Weiming Xia, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Texas Health Science Center at Houston
MS, University of Texas Health Science Center at Houston
BS, Fudan University



Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

Bedford VA - Edith Nourse Rogers Memorial VA Hosp




Big data and small molecules for Alzheimer's disease
09/30/2024 - 08/31/2029 (PI)
NIH/National Institute on Aging
2R01AG063913-02

3DDS: Alzheimer's Disease Pharmacomics in 3D (Year 4)
11/01/2018 - 10/31/2024 (PI)
Cure Alzheimer's Fund


Big data and small molecules for Alzheimer's disease
08/15/2019 - 06/30/2024 (Multi-PI)
PI: Weiming Xia, PhD
NIH/National Institute on Aging
3RF1AG063913-01S2

Early and late-life metal exposures and Alzheimer's disease
07/01/2017 - 04/30/2024 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health NIH NIEHS
5R01ES024165-05

Personnel Agreement for Research Services of Joshua Daniel Jackson
09/30/2022 - 09/29/2023 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Joshua Jackson
10/01/2021 - 09/30/2022 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Jinhui Li
09/28/2021 - 09/27/2022 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Ryan O'Dea
09/28/2021 - 09/27/2022 (PI)
Department of Veterans Administration, Bedford


Alzheimer's disease burden of illness and care pathways in the real world clinical population served by the US Veterans Affairs Healthcare System
03/30/2020 - 03/30/2022 (PI)
Eisai, Inc.


Eye to Brain: Eye Biomarkers and Cognition
07/01/2019 - 02/28/2022 (Subcontract PI)
Boston Medical Center Corporation NIH NIA
5R03AG063255-02

Showing 10 of 15 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Exploring Alzheimer Therapeutics 5I01BX004730-05
2024 Big data and small molecules for Alzheimer's disease 2R01AG063913-02
2023 Exploring Alzheimer Therapeutics 5I01BX004730-04
2022 Exploring Alzheimer Therapeutics 5I01BX004730-03
2021 Exploring Alzheimer Therapeutics 5I01BX004730-02
2021 Big data and small molecules for Alzheimer's disease 3RF1AG063913-01S2
2021 Profiling Alzheimer's Biomarkers 5I01BX003527-04 4
2020 Exploring Alzheimer Therapeutics 1I01BX004730-01
2020 Big data and small molecules for Alzheimer's disease 3RF1AG063913-01S1
2020 Profiling Alzheimer's Biomarkers 5I01BX003527-03 4
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Aguilar BJ, Miller D, Jasuja G, Li X, Shishova E, O'Connor MK, Nguyen A, Morin P, Berlowitz D, Zhang R, Monfared AAT, Zhang Q, Xia W. Rule-Based Identification of Individuals with Mild Cognitive Impairment or Alzheimer's Disease Using Clinical Notes from the United States Veterans Affairs Healthcare System. Neurol Ther. 2023 Dec; 12(6):2067-2078.View Related Profiles. PMID: 37747662; PMCID: PMC10630261; DOI: 10.1007/s40120-023-00540-2;
     
  2. Chung J, Sahelijo N, Maruyama T, Hu J, Panitch R, Xia W, Mez J, Stein TD, Saykin AJ, Takeyama H, Farrer LA, Crane PK, Nho K, Jun GR. Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles. Alzheimers Dement. 2023 Nov; 19(11):5173-5184.View Related Profiles. PMID: 37166019; PMCID: PMC10638468; DOI: 10.1002/alz.13069;
     
  3. Morin PJ, Zhang Q, Xia W, Miller D, Querfurth H, Tahami Monfared AA. Clinical and Scientific Challenges to Effectiveness Studies Under Coverage with Evidence Development in Alzheimer's Disease. Neurol Ther. 2023 Jun; 12(3):721-726.View Related Profiles. PMID: 36933140; PMCID: PMC10195925; DOI: 10.1007/s40120-023-00462-z;
     
  4. Kirsch D, Shah A, Dixon E, Kelley H, Cherry JD, Xia W, Daley S, Aytan N, Cormier K, Kubilus C, Mathias R, Alvarez VE, Huber BR, McKee AC, Stein TD. Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2023 Jan 20; 82(2):127-139.View Related Profiles. PMID: 36617181; PMCID: PMC9852946; DOI: 10.1093/jnen/nlac122;
     
  5. Vig V, Garg I, Tuz-Zahra F, Xu J, Tripodis Y, Nicks R, Xia W, Alvarez VE, Alosco ML, Stein TD, Subramanian ML. Vitreous Humor Biomarkers Reflect Pathological Changes in the Brain for Alzheimer's Disease and Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2023; 93(3):1181-1193.View Related Profiles. PMID: 37182888; PMCID: PMC10258881; DOI: 10.3233/JAD-230167;
     
  6. Prasad M, Xu J, Agranat JS, Xia W, Daley S, Ness S, Chen X, Siegel NH, Stein TD, Chung J, Subramanian ML. Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous Retinal Detachments. Life (Basel). 2022 Dec 31; 13(1).View Related Profiles. PMID: 36676067; PMCID: PMC9862737; DOI: 10.3390/life13010118;
     
  7. Morin P, Li M, Wang Y, Aguilar BJ, Berlowitz D, Tahami Monfared AA, Irizarry M, Zhang Q, Xia W. Clinical Staging of Alzheimer's Disease: Concordance of Subjective and Objective Assessments in the Veteran's Affairs Healthcare System. Neurol Ther. 2022 Sep; 11(3):1341-1352.View Related Profiles. PMID: 35778542; PMCID: PMC9338180; DOI: 10.1007/s40120-022-00379-z;
     
  8. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles. PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;
     
  9. Panitch R, Hu J, Xia W, Bennett DA, Stein TD, Farrer LA, Jun GR. Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):30.View Related Profiles. PMID: 35139885; PMCID: PMC8830081; DOI: 10.1186/s13195-022-00975-z;
     
  10. Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 Nov; 18(11):2042-2054.View Related Profiles. PMID: 35142023; PMCID: PMC9360190; DOI: 10.1002/alz.12607;
     
Showing 10 of 126 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 126 publications over 27 distinct years, with a maximum of 9 publications in 2010

YearPublications
19953
19976
19985
19995
20008
20012
20024
20038
20042
20051
20066
20073
20087
20098
20109
20113
20128
20143
20155
20162
20171
20182
20194
20206
20215
20225
20235

2018 Department of Veterans Affairs Symposium on Digital Alzheimer Biomarker: Chair & Organizer
2017 Department of Veterans Affairs Conference on Alzheimer and Aging Research : Chair & Organizer
1998 Alzheimer's Association International Conference: Travel Award
1994 Travel Award
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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