Ella Zeldich, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, Tel Aviv University (TAU)
MS, Tel Aviv University (TAU)
BS, Tel Aviv University (TAU)

Dr. Ella Zeldich is an Assistant Professor of Anatomy and Neurobiology at the Chobanian and Avedisian School of Medicine. She obtained her Ph.D. (Physiology and Pharmacology) from Tel Aviv University in 2009. Her current studies aim to understand the mechanisms leading to intellectual deficits and Alzheimer’s disease in Down Syndrome. As a molecular neuroscientist, Dr. Zeldich investigates the mechanisms leading to intellectual deficits and Alzheimer’s disease in Down Syndrome. Her team uses induced pluripotent stem cells (iPSCs) derived from individuals with DS to generate cortical organoids and assembloids to mimic neurodevelopmental and neurodegenerative processes associated with trisomy 21. Dr. Zeldich utilizes cutting-edge technological approaches including CRISPR, single-cell multiome profiling, high-resolution imaging, and xenotransplantation of the organoids through a variety of collaborative studies.

There are several active projects in the lab including:
• Investigating the contribution of X-chromosome-linked genes to cellular phenotypes and AD-related pathology in Down Syndrome
• Defining epigenetic determinants in oligodendrocyte maturation in Down Syndrome.
• Developing strategies to assess activity of trisomic neurons using assembloids and xenotransplanted organoids.

Boston University Chobanian & Avedisian School of Medicine
Genome Science Institute

Boston University Chobanian & Avedisian School of Medicine
Neurophotonics Center

Boston University Chobanian & Avedisian School of Medicine
Center for Systems Neuroscience

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

The contribution of X-chromosome-linked genes to cellular phenotypes and AD-related pathology in Down Syndrome
12/01/2022 - 11/30/2024 (PI)
NIH/National Institute on Aging

Epigenetic determinants in oligodendrocyte maturation in Down Syndrome
07/01/2022 - 06/30/2024 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute of Neurological Disorders & Stroke

Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey
09/30/2021 - 05/31/2024 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute on Aging

Studying epigenetic dysregulation in Down Syndrome using fluorescent reporter cell lines
03/01/2022 - 02/28/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Transcriptomic, physiological, and neurochemical profiling of cortico-limbic projection neurons in monkey anterior cingulate cortex
01/01/2022 - 11/30/2023 (Multi-PI)
PI: Ella Zeldich, PhD
NIH/National Institute of Mental Health

Development of myelinating oligodendrocytes in Down syndrome
07/11/2019 - 06/30/2022 (PI)
NIH/National Institute of Child Health & Human Development

Billing Agreement for Samantha Shelton and Patricia Rein Shaw
07/27/2020 - 07/26/2021 (PI)
Children's National


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Campbell NB, Patel Y, Moore TL, Medalla M, Zeldich E. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome. Int J Mol Sci. 2023 Feb 09; 24(4).View Related Profiles. PMID: 36834891; PMCID: PMC9960302; DOI: 10.3390/ijms24043477;
  2. Farley SJ, Grishok A, Zeldich E. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain. Epigenetics Chromatin. 2022 Dec 03; 15(1):39.View Related Profiles. PMID: 36463299; PMCID: PMC9719135; DOI: 10.1186/s13072-022-00471-6;
  3. Li Z, Klein JA, Rampam S, Kurzion R, Campbell NB, Patel Y, Haydar TF, Zeldich E. Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome. Front Neurosci. 2022; 16:932384.View Related Profiles. PMID: 36161168; PMCID: PMC9504873; DOI: 10.3389/fnins.2022.932384;
  4. Klein JA, Li Z, Rampam S, Cardini J, Ayoub A, Shaw P, Rachubinski AL, Espinosa JM, Zeldich E, Haydar TF. Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21. Front Cell Neurosci. 2021; 15:794675.View Related Profiles. PMID: 35058753; PMCID: PMC8763807; DOI: 10.3389/fncel.2021.794675;
  5. Arbel Rubinstein T, Reuveni I, Hesin A, Klein-Goldberg A, Olauson H, Larsson TE, Abraham CR, Zeldich E, Bosch A, Chillón M, Hollander KS, Shabtay-Orbach A, Vainer GW, Wolf I, Rubinek T. A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy. Cancers (Basel). 2021 Dec 15; 13(24).View Related Profiles. PMID: 34944918; PMCID: PMC8699737; DOI: 10.3390/cancers13246297;
  6. Shelton SM, Soucy AR, Kurzion R, Zeldich E, Connor JH, Haydar TF. Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection. eNeuro. 2021 Sep-Oct; 8(5).View Related Profiles. PMID: 34272257; PMCID: PMC8431824; DOI: 10.1523/ENEURO.0108-21.2021;
  7. Li Z, Tyler WA, Zeldich E, Santpere Baró G, Okamoto M, Gao T, Li M, Sestan N, Haydar TF. Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex. Sci Adv. 2020 11; 6(45).View Related Profiles. PMID: 33158872; PMCID: PMC7673705; DOI: 10.1126/sciadv.abd2068;
  8. Chen CD, Rudy MA, Zeldich E, Abraham CR. A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone. FASEB J. 2020 06; 34(6):7234-7246.View Related Profiles. PMID: 32347987; PMCID: PMC7302970; DOI: 10.1096/fj.202000171R;
  9. Chen CD, Li Y, Chen AK, Rudy MA, Nasse JS, Zeldich E, Polanco TJ, Abraham CR. Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho. PLoS One. 2020; 15(1):e0226382.View Related Profiles. PMID: 31929539; PMCID: PMC6957300; DOI: 10.1371/journal.pone.0226382;
  10. Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Oct; 69(2):264-285.View Related Profiles. PMID: 31250273; PMCID: PMC7008951; DOI: 10.1007/s12031-019-01356-2;
Showing 10 of 33 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 4 publications in 2014


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

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