Tarik Haydar | Profiles RNS

Tarik Haydar, PhD

Professor

Boston University School of Medicine

Dept of Anatomy & Neurobiology

PhD, University of Maryland School of Medicine

Websites

Anatomy and Neurobiology Faculty

ORCID : 0000-0001-6772-3076

Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

2018 Boston University: Jack Spivack Excellence in Neurosciences Award

2008 CNMC: Master Mentor

1997 University of Maryland School of Medicine: Graduate Merit Award

1996-1997 University of Maryland School of Medicine: Neuroscience Program Fellowship

1994-1996 University of Maryland School of Medicine: Membrane Biology Program Fellowship

BU Sponsored Research
NIH RePORTER Sponsored Research

Heterogeneity of Forebrain Neural Precursors
09/30/2015 - 06/30/2020 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS095654-02

Assessment of infection route and vulnerability of neural precursor classes to Zika virus
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1R21NS101151-01

Role of FOXR1 in Mammalian Brain Development
07/01/2015 - 06/30/2018 (Co-PI)
NIH/National Institute of General Medical Sciences
5R21GM114629-02

Altered development and function of the spinal cord in Down syndrome
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS095340-02

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS089340-02

Rescue of Forebrain Defects in Mouse Models of Down Syndrome
09/19/2011 - 08/31/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS076503-07

Role of CLASP2 in Neurodevelopment
12/01/2013 - 11/30/2016 (Co-PI)
NIH/National Institute of Mental Health
5R21MH100581-02

Heterogeneity of forebrain neural precursors
01/15/2010 - 12/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS051852-11

Yr	Title	Project-Sub Proj	Pubs
2017	Assessment of infection route and vulnerability of neural precursor classes to Zika virus	5R21NS101151-02
2017	Altered development and function of the spinal cord in Down syndrome	5R21NS095340-02
2017	Heterogeneity of Forebrain Neural Precursors	5R01NS095654-03	1
2016	Assessment of infection route and vulnerability of neural precursor classes to Zika virus	1R21NS101151-01
2016	Altered development and function of the spinal cord in Down syndrome	1R21NS095340-01A1
2016	Heterogeneity of Forebrain Neural Precursors	5R01NS095654-02	1
2015	Heterogeneity of Forebrain Neural Precursors	1R01NS095654-01	1
2015	Effects of neural precursor lineage on pyramidal neuron function and morphology	5R21NS089340-02
2015	Rescue of Forebrain Defects in Mouse Models of Down syndrome	5R01NS076503-07	7
2014	Effects of neural precursor lineage on pyramidal neuron function and morphology	1R21NS089340-01A1

Showing 10 of 34 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Aziz NM, Guedj F, Pennings JLA, Olmos-Serrano JL, Siegel A, Haydar TF, Bianchi DW. Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome. Dis Model Mech. 2018 Apr 30.View Related Profiles.

Aziz, Nadine
Haydar, Tarik

PMID: 29716957.

Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2018 Feb 03.View Related Profiles.

Luebke, Jennifer
Medalla, Maria
Haydar, Tarik
Tyler, William

PMID: 29415216.

Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Neuron. 2017 Mar 22; 93(6):1344-1358.e5.View Related Profiles.

Haydar, Tarik
Tyler, William

PMID: 28285824; DOI: 10.1016/j.neuron.2017.02.039;.

Goodliffe JW, Olmos-Serrano JL, Aziz NM, Pennings JL, Guedj F, Bianchi DW, Haydar TF. Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome. J Neurosci. 2016 Mar 9; 36(10):2926-44.View Related Profiles.

Goodliffe, Joseph
Aziz, Nadine
Haydar, Tarik

PMID: 26961948; PMCID: PMC4783496; DOI: 10.1523/JNEUROSCI.2513-15.2016;.

Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22.View Related Profiles.

Peters, Alan
Delalle, Ivana
Goodliffe, Joseph
Pletikos, Mihovil
Haydar, Tarik
Tyler, William

PMID: 26924435; PMCID: PMC4795969; DOI: 10.1016/j.neuron.2016.01.042;.

Olmos-Serrano JL, Tyler WA, Cabral HJ, Haydar TF. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp Neurol. 2016 May; 279:40-56.View Related Profiles.

Cabral, Howard
Olmos Serrano, Jose Luis
Haydar, Tarik
Tyler, William

PMID: 26854932; DOI: 10.1016/j.expneurol.2016.02.005;.

Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. J Neurosci. 2015 Oct 14; 35(41):13843-52. PMID: 26468184; DOI: 10.1523/JNEUROSCI.2775-15.2015;.

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles.

Wolozin, Benjamin
Asai, Hirohide
Luebke, Jennifer
Medalla, Maria
Ikezu, Seiko
Haydar, Tarik
Ikezu, Tsuneya

PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.

Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles.

Luebke, Jennifer
Medalla, Maria
Haydar, Tarik
Tyler, William

PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.

Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Burke, Rebecca
Leeman, Susan
Haydar, Tarik
Mellott, Tiffany
Norman, Timothy

PMID: 24218590; PMCID: PMC3845152; DOI: 10.1073/pnas.1319297110;.

Showing 10 of 49 results. Show More

Tyler WA, Haydar TF. Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. J Neurosci. 2013 Mar 20; 33(12):5106-19.View Related Profiles.

Haydar, Tarik
Tyler, William

PMID: 23516277; PMCID: PMC3785112; DOI: 10.1523/JNEUROSCI.5380-12.2013;.

Haydar TF, Reeves RH. Trisomy 21 and early brain development. Trends Neurosci. 2012 Feb; 35(2):81-91. PMID: 22169531; PMCID: PMC3273608; DOI: 10.1016/j.tins.2011.11.001;.

Best TK, Cramer NP, Chakrabarti L, Haydar TF, Galdzicki Z. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Exp Neurol. 2012 Feb; 233(2):749-57. PMID: 22178330; DOI: 10.1016/j.expneurol.2011.11.033;.

Hevner RF, Haydar TF. The (not necessarily) convoluted role of basal radial glia in cortical neurogenesis. Cereb Cortex. 2012 Feb; 22(2):465-8. PMID: 22116731; PMCID: PMC3256413; DOI: 10.1093/cercor/bhr336;.

Chakrabarti L, Scafidi J, Gallo V, Haydar TF. Environmental enrichment rescues postnatal neurogenesis defect in the male and female Ts65Dn mouse model of Down syndrome. Dev Neurosci. 2011; 33(5):428-41. PMID: 21865665; PMCID: PMC3254041; DOI: 10.1159/000329423;.

Breunig JJ, Haydar TF, Rakic P. Neural stem cells: historical perspective and future prospects. Neuron. 2011 May 26; 70(4):614-25. PMID: 21609820; PMCID: PMC3225274; DOI: 10.1016/j.neuron.2011.05.005;.

Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG. Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system. J Neurosci. 2011 Apr 6; 31(14):5313-24. PMID: 21471366; PMCID: PMC3086773; DOI: 10.1523/JNEUROSCI.3867-10.2011;.

Chakrabarti L, Best TK, Cramer NP, Carney RS, Isaac JT, Galdzicki Z, Haydar TF. Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci. 2010 Aug; 13(8):927-34. PMID: 20639873; PMCID: PMC3249618; DOI: 10.1038/nn.2600;.

Tyler WA, Haydar TF. A new contribution to brain convolution: progenitor cell logistics during cortex development. Nat Neurosci. 2010 Jun; 13(6):656-7.View Related Profiles.

Haydar, Tarik
Tyler, William

PMID: 20498684; DOI: 10.1038/nn0610-656;.

Stancik EK, Navarro-Quiroga I, Sellke R, Haydar TF. Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex. J Neurosci. 2010 May 19; 30(20):7028-36. PMID: 20484645; PMCID: PMC2909740; DOI: 10.1523/JNEUROSCI.6131-09.2010;.

Loulier K, Lathia JD, Marthiens V, Relucio J, Mughal MR, Tang SC, Coksaygan T, Hall PE, Chigurupati S, Patton B, Colognato H, Rao MS, Mattson MP, Haydar TF, Ffrench-Constant C. beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol. 2009 Aug; 7(8):e1000176. PMID: 19688041; PMCID: PMC2720642; DOI: 10.1371/journal.pbio.1000176;.

Gadea A, Aguirre A, Haydar TF, Gallo V. Endothelin-1 regulates oligodendrocyte development. J Neurosci. 2009 Aug 12; 29(32):10047-62. PMID: 19675238; PMCID: PMC2754292; DOI: 10.1523/JNEUROSCI.0822-09.2009;.

Ma JS, Haydar TF, Radoja S. Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity. J Immunol. 2008 Oct 1; 181(7):4716-22. PMID: 18802074.

Corbin JG, Gaiano N, Juliano SL, Poluch S, Stancik E, Haydar TF. Regulation of neural progenitor cell development in the nervous system. J Neurochem. 2008 Sep; 106(6):2272-87. PMID: 18819190; PMCID: PMC2640107.

Liu X, Hashimoto-Torii K, Torii M, Haydar TF, Rakic P. The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11802-7. PMID: 18689674; PMCID: PMC2575326; DOI: 10.1073/pnas.0805180105;.

Haydar TF, Chakrabarti L. Disorders of histogenesis: Neuron Proliferation: Downs syndrome. L.R. Squire (Editor). New Encyclopedia of Neuroscience. Elsevier Ltd. UK. 2008.

Slotkin JR, Chakrabarti L, Dai HN, Carney RS, Hirata T, Bregman BS, Gallicano GI, Corbin JG, Haydar TF. In vivo quantum dot labeling of mammalian stem and progenitor cells. Dev Dyn. 2007 Dec; 236(12):3393-401. PMID: 17626285; PMCID: PMC2670617.

Chakrabarti L, Galdzicki Z, Haydar TF. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci. 2007 Oct 24; 27(43):11483-95. PMID: 17959791.

Corbin JG, Haydar TF. Quantum dots for neuroscience research: new tools for old problems? Nanomedicine (Lond). 2007 Oct; 2(5):579-81. PMID: 17976020.

Ma JS, Monu N, Shen DT, Mecklenbräuker I, Radoja N, Haydar TF, Leitges M, Frey AB, Vukmanovic S, Radoja S. Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL. J Immunol. 2007 Jun 15; 178(12):7814-21. PMID: 17548619; PMCID: PMC3712856.

Navarro-Quiroga I, Chittajallu R, Gallo V, Haydar TF. Long-term, selective gene expression in developing and adult hippocampal pyramidal neurons using focal in utero electroporation. J Neurosci. 2007 May 9; 27(19):5007-11. PMID: 17494686; PMCID: PMC2710030.

Harashima C, Jacobowitz DM, Stoffel M, Chakrabarti L, Haydar TF, Siarey RJ, Galdzicki Z. Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):719-34. PMID: 16783527.

Gal JS, Morozov YM, Ayoub AE, Chatterjee M, Rakic P, Haydar TF. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci. 2006 Jan 18; 26(3):1045-56. PMID: 16421324; PMCID: PMC3249619.

Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci. 2005 Sep; 8(9):1179-87. PMID: 16116450; PMCID: PMC1380263.

Haydar TF. Advanced microscopic imaging methods to investigate cortical development and the etiology of mental retardation. Ment Retard Dev Disabil Res Rev. 2005; 11(4):303-16. PMID: 16240412; PMCID: PMC2670616.

Cheng A, Haydar TF, Yarowsky PJ, Krueger BK. Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex. Dev Neurosci. 2004 Mar-Aug; 26(2-4):255-65. PMID: 15711065.

Ang ES, Haydar TF, Gluncic V, Rakic P. Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex. J Neurosci. 2003 Jul 2; 23(13):5805-15. PMID: 12843285.

Gallo V, Haydar T. GABA: exciting again in its own right. J Physiol. 2003 Aug 1; 550(Pt 3):665. PMID: 12807982; PMCID: PMC2343072.

Haydar TF, Ang E, Rakic P. Mitotic spindle rotation and mode of cell division in the developing telencephalon. Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5):2890-5. PMID: 12589023; PMCID: PMC151436.

Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15; 15(18):2421-32. PMID: 11562351; PMCID: PMC312784.

Haydar TF, Wang F, Schwartz ML, Rakic P. Differential modulation of proliferation in the neocortical ventricular and subventricular zones. J Neurosci. 2000 Aug 1; 20(15):5764-74. PMID: 10908617; PMCID: PMC3823557.

Haydar TF, Nowakowski RS, Yarowsky PJ, Krueger BK. Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. J Neurosci. 2000 Jun 1; 20(11):4156-64. PMID: 10818151.

Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P. Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc Natl Acad Sci U S A. 2000 Jan 4; 97(1):466-71. PMID: 10618441; PMCID: PMC26686.

Haydar TF, Bambrick LL, Krueger BK, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex. Brain Res Brain Res Protoc. 1999 Dec; 4(3):425-37. PMID: 10592354.

Haydar TF, Kuan CY, Flavell RA, Rakic P. The role of cell death in regulating the size and shape of the mammalian forebrain. Cereb Cortex. 1999 Sep; 9(6):621-6. PMID: 10498280.

Flavell RA, Kuida K, Zheng TS, Haydar TF, Kuan C-Y, Su MS, Rakic P. The role of caspases in apoptosis in vivo studied by gene targeting. SKB Symposium. 1999.

Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998 Aug 7; 94(3):325-37. PMID: 9708735.

Haydar TF, Blue ME, Molliver ME, Krueger BK, Yarowsky PJ. Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome. J Neurosci. 1996 Oct 1; 16(19):6175-82. PMID: 8815899.

Cascone PJ, Haydar TF, Simon AE. Sequences and structures required for recombination between virus-associated RNAs. Science. 1993 May 7; 260(5109):801-5. PMID: 8484119.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 20 distinct years, with a maximum of 6 publications in 2011

Bar chart showing 49 publications over 20 distinct years, with a maximum of 6 publications in 2011

Year	Publications
1993	1
1996	1
1998	1
1999	3
2000	3
2001	1
2003	3
2004	1
2005	2
2006	2
2007	5
2008	4
2009	2
2010	3
2011	6
2013	2
2015	3
2016	3
2017	1
2018	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

confocal
development
DNA regulation
in utero electroporation
neocortex
time-lapse imaging

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