Ann C. McKee, MD
Professor
Boston University School of Medicine
Dept of Neurology

MD, Case School of Medicine



Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank. Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences


VA Boston Healthcare System




Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
09/15/2017 - 06/30/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

Biochemical and Genetic Investigation of Tau in Chronic Encephalopathy
11/01/2015 - 10/31/2018 (PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch


Personnel Agreement for Research Services of David Kwasnik
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Bobak Abdolmohammadi
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Jason Miller
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Laney Evers
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Sarah Svirsky
07/01/2017 - 06/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for research service Rebecca Mathias
02/01/2015 - 06/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Jonathan Cherry
07/01/2016 - 06/30/2017 (PI)
VA Boston Healthcare System


Showing 10 of 22 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 CENC-VA TBI Brain Tissue Repository 5I01RX002170-03
2018 Tau Biomarkers following Blast mTBI in OEF/OIF Veterans 5I01RX000991-05
2017 Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation 1RF1AG057902-01
2017 CENC-VA TBI Brain Tissue Repository 5I01RX002170-02
2017 CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging 5U01NS086659-04 15
2017 Core D: Neuropathology Core 2P30AG013846-21-6897 428
2016 CENC-VA TBI Brain Tissue Repository 1I01RX002170-01
2016 ShEEP Request for Advanced Multiphoton Laser Upgrade for Dissection of Neural Circuits 1IS1BX003544-01
2016 ShEEP Request for Zeiss LSM880 with Airyscan 1IS1BX003538-01
2016 CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging 5U01NS086659-03 15
Showing 10 of 30 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901.View Related Profiles. PMID: 29710395.
     
  2. Mufson EJ, He B, Ginsberg SD, Carper BA, Bieler GS, Crawford F, Alvarez VE, Huber BR, Stein TD, McKee AC, Perez SE. Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma. 2018 Jun 01; 35(11):1260-1271.View Related Profiles. PMID: 29338612.
     
  3. Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 Feb 01; 141(2):422-458.View Related Profiles. PMID: 29360998; DOI: 10.1093/brain/awx350;.
     
  4. Kriegel J, Papadopoulos Z, McKee AC. Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation? Cold Spring Harb Perspect Med. 2018 Feb 01; 8(2). PMID: 28096246; DOI: 10.1101/cshperspect.a024059;.
     
  5. Moszczynski AJ, Strong W, Xu K, McKee A, Brown A, Strong MJ. Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS. Neurology. 2018 Jan 30; 90(5):e380-e387. PMID: 29298849.
     
  6. Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360.View Related Profiles. PMID: 29843242; DOI: 10.3233/JAD-180017;.
     
  7. Cherry JD, Zeineddin A, Dammer EB, Webster JA, Duong D, Seyfried NT, Levey AI, Alvarez VE, Huber BR, Stein TD, Kiernan PT, McKee AC, Lah JJ, Hales CM. Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):40-49.View Related Profiles. PMID: 29145658.
     
  8. Kenney K, Iacono D, Edlow BL, Katz DI, Diaz-Arrastia R, Dams-O'Connor K, Daneshvar DH, Stevens A, Moreau AL, Tirrell LS, Varjabedian A, Yendiki A, van der Kouwe A, Mareyam A, McNab JA, Gordon WA, Fischl B, McKee AC, Perl DP. Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):50-63.View Related Profiles. PMID: 29155947.
     
  9. McKee AC, Mez J, Abdolmohammadi B. Chronic Traumatic Encephalopathy in Football Players-Reply. JAMA. 2017 12 19; 318(23):2353.View Related Profiles. PMID: 29260223.
     
  10. Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 Feb; 17(1).View Related Profiles. PMID: 29130578.
     
Showing 10 of 134 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 134 publications over 28 distinct years, with a maximum of 18 publications in 2015

YearPublications
19881
19891
19903
19911
19921
19934
19941
19952
19981
19993
20002
20012
20021
20042
20052
20064
20071
20084
20093
20105
20119
201210
20136
201412
201518
201612
201715
20188
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