Weiming Xia, PhD
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, University of Texas Health Science Center at Houston
MS, University of Texas Health Science Center at Houston

Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

Bedford VA - Edith Nourse Rogers Memorial VA Hosp

2018 Department of Veterans Affairs Symposium on Digital Alzheimer Biomarker: Chair & Organizer
2017 Department of Veterans Affairs Conference on Alzheimer and Aging Research : Chair & Organizer
1998 Alzheimer's Association International Conference: Travel Award
1994 Travel Award

Early and late-life metal exposures and Alzheimer's disease
07/01/2017 - 04/30/2019 (PI)
The President and Fellows of Harvard College on behalf of the Harvard T. H. Chan School of Public Health NIH NIEHS

Alzheimer's Disease Stem Cell Drug Screening in 3D
10/27/2017 - 10/26/2018 (PI)
Cure Alzheimer's Fund

Tocotrienols for Alzheimer's disease
12/15/2015 - 06/30/2018 (PI)
Texas Tech Univ. Health Science Center Amer River Nutr, Inc

Alzheimer's Disease Drug Discovery in 3D
09/01/2015 - 12/31/2017 (PI)
Cure Alzheimer's Fund

Yr Title Project-Sub Proj Pubs
2019 ShEEP Request for Imaging Mass Spectrometry System 1IS1BX004390-01A1
2019 Three dimensional neuronal model for Alzheimer's brain 5I21BX003807-02 1
2019 Profiling Alzheimer's Biomarkers 5I01BX003527-02 2
2018 Profiling Alzheimer's Biomarkers 1I01BX003527-01A1 2
2018 Three dimensional neuronal model for Alzheimer's brain 1I21BX003807-01 1
2017 ShEEP request for a Helios CyTOF MS 1IS1BX003546-01A1
2016 iPSC for Neurodegenerative Diseases 5I21BX002215-02 3
2015 iPSC for Neurodegenerative Diseases 1I21BX002215-01A2 3
2012 Reagents, ELISA and y-secretase Assay Core 5P01AG015379-15-9005 149
2011 Reagents, ELISA and y-secretase Assay Core 5P01AG015379-14-9005 149
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Xia W. ?-Secretase and its modulators: Twenty years and beyond. Neurosci Lett. 2019 05 14; 701:162-169. PMID: 30763650.
  2. Wright LM, Stein TD, Jun G, Chung J, McConnell K, Fiorello M, Siegel N, Ness S, Xia W, Turner KL, Subramanian ML. Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor. J Alzheimers Dis. 2019; 68(4):1429-1438.View Related Profiles. PMID: 30856114.
  3. Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles. PMID: 30776010.
  4. Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics. 2018 Jun 30; 182:21-33.View Related Profiles. PMID: 29709615.
  5. Chen M, Song H, Cui J, Johnson CE, Hubler GK, DePalma RG, Gu Z, Xia W. Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau. J Alzheimers Dis. 2018; 66(2):751-773. PMID: 30347620.
  6. Zhu H, Stern RA, Tao Q, Bourlas A, Essis MD, Chivukula M, Rosenzweig J, Steenkamp D, Xia W, Mercier GA, Tripodis Y, Farlow M, Kowall N, Qiu WQ. An amylin analog used as a challenge test for Alzheimer's disease. Alzheimers Dement (N Y). 2017 Jan; 3(1):33-43.View Related Profiles. PMID: 28503657; DOI: 10.1016/j.trci.2016.12.002;.
  7. Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. PLoS One. 2016; 11(9):e0163072.View Related Profiles. PMID: 27684569; DOI: 10.1371/journal.pone.0163072;.
  8. Lee HK, Morin P, Xia W. Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient. Stem Cell Res. 2016 Mar; 16(2):213-5.View Related Profiles. PMID: 27345971; DOI: 10.1016/j.scr.2015.12.050;.
  9. Xia W, Mo H. Potential of tocotrienols in the prevention and therapy of Alzheimer's disease. J Nutr Biochem. 2016 May; 31:1-9. PMID: 27133418; DOI: 10.1016/j.jnutbio.2015.10.011;.
  10. Lee HK, Morin P, Wells J, Hanlon EB, Xia W. Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells. Stem Cell Res. 2015 Sep; 15(2):325-7.View Related Profiles. PMID: 26246272; DOI: 10.1016/j.scr.2015.07.004;.
Showing 10 of 104 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 104 publications over 23 distinct years, with a maximum of 9 publications in 2010

Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
Google Map

Xia's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department