From CTE — And The Tragic Outcomes

Oxygen 6/26/2018

Boynton joins NHL concussion lawsuit, pledges brain to science

TSN 6/21/2018

NHL Commissioner Bettman sidesteps question about concussions

Los Angeles Times 5/28/2018

Naperville Park District latest to add flag football as parents' fear of concussions grows

Chicago Tribune 5/5/2018

The Tragic Diagnosis They Already Knew: Their Brother Died With C.T.E.

The New York Times 5/3/2018

Former NHLer Parker had CTE when he died

TSN 5/3/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing football young may mean earlier cognitive, emotional problems

CNN Health 4/30/2018

TIME’s 100 Most influential People: BU’s Ann McKee

Time 4/19/2018

Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so

Philly.com 4/19/2018

Experts say CTE ‘is associated with ice hockey play'

Daily News 4/12/2018

Family of Late Minnesota Hockey Star Waiting for Results from CTE Lab

KSTP 2/27/2018

Former Seahawks' brains shed light on NFL head injuries

King 5 News 2/21/2018

Intercepted Podcast Bonus: The NFL’s Violent Ballet

The Intercept 2/1/2018

Bob Costas will skip the Super Bowl because of the NFL’s connection to brain trauma

SB Nation 1/24/2018

Kevin Turner’s rugged road

ESPN 3/16/2011
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