Weiming Xia, PhD
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, University of Texas Health Science Center at Houston
MS, University of Texas Health Science Center at Houston

Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

Bedford VA - Edith Nourse Rogers Memorial VA Hosp

2018 Department of Veterans Affairs Symposium on Digital Alzheimer Biomarker: Chair & Organizer
2017 Department of Veterans Affairs Conference on Alzheimer and Aging Research : Chair & Organizer
1998 Alzheimer's Association International Conference: Travel Award
1994 Travel Award

Big data and small molecules for Alzheimer's disease
08/15/2019 - 03/31/2024 (Multi-PI)
PI: Weiming Xia, PhD
NIH/National Institute on Aging

Alzheimer's disease burden of illness and care pathways in the real world clinical population served by the US Veterans Affairs Healthcare System
03/30/2020 - 03/30/2022 (PI)
Eisai, Inc

Early and late-life metal exposures and Alzheimer's disease
07/01/2017 - 04/30/2021 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health NIH NIEHS

Driving optic nerve regeneration and repair through constitutive activation of IGF-1 receptor
09/30/2018 - 02/28/2021 (Subcontract PI)
Schepens Eye Research Institute NIH NEI

3DDS: Alzheimer's Disease Pharmacomics in 3D (Year 4)
11/01/2018 - 10/31/2020 (PI)
Cure Alzheimer's Fund

Eye to Brain: Eye Biomarkers and Cognition
07/01/2019 - 06/30/2020 (Subcontract PI)
Boston Medical Center Corporation NIH NIA

Alzheimer's Disease Stem Cell Drug Screening in 3D
10/27/2017 - 10/26/2018 (PI)
Cure Alzheimer's Fund

Tocotrienols for Alzheimer's disease
12/15/2015 - 06/30/2018 (Subcontract PI)
Texas Tech Univ. Health Science Center Amer River Nutr, Inc

Alzheimer's Disease Drug Discovery in 3D
09/01/2015 - 12/31/2017 (PI)
Cure Alzheimer's Fund


Yr Title Project-Sub Proj Pubs
2020 Exploring Alzheimer Therapeutics 1I01BX004730-01
2020 Exploring Alzheimer Therapeutics 1I01BX004730-01
2020 Exploring Alzheimer Therapeutics 1I01BX004730-01
2020 Big data and small molecules for Alzheimer's disease 3RF1AG063913-01S1
2020 Profiling Alzheimer's Biomarkers 5I01BX003527-03 4
2019 Big data and small molecules for Alzheimer's disease 1RF1AG063913-01
2019 ShEEP Request for Imaging Mass Spectrometry System 1IS1BX004390-01A1
2019 Three dimensional neuronal model for Alzheimer's brain 5I21BX003807-02 3
2019 Profiling Alzheimer's Biomarkers 5I01BX003527-02 4
2018 Profiling Alzheimer's Biomarkers 1I01BX003527-01A1 4
Showing 10 of 23 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Subramanian ML, Vig V, Chung J, Fiorello MG, Xia W, Zetterberg H, Blennow K, Zetterberg M, Shareef F, Siegel NH, Ness S, Jun GR, Stein TD. Neurofilament light chain in the vitreous humor of the eye. Alzheimers Res Ther. 2020 09 17; 12(1):111.View Related Profiles. PMID: 32943089
  2. Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles. PMID: 32301581
  3. Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype. Sci Rep. 2020 02 19; 10(1):2924.View Related Profiles. PMID: 32076055
  4. Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49.View Related Profiles. PMID: 32035230
  5. Chen M, Xia W. Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers. J Alzheimers Dis. 2020; 76(1):349-368. PMID: 32474469
  6. Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 09; 138(3):401-413.View Related Profiles. PMID: 31183671
  7. Xia W. ?-Secretase and its modulators: Twenty years and beyond. Neurosci Lett. 2019 05 14; 701:162-169. PMID: 30763650
  8. Wright LM, Stein TD, Jun G, Chung J, McConnell K, Fiorello M, Siegel N, Ness S, Xia W, Turner KL, Subramanian ML. Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor. J Alzheimers Dis. 2019; 68(4):1429-1438.View Related Profiles. PMID: 30856114
  9. Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles. PMID: 30776010
  10. Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics. 2018 06 30; 182:21-33.View Related Profiles. PMID: 29709615
Showing 10 of 110 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 110 publications over 24 distinct years, with a maximum of 9 publications in 2010

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