Ann McKee | Profiles RNS

Ann C. McKee, MD

William Fairfield Warren Distinguished Professor

Boston University School of Medicine

Dept of Neurology

MD, Case School of Medicine

Websites

	CTE Center Faculty
	Neurology Faculty
	Wikipedia
	LinkedIn
	Public Relations - BU Experts

Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank.

Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy.

Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine

Investigator
Framingham Heart Study

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

VA Boston Healthcare System

2018 Time Magazine: 100 Most Influential People of 2018

2018 Alzheimer’s Association: Henry Wisniewski Lifetime Achievement Award

Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes
09/30/2019 - 07/31/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U54NS115266-02

The Contribution of Age-Related Tauopathies to Alzheimer's Disease
09/30/2018 - 05/31/2023 (PI)
NIH/National Institute on Aging
5R01AG062348-03

Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
09/15/2017 - 03/31/2022 (PI)
NIH/National Institute on Aging
1RF1AG057902-01

Updating the Neuropathological Criteria for PSP
12/01/2020 - 07/31/2021 (Subcontract PI)
The Regents of the University of California, San Francisco Rainwater Char. Fdn

Personnel Agreement for Research Services of Rebecca Mathias
10/01/2019 - 04/30/2020 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Rebecca Mathias
08/01/2018 - 07/31/2019 (PI)
VA Boston Healthcare System

CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
01/01/2014 - 12/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS086659-04

Biochemical and Genetic Investigation of Tau in Chronic Encephalopathy
11/01/2015 - 10/31/2018 (Subcontract PI)
Icahn School of Medicine at Mount Sinai DOD Army Med Resrch

Personnel Agreement for Research Services of David Kwasnik
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Bobak Abdolmohammadi
10/01/2017 - 09/30/2018 (PI)
VA Boston Healthcare System

Showing 10 of 27 results. Show All Results

Title
Boston University Alzheimer's Disease Core Center
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging
CENC-VA TBI Brain Tissue Repository
Molecular and Genetic Investigation of Tau in Chronic Traumatic Encephalopathy (CTE)

Yr	Title	Project-Sub Proj	Pubs
2021	CTBI:CBI Tauopathy in Mice and Human: Neurodegeneration after Repetitive Neurotrauma: Mechanisms and Biomarker Discovery	5I01BX004613-02
2021	The Contribution of Age-Related Tauopathies to Alzheimer's Disease	5R01AG062348-04	6
2020	Neuropath Core	1U19AG068753-01-8038
2020	CTBI:CBI Tauopathy in Mice and Human: Neurodegeneration after Repetitive Neurotrauma: Mechanisms and Biomarker Discovery	1I01BX004613-01
2020	Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes	5U54NS115266-02
2020	Admin Core	5U54NS115266-02-6597
2020	Brain Bank Core	5U54NS115266-02-6599
2020	The Contribution of Age-Related Tauopathies to Alzheimer's Disease	5R01AG062348-03	6
2019	Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes	1U54NS115266-01
2019	ShEEP Request for Nikon N-Storm Super-resolution microscope	1IS1BX004787-01

Showing 10 of 48 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Gutierrez-Quiceno L, Dammer EB, Johnson AG, Webster JA, Shah R, Duong D, Yin L, Seyfried NT, Alvarez VE, Stein TD, McKee AC, Hales CM. A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy. Mol Neurodegener. 2021 Jun 25; 16(1):40.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 34172091; PMCID: PMC8235576; DOI: 10.1186/s13024-021-00462-3;

Chancellor KB, Chancellor SE, Duke-Cohan JE, Huber BR, Stein TD, Alvarez VE, Okaty BW, Dymecki SM, McKee AC. Altered oligodendroglia and astroglia in chronic traumatic encephalopathy. Acta Neuropathol. 2021 Aug; 142(2):295-321.View Related Profiles.

McKee, Ann
Huber, Bertrand
Stein, Thor
Alvarez, Victor

PMID: 34019156

Cherry JD, Esnault CD, Baucom ZH, Tripodis Y, Huber BR, Alvarez VE, Stein TD, Dickson DW, McKee AC. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta Neuropathol Commun. 2021 05 12; 9(1):86.View Related Profiles.

McKee, Ann
Huber, Bertrand
Cherry, Jonathan
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 33980303; PMCID: PMC8114683; DOI: 10.1186/s40478-021-01189-4;

Mez J, Alosco ML, Daneshvar DH, Saltiel N, Baucom Z, Abdolmohammadi B, Uretsky M, Nicks R, Martin BM, Palmisano JN, Nowinski CJ, Montenigro P, Solomon TM, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Goldstein LE, Katz DI, Cantu RC, Kowall NW, Tripodis Y, Huber BR, Stein TD, Stern RA, McKee AC. Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology. Alzheimers Dement. 2021 Apr 07.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mahar, Ian
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Montenigro, Philip
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 33826224

Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O'Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley ÉM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome. Neurology. 2021 05 04; 96(18):848-863.View Related Profiles.

McKee, Ann
Katz, Douglas
Mez, Jesse
Alosco, Michael
Stern, Robert
Tripodis, Yorghos

PMID: 33722990; PMCID: PMC8166432; DOI: 10.1212/WNL.0000000000011850;

Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Dams-O'Connor K, Gordon WA, Tripodis Y, Alvarez VE, Mez J, Alosco ML, McKee AC. The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2021 Feb 22; 80(3):210-219.View Related Profiles.

McKee, Ann
Mez, Jesse
Alosco, Michael
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 33611507; PMCID: PMC7899277; DOI: 10.1093/jnen/nlab001;

Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111.View Related Profiles.

Budson, Andrew
McKee, Ann
Stein, Thor

PMID: 33367843

Greco FA, McKee AC, Kowall NW, Hanlon EB. Near-Infrared Optical Spectroscopy In Vivo Distinguishes Subjects with Alzheimer's Disease from Age-Matched Controls. J Alzheimers Dis. 2021; 82(2):791-802.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 34092628

Cherry JD, Meng G, Daley S, Xia W, Svirsky S, Alvarez VE, Nicks R, Pothast M, Kelley H, Huber B, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy. J Neuroinflammation. 2020 Dec 05; 17(1):370.View Related Profiles.

McKee, Ann
Huber, Bertrand
Mez, Jesse
Cherry, Jonathan
Alosco, Michael
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 33278887; PMCID: PMC7718711; DOI: 10.1186/s12974-020-02036-4;

Alosco ML, Tripodis Y, Rowland B, Chua AS, Liao H, Martin B, Jarnagin J, Chaisson CE, Pasternak O, Karmacharya S, Koerte IK, Cantu RC, Kowall NW, McKee AC, Shenton ME, Greenwald R, McClean M, Stern RA, Lin A. A magnetic resonance spectroscopy investigation in symptomatic former NFL players. Brain Imaging Behav. 2020 Oct; 14(5):1419-1429.View Related Profiles.

McKee, Ann
Alosco, Michael
McClean, Michael
Kowall, Neil
Stern, Robert
Cantu, Robert
Tripodis, Yorghos

PMID: 30848432; PMCID: PMC6994233; DOI: 10.1007/s11682-019-00060-4;

Showing 10 of 182 results. Show More

Warling A, Uchida R, Shin H, Dodelson C, Garcia ME, Shea-Shumsky NB, Svirsky S, Pothast M, Kelley H, Schumann CM, Brzezinski C, Bauman MD, Alexander A, McKee AC, Stein TD, Schall M, Jacobs B. Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration. J Comp Neurol. 2021 May 01; 529(7):1308-1326.View Related Profiles.

McKee, Ann
Stein, Thor

PMID: 32869318

Adams JW, Alosco ML, Mez J, Alvarez VE, Huber BR, Tripodis Y, Adler CH, Kubilius C, Cormier KA, Mathais R, Nicks R, Kelley HJ, Saltiel N, Uretsky M, Nair E, Aytan N, Cherry JD, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy. Acta Neuropathol. 2020 12; 140(6):851-862.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Nowinski, Christopher
Katz, Douglas
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Aytan, Nurgul
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 32939646; PMCID: PMC7669574; DOI: 10.1007/s00401-020-02206-x;

Mez J, Stern RA, McKee AC. Chronic Traumatic Encephalopathy. Semin Neurol. 2020 Aug; 40(4):351-352.View Related Profiles.

McKee, Ann
Mez, Jesse
Stern, Robert

PMID: 32906179

Mez J, Daneshvar DH, Alosco ML, Alvarez VE, Huber BR, Stein TD, McKee AC. Reply to "Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy". Ann Neurol. 2020 11; 88(5):1052-1053.View Related Profiles.

McKee, Ann
Huber, Bertrand
Daneshvar, Daniel
Mez, Jesse
Alosco, Michael
Stein, Thor
Alvarez, Victor

PMID: 32754941

Alosco ML, Cherry JD, Huber BR, Tripodis Y, Baucom Z, Kowall NW, Saltiel N, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Palmisano JN, Martin B, Cantu RC, Stern RA, Alvarez VE, Mez J, Stein TD, McKee AC. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme. Acta Neuropathol. 2020 10; 140(4):495-512.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 32778942; PMCID: PMC7914059; DOI: 10.1007/s00401-020-02197-9;

Spencer KR, Foster ZW, Rauf NA, Guilderson L, Collins D, Averill JG, Walker SE, Robey I, Cherry JD, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB, Stein TD. Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans. Brain Pathol. 2020 11; 30(6):1028-1040.View Related Profiles.

McKee, Ann
Huber, Bertrand
Brady, Christopher
Cherry, Jonathan
Kowall, Neil
Stein, Thor
Alvarez, Victor

PMID: 32633852

McKee AC, Stein TD, Crary JF, Bieniek KF, Cantu RC, Kovacs GG. Practical Considerations in the Diagnosis of Mild Chronic Traumatic Encephalopathy and Distinction From Age-Related Tau Astrogliopathy. J Neuropathol Exp Neurol. 2020 08 01; 79(8):921-924.View Related Profiles.

McKee, Ann
Stein, Thor

PMID: 32688381; PMCID: PMC7395709; DOI: 10.1093/jnen/nlaa047;

McKee AC. The Neuropathology of Chronic Traumatic Encephalopathy: The Status of the Literature. Semin Neurol. 2020 Aug; 40(4):359-369. PMID: 32712946

Cherry JD, Kim SH, Stein TD, Pothast MJ, Nicks R, Meng G, Huber BR, Mez J, Alosco ML, Tripodis Y, Farrell K, Alvarez VE, McKee AC, Crary JF. Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain Pathol. 2020 09; 30(5):913-925.View Related Profiles.

McKee, Ann
Huber, Bertrand
Mez, Jesse
Cherry, Jonathan
Alosco, Michael
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 32500646; PMCID: PMC7484331; DOI: 10.1111/bpa.12867;

Alosco ML, Tripodis Y, Baucom ZH, Mez J, Stein TD, Martin B, Haller O, Conneely S, McClean M, Nosheny R, Mackin S, McKee AC, Weiner MW, Stern RA. Late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology. 2020 08 18; 95(7):e793-e804.View Related Profiles.

McKee, Ann
Mez, Jesse
Alosco, Michael
McClean, Michael
Stern, Robert
Stein, Thor
Tripodis, Yorghos

PMID: 32591472; PMCID: PMC7605500; DOI: 10.1212/WNL.0000000000010040;

Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Sci Rep. 2020 06 01; 10(1):8811.View Related Profiles.

McKee, Ann
Ryu, Hoon
Kowall, Neil
Stein, Thor
Alvarez, Victor

PMID: 32483284; PMCID: PMC7264177; DOI: 10.1038/s41598-020-65916-y;

Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisano JN, Steinberg EG, Simkin I, Budson AE, Killiany R, O'Connor MK, Au R, Qiu WWQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiol Aging. 2020 10; 94:60-70.View Related Profiles.

Budson, Andrew
McKee, Ann
Steinberg, Eric
Mez, Jesse
Goldstein, Lee
O'Connor, Maureen
Alosco, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Tripodis, Yorghos

PMID: 32585491; PMCID: PMC7484086; DOI: 10.1016/j.neurobiolaging.2020.05.011;

Lee MY, Lee J, Hyeon SJ, Cho H, Hwang YJ, Shin JY, McKee AC, Kowall NW, Kim JI, Stein TD, Hwang D, Ryu H. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease. Aging Cell. 2020 06; 19(6):e13153.View Related Profiles.

McKee, Ann
Ryu, Hoon
Kowall, Neil
Stein, Thor

PMID: 32419307; PMCID: PMC7294781; DOI: 10.1111/acel.13153;

Pelcher I, Puzo C, Tripodis Y, Aparicio HJ, Steinberg EG, Phelps A, Martin B, Palmisano JN, Vassey E, Lindbergh C, McKee AC, Stein TD, Killiany RJ, Au R, Kowall NW, Stern RA, Mez J, Alosco ML. Revised Framingham Stroke Risk Profile: Association with Cognitive Status and MRI-Derived Volumetric Measures. J Alzheimers Dis. 2020; 78(4):1393-1408.View Related Profiles.

McKee, Ann
Vassey, Elizabeth
Steinberg, Eric
Aparicio, Hugo
Mez, Jesse
Alosco, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Tripodis, Yorghos

PMID: 33164933; PMCID: PMC7887636; DOI: 10.3233/JAD-200803;

Minaeva O, Hua N, Franz ES, Lupoli N, Mian AZ, Farris CW, Hildebrandt AM, Kiernan PT, Evers LE, Griffin AD, Liu X, Chancellor SE, Babcock KJ, Moncaster JA, Jara H, Alvarez VE, Huber BR, Guermazi A, Latour LL, McKee AC, Soto JA, Anderson SW, Goldstein LE. Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans. Radiology. 2020 02; 294(2):377-385.View Related Profiles.

Guermazi, Ali
McKee, Ann
Mian, Asim
Huber, Bertrand
Farris, Chad
Jara, Hernan
Soto, Jorge
Moncaster, Juliet
Babcock, Katharine
Goldstein, Lee
Hua, Ning
Minaeva, Olga
Anderson, Stephan
Alvarez, Victor

PMID: 31769744; PMCID: PMC6996690; DOI: 10.1148/radiol.2019190461;

Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT, Evers L, Marshall L, Martin BM, Palmisano JN, Nowinski CJ, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Huber BR, Stein TD, Goldstein LE, Katz DI, Cantu RC, Au R, Kowall NW, Stern RA, McClean MD, Weuve J, Tripodis Y, McKee AC. Duration of American Football Play and Chronic Traumatic Encephalopathy. Ann Neurol. 2020 01; 87(1):116-131.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mahar, Ian
Weuve, Jennifer
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
McClean, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 31589352; PMCID: PMC6973077; DOI: 10.1002/ana.25611;

Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Ann Clin Transl Neurol. 2019 12; 6(12):2403-2412.View Related Profiles.

Beiser, Alexa
McKee, Ann
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Stein, Thor
Alvarez, Victor

PMID: 31691546; PMCID: PMC6917310; DOI: 10.1002/acn3.50936;

Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, Martin B, Cherry JD, Mahar I, Killiany RJ, McClean MD, Au R, Alvarez V, Stern RA, Mez J, McKee AC. Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. JAMA Neurol. 2019 Nov 01; 76(11):1298-1308.View Related Profiles.

McKee, Ann
Huber, Bertrand
Katz, Douglas
Mahar, Ian
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
McClean, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 31380975; PMCID: PMC6686769; DOI: 10.1001/jamaneurol.2019.2244;

Marquié M, Agüero C, Amaral AC, Villarejo-Galende A, Ramanan P, Chong MST, Sáez-Calveras N, Bennett RE, Verwer EE, Kim SJW, Dhaynaut M, Alvarez VE, Johnson KA, McKee AC, Frosch MP, Gómez-Isla T. [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. Acta Neuropathol Commun. 2019 10 28; 7(1):164.View Related Profiles.

McKee, Ann
Alvarez, Victor

PMID: 31661038; PMCID: PMC6816221; DOI: 10.1186/s40478-019-0808-1;

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. Author CoView Related Profiles.

Beiser, Alexa
DeStefano, Anita
McKee, Ann
Sarnowski, Chloe
Jun, Gyungah
Himali, Jayandra
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha

PMID: 31417202; PMCID: PMC7265117; DOI: 10.1038/s41588-019-0495-7;

Puzo C, Labriola C, Sugarman MA, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Stein TD, Kowall NW, McKee AC, Mez J, Killiany RJ, Stern RA, Alosco ML. Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer's Coordinating Center Uniform Data Set. Alzheimers Res Ther. 2019 07 27; 11(1):64.View Related Profiles.

McKee, Ann
Steinberg, Eric
Mez, Jesse
Alosco, Michael
Kowall, Neil
Stern, Robert
Killiany, Ronald
Stein, Thor
Tripodis, Yorghos

PMID: 31351489; PMCID: PMC6661103; DOI: 10.1186/s13195-019-0521-0;

Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Oct; 69(2):264-285.View Related Profiles.

McKee, Ann
Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Nasse, Jason
Cherry, Jonathan
Lau, Nelson

PMID: 31250273; PMCID: PMC7008951; DOI: 10.1007/s12031-019-01356-2;

Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H. Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy. Exp Neurobiol. 2019 Jun; 28(3):362-375.View Related Profiles.

McKee, Ann
Choi, Han-Pil
Ryu, Hoon
Kowall, Neil

PMID: 31308796; PMCID: PMC6614068; DOI: 10.5607/en.2019.28.3.362;

Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 09; 138(3):401-413.View Related Profiles.

McKee, Ann
Huber, Bertrand
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Mahar, Ian
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Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Stern, Robert
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 31183671; PMCID: PMC6689453; DOI: 10.1007/s00401-019-02031-x;

Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimers Dement. 2019 05; 15(5):686-698.View Related Profiles.

McKee, Ann
Steinberg, Eric
Mez, Jesse
O'Connor, Maureen
Alosco, Michael
McClean, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Tripodis, Yorghos

PMID: 30852157; PMCID: PMC6511462; DOI: 10.1016/j.jalz.2018.12.015;

McKee AC, Alosco ML. Assessing Subconcussive Head Impacts in Athletes Playing Contact Sports-The Eyes Have It. JAMA Ophthalmol. 2019 03 01; 137(3):270-271.View Related Profiles.

McKee, Ann
Alosco, Michael

PMID: 30570658

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. GenetView Related Profiles.

Beiser, Alexa
DeStefano, Anita
McKee, Ann
Sarnowski, Chloe
Jun, Gyungah
Lin, Honghuang
Himali, Jayandra
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha

PMID: 30820047; PMCID: PMC6463297; DOI: 10.1038/s41588-019-0358-2;

Signaevsky M, Prastawa M, Farrell K, Tabish N, Baldwin E, Han N, Iida MA, Koll J, Bryce C, Purohit D, Haroutunian V, McKee AC, Stein TD, White CL, Walker J, Richardson TE, Hanson R, Donovan MJ, Cordon-Cardo C, Zeineh J, Fernandez G, Crary JF. Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy. Lab Invest. 2019 07; 99(7):1019-1029.View Related Profiles.

McKee, Ann
Stein, Thor

PMID: 30770886; PMCID: PMC7684013; DOI: 10.1038/s41374-019-0202-4;

Robinson ME, McKee AC, Salat DH, Rasmusson AM, Radigan LJ, Catana C, Milberg WP, McGlinchey RE. Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma. Neuroimage Clin. 2019; 21:101651.View Related Profiles.

McKee, Ann
Rasmusson, Ann
McGlinchey, Regina
Milberg, William

PMID: 30642757; PMCID: PMC6412062; DOI: 10.1016/j.nicl.2019.101651;

Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci. 2019 Mar; 40(3):529-533.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 30564964; PMCID: PMC6433808; DOI: 10.1007/s10072-018-3686-6;

Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 12 01; 77(12):1091-1100.View Related Profiles.

McKee, Ann
Huber, Bertrand
Brady, Christopher
Kowall, Neil
Stein, Thor
Alvarez, Victor

PMID: 30299493; PMCID: PMC6927868; DOI: 10.1093/jnen/nly092;

Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Nowinski, Christopher
Katz, Douglas
Mahar, Ian
Mez, Jesse
Cherry, Jonathan
Babcock, Katharine
Goldstein, Lee
Farrer, Lindsay
Alosco, Michael
Kowall, Neil
Stern, Robert
Cantu, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 30390709; PMCID: PMC6215686; DOI: 10.1186/s40478-018-0619-9;

Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019 01 23; 692:204-209.View Related Profiles.

McKee, Ann
Huber, Bertrand
Wolf, Erika
Cherry, Jonathan
Logue, Mark
Miller, Mark
Stein, Thor
Alvarez, Victor

PMID: 30366016; PMCID: PMC6351202; DOI: 10.1016/j.neulet.2018.10.027;

Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 12; 136(6):955-972.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 30194648

Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 09 01; 77(9):757-768.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Aytan, Nurgul
Au, Rhoda
Stern, Robert
Cantu, Robert
Auerbach, Sanford
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 30053297; PMCID: PMC6097837; DOI: 10.1093/jnen/nly065;

Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 09; 14(9):1159-1170.View Related Profiles.

McKee, Ann
Mez, Jesse
Alosco, Michael
Stern, Robert
Cantu, Robert
Stein, Thor
Tripodis, Yorghos

PMID: 30049650; PMCID: PMC6131058; DOI: 10.1016/j.jalz.2018.05.004;

Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 05; 83(5):886-901.View Related Profiles.

McKee, Ann
Huber, Bertrand
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Goldstein, Lee
Alosco, Michael
McClean, Michael
Kowall, Neil
Stern, Robert
Cantu, Robert
Stein, Thor
Tripodis, Yorghos

PMID: 29710395; PMCID: PMC6367933; DOI: 10.1002/ana.25245;

Mufson EJ, He B, Ginsberg SD, Carper BA, Bieler GS, Crawford F, Alvarez VE, Huber BR, Stein TD, McKee AC, Perez SE. Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma. 2018 06 01; 35(11):1260-1271.View Related Profiles.

McKee, Ann
Huber, Bertrand
Stein, Thor
Alvarez, Victor

PMID: 29338612; PMCID: PMC5962931; DOI: 10.1089/neu.2017.5368;

Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 02 01; 141(2):422-458.View Related Profiles.

McKee, Ann
Huber, Bertrand
Nowinski, Christopher
Hamilton, James
Moncaster, Juliet
Goldstein, Lee
Wojnarowicz, Mark
Kowall, Neil
Hua, Ning
Casey, Noel
Minaeva, Olga
Cantu, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 29360998; PMCID: PMC5837414; DOI: 10.1093/brain/awx350;

Kriegel J, Papadopoulos Z, McKee AC. Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation? Cold Spring Harb Perspect Med. 2018 02 01; 8(2). PMID: 28096246; PMCID: PMC5793739; DOI: 10.1101/cshperspect.a024059;

Moszczynski AJ, Strong W, Xu K, McKee A, Brown A, Strong MJ. Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS. Neurology. 2018 01 30; 90(5):e380-e387. PMID: 29298849; PMCID: PMC5791789; DOI: 10.1212/WNL.0000000000004899;

Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360.View Related Profiles.

McKee, Ann
Mez, Jesse
Alosco, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Tripodis, Yorghos

PMID: 29843242; PMCID: PMC6081639; DOI: 10.3233/JAD-180017;

Mckee AC, Abdolmohammadi B, Stein TD. The neuropathology of chronic traumatic encephalopathy. Handb Clin Neurol. 2018; 158:297-307.View Related Profiles.

McKee, Ann
Stein, Thor

PMID: 30482357

Cherry JD, Zeineddin A, Dammer EB, Webster JA, Duong D, Seyfried NT, Levey AI, Alvarez VE, Huber BR, Stein TD, Kiernan PT, McKee AC, Lah JJ, Hales CM. Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):40-49.View Related Profiles.

McKee, Ann
Huber, Bertrand
Cherry, Jonathan
Stein, Thor
Alvarez, Victor

PMID: 29145658; PMCID: PMC5939631; DOI: 10.1093/jnen/nlx100;

Kenney K, Iacono D, Edlow BL, Katz DI, Diaz-Arrastia R, Dams-O'Connor K, Daneshvar DH, Stevens A, Moreau AL, Tirrell LS, Varjabedian A, Yendiki A, van der Kouwe A, Mareyam A, McNab JA, Gordon WA, Fischl B, McKee AC, Perl DP. Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):50-63.View Related Profiles.

McKee, Ann
Daneshvar, Daniel
Katz, Douglas

PMID: 29155947; PMCID: PMC5939622; DOI: 10.1093/jnen/nlx101;

McKee AC, Mez J, Abdolmohammadi B. Chronic Traumatic Encephalopathy in Football Players-Reply. JAMA. 2017 12 19; 318(23):2353.View Related Profiles.

McKee, Ann
Mez, Jesse

PMID: 29260223

Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 02; 17(1).View Related Profiles.

McKee, Ann
Ryu, Hoon
Lee, Junghee
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PMID: 29130578; PMCID: PMC5771400; DOI: 10.1111/acel.12679;

Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J, Rahimpour Y, Puzo C, Healy RC, Martin B, Chaisson CE, Cantu RC, Au R, McClean M, McKee AC, Lin AP, Shenton ME, Killiany RJ, Stern RA. White matter signal abnormalities in former National Football League players. Alzheimers Dement (Amst). 2018; 10:56-65.View Related Profiles.

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Chaisson, Christine
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Cantu, Robert
Killiany, Ronald
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PMID: 29201991; PMCID: PMC5699890; DOI: 10.1016/j.dadm.2017.10.003;

Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC. CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. PLoS One. 2017; 12(9):e0185541.View Related Profiles.

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Huber, Bertrand
Daneshvar, Daniel
Mez, Jesse
Cherry, Jonathan
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Au, Rhoda
Stein, Thor
Alvarez, Victor
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PMID: 28950005; PMCID: PMC5614644; DOI: 10.1371/journal.pone.0185541;

Alosco ML, Kasimis AB, Stamm JM, Chua AS, Baugh CM, Daneshvar DH, Robbins CA, Mariani M, Hayden J, Conneely S, Au R, Torres A, McClean MD, McKee AC, Cantu RC, Mez J, Nowinski CJ, Martin BM, Chaisson CE, Tripodis Y, Stern RA. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl Psychiatry. 2017 Sep 19; 7(9):e1236.View Related Profiles.

Torres, Alcy
McKee, Ann
Chaisson, Christine
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Stern, Robert
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PMID: 28926003; PMCID: PMC5639242; DOI: 10.1038/tp.2017.197;

Mahar I, Alosco ML, McKee AC. Psychiatric phenotypes in chronic traumatic encephalopathy. Neurosci Biobehav Rev. 2017 Dec; 83:622-630.View Related Profiles.

McKee, Ann
Mahar, Ian
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PMID: 28888534

Sours C, Hinds SR, McKee AC, Perl DP, Leggieri MJ. Brain Banks and Tissue Repositories for Blast-Related Chronic Traumatic Encephalopathy Research. J Neurotrauma. 2017 09; 34(S1):S4-S5. PMID: 28937954

Goldstein LE, McKee AC. Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers. JAMA Neurol. 2017 09 01; 74(9):1045-1047.View Related Profiles.

McKee, Ann
Goldstein, Lee

PMID: 28738117

Friedman MJ, Huber BR, Brady CB, Ursano RJ, Benedek DM, Kowall NW, McKee AC. VA's National PTSD Brain Bank: a National Resource for Research. Curr Psychiatry Rep. 2017 Aug 25; 19(10):73.View Related Profiles.

McKee, Ann
Huber, Bertrand
Brady, Christopher
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Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR, Alosco ML, Solomon TM, Nowinski CJ, McHale L, Cormier KA, Kubilus CA, Martin BM, Murphy L, Baugh CM, Montenigro PH, Chaisson CE, Tripodis Y, Kowall NW, Weuve J, McClean MD, Cantu RC, Goldstein LE, Katz DI, Stern RA, Stein TD, McKee AC. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017 Jul 25; 318(4):360-370.View Related Profiles.

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Huber, Bertrand
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Kowall, Neil
Stern, Robert
Cantu, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 28742910; PMCID: PMC5807097; DOI: 10.1001/jama.2017.8334;

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, et al. RarView Related Profiles.

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DeStefano, Anita
McKee, Ann
O'Donnell, Christopher
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Lin, Honghuang
Himali, Jayandra
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha

PMID: 28714976; PMCID: PMC5669039; DOI: 10.1038/ng.3916;

Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 05 19; 49(5):e333.View Related Profiles.

McKee, Ann
Ryu, Hoon
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PMID: 28524178; PMCID: PMC5454448; DOI: 10.1038/emm.2017.56;

Gangolli M, Holleran L, Hee Kim J, Stein TD, Alvarez V, McKee AC, Brody DL. Quantitative validation of a nonlinear histology-MRI coregistration method using generalized Q-sampling imaging in complex human cortical white matter. Neuroimage. 2017 Jun; 153:152-167.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 28365421; PMCID: PMC5497585; DOI: 10.1016/j.neuroimage.2017.03.059;

Alosco ML, Duskin J, Besser LM, Martin B, Chaisson CE, Gunstad J, Kowall NW, McKee AC, Stern RA, Tripodis Y. Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set. J Alzheimers Dis. 2017; 57(3):953-968.View Related Profiles.

McKee, Ann
Chaisson, Christine
Alosco, Michael
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PMID: 28304301; PMCID: PMC5526463; DOI: 10.3233/JAD-161205;

Armstrong RA, McKee AC, Cairns NJ. Pathology of the Superior Colliculus in Chronic Traumatic Encephalopathy. Optom Vis Sci. 2017 Jan; 94(1):33-42. PMID: 27391531; DOI: 10.1097/OPX.0000000000000911;

Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8187-E8196. PMID: 27911827; PMCID: PMC5167200; DOI: 10.1073/pnas.1616344113;

Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, Mez J, Montenigro PH, Solomon TM, Alosco ML, Stern RA, McKee AC, Stein TD. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016 Oct 28; 4(1):112.View Related Profiles.

McKee, Ann
Huber, Bertrand
Daneshvar, Daniel
Mez, Jesse
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Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 27793189; PMCID: PMC5084333; DOI: 10.1186/s40478-016-0382-8;

Armstrong RA, McKee AC, Alvarez VE, Cairns NJ. Clustering of tau-immunoreactive pathology in chronic traumatic encephalopathy. J Neural Transm (Vienna). 2017 Feb; 124(2):185-192.View Related Profiles.

McKee, Ann
Alvarez, Victor

PMID: 27770214; PMCID: PMC5288283; DOI: 10.1007/s00702-016-1635-1;

McKee AC, Alosco ML, Huber BR. Repetitive Head Impacts and Chronic Traumatic Encephalopathy. Neurosurg Clin N Am. 2016 Oct; 27(4):529-35.View Related Profiles.

McKee, Ann
Huber, Bertrand
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PMID: 27637402; PMCID: PMC5028120; DOI: 10.1016/j.nec.2016.05.009;

Alosco ML, Mez J, Kowall NW, Stein TD, Goldstein LE, Cantu RC, Katz DI, Solomon TM, Kiernan PT, Murphy L, Abdolmohammadi B, Daneshvar D, Montenigro PH, Nowinski CJ, Stern RA, McKee AC. Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination. J Neuropsychiatry Clin Neurosci. 2017; 29(1):6-12.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
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Montenigro, Philip
Stern, Robert
Cantu, Robert
Stein, Thor

PMID: 27539377; PMCID: PMC5288278; DOI: 10.1176/appi.neuropsych.16030043;

Besser LM, Alosco ML, Ramirez Gomez L, Zhou XH, McKee AC, Stern RA, Gunstad J, Schneider JA, Chui H, Kukull WA. Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol. 2016 Oct; 75(10):955-962.View Related Profiles.

McKee, Ann
Alosco, Michael
Stern, Robert

PMID: 27516116; PMCID: PMC5029440; DOI: 10.1093/jnen/nlw072;

Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology. J Alzheimers Dis. 2016 07 06; 53(4):1553-62.View Related Profiles.

Beiser, Alexa
McKee, Ann
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 27392855; PMCID: PMC5494258; DOI: 10.3233/JAD-160163;

Montenigro PH, Alosco ML, Martin BM, Daneshvar DH, Mez J, Chaisson CE, Nowinski CJ, Au R, McKee AC, Cantu RC, McClean MD, Stern RA, Tripodis Y. Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma. 2017 Jan 15; 34(2):328-340.View Related Profiles.

McKee, Ann
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Mez, Jesse
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Au, Rhoda
Stern, Robert
Cantu, Robert
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PMID: 27029716; PMCID: PMC5220530; DOI: 10.1089/neu.2016.4413;

Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. A quantitative study of tau pathology in 11 cases of chronic traumatic encephalopathy. Neuropathol Appl Neurobiol. 2017 Feb; 43(2):154-166.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 26998921; PMCID: PMC5104666; DOI: 10.1111/nan.12323;

Mez J, Solomon TM, Daneshvar DH, Stein TD, McKee AC. Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player. JAMA Neurol. 2016 Mar; 73(3):353-5.View Related Profiles.

McKee, Ann
Daneshvar, Daniel
Mez, Jesse
Stein, Thor

PMID: 26747562; PMCID: PMC4792748; DOI: 10.1001/jamaneurol.2015.3998;

Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Inj. 2016; 30(12):1399-1413.View Related Profiles.

McKee, Ann
Alvarez, Victor

PMID: 27834536; PMCID: PMC5348250; DOI: 10.1080/02699052.2016.1219058;

Huber BR, Alosco ML, Stein TD, McKee AC. Potential Long-Term Consequences of Concussive and Subconcussive Injury. Phys Med Rehabil Clin N Am. 2016 May; 27(2):503-11.View Related Profiles.

McKee, Ann
Huber, Bertrand
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Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2016 Jan; 75(1):19-34.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 26671985; PMCID: PMC4891281; DOI: 10.1093/jnen/nlv001;

McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Tripodis Y, Crary JF, Bieniek KF, Dams-O'Connor K, Alvarez VE, Gordon WA. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol. 2016 Jan; 131(1):75-86.View Related Profiles.

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Mez, Jesse
Stein, Thor
Alvarez, Victor
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PMID: 26667418; PMCID: PMC4698281; DOI: 10.1007/s00401-015-1515-z;

Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL, Wisniewski T, Woulfe JM, Yamada M, Dickson DW. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol. 2016 Jan; 131(1):87-102. PMID: 26659578; PMCID: PMC4879001; DOI: 10.1007/s00401-015-1509-x;

Martinez-Ramirez S, Romero JR, Shoamanesh A, McKee AC, Van Etten E, Pontes-Neto O, Macklin EA, Ayres A, Auriel E, Himali JJ, Beiser AS, DeCarli C, Stein TD, Alvarez VE, Frosch MP, Rosand J, Greenberg SM, Gurol ME, Seshadri S, Viswanathan A. Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage. Alzheimers Dement. 2015 Dec; 11(12):1480-8.View Related Profiles.

Beiser, Alexa
McKee, Ann
Shoamanesh, Ashkan
Himali, Jayandra
Romero, Jose
Martinez-Ramirez, Sergi
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Stein, Thor
Alvarez, Victor

PMID: 26079413; PMCID: PMC4677060; DOI: 10.1016/j.jalz.2015.04.009;

Bieniek KF, Ross OA, Cormier KA, Walton RL, Soto-Ortolaza A, Johnston AE, DeSaro P, Boylan KB, Graff-Radford NR, Wszolek ZK, Rademakers R, Boeve BF, McKee AC, Dickson DW. Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol. 2015 Dec; 130(6):877-89. PMID: 26518018; PMCID: PMC4655127; DOI: 10.1007/s00401-015-1502-4;

Mez J, Solomon TM, Daneshvar DH, Murphy L, Kiernan PT, Montenigro PH, Kriegel J, Abdolmohammadi B, Fry B, Babcock KJ, Adams JW, Bourlas AP, Papadopoulos Z, McHale L, Ardaugh BM, Martin BR, Dixon D, Nowinski CJ, Chaisson C, Alvarez VE, Tripodis Y, Stein TD, Goldstein LE, Katz DI, Kowall NW, Cantu RC, Stern RA, McKee AC. Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study. Alzheimers Res Ther. 2015; 7(1):62.View Related Profiles.

McKee, Ann
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Katz, Douglas
Mez, Jesse
Babcock, Katharine
Goldstein, Lee
Kowall, Neil
Montenigro, Philip
Stern, Robert
Cantu, Robert
Stein, Thor
Alvarez, Victor
Tripodis, Yorghos

PMID: 26455775; PMCID: PMC4601147; DOI: 10.1186/s13195-015-0148-8;

Stein TD, Alvarez VE, McKee AC. Concussion in Chronic Traumatic Encephalopathy. Curr Pain Headache Rep. 2015 Oct; 19(10):47.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 26260277; PMCID: PMC4633042; DOI: 10.1007/s11916-015-0522-z;

Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein LE, Pascual-Leone A, McKee AC, Meehan W, Zhou XZ, Lu KP. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015 Jul 23; 523(7561):431-6.View Related Profiles.

McKee, Ann
Moncaster, Juliet
Goldstein, Lee

PMID: 26176913; PMCID: PMC4718588; DOI: 10.1038/nature14658;

Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 Jul; 130(1):21-34.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Mez, Jesse
Babcock, Katharine
Kowall, Neil
Montenigro, Philip
Stern, Robert
Cantu, Robert
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 25943889; PMCID: PMC4529056; DOI: 10.1007/s00401-015-1435-y;

McKee AC, Stein TD, Kiernan PT, Alvarez VE. The neuropathology of chronic traumatic encephalopathy. Brain Pathol. 2015 May; 25(3):350-64.View Related Profiles.

McKee, Ann
Stein, Thor
Alvarez, Victor

PMID: 25904048; PMCID: PMC4526170; DOI: 10.1111/bpa.12248;

Iglesias JE, Augustinack JC, Nguyen K, Player CM, Player A, Wright M, Roy N, Frosch MP, McKee AC, Wald LL, Fischl B, Van Leemput K. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI. Neuroimage. 2015 Jul 15; 115:117-37. PMID: 25936807; PMCID: PMC4461537; DOI: 10.1016/j.neuroimage.2015.04.042;

Daneshvar DH, Goldstein LE, Kiernan PT, Stein TD, McKee AC. Post-traumatic neurodegeneration and chronic traumatic encephalopathy. Mol Cell Neurosci. 2015 May; 66(Pt B):81-90.View Related Profiles.

McKee, Ann
Daneshvar, Daniel
Goldstein, Lee
Stein, Thor

PMID: 25758552; DOI: 10.1016/j.mcn.2015.03.007;

Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz DV, Giza CC, Greenwald RM, Herring SA, Hoshizaki TB, Hudziak JJ, Huston J, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead JR, Wiese-Bjornstal DM. Ice hockey summit II: zero tolerance for head hits and fighting. PM R. 2015 Mar; 7(3):283-95. PMID: 25797614; DOI: 10.1016/j.pmrj.2015.02.002;

Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz DV, Giza CC, Greenwald RM, Herring SA, Hoshizaki TB, Hudziak JJ, Huston J, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead JR, Wiese-Bjornstal DM. Ice Hockey Summit II: zero tolerance for head hits and fighting. Curr Sports Med Rep. 2015 Mar-Apr; 14(2):135-44. PMID: 25757010; DOI: 10.1249/JSR.0000000000000132;

Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz D, Giza CC, Greenwald RM, Herring S, Hoshizaki TB, Hudziak JJ, Huston J, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead J, Wiese-Bjornstal DM. Ice Hockey Summit II: zero tolerance for head hits and fighting. Clin J Sport Med. 2015 Mar; 25(2):78-87. PMID: 25866860; DOI: 10.1097/JSM.0000000000000195;

Kiernan PT, Montenigro PH, Solomon TM, McKee AC. Chronic traumatic encephalopathy: a neurodegenerative consequence of repetitive traumatic brain injury. Semin Neurol. 2015 Feb; 35(1):20-8.View Related Profiles.

McKee, Ann
Montenigro, Philip

PMID: 25714864; DOI: 10.1055/s-0035-1545080;

Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16.View Related Profiles.

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Jun, Gyungah
Farrer, Lindsay
Kowall, Neil
Stern, Robert

PMID: 25531812; PMCID: PMC4324097; DOI: 10.1001/jamaneurol.2014.2157;

Mckee AC, Daneshvar DH. The neuropathology of traumatic brain injury. Handb Clin Neurol. 2015; 127:45-66.View Related Profiles.

McKee, Ann
Daneshvar, Daniel

PMID: 25702209; PMCID: PMC4694720; DOI: 10.1016/B978-0-444-52892-6.00004-0;

Baugh CM, Kiernan PT, Kroshus E, Daneshvar DH, Montenigro PH, McKee AC, Stern RA. Frequency of head-impact-related outcomes by position in NCAA division I collegiate football players. J Neurotrauma. 2015 Mar 1; 32(5):314-26.View Related Profiles.

McKee, Ann
Daneshvar, Daniel
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PMID: 25155288; PMCID: PMC4628259; DOI: 10.1089/neu.2014.3582;

Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.View Related Profiles.

McKee, Ann
Jun, Gyungah
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PMID: 25199842; PMCID: PMC4314944; DOI: 10.1001/jamaneurol.2014.1491;

Goldstein LE, McKee AC, Stanton PK. Considerations for animal models of blast-related traumatic brain injury and chronic traumatic encephalopathy. Alzheimers Res Ther. 2014; 6(5):64.View Related Profiles.

McKee, Ann
Goldstein, Lee

PMID: 25478023; PMCID: PMC4255537; DOI: 10.1186/s13195-014-0064-3;

Baugh CM, Robbins CA, Stern RA, McKee AC. Current understanding of chronic traumatic encephalopathy. Curr Treat Options Neurol. 2014 Sep; 16(9):306.View Related Profiles.

McKee, Ann
Baugh, Christine
Stern, Robert

PMID: 25023937; PMCID: PMC4255271; DOI: 10.1007/s11940-014-0306-5;

Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LI. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimers Dement. 2015 Jan; 11(1):70-98. PMID: 25022540; PMCID: PMC4287457; DOI: 10.1016/j.jalz.2014.04.514;

Kaur B, Himali JJ, Seshadri S, Beiser AS, Au R, McKee AC, Auerbach S, Wolf PA, DeCarli CS. Association between neuropathology and brain volume in the Framingham Heart Study. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):219-25.View Related Profiles.

Beiser, Alexa
McKee, Ann
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Wolf, Philip
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Auerbach, Sanford
Seshadri, Sudha

PMID: 24614264; PMCID: PMC4139422; DOI: 10.1097/WAD.0000000000000032;

McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S242-53.View Related Profiles.

McKee, Ann
Robinson, Meghan

PMID: 24924675; PMCID: PMC4255273; DOI: 10.1016/j.jalz.2014.04.003;

Robbins CA, Daneshvar DH, Picano JD, Gavett BE, Baugh CM, Riley DO, Nowinski CJ, McKee AC, Cantu RC, Stern RA. Self-reported concussion history: impact of providing a definition of concussion. Open Access J Sports Med. 2014; 5:99-103.View Related Profiles.

McKee, Ann
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
Stern, Robert
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PMID: 24891816; PMCID: PMC4019619; DOI: 10.2147/OAJSM.S58005;

McKee AC. Author's reply: To PMID 19535999. J Neuropathol Exp Neurol. 2014 Apr; 73(4):375. PMID: 24662934; DOI: 10.1097/01.jnen.0000445642.03138.6e;

Stein TD, Alvarez VE, McKee AC. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimers Res Ther. 2014; 6(1):4.View Related Profiles.

McKee, Ann
Stein, Thor
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PMID: 24423082; PMCID: PMC3979082; DOI: 10.1186/alzrt234;

McKee AC, Daneshvar DH, Alvarez VE, Stein TD. The neuropathology of sport. Acta Neuropathol. 2014 Jan; 127(1):29-51.View Related Profiles.

McKee, Ann
Daneshvar, Daniel
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PMID: 24366527; PMCID: PMC4255282; DOI: 10.1007/s00401-013-1230-6;

Saman S, Lee NC, Inoyo I, Jin J, Li Z, Doyle T, McKee AC, Hall GF. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease. J Alzheimers Dis. 2014; 40 Suppl 1:S47-70. PMID: 24718102; PMCID: PMC5977388; DOI: 10.3233/JAD-132135;

Mez J, Stern RA, McKee AC. Chronic traumatic encephalopathy: where are we and where are we going? Curr Neurol Neurosci Rep. 2013 Dec; 13(12):407.View Related Profiles.

McKee, Ann
Mez, Jesse
Stern, Robert

PMID: 24136455; PMCID: PMC4550089; DOI: 10.1007/s11910-013-0407-7;

Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain Res. 2013 Dec 6; 1541:115-27.View Related Profiles.

Dedeoglu, Alpaslan
McKee, Ann
Carreras, Isabel
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PMID: 24161403; PMCID: PMC3863610; DOI: 10.1016/j.brainres.2013.10.025;

Brady CB, Trevor KT, Stein TD, Deykin EY, Perkins SD, Averill JG, Guilderson L, McKee AC, Renner SW, Kowall NW. The Department of Veterans Affairs Biorepository Brain Bank: a national resource for amyotrophic lateral sclerosis research. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec; 14(7-8):591-7.View Related Profiles.

McKee, Ann
Brady, Christopher
Kowall, Neil
Stein, Thor

PMID: 23971854; DOI: 10.3109/21678421.2013.822516;

Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013 Sep 24; 81(13):1122-9.View Related Profiles.

Budson, Andrew
McKee, Ann
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
Seichepine, Daniel
Stamm, Julie
Goldstein, Lee
Kowall, Neil
Montenigro, Philip
Stern, Robert
Cantu, Robert
Stein, Thor
Alvarez, Victor

PMID: 23966253; PMCID: PMC3795597; DOI: 10.1212/WNL.0b013e3182a55f7f;

Seichepine DR, Stamm JM, Daneshvar DH, Riley DO, Baugh CM, Gavett BE, Tripodis Y, Martin B, Chaisson C, McKee AC, Cantu RC, Nowinski CJ, Stern RA. Profile of self-reported problems with executive functioning in college and professional football players. J Neurotrauma. 2013 Jul 15; 30(14):1299-304.View Related Profiles.

McKee, Ann
Baugh, Christine
Chaisson, Christine
Nowinski, Christopher
Daneshvar, Daniel
Seichepine, Daniel
Stamm, Julie
Stern, Robert
Cantu, Robert
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PMID: 23421745; PMCID: PMC3713446; DOI: 10.1089/neu.2012.2690;

Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12066-71.View Related Profiles.

McKee, Ann
Ryu, Hoon
Lee, Junghee
Kowall, Neil

PMID: 23818595; PMCID: PMC3718122; DOI: 10.1073/pnas.1300894110;

McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Abraham, Carmela
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Nowinski, Christopher
Daneshvar, Daniel
Goldstein, Lee
Kowall, Neil
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya
Alvarez, Victor

PMID: 23208308; PMCID: PMC3624697; DOI: 10.1093/brain/aws307;

Le MN, Kim W, Lee S, McKee AC, Hall GF. Multiple mechanisms of extracellular tau spreading in a non-transgenic tauopathy model. Am J Neurodegener Dis. 2012; 1(3):316-33. PMID: 23383401; PMCID: PMC3560471

Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, St George-Hyslop P, Goldstein LE, Farrer LA. d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS One. 2012; 7(9):e43728.View Related Profiles.

McKee, Ann
Jun, Gyungah
Moncaster, Juliet
Goldstein, Lee
Farrer, Lindsay
Wolf, Philip
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PMID: 22984439; PMCID: PMC3439481; DOI: 10.1371/journal.pone.0043728;

Augustinack JC, Huber KE, Stevens AA, Roy M, Frosch MP, van der Kouwe AJ, Wald LL, Van Leemput K, McKee AC, Fischl B. Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI. Neuroimage. 2013 Jan 01; 64:32-42. PMID: 22960087; PMCID: PMC3508349; DOI: 10.1016/j.neuroimage.2012.08.071;

Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64.View Related Profiles.

McKee, Ann
Delalle, Ivana
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PMID: 22710966; PMCID: PMC3398703; DOI: 10.1097/NEN.0b013e31825d06b7;

Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee AC. The Framingham Brain Donation Program: neuropathology along the cognitive continuum. Curr Alzheimer Res. 2012 Jul; 9(6):673-86.View Related Profiles.

Beiser, Alexa
McKee, Ann
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Wolf, Philip
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Auerbach, Sanford
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PMID: 22471865; PMCID: PMC3622706

Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8.View Related Profiles.

McKee, Ann
Jun, Gyungah
Lunetta, Kathryn
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PMID: 22722634; PMCID: PMC3398432; DOI: 10.1212/WNL.0b013e3182605801;

Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, Nowinski CJ, Cantu RC, McKee AC, Stern RA. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012 Jun; 6(2):244-54.View Related Profiles.

McKee, Ann
Baugh, Christine
Nowinski, Christopher
Stamm, Julie
Stern, Robert
Cantu, Robert

PMID: 22552850; DOI: 10.1007/s11682-012-9164-5;

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
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Casey, Noel
Minaeva, Olga
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya

PMID: 22593173; PMCID: PMC3739428; DOI: 10.1126/scitranslmed.3003716;

Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012 May; 71(5):362-81. PMID: 22487856; PMCID: PMC3560290; DOI: 10.1097/NEN.0b013e31825018f7;

Gavett BE, Cantu RC, Shenton M, Lin AP, Nowinski CJ, McKee AC, Stern RA. Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions. Curr Opin Neurol. 2011 Dec; 24(6):525-31.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Stern, Robert
Cantu, Robert

PMID: 22045219; DOI: 10.1097/WCO.0b013e32834cd477;

Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, Jackson B, McKee AC, Alvarez VE, Lee NC, Hall GF. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem. 2012 Feb 3; 287(6):3842-9.View Related Profiles.

McKee, Ann
Alvarez, Victor

PMID: 22057275; PMCID: PMC3281682; DOI: 10.1074/jbc.M111.277061;

Sullivan CP, Berg EA, Elliott-Bryant R, Fishman JB, McKee AC, Morin PJ, Shia MA, Fine RE. Pyroglutamate-Aß 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aß 11 forming the central core. Neurosci Lett. 2011 Nov 14; 505(2):109-12.View Related Profiles.

McKee, Ann
Morin, Peter
Fine, Richard

PMID: 22001577; PMCID: PMC3253715; DOI: 10.1016/j.neulet.2011.09.071;

Stern RA, Riley DO, Daneshvar DH, Nowinski CJ, Cantu RC, McKee AC. Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy. PM R. 2011 Oct; 3(10 Suppl 2):S460-7.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
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PMID: 22035690; DOI: 10.1016/j.pmrj.2011.08.008;

Daneshvar DH, Riley DO, Nowinski CJ, McKee AC, Stern RA, Cantu RC. Long-term consequences: effects on normal development profile after concussion. Phys Med Rehabil Clin N Am. 2011 Nov; 22(4):683-700, ix.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
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Cantu, Robert

PMID: 22050943; PMCID: PMC3208826; DOI: 10.1016/j.pmr.2011.08.009;

Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41.View Related Profiles.

McKee, Ann
Baldwin, Clinton
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Kowall, Neil
Stern, Robert

PMID: 21460841; PMCID: PMC3090745; DOI: 10.1038/ng.801;

Daneshvar DH, Nowinski CJ, McKee AC, Cantu RC. The epidemiology of sport-related concussion. Clin Sports Med. 2011 Jan; 30(1):1-17, vii.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Cantu, Robert

PMID: 21074078; PMCID: PMC2987636; DOI: 10.1016/j.csm.2010.08.006;

Daneshvar DH, Baugh CM, Nowinski CJ, McKee AC, Stern RA, Cantu RC. Helmets and mouth guards: the role of personal equipment in preventing sport-related concussions. Clin Sports Med. 2011 Jan; 30(1):145-63, x.View Related Profiles.

McKee, Ann
Baugh, Christine
Nowinski, Christopher
Daneshvar, Daniel
Stern, Robert
Cantu, Robert

PMID: 21074089; PMCID: PMC2987604; DOI: 10.1016/j.csm.2010.09.006;

Gavett BE, Stern RA, McKee AC. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clin Sports Med. 2011 Jan; 30(1):179-88, xi.View Related Profiles.

McKee, Ann
Stern, Robert

PMID: 21074091; PMCID: PMC2995699; DOI: 10.1016/j.csm.2010.09.007;

Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta Neuropathol. 2011 Apr; 121(4):487-98.View Related Profiles.

McKee, Ann
Ryu, Hoon
Lee, Junghee
Kowall, Neil

PMID: 21161248; PMCID: PMC3151672; DOI: 10.1007/s00401-010-0788-5;

Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010; 5(10):e13250.View Related Profiles.

McKee, Ann
Wolozin, Benjamin
Sherman, Michael
Zaarur, Nava
Vanderweyde, Tara

PMID: 20948999; PMCID: PMC2952586; DOI: 10.1371/journal.pone.0013250;

McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010 Sep; 69(9):918-29.View Related Profiles.

Budson, Andrew
McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Kowall, Neil
Morin, Peter
Stern, Robert
Cantu, Robert

PMID: 20720505; PMCID: PMC2951281; DOI: 10.1097/NEN.0b013e3181ee7d85;

Gavett BE, Stern RA, Cantu RC, Nowinski CJ, McKee AC. Mild traumatic brain injury: a risk factor for neurodegeneration. Alzheimers Res Ther. 2010; 2(3):18.View Related Profiles.

McKee, Ann
Gavett, Brandon
Nowinski, Christopher
Stern, Robert
Cantu, Robert

PMID: 20587081; PMCID: PMC2919698; DOI: 10.1186/alzrt42;

Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673; PMCID: PMC2828525; DOI: 10.1038/ng.536;

Yamin R, Zhao C, O'Connor PB, McKee AC, Abraham CR. Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Mol Neurodegener. 2009; 4:33.View Related Profiles.

McKee, Ann
Abraham, Carmela

PMID: 19627603; PMCID: PMC2726140; DOI: 10.1186/1750-1326-4-33;

McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009 Jul; 68(7):709-35.View Related Profiles.

Budson, Andrew
McKee, Ann
Gavett, Brandon
Nowinski, Christopher
Stern, Robert
Cantu, Robert

PMID: 19535999; PMCID: PMC2945234; DOI: 10.1097/NEN.0b013e3181a9d503;

Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11):1501-9.View Related Profiles.

McKee, Ann
Hamilton, James
Decano, Julius
Ruiz-Opazo, Nelson
Herrera, Victoria

PMID: 19273719; PMCID: PMC2825876; DOI: 10.1161/CIRCULATIONAHA.108.833327;

T Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol. 2008 Dec; 65(12):1640-8.View Related Profiles.

McKee, Ann
Baldwin, Clinton
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay

PMID: 19064752; PMCID: PMC2719762; DOI: 10.1001/archneur.65.12.1640;

Harper DG, Stopa EG, Kuo-Leblanc V, McKee AC, Asayama K, Volicer L, Kowall N, Satlin A. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain. 2008 Jun; 131(Pt 6):1609-17.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 18372313; PMCID: PMC3286014; DOI: 10.1093/brain/awn049;

Hanlon EB, Perelman LT, Vitkin EI, Greco FA, McKee AC, Kowall NW. Scattering differentiates Alzheimer disease in vitro. Opt Lett. 2008 Mar 15; 33(6):624-6.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 18347731

McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 1; 1207:225-36.View Related Profiles.

Dedeoglu, Alpaslan
McKee, Ann
Ryu, Hoon
Carreras, Isabel
Kowall, Neil

PMID: 18374906; PMCID: PMC2587244; DOI: 10.1016/j.brainres.2008.01.095;

Tobin JE, Cui J, Wilk JB, Latourelle JC, Laramie JM, McKee AC, Guttman M, Karamohamed S, DeStefano AL, Myers RH. Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain Res. 2007 Mar 30; 1139:42-7.View Related Profiles.

DeStefano, Anita
McKee, Ann
Latourelle, Jeanne
Myers, Richard

PMID: 17270157; PMCID: PMC1868471; DOI: 10.1016/j.brainres.2007.01.001;

McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Wolf PA. Visual association pathology in preclinical Alzheimer disease. J Neuropathol Exp Neurol. 2006 Jun; 65(6):621-30.View Related Profiles.

McKee, Ann
Cabral, Howard
Kowall, Neil
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 16783172

Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. J Neurosci Res. 2006 May 15; 83(7):1262-70.View Related Profiles.

McKee, Ann
Carreras, Isabel
Ullman, M.
Fine, Richard

PMID: 16511862

Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet. 2006 May; 38(5):518-20.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 16604072

Wolozin B, Manger J, Bryant R, Cordy J, Green RC, McKee A. Re-assessing the relationship between cholesterol, statins and Alzheimer's disease. Acta Neurol Scand Suppl. 2006; 185:63-70.View Related Profiles.

McKee, Ann
Wolozin, Benjamin

PMID: 16866913

Yip AG, McKee AC, Green RC, Wells J, Young H, Cupples LA, Farrer LA. APOE, vascular pathology, and the AD brain. Neurology. 2005 Jul 26; 65(2):259-65.View Related Profiles.

McKee, Ann
Cupples, L
Farrer, Lindsay

PMID: 16043796

Harper DG, Volicer L, Stopa EG, McKee AC, Nitta M, Satlin A. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry. 2005 May; 13(5):359-68. PMID: 15879584

Conn KJ, Gao W, McKee A, Lan MS, Ullman MD, Eisenhauer PB, Fine RE, Wells JM. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain Res. 2004 Oct 1; 1022(1-2):164-72.View Related Profiles.

McKee, Ann
Ullman, M.
Fine, Richard

PMID: 15353226

Harper DG, Stopa EG, McKee AC, Satlin A, Fish D, Volicer L. Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease. Neurobiol Aging. 2004 Jul; 25(6):771-81. PMID: 15165702

Georgopoulos S, McKee A, Kan HY, Zannis VI. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry. 2002 Jul 30; 41(30):9293-301.View Related Profiles.

McKee, Ann
Zannis, Vassilis

PMID: 12135350

Volicer L, McKee A, Hewitt S. Dementia. Neurol Clin. 2001 Nov; 19(4):867-85. PMID: 11854104

Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R, Volicer L. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry. 2001 Apr; 58(4):353-60. PMID: 11296096

Chung TF, Sipe JD, McKee A, Fine RE, Schreiber BM, Liang JS, Johnson RJ. Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane. Amyloid. 2000 Jun; 7(2):105-10.View Related Profiles.

McKee, Ann
Schreiber, Barbara
Fine, Richard

PMID: 10842712

Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, Ferrante RJ. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport. 2000 Jan 17; 11(1):211-3.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 10683860

Volicer L, Wells JM, McKee AC, Kowall NW. Enhanced inhibition of free radical-induced deoxyribose breakdown by Alzheimer brain homogenates. Neurosci Lett. 1999 Aug 6; 270(3):169-72.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 10462121

Hanlon EB, Itzkan I, Dasari RR, Feld MS, Ferrante RJ, McKee AC, Lathi D, Kowall NW. Near-infrared fluorescence spectroscopy detects Alzheimer's disease in vitro. Photochem Photobiol. 1999 Aug; 70(2):236-42.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 10461462

McKee AC. Brain banking: basic science methods. Alzheimer Dis Assoc Disord. 1999 Apr-Jun; 13 Suppl 1:S39-44. PMID: 10369517

McKee AC, Kowall NW, Schumacher JS, Beal MF. The neurotoxicity of amyloid beta protein in aged primates. Amyloid. 1998 Mar; 5(1):1-9.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 9546999

Farrer LA, Abraham CR, Volicer L, Foley EJ, Kowall NW, McKee AC, Wells JM. Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. Exp Neurol. 1995 Dec; 136(2):162-70.View Related Profiles.

McKee, Ann
Abraham, Carmela
Farrer, Lindsay
Kowall, Neil

PMID: 7498406

Vonsattel JP, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M, Gusella JF, Landwehrmeyer GB, Bird ED, Richardson EP, et al. An improved approach to prepare human brains for research. J Neuropathol Exp Neurol. 1995 Jan; 54(1):42-56. PMID: 7815079

Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, McKee AC, Beal MF, Graham BH, Wallace DC. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics. 1994 Sep 15; 23(2):471-6. PMID: 7835898

Markesbery WR, Wang HZ, Kowall NW, Kosik KS, McKee AC. Morphometric image analysis of neuropil threads in Alzheimer's disease. Neurobiol Aging. 1993 Jul-Aug; 14(4):303-7.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 8367011

Delaney GA, McKee AC. Inter- and intra-rater reliability of the pressure threshold meter in measurement of myofascial trigger point sensitivity. Am J Phys Med Rehabil. 1993 Jun; 72(3):136-9. PMID: 8512674

Kowall NW, McKee AC. The histopathology of neuronal degeneration and plasticity in Alzheimer disease. Adv Neurol. 1993; 59:5-33.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 8420123

Nihei K, McKee AC, Kowall NW. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol. 1993; 86(1):55-64.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 8396837

Kowall NW, McKee AC, Yankner BA, Beal MF. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging. 1992 Sep-Oct; 13(5):537-42.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 1461341

McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol. 1991 Aug; 30(2):156-65.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 1910274

McKee AC, Levine DN, Kowall NW, Richardson EP. Peduncular hallucinosis associated with isolated infarction of the substantia nigra pars reticulata. Ann Neurol. 1990 May; 27(5):500-4.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 2360791

Newman NJ, Bell IR, McKee AC. Paraneoplastic limbic encephalitis: neuropsychiatric presentation. Biol Psychiatry. 1990 Mar 1; 27(5):529-42. PMID: 2155672

McKee AC, Kosik KS, Kennedy MB, Kowall NW. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase. J Neuropathol Exp Neurol. 1990 Jan; 49(1):49-63.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 2153760

McKee AC, Kowall NW, Kosik KS. Microtubular reorganization and dendritic growth response in Alzheimer's disease. Ann Neurol. 1989 Nov; 26(5):652-9.View Related Profiles.

McKee, Ann
Kowall, Neil

PMID: 2817839

Ogilvy CS, McKee AC, Newman NJ, Donnelly SM, Kiwak KJ. Embolism of cerebral tissue to lungs: report of two cases and review of the literature. Neurosurgery. 1988 Oct; 23(4):511-6. PMID: 3059214

McKee AC, Winkelman MD, Banker BQ. Central pontine myelinolysis in severely burned patients: relationship to serum hyperosmolality. Neurology. 1988 Aug; 38(8):1211-7. PMID: 3399069

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 182 publications over 31 distinct years, with a maximum of 18 publications in 2015

Bar chart showing 182 publications over 31 distinct years, with a maximum of 18 publications in 2015

Year	Publications
1988	2
1989	1
1990	3
1991	1
1992	1
1993	4
1994	1
1995	2
1998	1
1999	3
2000	2
2001	2
2002	1
2004	2
2005	2
2006	4
2007	1
2008	4
2009	3
2010	5
2011	9
2012	10
2013	6
2014	12
2015	18
2016	12
2017	15
2018	16
2019	15
2020	16
2021	8

Media Mentions

Recent (within 3 months)

“He had no memories of it whatsoever’: How Chuck Crist’s family discovered he had CTE

Buffalo News 7/11/2021

Older

Olympic Bobsledder Who Killed Himself Likely Had C.T.E.

New York Times 4/8/2021

Doctors provide consensus symptoms of CTE among living, a major step for researchers

The Washington Post 3/15/2021

More football leads to worse CTE, scientists say. Consider NFL great Willie Wood

The Washington Post 3/12/2021

Vincent Jackson's brain will be donated for CTE research

USA Today 2/18/2021

Super Bowl 2021: Dark side of the NFL including murder cases, suicides, & the horror brain disease found in dead players

The Sun 2/7/2021

How a Damaged Drainage System May Lead to More Severe Concussions

Smithsonian Magazine 2/1/2021

The Good Kind of Brain Drain

The Atlantic 1/23/2021

A new way of looking at concussions

Knowable Magazine 1/20/2021

Dr Ann McKee: Rugby is ready to explode. Children should not be playing it

The Times 1/13/2021

The NFL and Nickelodeon made football kid-friendly. In light of concussions, is that wise?

Yahoo 1/13/2021

Steve Thompson in group of ex-rugby union internationals to sue for brain damage

BBC 12/8/2020

Team Canada's Erin Ambrose donating brain for concussion research

The Sudbury Star 12/1/2020

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

League of Fans 10/29/2020

Ministry Of Sport Brain Health Week Kicks Off With Dr. Ann McKee

Ministry of Sport 9/13/2020

Disease Caused by Concussions Led to Football Player’s Suicide: ‘He Wanted Us to Tell His Story’

People Magazine 9/10/2020

Tackle Football in Childhood: Does Age Matter?

Medpage Today 9/10/2020

Researchers at BU hoping results from recent CTE study will help lead to development of treatments

WHDH-TV 8/11/2020

L.A. firefighter fights against time in battle with ALS

The Los Angeles Times 5/22/2020

We Know Repeated Head Hits Contribute to CTE—But What About Alzheimer’s Disease?

BU Today 4/29/2020

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

People 3/14/2020

‘They Keep Telling Me I’m Crazy’: A Navy SEAL’s Desperate Search for Answers About His Own Brain Injury & His Family’s Cause Now

People Magazine 3/14/2020

Helmets protect athletes’ skulls. Will the NFL use neuroscience to protect their brains?

Salon 3/9/2020

In brains of dead athletes, researchers seek clues to head trauma

Reuters 2/20/2020

In Brains of Dead Athletes, Researchers Seek Clues to Head Trauma

Reuters 2/20/2020

CTE doctor Bennet Omalu claims NFL behind Washington Post hit piece

New York Post 2/10/2020

Exactly How Dangerous Is Football?

The New Yorker 2/1/2020

What a lifetime of playing football can do to the human brain

VOX 2/1/2020

Does Football Bear Responsibility for a Chiefs Legend’s 1980 Murder-Suicide?

Slate 1/31/2020

What Does Football Do to the Brain?

BU Today 1/30/2020

The Perfect ’72 Dolphins and Football’s Ultimate Toll

The New York Times 1/30/2020

From Scientist to Salesman

The Washington Post 1/22/2020

Experts rip doctor-turned-evangelist Bennet Omalu for CTE claims

The New York Post 1/22/2020

Aaron Hernandez: Netflix documentary investigates CTE injury

Fox Sports Australia 1/20/2020

Aaron Hernandez” 5 Bombshell Details We Learned From Netflix’s Docu-Series

BET 1/17/2020

How Netflix’s Aaron Hernandez documentary could bring attention back to the hidden epidemic in American’s national sport

The Independent 1/16/2020

Aaron Hernandez Netflix documentary: 10 questions still unanswered in ‘Killer Inside’

Mass Live 1/15/2020

Netflix’s Aaron Hernandez Doc Examines the Full Story of the NFL Star Turned Convicted Murderer

Esquire 1/15/2020

CTE Rears its Ugly Head Again with New Aaron Hernandez Documentary

LA Times 1/15/2020

Netflix’s New Docuseries ‘Killer Inside’ Examines The Fall of Aaron Hernandez

Oxygen 1/8/2020

'We NEED more studies': Neurologists demand urgent research into whether contact sports cause motor neurone disease after rugby star Rob Burrow is diagnosed aged 37

Daily Mail 12/20/2019

A Troubled Ex-USC Football Star Died at 31. His Family Hoped That Studying His Brain for CTE Would Help Others

LA Times 12/3/2019

Pro Soccer Players More Likely to Develop Dementia: Study

U.S. News & World Report 10/21/2019

Pro Soccer Players More Likely to Develop Dementia: Study

HealthDay 10/21/2019

Study reveals concussions in high school sports have dropped 40% since 2013 - but football head trauma that causes CTE is still on rise

The Daily Mail 10/15/2019

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Sporting News 10/14/2019

Watch: PSA Claims ‘Tackle Football Is Like Smoking’

Breitbart 10/14/2019

More Years of Football, Higher Odds for Brain Disease Later

HealthDay 10/10/2019

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

ZME Science 10/9/2019

More Years of Football, Higher Odds for Brain Disease Later

U.S. News & World Report 10/9/2019

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

Daily Mail 10/8/2019

CTE Risk Goes Up 30% For Each Year Of Playing Football

Futurity 10/8/2019

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Daily Mail 10/8/2019

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

The Daily Wire 10/8/2019

CTE Risk More Than Doubles after Just Three Years of Playing Football

BU Today 10/7/2019

CTE Risk, Severity Increases With Years Playing Football, Study Shows

Boston Herald 10/7/2019

The Transformers

BU Today 9/20/2019

Study Shows Hockey Great Stan Mikita Suffered from CTE

AP 9/13/2019

Why Women’s Soccer Players are Worried About Their Brains

Bleacher Report 9/10/2019

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

Forbes 9/2/2019

Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Patriots Legend Nick Buoniconti Dies

BU Today 8/1/2019

Aaron Hernandez's estate reaches secret settlement with the families of two men the deceased ex-Patriots star was acquitted of killing during a night club altercation in 2012

Daily Mail 7/26/2019

Do Brain Injuries Affect Women Differently Than Men?

New York Times Magazine 6/26/2019

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Genetic Literacy Project 6/13/2019

Ann McKee Urges MED Graduates to Speak Up for the Voiceless

BU Today 5/28/2019

Exploring the real science behind tackle football's risks

WPVI-TV 5/28/2019

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

Widow Of Hockey Enforcer Todd Ewen Blames NHL For CTE, His Death

NBC News 5/6/2019

The Tragic Post-Hockey Life of an NHL ‘Enforcer’

The Atlantic 4/25/2019

Four BU Professors Receive University’s Highest Faculty Honor

BU Today 4/20/2019

Gronk’s retirement becomes a flashpoint in CTE debate

NBC Sports 3/30/2019

Gronk Retires. Were Concussions and CTE a Factor?

BU Today 3/27/2019

Before CTE Diagnosis, Tommy Nobis’ Family Was Troubled By His Behavior

Atlanta Journal Constitution 1/30/2019

A somber Super Bowl reminder in ‘Mr. Falcon’ CTE diagnosis

Associated Press 1/29/2019

Subconcussive Head Impacts Alter Oculomotor Responses

Reuters Health 12/26/2018

Tim Green’s ALS: Is it fair to blame football?

Syracuse 12/17/2018

Why We Still Don’t Know How Many NFL Players Have CTE

Five Thirty Eight 12/17/2018

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Ex-Patriot Kevin Turner’s children are battling the nurse who became his wife and heir

The Boston Globe 12/7/2018

Doctors Said Hockey Enforcer Todd Ewen Did Not Have C.T.E. But He Did

The New York Times 11/30/2018

Gene Variation May Explain Most Severe CTE

Futurity 11/29/2018

VA researchers named most influential people in health care by TIME magazine

Military Times 11/28/2018

T 100 2018

Time 11/28/2018

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

NHL Won't Admit Liability, Will Pay Around $19 Million In Concussion Lawsuit Settlement

Deadspin 11/13/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

CBS News 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Analysis shows 147 college football programs had at least one player diagnosed with CTE

USA Today 11/2/2018

In football, CTE skeptics like Merril Hoge challenge brain-damage conclusions, but Doug Baldwin cites ‘common sense’

The Seattle Times 10/26/2018

Merril Hoge, co-author of new book are way off target in discussing football, CTE

USA Today 10/24/2018

10 key points from Gladiator: Aaron Hernandez and Football Inc.

The Boston Globe 10/23/2018

How one flawed study and irresponsible reporting launched a wave of CTE hysteria

Yahoo Sports 10/23/2018

A Terrible Thing To Waste

The Boston Globe 10/18/2018

Ann Mckee Elected to the National Academy of Medicine

BU Today 10/15/2018

CTE researchers seek to study more female brains

The Washington Post 10/11/2018

Scientists seek veterans to help treat CTE

60 Minutes – CBS News 9/16/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

While adjusting to NFL's new helmet rule, Ravens players, coaches wonder how it will affect the game

Baltimore Sun 9/5/2018

Researchers close in on CTE diagnosis in living, one brain at a time

USA Today 8/24/2018

Startling jump in NFL player claims for Parkinson's and ALS pushes payout projections past 65-year total in 18 months

Los Angeles Times 8/8/2018

Another CTE diagnosis in soccer adds to growing concern

Yahoo Finance 8/7/2018

Athletes Who May Have Suffered From CTE — And The Tragic Outcomes

Oxygen 6/26/2018

Boynton joins NHL concussion lawsuit, pledges brain to science

TSN 6/21/2018

NHL Commissioner Bettman sidesteps question about concussions

Los Angeles Times 5/28/2018

Naperville Park District latest to add flag football as parents' fear of concussions grows

Chicago Tribune 5/5/2018

The Tragic Diagnosis They Already Knew: Their Brother Died With C.T.E.

The New York Times 5/3/2018

Former NHLer Parker had CTE when he died

TSN 5/3/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing football young may mean earlier cognitive, emotional problems

CNN Health 4/30/2018

TIME’s 100 Most influential People: BU’s Ann McKee

Time 4/19/2018

Is the NHL doing enough to prevent concussions? Eric Lindros, others don't think so

Philly.com 4/19/2018

Experts say CTE ‘is associated with ice hockey play'

Daily News 4/12/2018

Family of Late Minnesota Hockey Star Waiting for Results from CTE Lab

KSTP 2/27/2018

Former Seahawks' brains shed light on NFL head injuries

King 5 News 2/21/2018

Intercepted Podcast Bonus: The NFL’s Violent Ballet

The Intercept 2/1/2018

Bob Costas will skip the Super Bowl because of the NFL’s connection to brain trauma

SB Nation 1/24/2018

Kevin Turner’s rugged road

ESPN 3/16/2011

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

neuropathological alterations of neurodegenerative diseases
tau protein
axonal injury
trauma
vascular injury
neurodegeneration
pathological disease
neuroanatomical localization of clinical symptoms

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