Ella Zeldich | Profiles RNS

Ella Zeldich, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Anatomy & Neurobiology

PhD, Tel Aviv University (TAU)
MS, Tel Aviv University (TAU)
BS, Tel Aviv University (TAU)

Websites

	Zeldich Lab
	Anatomy & Neurobiology
	Boston University Neuroscience
	Chobanian & Avedisian School of Medicine
	My NCBI

ORCID : 0000-0002-9946-4512

Dr. Ella Zeldich is an Assistant Professor of Anatomy and Neurobiology at the Chobanian and Avedisian School of Medicine. She obtained her Ph.D. (Physiology and Pharmacology) from Tel Aviv University in 2009. Her current studies aim to understand the mechanisms leading to intellectual deficits and Alzheimer’s disease in Down Syndrome. As a molecular neuroscientist, Dr. Zeldich investigates the mechanisms leading to intellectual deficits and Alzheimer’s disease in Down Syndrome. Her team uses induced pluripotent stem cells (iPSCs) derived from individuals with DS to generate cortical organoids and assembloids to mimic neurodevelopmental and neurodegenerative processes associated with trisomy 21. Dr. Zeldich utilizes cutting-edge technological approaches including CRISPR, single-cell multiome profiling, high-resolution imaging, and xenotransplantation of the organoids through a variety of collaborative studies.

There are several active projects in the lab including:
• Investigating the contribution of X-chromosome-linked genes to cellular phenotypes and AD-related pathology in Down Syndrome
• Defining epigenetic determinants in oligodendrocyte maturation in Down Syndrome.
• Developing strategies to assess activity of trisomic neurons using assembloids and xenotransplanted organoids.

Member
Boston University Chobanian & Avedisian School of Medicine
Genome Science Institute

Member
Boston University Chobanian & Avedisian School of Medicine
Neurophotonics Center

Member
Boston University Chobanian & Avedisian School of Medicine
Center for Systems Neuroscience

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research

The contribution of X-chromosome-linked genes to cellular phenotypes and AD-related pathology in Down Syndrome
12/01/2022 - 11/30/2024 (PI)
NIH/National Institute on Aging
1R21AG080269-01

Epigenetic determinants in oligodendrocyte maturation in Down Syndrome
07/01/2022 - 06/30/2024 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS125469-01A1

Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey
09/30/2021 - 05/31/2024 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute on Aging
5R21AG072069-02

Studying epigenetic dysregulation in Down Syndrome using fluorescent reporter cell lines
03/01/2022 - 02/28/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R03NS126864-02

Transcriptomic, physiological, and neurochemical profiling of cortico-limbic projection neurons in monkey anterior cingulate cortex
01/01/2022 - 11/30/2023 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute of Mental Health
5R21MH126250-02

Development of myelinating oligodendrocytes in Down syndrome
07/11/2019 - 06/30/2022 (PI)
NIH/National Institute of Child Health & Human Development
5R21HD098542-02

Billing Agreement for Samantha Shelton and Patricia Rein Shaw
07/27/2020 - 07/26/2021 (PI)
Children's National

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Campbell NB, Patel Y, Moore TL, Medalla M, Zeldich E. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome. Int J Mol Sci. 2023 Feb 09; 24(4).View Related Profiles.

Zeldich, Ella
Moore, Tara

PMID: 36834891; PMCID: PMC9960302; DOI: 10.3390/ijms24043477;

Farley SJ, Grishok A, Zeldich E. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain. Epigenetics Chromatin. 2022 Dec 03; 15(1):39.View Related Profiles.

Grishok, Alla
Zeldich, Ella

PMID: 36463299; PMCID: PMC9719135; DOI: 10.1186/s13072-022-00471-6;

Li Z, Klein JA, Rampam S, Kurzion R, Campbell NB, Patel Y, Haydar TF, Zeldich E. Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome. Front Neurosci. 2022; 16:932384.View Related Profiles.

Zeldich, Ella
Klein, Jenny
Haydar, Tarik

PMID: 36161168; PMCID: PMC9504873; DOI: 10.3389/fnins.2022.932384;

Klein JA, Li Z, Rampam S, Cardini J, Ayoub A, Shaw P, Rachubinski AL, Espinosa JM, Zeldich E, Haydar TF. Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21. Front Cell Neurosci. 2021; 15:794675.View Related Profiles.

Zeldich, Ella
Klein, Jenny
Haydar, Tarik

PMID: 35058753; PMCID: PMC8763807; DOI: 10.3389/fncel.2021.794675;

Arbel Rubinstein T, Reuveni I, Hesin A, Klein-Goldberg A, Olauson H, Larsson TE, Abraham CR, Zeldich E, Bosch A, Chillón M, Hollander KS, Shabtay-Orbach A, Vainer GW, Wolf I, Rubinek T. A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy. Cancers (Basel). 2021 Dec 15; 13(24).View Related Profiles.

Abraham, Carmela
Zeldich, Ella

PMID: 34944918; PMCID: PMC8699737; DOI: 10.3390/cancers13246297;

Shelton SM, Soucy AR, Kurzion R, Zeldich E, Connor JH, Haydar TF. Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection. eNeuro. 2021 Sep-Oct; 8(5).View Related Profiles.

Zeldich, Ella
Connor, John
Haydar, Tarik

PMID: 34272257; PMCID: PMC8431824; DOI: 10.1523/ENEURO.0108-21.2021;

Li Z, Tyler WA, Zeldich E, Santpere Baró G, Okamoto M, Gao T, Li M, Sestan N, Haydar TF. Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex. Sci Adv. 2020 11; 6(45).View Related Profiles.

Zeldich, Ella
Haydar, Tarik
Tyler, William

PMID: 33158872; PMCID: PMC7673705; DOI: 10.1126/sciadv.abd2068;

Chen CD, Rudy MA, Zeldich E, Abraham CR. A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone. FASEB J. 2020 06; 34(6):7234-7246.View Related Profiles.

Abraham, Carmela
Zeldich, Ella

PMID: 32347987; PMCID: PMC7302970; DOI: 10.1096/fj.202000171R;

Chen CD, Li Y, Chen AK, Rudy MA, Nasse JS, Zeldich E, Polanco TJ, Abraham CR. Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho. PLoS One. 2020; 15(1):e0226382.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Nasse, Jason

PMID: 31929539; PMCID: PMC6957300; DOI: 10.1371/journal.pone.0226382;

Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Oct; 69(2):264-285.View Related Profiles.

McKee, Ann
Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Nasse, Jason
Cherry, Jonathan
Lau, Nelson

PMID: 31250273; PMCID: PMC7008951; DOI: 10.1007/s12031-019-01356-2;

Showing 10 of 33 results. Show More

Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Porco, John
Brown, Lauren
Xia, Weiming

PMID: 30776010; PMCID: PMC6474660; DOI: 10.3233/JAD-180923;

Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 06; 13(2):254-264.View Related Profiles.

Abraham, Carmela
Zeldich, Ella
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Ikezu, Tsuneya

PMID: 29516269; PMCID: PMC5928172; DOI: 10.1007/s11481-018-9781-x;

Chen CD, Zeldich E, Li Y, Yuste A, Abraham CR. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. J Mol Neurosci. 2018 Feb; 64(2):175-184.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella

PMID: 29352444; PMCID: PMC5826803; DOI: 10.1007/s12031-017-1011-0;

Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. Vitam Horm. 2016; 101:215-38.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella

PMID: 27125744; DOI: 10.1016/bs.vh.2016.02.004;

Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination. J Mol Neurosci. 2015 Oct; 57(2):185-96.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella

PMID: 26067431; DOI: 10.1007/s12031-015-0598-2;

Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014 Sep 2; 53(34):5579-87.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella

PMID: 25110992; PMCID: PMC4151695; DOI: 10.1021/bi500409n;

Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Jun, Gyungah
Asai, Hirohide
Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Ikezu, Tsuneya

PMID: 25043464; PMCID: PMC4830273; DOI: 10.1002/ana.24219;

Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29; 289(35):24700-15.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Harris, David
Zeldich, Ella
Bove-Fenderson, Erin
Colvin, Teresa

PMID: 25037225; PMCID: PMC4148892; DOI: 10.1074/jbc.M114.567321;

Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci. 2015 Jan; 55(1):76-90.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Hixson, Kathryn

PMID: 24907942; PMCID: PMC5154549; DOI: 10.1007/s12031-014-0336-1;

Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39.View Related Profiles.

Dedeoglu, Alpaslan
Abraham, Carmela
Chen, Ci-Di
Rosene, Douglas
Zeldich, Ella
Giannaris, Eustathia Lela
Luebke, Jennifer
Aytan, Nurgul

PMID: 23365232; PMCID: PMC3711388; DOI: 10.1523/JNEUROSCI.2080-12.2013;

Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem. 2012 Sep; 4(13):1671-9.View Related Profiles.

Abraham, Carmela
Zeldich, Ella

PMID: 22924505; PMCID: PMC3564652; DOI: 10.4155/fmc.12.134;

King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. Biochem J. 2012 Jan 1; 441(1):453-61.View Related Profiles.

Abraham, Carmela
Zeldich, Ella

PMID: 21939436; PMCID: PMC3677209; DOI: 10.1042/BJ20101909;

So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella

PMID: 22822474; PMCID: PMC3560454

Zeldich E, Koren R, Dard M, Weinberg E, Weinreb M, Nemcovsky CE. Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase. J Periodontal Res. 2010 Apr; 45(2):200-6. PMID: 19909407; DOI: 10.1111/j.1600-0765.2009.01218.x;

Weinberg E, Zeldich E, Weinreb MM, Moses O, Nemcovsky C, Weinreb M. Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac. J Cell Biochem. 2009 Sep 1; 108(1):207-15. PMID: 19582788; DOI: 10.1002/jcb.22242;

Zeldich E, Koren R, Dard M, Nemcovsky C, Weinreb M. EGFR in Enamel Matrix Derivative-induced gingival fibroblast mitogenesis. J Dent Res. 2008 Sep; 87(9):850-5. PMID: 18719212

Zeldich E, Koren R, Dard M, Nemcovsky C, Weinreb M. Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by inhibiting caspase activation. J Cell Physiol. 2007 Dec; 213(3):750-8. PMID: 17607712

Zeldich E, Koren R, Nemcovsky C, Weinreb M. Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK. J Dent Res. 2007 Jan; 86(1):41-6. PMID: 17189461

Levkovitz Y, Gil-Ad I, Zeldich E, Dayag M, Weizman A. Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci. 2005; 27(1):29-42. PMID: 16055945

Strous RD, Maayan R, Lapidus R, Goredetsky L, Zeldich E, Kotler M, Weizman A. Increased circulatory dehydroepiandrosterone and dehydroepiandrosterone-sulphate in first-episode schizophrenia: relationship to gender, aggression and symptomatology. Schizophr Res. 2004 Dec 1; 71(2-3):427-34. PMID: 15474914

Maayan R, Fisch B, Galdor M, Kaplan B, Shinnar N, Kinor N, Zeldich E, Valevski A, Weizman A. Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women. Brain Res. 2004 Sep 10; 1020(1-2):167-72. PMID: 15312799

Gil-Ad I, Shtaif B, Levkovitz Y, Dayag M, Zeldich E, Weizman A. Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors. J Mol Neurosci. 2004; 22(3):189-98. PMID: 14997012

Savion S, Zeldich E, Orenstein H, Shepshelovich J, Torchinsky A, Carp H, Toder V, Fein A. Cytokine expression in the uterus of mice with pregnancy loss: effect of maternal immunopotentiation with GM-CSF. Reproduction. 2002 Mar; 123(3):399-409. PMID: 11882017

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 4 publications in 2014

Bar chart showing 33 publications over 17 distinct years, with a maximum of 4 publications in 2014

Year	Publications
2002	1
2004	3
2005	1
2007	2
2008	1
2009	2
2012	3
2013	1
2014	4
2015	1
2016	1
2018	2
2019	2
2020	3
2021	2
2022	3
2023	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Neurogenesis
IPS Cell
Oligodendrocytes
Organoids

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