Weiming Xia, PhD
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, University of Texas Health Science Center at Houston
MS, University of Texas Health Science Center at Houston

Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

Bedford VA - Edith Nourse Rogers Memorial VA Hosp

2018 Department of Veterans Affairs Symposium on Digital Alzheimer Biomarker: Chair & Organizer
2017 Department of Veterans Affairs Conference on Alzheimer and Aging Research : Chair & Organizer
1998 Alzheimer's Association International Conference: Travel Award
1994 Travel Award

Alzheimer's Disease Stem Cell Drug Screening in 3D
10/27/2017 - 10/26/2018 (PI)
Cure Alzheimer's Fund

Tocotrienols for Alzheimer's disease
12/15/2015 - 06/30/2018 (PI)
Texas Tech Univ. Health Science Center Amer River Nutr, Inc

Early and late-life metal exposures and Alzheimer's disease
07/01/2017 - 04/30/2018 (PI)
The President and Fellows of Harvard College on behalf of the Harvard T. H. Chan School of Public Health NIH NIEHS

Alzheimer's Disease Drug Discovery in 3D
09/01/2015 - 12/31/2017 (PI)
Cure Alzheimer's Fund

Yr Title Project-Sub Proj Pubs
2018 Profiling Alzheimer's Biomarkers 1I01BX003527-01A1
2018 Three dimensional neuronal model for Alzheimer's brain 1I21BX003807-01
2017 ShEEP request for a Helios CyTOF MS 1IS1BX003546-01A1
2016 iPSC for Neurodegenerative Diseases 5I21BX002215-02
2015 iPSC for Neurodegenerative Diseases 1I21BX002215-01A2
2012 Reagents, ELISA and y-secretase Assay Core 5P01AG015379-15-9005 107
2011 Reagents, ELISA and y-secretase Assay Core 5P01AG015379-14-9005 107
2010 Reagents, ELISA and y-secretase Assay Core 5P01AG015379-13-9005 107
2009 Reagents, ELISA and y-secretase Assay Core 5P01AG015379-12-9005 107
2008 Reagents, ELISA and y-secretase Assay Core 2P01AG015379-11-9005 107
Showing 10 of 14 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics. 2018 Jun 30; 182:21-33.View Related Profiles. PMID: 29709615.
  2. Zhu H, Stern RA, Tao Q, Bourlas A, Essis MD, Chivukula M, Rosenzweig J, Steenkamp D, Xia W, Mercier GA, Tripodis Y, Farlow M, Kowall N, Qiu WQ. An amylin analog used as a challenge test for Alzheimer's disease. Alzheimers Dement (N Y). 2017 Jan; 3(1):33-43.View Related Profiles. PMID: 28503657; DOI: 10.1016/j.trci.2016.12.002;.
  3. Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. PLoS One. 2016; 11(9):e0163072. PMID: 27684569; DOI: 10.1371/journal.pone.0163072;.
  4. Lee HK, Morin P, Xia W. Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient. Stem Cell Res. 2016 Mar; 16(2):213-5. PMID: 27345971; DOI: 10.1016/j.scr.2015.12.050;.
  5. Xia W, Mo H. Potential of tocotrienols in the prevention and therapy of Alzheimer's disease. J Nutr Biochem. 2016 May; 31:1-9. PMID: 27133418; DOI: 10.1016/j.jnutbio.2015.10.011;.
  6. Lee HK, Morin P, Wells J, Hanlon EB, Xia W. Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells. Stem Cell Res. 2015 Sep; 15(2):325-7. PMID: 26246272; DOI: 10.1016/j.scr.2015.07.004;.
  7. Kong R, Chang S, Xia W, Wong ST. Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1. J Struct Biol. 2015 Aug; 191(2):120-9. PMID: 26142917; DOI: 10.1016/j.jsb.2015.07.001;.
  8. Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 Jul; 130(1):21-34.View Related Profiles. PMID: 25943889; PMCID: PMC4529056; DOI: 10.1007/s00401-015-1435-y;.
  9. Findeis MA, Schroeder FC, Creaser SP, McKee TD, Xia W. Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts. Medicines. 2015; (2):127-140. View Publication
  10. Zhang Y, Shao H, Dong Y, Swain CA, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener. 2014; 3(1):8. PMID: 24725331; PMCID: PMC3989795; DOI: 10.1186/2047-9158-3-8;.
Showing 10 of 100 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 100 publications over 22 distinct years, with a maximum of 9 publications in 2010

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72 E. Concord St Instructional (L)
Boston MA 02118
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