Ella Zeldich, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Anatomy & Neurobiology

PhD, Tel Aviv University (TAU)
MS, Tel Aviv University (TAU)
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Ella Zeldich, PhD, is an Assistant Professor of Anatomy & Neurobiology at Chobanian and Avedisian School of Medicine. She joined Dr. Carmela Abraham's lab as a postdoctoral associate in 2011. She has been studying the link between Klotho and myelin. One of the laboratory's focuses is the reduction of the accumulation of neurotoxic amyloid beta (Abeta), which is the main component of the amyloid plaques found in the brains of Alzheimer patients. Her research interests are Alzheimer’s disease and aging, neuroprotection, and klotho transcriptional regulation.

Epigenetic determinants in oligodendrocyte maturation in Down Syndrome
07/01/2022 - 06/30/2024 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute of Neurological Disorders & Stroke

Studying epigenetic dysregulation in Down Syndrome using fluorescent reporter cell lines
03/01/2022 - 02/28/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Transcriptomic, physiological, and neurochemical profiling of cortico-limbic projection neurons in monkey anterior cingulate cortex
01/01/2022 - 11/30/2023 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute of Mental Health

Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey
09/30/2021 - 05/31/2023 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute on Aging

Development of myelinating oligodendrocytes in Down syndrome
07/11/2019 - 06/30/2022 (PI)
NIH/National Institute of Child Health & Human Development

Billing Agreement for Samantha Shelton and Patricia Rein Shaw
07/27/2020 - 07/26/2021 (PI)
Children's National


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Klein JA, Li Z, Rampam S, Cardini J, Ayoub A, Shaw P, Rachubinski AL, Espinosa JM, Zeldich E, Haydar TF. Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21. Front Cell Neurosci. 2021; 15:794675.View Related Profiles. PMID: 35058753; PMCID: PMC8763807; DOI: 10.3389/fncel.2021.794675;
  2. Arbel Rubinstein T, Reuveni I, Hesin A, Klein-Goldberg A, Olauson H, Larsson TE, Abraham CR, Zeldich E, Bosch A, Chillón M, Hollander KS, Shabtay-Orbach A, Vainer GW, Wolf I, Rubinek T. A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy. Cancers (Basel). 2021 Dec 15; 13(24).View Related Profiles. PMID: 34944918; PMCID: PMC8699737; DOI: 10.3390/cancers13246297;
  3. Shelton SM, Soucy AR, Kurzion R, Zeldich E, Connor JH, Haydar TF. Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection. eNeuro. 2021 Sep-Oct; 8(5).View Related Profiles. PMID: 34272257; PMCID: PMC8431824; DOI: 10.1523/ENEURO.0108-21.2021;
  4. Li Z, Tyler WA, Zeldich E, Santpere Baró G, Okamoto M, Gao T, Li M, Sestan N, Haydar TF. Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex. Sci Adv. 2020 11; 6(45).View Related Profiles. PMID: 33158872; PMCID: PMC7673705; DOI: 10.1126/sciadv.abd2068;
  5. Chen CD, Rudy MA, Zeldich E, Abraham CR. A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone. FASEB J. 2020 06; 34(6):7234-7246.View Related Profiles. PMID: 32347987; PMCID: PMC7302970; DOI: 10.1096/fj.202000171R;
  6. Chen CD, Li Y, Chen AK, Rudy MA, Nasse JS, Zeldich E, Polanco TJ, Abraham CR. Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho. PLoS One. 2020; 15(1):e0226382.View Related Profiles. PMID: 31929539; PMCID: PMC6957300; DOI: 10.1371/journal.pone.0226382;
  7. Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Oct; 69(2):264-285.View Related Profiles. PMID: 31250273; PMCID: PMC7008951; DOI: 10.1007/s12031-019-01356-2;
  8. Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles. PMID: 30776010; PMCID: PMC6474660; DOI: 10.3233/JAD-180923;
  9. Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 06; 13(2):254-264.View Related Profiles. PMID: 29516269; PMCID: PMC5928172; DOI: 10.1007/s11481-018-9781-x;
  10. Chen CD, Zeldich E, Li Y, Yuste A, Abraham CR. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. J Mol Neurosci. 2018 Feb; 64(2):175-184.View Related Profiles. PMID: 29352444; PMCID: PMC5826803; DOI: 10.1007/s12031-017-1011-0;
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 16 distinct years, with a maximum of 4 publications in 2014


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

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