Ann C. McKee, MD
William Fairfield Warren Distinguished Professor
Boston University School of Medicine
Dept of Neurology

MD, Case School of Medicine




Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences


VA Boston Healthcare System



2018 Time Magazine: 100 Most Influential People of 2018
2018 Alzheimer’s Association: Henry Wisniewski Lifetime Achievement Award


The Contribution of Age-Related Tauopathies to Alzheimer's Disease
09/30/2018 - 05/31/2023 (PI)
NIH/National Institute on Aging
1R01AG062348-01

Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
09/15/2017 - 06/30/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

Personnel Agreement for Research Services of Rebecca Mathias
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System


CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

Biochemical and Genetic Investigation of Tau in Chronic Encephalopathy
11/01/2015 - 10/31/2018 (PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch


Personnel Agreement for Research Services of David Kwasnik
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Bobak Abdolmohammadi
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Jason Miller
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Laney Evers
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Sarah Svirsky
07/01/2017 - 06/30/2018 (PI)
VA Boston Healthcare System


Showing 10 of 24 results. Show All Results



Yr Title Project-Sub Proj Pubs
2019 ShEEP Request for Nikon N-Storm Super-resolution microscope 1IS1BX004787-01
2019 CENC-VA TBI Brain Tissue Repository 5I01RX002170-04 1
2018 The Contribution of Age-Related Tauopathies to Alzheimer's Disease 1R01AG062348-01 1
2018 CENC-VA TBI Brain Tissue Repository 5I01RX002170-03 1
2018 Tau Biomarkers following Blast mTBI in OEF/OIF Veterans 5I01RX000991-05 3
2018 Core D: Neuropathology Core 5P30AG013846-22-6897 805
2017 Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation 1RF1AG057902-01 4
2017 CENC-VA TBI Brain Tissue Repository 5I01RX002170-02 1
2017 CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging 5U01NS086659-04 51
2017 Tau Biomarkers following Blast mTBI in OEF/OIF Veterans 5I01RX000991-04 3
Showing 10 of 35 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Alosco ML, Tripodis Y, Rowland B, Chua AS, Liao H, Martin B, Jarnagin J, Chaisson CE, Pasternak O, Karmacharya S, Koerte IK, Cantu RC, Kowall NW, McKee AC, Shenton ME, Greenwald R, McClean M, Stern RA, Lin A. A magnetic resonance spectroscopy investigation in symptomatic former NFL players. Brain Imaging Behav. 2019 Mar 08.View Related Profiles. PMID: 30848432; DOI: 10.1007/s11682-019-00060-4;.
     
  2. Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimers Dement. 2019 May; 15(5):686-698.View Related Profiles. PMID: 30852157; DOI: 10.1016/j.jalz.2018.12.015;.
     
  3. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. GenetView Related Profiles. PMID: 30820047; DOI: 10.1038/s41588-019-0358-2;.
     
  4. Signaevsky M, Prastawa M, Farrell K, Tabish N, Baldwin E, Han N, Iida MA, Koll J, Bryce C, Purohit D, Haroutunian V, McKee AC, Stein TD, White CL, Walker J, Richardson TE, Hanson R, Donovan MJ, Cordon-Cardo C, Zeineh J, Fernandez G, Crary JF. Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy. Lab Invest. 2019 Feb 15.View Related Profiles. PMID: 30770886.
     
  5. Robinson ME, McKee AC, Salat DH, Rasmusson AM, Radigan LJ, Catana C, Milberg WP, McGlinchey RE. Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma. Neuroimage Clin. 2019; 21:101651.View Related Profiles. PMID: 30642757.
     
  6. McKee AC, Alosco ML. Assessing Subconcussive Head Impacts in Athletes Playing Contact Sports-The Eyes Have It. JAMA Ophthalmol. 2018 Dec 20.View Related Profiles. PMID: 30570658.
     
  7. Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci. 2019 Mar; 40(3):529-533.View Related Profiles. PMID: 30564964.
     
  8. Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1091-1100.View Related Profiles. PMID: 30299493.
     
  9. Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115.View Related Profiles. PMID: 30390709.
     
  10. Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019 Jan 23; 692:204-209.View Related Profiles. PMID: 30366016.
     
Showing 10 of 148 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 148 publications over 29 distinct years, with a maximum of 18 publications in 2015

YearPublications
19881
19891
19903
19911
19921
19934
19941
19952
19981
19993
20002
20012
20021
20042
20052
20064
20071
20084
20093
20105
20119
201210
20136
201412
201518
201612
201715
201817
20195
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Recent (within 3 months)

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

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Military Times 11/28/2018

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Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

NHL Won't Admit Liability, Will Pay Around $19 Million In Concussion Lawsuit Settlement

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Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

CBS News 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Analysis shows 147 college football programs had at least one player diagnosed with CTE

USA Today 11/2/2018

In football, CTE skeptics like Merril Hoge challenge brain-damage conclusions, but Doug Baldwin cites ‘common sense’

The Seattle Times 10/26/2018

Merril Hoge, co-author of new book are way off target in discussing football, CTE

USA Today 10/24/2018

10 key points from Gladiator: Aaron Hernandez and Football Inc.

The Boston Globe 10/23/2018

How one flawed study and irresponsible reporting launched a wave of CTE hysteria

Yahoo Sports 10/23/2018

A Terrible Thing To Waste

The Boston Globe 10/18/2018

Ann Mckee Elected to the National Academy of Medicine

BU Today 10/15/2018

CTE researchers seek to study more female brains

The Washington Post 10/11/2018

Scientists seek veterans to help treat CTE

60 Minutes – CBS News 9/16/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Baltimore Sun 9/5/2018

Researchers close in on CTE diagnosis in living, one brain at a time

USA Today 8/24/2018

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

Los Angeles Times 8/8/2018

Another CTE diagnosis in soccer adds to growing concern

Yahoo Finance 8/7/2018

Athletes Who May Have Suffered From CTE — And The Tragic Outcomes

Oxygen 6/26/2018

Boynton joins NHL concussion lawsuit, pledges brain to science

TSN 6/21/2018

NHL Commissioner Bettman sidesteps question about concussions

Los Angeles Times 5/28/2018

Naperville Park District latest to add flag football as parents' fear of concussions grows

Chicago Tribune 5/5/2018

The Tragic Diagnosis They Already Knew: Their Brother Died With C.T.E.

The New York Times 5/3/2018

Former NHLer Parker had CTE when he died

TSN 5/3/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing football young may mean earlier cognitive, emotional problems

CNN Health 4/30/2018

TIME’s 100 Most influential People: BU’s Ann McKee

Time 4/19/2018

Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so

Philly.com 4/19/2018

Experts say CTE ‘is associated with ice hockey play'

Daily News 4/12/2018

Family of Late Minnesota Hockey Star Waiting for Results from CTE Lab

KSTP 2/27/2018

Former Seahawks' brains shed light on NFL head injuries

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The Intercept 2/1/2018

Bob Costas will skip the Super Bowl because of the NFL’s connection to brain trauma

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