Keywords
Last Name

Ann Rasmusson, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPsychiatry
DivisionGeneral Psychiatry
Address150 S Huntington Avenue
Jamaica Plain MA 02130
Phone(203) 710-2347
Other Positions
InstitutionVA Boston Healthcare System

 Research Expertise & Professional Interests
Ann Rasmusson, MD is the Psychiatry Liaison, PTSD Research and Education, at VA Boston Healthcare System, a Research Associate of the VA National Center for PTSD, Women's Health Science Division, and an Associate Professor of Psychiatry at Boston University. She earned her undergraduate degree at North Dakota State University and MD at the University of Chicago before completing a residency in pediatrics at Johns Hopkins and a neuropsychopharmacology research fellowship and psychiatry residency at Yale University School of Medicine.

Dr. Rasmusson’s basic research focused on understanding the role of the amygdala, prefrontal cortex, and hippocampus in coordinating hypothalamic-pituitary-adrenal (HPA) axis, mesoprefrontal cortical monoamine, and behavioral responses to unconditioned and conditioned stress. Her clinical research has contributed to the current expanded view of neurobiological factors that contribute to PTSD risk and stress resilience. This research has evolved to focus on gender differences in the neurobiology of PTSD and a role for neuroactive steroids and neuropeptides in the pathophysiology and treatment of PTSD and its comorbidities. She is currently a Lead Investigator of a DOD sponsored multisite Phase II investigation of the GABAergic neuroactive steroid ganaxolone in the treatment of PTSD and Principal Investigator on an NIMH study of GABAergic neuroactive steroids in the pathophysiology of PTSD, a VA Merit Review investigating gender-related neurobiological factors that promote refractory nicotine dependence in veterans with PTSD, and the VA RR&D sponsored Translational Center for Traumatic Brain Injury and Stress (TRACTS) investigation of Cognitive Processing Therapy (CPT) efficacy in PTSD with and without TBI. She is the author of 56 peer-reviewed papers, reviews, and chapters and is the mother of one lovely teenage daughter.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2008 GABAergic Neurotransmission in PTSD 7R21MH081113-02
2007 GABAergic Neurotransmission in PTSD 1R21MH081113-01
2004 Effects of Gender on Executive Function During Smoking Withdrawal 5M01RR000125-41-1081 294


 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rasmusson AM. The gut peptide neuropeptide Y and post-traumatic stress disorder. Curr Opin Endocrinol Diabetes Obes. 2017 Feb; 24(1):3-8. PMID: 27898588.
    View in: PubMed
  2. Familoni BO, Gregor KL, Dodson TS, Krzywicki AT, Lowery BN, Orr SP, Suvak MK, Rasmusson AM. Sweat pore reactivity as a surrogate measure of sympathetic nervous system activity in trauma-exposed individuals with and without posttraumatic stress disorder. Psychophysiology. 2016 Sep; 53(9):1417-28. PMID: 27286885.
    View in: PubMed
  3. Pineles SL, Blumenthal TD, Curreri AJ, Nillni YI, Putnam KM, Resick PA, Rasmusson AM, Orr SP. Prepulse inhibition deficits in women with PTSD. Psychophysiology. 2016 Sep; 53(9):1377-85. PMID: 27237725.
    View in: PubMed
  4. Scioli-Salter ER, Johnides BD, Mitchell KS, Smith BN, Resick PA, Rasmusson AM. Depression and dissociation as predictors of physical health symptoms among female rape survivors with posttraumatic stress disorder. Psychol Trauma. 2016 Sep; 8(5):585-91. PMID: 27149157.
    View in: PubMed
  5. Lee DJ, Schnitzlein CW, Wolf JP, Vythilingam M, Rasmusson AM, Hoge CW. PSYCHOTHERAPY VERSUS PHARMACOTHERAPY FOR POSTTRAUMATIC STRESS DISORDER: SYSTEMIC REVIEW AND META-ANALYSES TO DETERMINE FIRST-LINE TREATMENTS. Depress Anxiety. 2016 Sep; 33(9):792-806. PMID: 27126398.
    View in: PubMed
  6. Pineles SL, Nillni YI, King MW, Patton SC, Bauer MR, Mostoufi SM, Gerber MR, Hauger R, Resick PA, Rasmusson AM, Orr SP. Extinction retention and the menstrual cycle: Different associations for women with posttraumatic stress disorder. J Abnorm Psychol. 2016 Apr; 125(3):349-55. PMID: 26866677.
    View in: PubMed
  7. Scioli-Salter E, Forman DE, Otis JD, Tun C, Allsup K, Marx CE, Hauger RL, Shipherd JC, Higgins D, Tyzik A, Rasmusson AM. Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study. J Rehabil Res Dev. 2016; 53(1):95-106. PMID: 27006290.
    View in: PubMed
  8. Japuntich SJ, Gregor K, Pineles SL, Gradus JL, Street AE, Prabhala R, Rasmusson AM. Deployment stress, tobacco use, and postdeployment posttraumatic stress disorder: Gender differences. Psychol Trauma. 2016 Mar; 8(2):123-6. PMID: 26654688.
    View in: PubMed
  9. Scioli-Salter ER, Forman DE, Otis JD, Gregor K, Valovski I, Rasmusson AM. The shared neuroanatomy and neurobiology of comorbid chronic pain and PTSD: therapeutic implications. Clin J Pain. 2015 Apr; 31(4):363-74. PMID: 24806468.
    View in: PubMed
  10. Nillni YI, Pineles SL, Patton SC, Rouse MH, Sawyer AT, Rasmusson AM. Menstrual cycle effects on psychological symptoms in women with PTSD. J Trauma Stress. 2015 Feb; 28(1):1-7. PMID: 25613589.
    View in: PubMed
  11. Pinna G, Rasmusson AM. Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder. Front Cell Neurosci. 2014; 8:256. PMID: 25309317.
    View in: PubMed
  12. Mitchell KS, Rasmusson A, Bartlett B, Gerber MR. Eating disorders and associated mental health comorbidities in female veterans. Psychiatry Res. 2014 Nov 30; 219(3):589-91. PMID: 25015710.
    View in: PubMed
  13. Wolf EJ, Rasmusson AM, Mitchell KS, Logue MW, Baldwin CT, Miller MW. A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. Depress Anxiety. 2014 Apr; 31(4):352-60. PMID: 24677629.
    View in: PubMed
  14. Bauer MS, Lee A, Li M, Bajor L, Rasmusson A, Kazis LE. Off-label use of second generation antipsychotics for post-traumatic stress disorder in the Department of Veterans Affairs: time trends and sociodemographic, comorbidity, and regional correlates. Pharmacoepidemiol Drug Saf. 2014 Jan; 23(1):77-86. PMID: 23996688.
    View in: PubMed
  15. Heinrichs SC, Leite-Morris KA, Rasmusson AM, Kaplan GB. Repeated valproate treatment facilitates fear extinction under specific stimulus conditions. Neurosci Lett. 2013 Sep 27; 552:108-13. PMID: 23916657.
    View in: PubMed
  16. Amick MM, Clark A, Fortier CB, Esterman M, Rasmusson AM, Kenna A, Milberg WP, McGlinchey R. PTSD modifies performance on a task of affective executive control among deployed OEF/OIF veterans with mild traumatic brain injury. J Int Neuropsychol Soc. 2013 Aug; 19(7):792-801. PMID: 23823533.
    View in: PubMed
  17. Pitman RK, Rasmusson AM, Koenen KC, Shin LM, Orr SP, Gilbertson MW, Milad MR, Liberzon I. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 2012 Nov; 13(11):769-87. PMID: 23047775.
    View in: PubMed
  18. Pineles SL, Rasmusson AM, Yehuda R, Lasko NB, Macklin ML, Pitman RK, Orr SP. Predicting emotional responses to potentially traumatic events from pre-exposure waking cortisol levels: a longitudinal study of police and firefighters. Anxiety Stress Coping. 2013; 26(3):241-53. PMID: 22574657.
    View in: PubMed
  19. Pinna G, Rasmusson AM. Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. J Neuroendocrinol. 2012 Jan; 24(1):102-16. PMID: 21981145.
    View in: PubMed
  20. Rasmusson AM, Schnurr PP, Zukowska Z, Scioli E, Forman DE. Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. Exp Biol Med (Maywood). 2010 Oct; 235(10):1150-62. PMID: 20881319.
    View in: PubMed
  21. Morgan CA, Rasmusson A, Pietrzak RH, Coric V, Southwick SM. Relationships among plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate, cortisol, symptoms of dissociation, and objective performance in humans exposed to underwater navigation stress. Biol Psychiatry. 2009 Aug 15; 66(4):334-40. PMID: 19500775.
    View in: PubMed
  22. Morgan CA, Hazlett G, Southwick S, Rasmusson A, Lieberman HR. Effect of carbohydrate administration on recovery from stress-induced deficits in cognitive function: a double-blind, placebo-controlled study of soldiers exposed to survival school stress. Mil Med. 2009 Feb; 174(2):132-8. PMID: 19317193.
    View in: PubMed
  23. Davis LL, Ward C, Rasmusson A, Newell JM, Frazier E, Southwick SM. A placebo-controlled trial of guanfacine for the treatment of posttraumatic stress disorder in veterans. Psychopharmacol Bull. 2008; 41(1):8-18. PMID: 18362867.
    View in: PubMed
  24. Dimoulas E, Steffian L, Steffian G, Doran AP, Rasmusson AM, Morgan C. Dissociation During Intense Military Stress is Related to Subsequent Somatic Symptoms in Women. Psychiatry (Edgmont). 2007 Feb; 4(2):66-73. PMID: 20805901.
    View in: PubMed
  25. Cascade EF, Kalali AH, Rasmusson AM, Monson C. What Treatments are Prescribed for Posttraumatic Stress Disorder? Psychiatry (Edgmont). 2007 Feb; 4(2):25-6. PMID: 20805896.
    View in: PubMed
  26. Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry. 2006 Oct 1; 60(7):704-13. PMID: 16934764.
    View in: PubMed
  27. Rasmusson AM, Wu R, Paliwal P, Anderson GM, Krishnan-Sarin S. A decrease in the plasma DHEA to cortisol ratio during smoking abstinence may predict relapse: a preliminary study. Psychopharmacology (Berl). 2006 Jun; 186(3):473-80. PMID: 16609903.
    View in: PubMed
  28. Rasmusson AM, Picciotto MR, Krishnan-Sarin S. Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review. J Psychopharmacol. 2006 Sep; 20(5):693-707. PMID: 16401662.
    View in: PubMed
  29. Lipschitz DS, Mayes LM, Rasmusson AM, Anyan W, Billingslea E, Gueorguieva R, Southwick SM. Baseline and modulated acoustic startle responses in adolescent girls with posttraumatic stress disorder. J Am Acad Child Adolesc Psychiatry. 2005 Aug; 44(8):807-14. PMID: 16034283.
    View in: PubMed
  30. Rasmusson AM, Vasek J, Lipschitz DS, Vojvoda D, Mustone ME, Shi Q, Gudmundsen G, Morgan CA, Wolfe J, Charney DS. An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD. Neuropsychopharmacology. 2004 Aug; 29(8):1546-57. PMID: 15199367.
    View in: PubMed
  31. Morgan CA, Southwick S, Hazlett G, Rasmusson A, Hoyt G, Zimolo Z, Charney D. Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed to acute stress. Arch Gen Psychiatry. 2004 Aug; 61(8):819-25. PMID: 15289280.
    View in: PubMed
  32. Morgan CA, Rasmusson AM, Winters B, Hauger RL, Morgan J, Hazlett G, Southwick S. Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels. Biol Psychiatry. 2003 Nov 15; 54(10):1087-91. PMID: 14625151.
    View in: PubMed
  33. Lipschitz DS, Rasmusson AM, Anyan W, Gueorguieva R, Billingslea EM, Cromwell PF, Southwick SM. Posttraumatic stress disorder and substance use in inner-city adolescent girls. J Nerv Ment Dis. 2003 Nov; 191(11):714-21. PMID: 14614338.
    View in: PubMed
  34. Lipschitz DS, Rasmusson AM, Yehuda R, Wang S, Anyan W, Gueoguieva R, Grilo CM, Fehon DC, Southwick SM. Salivary cortisol responses to dexamethasone in adolescents with posttraumatic stress disorder. J Am Acad Child Adolesc Psychiatry. 2003 Nov; 42(11):1310-7. PMID: 14566168.
    View in: PubMed
  35. Bremner JD, Vythilingam M, Anderson G, Vermetten E, McGlashan T, Heninger G, Rasmusson A, Southwick SM, Charney DS. Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder. Biol Psychiatry. 2003 Oct 1; 54(7):710-8. PMID: 14512211.
    View in: PubMed
  36. Rasmusson AM, Vythilingam M, Morgan CA. The neuroendocrinology of posttraumatic stress disorder: new directions. CNS Spectr. 2003 Sep; 8(9):651-6, 665-7. PMID: 15079139.
    View in: PubMed
  37. Rasmusson AM, Shi L, Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology. 2002 Aug; 27(2):133-42. PMID: 12093587.
    View in: PubMed
  38. Morgan CA, Rasmusson AM, Wang S, Hoyt G, Hauger RL, Hazlett G. Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report. Biol Psychiatry. 2002 Jul 15; 52(2):136-42. PMID: 12114005.
    View in: PubMed
  39. Rasmusson AM, Lipschitz DS, Wang S, Hu S, Vojvoda D, Bremner JD, Southwick SM, Charney DS. Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biol Psychiatry. 2001 Dec 15; 50(12):965-77. PMID: 11750893.
    View in: PubMed
  40. Guidotti A, Dong E, Matsumoto K, Pinna G, Rasmusson AM, Costa E. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res Brain Res Rev. 2001 Nov; 37(1-3):110-5. PMID: 11744079.
    View in: PubMed
  41. Morgan CA, Wang S, Rasmusson A, Hazlett G, Anderson G, Charney DS. Relationship among plasma cortisol, catecholamines, neuropeptide Y, and human performance during exposure to uncontrollable stress. Psychosom Med. 2001 May-Jun; 63(3):412-22. PMID: 11382268.
    View in: PubMed
  42. Lipschitz DS, Rasmusson AM, Anyan W, Cromwell P, Southwick SM. Clinical and functional correlates of posttraumatic stress disorder in urban adolescent girls at a primary care clinic. J Am Acad Child Adolesc Psychiatry. 2000 Sep; 39(9):1104-11. PMID: 10986806.
    View in: PubMed
  43. Morgan CA, Wang S, Southwick SM, Rasmusson A, Hazlett G, Hauger RL, Charney DS. Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biol Psychiatry. 2000 May 15; 47(10):902-9. PMID: 10807963.
    View in: PubMed
  44. Rasmusson AM, Hauger RL, Morgan CA, Bremner JD, Charney DS, Southwick SM. Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD. Biol Psychiatry. 2000 Mar 15; 47(6):526-39. PMID: 10715359.
    View in: PubMed
  45. Southwick SM, Bremner JD, Rasmusson A, Morgan CA, Arnsten A, Charney DS. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry. 1999 Nov 1; 46(9):1192-204. PMID: 10560025.
    View in: PubMed
  46. Morrow BA, Elsworth JD, Rasmusson AM, Roth RH. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience. 1999; 92(2):553-64. PMID: 10408604.
    View in: PubMed
  47. Rasmusson AM, Southwick SM, Hauger RL, Charney DS. Plasma neuropeptide Y (NPY) increases in humans in response to the alpha 2 antagonist yohimbine. Neuropsychopharmacology. 1998 Jul; 19(1):95-8. PMID: 9608581.
    View in: PubMed
  48. Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3239-44. PMID: 9501247.
    View in: PubMed
  49. Rasmusson AM, Charney DS. Animal models of relevance to PTSD. Ann N Y Acad Sci. 1997 Jun 21; 821:332-51. PMID: 9238215.
    View in: PubMed
  50. Rasmusson AM, Anderson GM, Lynch KA, McSwiggan-Hardin M, Scahill LD, Mazure CM, Goodman WK, Price LH, Cohen DJ, Leckman JF. A preliminary study of tryptophan depletion on tics, obsessive-compulsive symptoms, and mood in Tourette's syndrome. Biol Psychiatry. 1997 Jan 1; 41(1):117-21. PMID: 8988803.
    View in: PubMed
  51. Scahill L, Riddle MA, King RA, Hardin MT, Rasmusson A, Makuch RW, Leckman JF. Fluoxetine has no marked effect on tic symptoms in patients with Tourette's syndrome: a double-blind placebo-controlled study. J Child Adolesc Psychopharmacol. 1997; 7(2):75-85. PMID: 9334893.
    View in: PubMed
  52. Goldstein LE, Rasmusson AM, Bunney BS, Roth RH. Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to psychological stress in the rat. J Neurosci. 1996 Aug 1; 16(15):4787-98. PMID: 8764665.
    View in: PubMed
  53. Rasmusson AM, Goldstein LE, Deutch AY, Bunney BS, Roth RH. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse. 1994 Nov; 18(3):218-24. PMID: 7855734.
    View in: PubMed
  54. Goldstein LE, Rasmusson AM, Bunney BS, Roth RH. The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. J Neurosci. 1994 Aug; 14(8):4937-50. PMID: 8046462.
    View in: PubMed
  55. Riddle MA, Rasmusson AM, Woods SW, Hoffer PB. SPECT imaging of cerebral blood flow in Tourette syndrome. Adv Neurol. 1992; 58:207-11. PMID: 1414625.
    View in: PubMed
  56. Riddle MA, Nelson JC, Kleinman CS, Rasmusson A, Leckman JF, King RA, Cohen DJ. Sudden death in children receiving Norpramin: a review of three reported cases and commentary. J Am Acad Child Adolesc Psychiatry. 1991 Jan; 30(1):104-8. PMID: 2005044.
    View in: PubMed
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