Tarik Haydar, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Maryland School of Medicine




Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

Faculty
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2018 Boston University: Jack Spivack Excellence in Neurosciences Award
2008 CNMC: Master Mentor
1997 University of Maryland School of Medicine: Graduate Merit Award
1996-1997 University of Maryland School of Medicine: Neuroscience Program Fellowship
1994-1996 University of Maryland School of Medicine: Membrane Biology Program Fellowship


Heterogeneity of forebrain neural precursors
09/30/2015 - 06/30/2021 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS095654-05

Mechanisms of white matter development in Down syndrome
04/01/2018 - 07/31/2020 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS105138-03

Assessment of infection route and vulnerability of neural precursor classes to Zika virus
09/30/2016 - 08/31/2018 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS101151-02

Role of FOXR1 in Mammalian Brain Development
07/01/2015 - 06/30/2018 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of General Medical Sciences
5R21GM114629-02

Altered development and function of the spinal cord in Down syndrome
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS095340-02

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS089340-02

Rescue of Forebrain Defects in Mouse Models of Down Syndrome
09/19/2011 - 08/31/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS076503-07

Role of CLASP2 in Neurodevelopment
12/01/2013 - 11/30/2016 (Multi-PI)
PI: Tarik Haydar, PhD
NIH/National Institute of Mental Health
5R21MH100581-02

Heterogeneity of forebrain neural precursors
01/15/2010 - 12/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS051852-11



Title


Yr Title Project-Sub Proj Pubs
2021 District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32) 1T32NS115656-01A1
2021 Comparative Genomics of Precursor Diversity and Function 1R01NS116418-01A1
2021 Mechanisms of White Matter Development in Down Syndrome 7R01NS105138-04 1
2021 Mechanisms of White Matter Development in Down Syndrome 5R01NS105138-05 1
2020 Mechanisms of white matter development in Down syndrome 5R01NS105138-03 1
2019 Development of myelinating oligodendrocytes in Down syndrome 1R21HD098542-01
2019 Mechanisms of white matter development in Down syndrome 5R01NS105138-02 1
2019 Heterogeneity of Forebrain Neural Precursors 5R01NS095654-05 2
2018 Mechanisms of white matter development in Down syndrome 3R01NS105138-01A1S1 1
2018 Mechanisms of white matter development in Down syndrome 1R01NS105138-01A1 1
Showing 10 of 45 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shelton SM, Soucy AR, Kurzion R, Zeldich E, Connor JH, Haydar TF. Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection. eNeuro. 2021 Sep-Oct; 8(5).View Related Profiles. PMID: 34272257; PMCID: PMC8431824; DOI: 10.1523/ENEURO.0108-21.2021;
     
  2. Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218. PMID: 34421499; PMCID: PMC8339505; DOI: 10.1159/000514437;
     
  3. Shaw PR, Haydar TF. Mitigating Cognitive Deficits in Down Syndrome by Managing Microglia Activation. Neuron. 2020 12 09; 108(5):799-800. PMID: 33301721
     
  4. Li Z, Tyler WA, Zeldich E, Santpere Baró G, Okamoto M, Gao T, Li M, Sestan N, Haydar TF. Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex. Sci Adv. 2020 Nov; 6(45).View Related Profiles. PMID: 33158872; PMCID: PMC7673705; DOI: 10.1126/sciadv.abd2068;
     
  5. Shaw PR, Klein JA, Aziz NM, Haydar TF. Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. Dis Model Mech. 2020 09 25; 13(9).View Related Profiles. PMID: 32817053; PMCID: PMC7522024; DOI: 10.1242/dmm.046243;
     
  6. Li Z, Tyler WA, Haydar TF. Lessons from single cell sequencing in CNS cell specification and function. Curr Opin Genet Dev. 2020 12; 65:138-143.View Related Profiles. PMID: 32679535; PMCID: PMC7749065; DOI: 10.1016/j.gde.2020.05.043;
     
  7. Haydar TF. Neurogenesis, Myelination, and Circuitry: The Case for a Distributed Therapeutic Regimen in Down Syndrome. Am J Intellect Dev Disabil. 2020 03; 125(2):100-102. PMID: 32058811; PMCID: PMC8265276; DOI: 10.1352/1944-7558-125.2.100;
     
  8. Shaw PR, Klein JA, Aziz NM, Haydar TF. Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. Dis Model Mech. 2020 Jan 01.View Related Profiles. PMID: 34005176
     
  9. Aziz NM, Klein JA, Brady MR, Olmos-Serrano JL, Gallo V, Haydar TF. Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome. J Neurodev Disord. 2019 12 16; 11(1):35.View Related Profiles. PMID: 31839007; PMCID: PMC6913030; DOI: 10.1186/s11689-019-9294-9;
     
  10. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2019 03 01; 29(3):1121-1138.View Related Profiles. PMID: 29415216; PMCID: PMC6373699; DOI: 10.1093/cercor/bhy019;
     
Showing 10 of 66 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 65 publications over 23 distinct years, with a maximum of 6 publications in 2008 and 2011 and 2020

YearPublications
19931
19961
19981
19993
20003
20011
20033
20041
20052
20063
20075
20086
20092
20104
20116
20132
20155
20164
20171
20181
20192
20206
20212
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

confocal
development
DNA regulation
in utero electroporation
neocortex
time-lapse imaging
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72 E. Concord St Instructional (L)
Boston MA 02118
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