Tarik Haydar, PhD
Chair
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, University of Maryland School of Medicine
BS, University of Massachusetts Amherst



Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

Waterhouse Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology


Faculty
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Heterogeneity of forebrain neural precursors
09/30/2015 - 06/30/2024 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS095654-05

Molecular Mechanisms of Defective Oligodendrocyte Differentiation in Down Syndrome
09/28/2020 - 05/31/2022 (Key Person / Mentor)
PI: Jenny Klein
NIH/National Institute of Neurological Disorders & Stroke
5F31NS118968-02

Billing Agreement for Samantha Shelton and Patricia Rein Shaw
07/27/2020 - 07/26/2021 (Key Person / Mentor)
PI: Ella Zeldich, PhD
Children's National


Mechanisms of white matter development in Down syndrome
04/01/2018 - 07/31/2020 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS105138-03

Assessment of infection route and vulnerability of neural precursor classes to Zika virus
09/30/2016 - 08/31/2018 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS101151-02

Role of FOXR1 in Mammalian Brain Development
07/01/2015 - 06/30/2018 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of General Medical Sciences
5R21GM114629-02

Altered development and function of the spinal cord in Down syndrome
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS095340-02

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS089340-02

Rescue of Forebrain Defects in Mouse Models of Down Syndrome
09/19/2011 - 08/31/2017 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS076503-07

Role of CLASP2 in Neurodevelopment
12/01/2013 - 11/30/2016 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Mental Health
5R21MH100581-02

Showing 10 of 11 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2025 Mentored Experience to Expand Opportunities in Research version 3 (METEOR v. 3) 5R25NS130654-02
2024 Direct and Indirect Neurogenesis in the Mammalian Neocortex 1R01NS136246-01
2024 Mentored Experience to Expand Opportunities in Research version 3 (METEOR v. 3) 1R25NS130654-01A1
2024 District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC) 5P50HD105328-04
2024 District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32) 5T32NS115656-04
2024 Comparative Genomics of Precursor Diversity and Function 5R01NS116418-04
2023 The developmental origins and fate of neurons in the gyrencephalic neocortex 5R21NS127051-02
2023 Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity 5R21MH129995-02
2023 Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity 3R21MH129995-02S1
2023 District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32) 5T32NS115656-03
Showing 10 of 61 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Abdelmalek CM, Singh S, Fasil B, Horvath AR, Mulkey SB, Curé C, Campos M, Cavalcanti DP, Tong VT, Mercado M, Daza M, Benavides MM, Acosta J, Gilboa S, Valencia D, Sancken CL, Newton S, Scalabrin DMF, Mussi-Pinhata MM, Vasconcelos Z, Chakhtoura N, Moye J, Leslie EJ, Bulas D, Vezina G, Marques FJP, Leyser M, Del Campo M, Vilain E, DeBiasi RL, Wang T, Nath A, Haydar T, Muenke M, Mansour TA, du Plessis AJ, Murray JC, Cordero JF, Kousa YA. Building a growing genomic repository for maternal and fetal health through the PING Consortium. Pediatr Res. 2025 Jan 03. PMID: 39753885
     
  2. Li Z, Haydar TF. MuMu: a sample multiplexing protocol for droplet-based simultaneous single nuclei RNA- and ATAC-seq systems. bioRxiv. 2024 Nov 29. PMID: 39651229; PMCID: PMC11623611; DOI: 10.1101/2024.11.27.625728;
     
  3. Saric N, Atak Z, Sade CF, Reddy N, Bell G, Tolete C, Rajtboriraks MT, Hashimoto-Torii K, Jevtovic-Todorovic V, Haydar TF, Ishibashi N. Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits. bioRxiv. 2024 Nov 27. PMID: 39651246; PMCID: PMC11623571; DOI: 10.1101/2024.11.27.624302;
     
  4. Abdelmalek CM, Singh S, Fasil B, Horvath AR, Mulkey SB, Curé C, Campos M, Cavalcanti DP, Tong VT, Mercado M, Daza M, Marcela Benavides M, Acosta J, Gilboa S, Valencia D, Sancken CL, Newton S, Scalabrin DMF, Mussi-Pinhata MM, Vasconcelos Z, Chakhtoura N, Moye J, Leslie EJ, Bulas D, Vezina G, Marques FJP, Leyser M, Del Campo M, Vilain E, DeBiasi RL, Wang T, Nath A, Haydar T, Muenke M, Mansour TA, du Plessis AJ, Murray JC, Cordero JF, Kousa YA. Building a growing genomic data repository for maternal and fetal health through the PING Consortium. medRxiv. 2024 May 25. PMID: 38826415; PMCID: PMC11142296; DOI: 10.1101/2024.05.24.24307899;
     
  5. Li Z, Klein JA, Rampam S, Kurzion R, Campbell NB, Patel Y, Haydar TF, Zeldich E. Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome. Front Neurosci. 2022; 16:932384.View Related Profiles. PMID: 36161168; PMCID: PMC9504873; DOI: 10.3389/fnins.2022.932384;
     
  6. Jablonska B, Adams KL, Kratimenos P, Li Z, Strickland E, Haydar TF, Kusch K, Nave KA, Gallo V. Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia. Nat Commun. 2022 Aug 15; 13(1):4771. PMID: 35970992; PMCID: PMC9378658; DOI: 10.1038/s41467-022-32462-2;
     
  7. Klein JA, Haydar TF. Neurodevelopment in Down syndrome: Concordance in humans and models. Front Cell Neurosci. 2022; 16:941855.View Related Profiles. PMID: 35910249; PMCID: PMC9334873; DOI: 10.3389/fncel.2022.941855;
     
  8. Klein JA, Li Z, Rampam S, Cardini J, Ayoub A, Shaw P, Rachubinski AL, Espinosa JM, Zeldich E, Haydar TF. Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21. Front Cell Neurosci. 2021; 15:794675.View Related Profiles. PMID: 35058753; PMCID: PMC8763807; DOI: 10.3389/fncel.2021.794675;
     
  9. Shelton SM, Soucy AR, Kurzion R, Zeldich E, Connor JH, Haydar TF. Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection. eNeuro. 2021 Sep-Oct; 8(5).View Related Profiles. PMID: 34272257; PMCID: PMC8431824; DOI: 10.1523/ENEURO.0108-21.2021;
     
  10. Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218. PMID: 34421499; PMCID: PMC8339505; DOI: 10.1159/000514437;
     
Showing 10 of 74 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 73 publications over 26 distinct years, with a maximum of 6 publications in 2008 and 2011 and 2020

YearPublications
19931
19961
19981
19993
20003
20011
20033
20041
20052
20063
20075
20086
20092
20104
20116
20132
20155
20164
20171
20181
20192
20206
20212
20224
20243
20251

2018 Boston University: Jack Spivack Excellence in Neurosciences Award
2008 CNMC: Master Mentor
1997 University of Maryland School of Medicine: Graduate Merit Award
1996-1997 University of Maryland School of Medicine: Neuroscience Program Fellowship
1994-1996 University of Maryland School of Medicine: Membrane Biology Program Fellowship
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

confocal
development
DNA regulation
in utero electroporation
neocortex
time-lapse imaging
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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