Mark McComb | Profiles RNS

Mark E. McComb, PhD

Research Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University Manitoba
MSc, University Manitoba
BSc, University Manitoba

Websites

	Biochemistry Faculty
	ResearchGate
	Scopus
	Google Scholar
	NCBI
	Center for Biomedical Mass Spectrometry Faculty

ORCID : 0000-0002-4249-485X

Dr. McComb is a Research Associate Professor of Biochemistry at Chobanian and Avedisian School of Medicine (BUSM), is the Director of the NHLBI Cardiovascular Proteomics Center (CPC) Core Research Laboratory at BUSM and is a Faculty Member of the BUSM Center for Biomedical Mass Spectrometry (CBMS). Dr. McComb has authored/co-authored more than 50 peer-review publications, reviews and textbook chapters and has over 200 conference proceedings including many as invited speaker. Dr. McComb has served as a panel member on several National committees, has served on several NIH peer review study sections and is an expert reviewer for NIH, NCI and other organizations. Dr. McComb is an active member of the Human Proteome Organization (HUPO) whose mission is to characterize the human proteome. Dr. McComb’s research aims are directed towards the identification and characterization of differentially expressed proteins and differentially observed peptides and post-translational modifications (PTMs) associated with human disease. His laboratory focuses on applying mass spectrometry and proteomics technologies for the identification and characterization of proteins which may be perturbed by disease with the aim to identify patterns of changes in order to gain a global comprehensive understanding of disease progression. Identification of specific proteins and PTMs which change as a function of disease will lead to the development of diagnostic and prognostic biomarkers which will have tremendous clinical utility. Specific biomedical applications of research include cancer, Alzheimer’s disease, systemic amyloidosis, prion diseases, and cardiovascular disease.

Member
Boston University
Whitaker Cardiovascular Institute

BU Research
NIH RePORTER Research

Protein biomarkers of pulmonary hypertension in sickle cell disease
01/01/2012 - 12/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5R21HL107993-02

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers
10/01/2012 - 09/30/2013 (Subcontract PI)
National Space Biomedical Research Institute NASA

Title

Yr	Title	Project-Sub Proj	Pubs
2013	Protein biomarkers of pulmonary hypertension in sickle cell disease	5R21HL107993-02	3
2012	Protein biomarkers of pulmonary hypertension in sickle cell disease	1R21HL107993-01A1	3
2011	2D-LC MALDI WITH ON-TARGET DIGESTION FOR HIGH-THROUGHPUT PROTEOMICS	5P41RR010888-15-5107	259
2010	2D-LC MALDI WITH ON-TARGET DIGESTION FOR HIGH-THROUGHPUT PROTEOMICS	5P41RR010888-14-6805	259
2009	2D-LC MALDI WITH ON-TARGET DIGESTION FOR HIGH-THROUGHPUT PROTEOMICS	5P41RR010888-13-6153	259
2008	2D-LC MALDI WITH ON-TARGET DIGESTION FOR HIGH-THROUGHPUT PROTEOMICS	5P41RR010888-12-5216	259
2007	2D-LC MALDI WITH ON-TARGET DIGESTION FOR HIGH-THROUGHPUT PROTEOMICS	2P41RR010888-11-8037	259

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Mustafa Rizvi SH, Shao D, Tsukahara Y, Pimentel DR, Weisbrod RM, Hamburg NM, McComb ME, Matsui R, Bachschmid MM. Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis. Free Radic Biol Med. 2021 10; 174:73-83.View Related Profiles.

Pimentel, David
Shao, Di
McComb, Mark
Hamburg, Naomi
Matsui, Reiko
Rizvi, Syed
Tsukahara, Yuko

PMID: 34332079; PMCID: PMC8432375; DOI: 10.1016/j.freeradbiomed.2021.07.037;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;

Azab E, Chandler KB, Uda Y, Sun N, Hussein A, Shuwaikan R, Lu V, Costello CE, McComb ME, Divieti Pajevic P. Osteocytes control myeloid cell proliferation and differentiation through Gsa-dependent and -independent mechanisms. FASEB J. 2020 08; 34(8):10191-10211.View Related Profiles.

Hussein, Amira
Costello, Catherine
Chandler, Kevin
McComb, Mark
Sun, Ningyuan
Divieti Pajevic, Paola

PMID: 32557809; PMCID: PMC7688590; DOI: 10.1096/fj.202000366R;

Yura Y, Chong BSH, Johnson RD, Watanabe Y, Tsukahara Y, Ferran B, Murdoch CE, Behring JB, McComb ME, Costello CE, Janssen-Heininger YMW, Cohen RA, Bachschmid MM, Matsui R. Endothelial cell-specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice. FASEB J. 2019 12; 33(12):14147-14158.View Related Profiles.

Chong, Brian
Costello, Catherine
Murdoch, Colin
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Tsukahara, Yuko

PMID: 31647879; PMCID: PMC6894059; DOI: 10.1096/fj.201900786R;

McDonald AJ, Leon DR, Markham KA, Wu B, Heckendorf CF, Schilling K, Showalter HD, Andrews PC, McComb ME, Pushie MJ, Costello CE, Millhauser GL, Harris DA. Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR. Structure. 2019 06 04; 27(6):907-922.e5.View Related Profiles.

Wu, Bei
Costello, Catherine
Harris, David
McComb, Mark

PMID: 30956132; PMCID: PMC6736647; DOI: 10.1016/j.str.2019.03.008;

Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 04; 22:101150.View Related Profiles.

Costello, Catherine
Yao, Chunxiang
Shao, Di
Seta, Francesca
Fry, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard

PMID: 30877853; PMCID: PMC6423473; DOI: 10.1016/j.redox.2019.101150;

Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon D, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway. Mol Cell Proteomics. 2018 09; 17(9):1778-1787.View Related Profiles.

Shao, Chun
Zaia, Joseph
Khatri, Kshitij
McComb, Mark
Raghunathan, Rekha

PMID: 29915149; PMCID: PMC6126385; DOI: 10.1074/mcp.RA118.000680;

Saito Â, Souza EE, Costa FC, Meirelles GV, Gonçalves KA, Santos MT, Bressan GC, McComb ME, Costello CE, Whelan SA, Kobarg J. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. J Proteome Res. 2017 Sep 01; 16(9):3147-3157.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 28695742; PMCID: PMC6699623; DOI: 10.1021/acs.jproteome.7b00001;

Khatri K, Klein JA, Haserick JR, Leon DR, Costello CE, McComb ME, Zaia J. Microfluidic Capillary Electrophoresis-Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides. Anal Chem. 2017 06 20; 89(12):6645-6655.View Related Profiles.

Costello, Catherine
Haserick, John
Zaia, Joseph
Khatri, Kshitij
McComb, Mark

PMID: 28530388; PMCID: PMC5554952; DOI: 10.1021/acs.analchem.7b00875;

Showing 10 of 67 results. Show More

Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW. Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res. 2016 Jul 01; 15(7):2254-64.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 27213235; PMCID: PMC7814404; DOI: 10.1021/acs.jproteome.6b00250;

Zhang Z, Costa FC, Tan EP, Bushue N, DiTacchio L, Costello CE, McComb ME, Whelan SA, Peterson KR, Slawson C. O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2ß Protein at the A?-Globin Promoter. J Biol Chem. 2016 Jul 22; 291(30):15628-40.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 27231347; PMCID: PMC4957047; DOI: 10.1074/jbc.M116.721928;

Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. J Biol Chem. 2016 Jun 17; 291(25):12917-29.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 27129262; PMCID: PMC4933211; DOI: 10.1074/jbc.M116.729236;

Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles.

Sverdlov, Aaron
Elezaby, Aly
Costello, Catherine
Yao, Chunxiang
Siwik, Deborah
Shao, Di
Seta, Francesca
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Whelan, Stephen
Colucci, Wilson
Yin, Xiaoyan

PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
McComb, Mark
Sherman, Michael
Zaarur, Nava

PMID: 26303906; PMCID: PMC4570522; DOI: 10.15252/embj.201591245;

Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310.View Related Profiles.

Costello, Catherine
Chui, David
McComb, Mark
Theberge, Roger

PMID: 26002792; PMCID: PMC4496427; DOI: 10.1007/s13361-015-1164-4;

Yao C, Yu J, Taylor L, Polgar P, McComb ME, Costello CE. Protein Expression by Human Pulmonary Artery Smooth Muscle Cells Containing a BMPR2 Mutation and the Action of ET-1 as Determined by Proteomic Mass Spectrometry. Int J Mass Spectrom. 2015 Feb 15; 378:347-359.View Related Profiles.

Costello, Catherine
Yao, Chunxiang
Taylor, Linda
McComb, Mark
Polgar, Peter

PMID: 25866469; PMCID: PMC4387548; DOI: 10.1016/j.ijms.2014.10.006;

de Souza EE, Meirelles GV, Godoy BB, Perez AM, Smetana JH, Doxsey SJ, McComb ME, Costello CE, Whelan SA, Kobarg J. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res. 2014 Sep 5; 13(9):4074-90.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 25093993; PMCID: PMC4156247; DOI: 10.1021/pr500437x;

Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87.View Related Profiles.

Costello, Catherine
Siwik, Deborah
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Whelan, Stephen
Kumar, Vikas
Colucci, Wilson

PMID: 24469991; PMCID: PMC4046179; DOI: 10.1096/fj.13-233445;

Spencer JL, Bhatia VN, Whelan SA, Costello CE, McComb ME. STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post-Translational Modifications. Curr Protoc Bioinformatics. 2013 Dec; 44:13.22.1-36.View Related Profiles.

Costello, Catherine
Spencer, Jean
McComb, Mark
Whelan, Stephen

PMID: 25422678; PMCID: PMC4240648; DOI: 10.1002/0471250953.bi1322s44;

Kehasse A, Rich CB, Lee A, McComb ME, Costello CE, Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am J Pathol. 2013 Dec; 183(6):1841-52.View Related Profiles.

Kehasse, Amanuel
Costello, Catherine
McComb, Mark
Trinkaus-Randall, Vickery

PMID: 24095926; PMCID: PMC5745543; DOI: 10.1016/j.ajpath.2013.08.015;

Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51.View Related Profiles.

Zaia, Joseph
McComb, Mark
Leymarie, Nancy

PMID: 23764502; PMCID: PMC3790302; DOI: 10.1074/mcp.M113.030643;

Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18; 122(3):376-85.View Related Profiles.

Leung, Amy
Costello, Catherine
Kotton, Darrell
Sherr, David
Chui, David
Murphy, George
Mostoslavsky, Gustavo
McComb, Mark
Steinberg, Martin
Theberge, Roger
Monti, Stefano

PMID: 23723449; PMCID: PMC3716202; DOI: 10.1182/blood-2012-11-466722;

Kumar V, Calamaras TD, Haeussler D, Colucci WS, Cohen RA, McComb ME, Pimentel D, Bachschmid MM. Cardiovascular redox and ox stress proteomics. Antioxid Redox Signal. 2012 Dec 1; 17(11):1528-59.View Related Profiles.

Haeussler, Dagmar
Pimentel, David
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Kumar, Vikas
Colucci, Wilson

PMID: 22607061; PMCID: PMC3448941; DOI: 10.1089/ars.2012.4706;

Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41.View Related Profiles.

Costello, Catherine
Lin, Cheng
Haeussler, Dagmar
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Kumar, Vikas

PMID: 22085642; PMCID: PMC3290434; DOI: 10.1096/fj.11-189415;

Leymarie N, McComb ME, Naimy H, Staples GO, Zaia J. Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Int J Mass Spectrom. 2012 Feb 15; 312:144-154.View Related Profiles.

Zaia, Joseph
McComb, Mark
Leymarie, Nancy

PMID: 22523474; PMCID: PMC3329220; DOI: 10.1016/j.ijms.2011.07.019;

Théberge R, Infusini G, Tong W, McComb ME, Costello CE. Top-Down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap. Potential for Mass Spectrometry-Based Clinical Assays for Transthyretin and Hemoglobin. Int J Mass Spectrom. 2011 Mar 01; 300(2-3):130-142.View Related Profiles.

Costello, Catherine
McComb, Mark
Theberge, Roger

PMID: 21607198; PMCID: PMC3098445; DOI: 10.1016/j.ijms.2010.08.012;

Chen VC, Sadler G, McComb ME, Perreault H, Duckworth HW. Characterization of Specific Binding by Mass Spectrometry Associations of Citrate Synthase with NADH and 2-AzidoATP. Int. J. Mass Spectrom. 2011; 305(2):238-246.

Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, Hou X, McComb ME, Costello CE, Cohen RA, Bachschmid MM. Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal. 2010 Oct 1; 13(7):1023-32.View Related Profiles.

Costello, Catherine
Pimentel, David
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard

PMID: 20392170; PMCID: PMC2959181; DOI: 10.1089/ars.2010.3251;

Bhatia VN, Perlman DH, Costello CE, McComb ME. Software tool for researching annotations of proteins: open-source protein annotation software with data visualization. Anal Chem. 2009 Dec 1; 81(23):9819-23.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 19839595; PMCID: PMC2787672; DOI: 10.1021/ac901335x;

Ying W, Perlman DH, Li L, Théberge R, Costello CE, McComb ME. Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography. Rapid Commun Mass Spectrom. 2009 Dec; 23(24):4019-30.View Related Profiles.

Costello, Catherine
McComb, Mark
Theberge, Roger

PMID: 19924777; PMCID: PMC3584324; DOI: 10.1002/rcm.4343;

Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009 Jul; 102(1):97-110.View Related Profiles.

Costello, Catherine
Freedman, Jane
Beaulieu, Lea
McComb, Mark
Vitseva, Olga

PMID: 19572074; PMCID: PMC2774228; DOI: 10.1160/TH08-08-0513;

Romesser PB, Perlman DH, Faller DV, Costello CE, McComb ME, Denis GV. Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma. Am J Pathol. 2009 Jul; 175(1):25-35.View Related Profiles.

Costello, Catherine
Faller, Douglas
Denis, Gerald
McComb, Mark

PMID: 19498000; PMCID: PMC2708791; DOI: 10.2353/ajpath.2009.080707;

Perlman DH, Bauer SM, Ashrafian H, Bryan NS, Garcia-Saura MF, Lim CC, Fernandez BO, Infusini G, McComb ME, Costello CE, Feelisch M. Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circ Res. 2009 Mar 27; 104(6):796-804.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 19229060; PMCID: PMC6731772; DOI: 10.1161/CIRCRESAHA.108.187005;

Lavatelli F, Perlman DH, Spencer B, Prokaeva T, McComb ME, Théberge R, Connors LH, Bellotti V, Seldin DC, Merlini G, Skinner M, Costello CE. Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics. 2008 Aug; 7(8):1570-83.View Related Profiles.

Costello, Catherine
Seldin, David
Connors, Lawreen
McComb, Mark
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 18474516; PMCID: PMC2494907; DOI: 10.1074/mcp.M700545-MCP200;

Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 18259167; DOI: 10.1038/nbt0208-164;

Saba JA, McComb ME, Potts DL, Costello CE, Amar S. Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components. J Proteome Res. 2007 Jun; 6(6):2211-21.View Related Profiles.

Costello, Catherine
McComb, Mark
Amar, Salomon

PMID: 17477557; PMCID: PMC3925766; DOI: 10.1021/pr070031u;

Perlman DH, Huang H, Dauly C, Costello CE, McComb ME. Coupling of protein HPLC to MALDI-TOF MS using an on-target device for fraction collection, concentration, digestion, desalting, and matrix/analyte cocrystallization. Anal Chem. 2007 Mar 1; 79(5):2058-66.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 17256876

Odhiambo A, Perlman DH, Huang H, Costello CE, Farber HW, Steinberg MH, McComb ME, Klings ES. Identification of oxidative post-translational modification of serum albumin in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension of sickle cell anemia. Rapid Commun Mass Spectrom. 2007; 21(14):2195-203.View Related Profiles.

Costello, Catherine
Klings, Elizabeth
Farber, Harrison
McComb, Mark
Steinberg, Martin

PMID: 17569101

McComb ME, Perlman DH, Huang H, Costello CE. Evaluation of an on-target sample preparation system for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in conjunction with normal-flow peptide high-performance liquid chromatography for peptide mass fingerprint analyses. Rapid Commun Mass Spectrom. 2007; 21(1):44-58.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 17133622

Sethuraman M, Clavreul N, Huang H, McComb ME, Costello CE, Cohen RA. Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry. Free Radic Biol Med. 2007 Mar 15; 42(6):823-9.View Related Profiles.

Costello, Catherine
McComb, Mark
Cohen, Richard

PMID: 17320764; PMCID: PMC1855198; DOI: 10.1016/j.freeradbiomed.2006.12.012;

Cohen RA, McComb ME. Preconditioning enters the era of "physiological proteomics". Circ Res. 2006 Sep 29; 99(7):663-5.View Related Profiles.

McComb, Mark
Cohen, Richard

PMID: 17008594

Dauly C, Perlman DH, Costello CE, McComb ME. Protein separation and characterization by np-RP-HPLC followed by intact MALDI-TOF mass spectrometry and peptide mass mapping analyses. J Proteome Res. 2006 Jul; 5(7):1688-700.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 16823977; PMCID: PMC2590652; DOI: 10.1021/pr060108z;

Denis GV, McComb ME, Faller DV, Sinha A, Romesser PB, Costello CE. Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res. 2006 Mar; 5(3):502-11.View Related Profiles.

Costello, Catherine
Faller, Douglas
Denis, Gerald
McComb, Mark

PMID: 16512664; PMCID: PMC2823066; DOI: 10.1021/pr050430u;

Pedrioli PG, Eng JK, Hubley R, Vogelzang M, Deutsch EW, Raught B, Pratt B, Nilsson E, Angeletti RH, Apweiler R, Cheung K, Costello CE, Hermjakob H, Huang S, Julian RK, Kapp E, McComb ME, Oliver SG, Omenn G, Paton NW, Simpson R, Smith R, Taylor CF, Zhu W, Aebersold R. A common open representation of mass spectrometry data and its application to proteomics research. Nat Biotechnol. 2004 Nov; 22(11):1459-66.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 15529173

Sethuraman M, McComb ME, Huang H, Huang S, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures. J Proteome Res. 2004 Nov-Dec; 3(6):1228-33.View Related Profiles.

Costello, Catherine
McComb, Mark
Cohen, Richard

PMID: 15595732

Sethuraman M, McComb ME, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag approach to identify and quantify oxidant-sensitive protein thiols. Mol Cell Proteomics. 2004 Mar; 3(3):273-8.View Related Profiles.

Costello, Catherine
McComb, Mark
Cohen, Richard

PMID: 14726493

Lim A, Sengupta S, McComb ME, Théberge R, Wilson WG, Costello CE, Jacobsen DW. In vitro and in vivo interactions of homocysteine with human plasma transthyretin. J Biol Chem. 2003 Dec 12; 278(50):49707-13.View Related Profiles.

Costello, Catherine
McComb, Mark
Theberge, Roger

PMID: 14507924

Lim A, Prokaeva T, McComb ME, Connors LH, Skinner M, Costello CE. Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis. Protein Sci. 2003 Aug; 12(8):1775-85.View Related Profiles.

Costello, Catherine
Connors, Lawreen
McComb, Mark
Skinner, Martha
Prokaeva, Tatiana

PMID: 12876326; PMCID: PMC2323963

Ratts R, Zeng H, Berg EA, Blue C, McComb ME, Costello CE, vanderSpek JC, Murphy JR. The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. J Cell Biol. 2003 Mar 31; 160(7):1139-50.View Related Profiles.

Murphy, John
McComb, Mark

PMID: 12668662; PMCID: PMC2172777

Leymarie N, Berg EA, McComb ME, O'Connor PB, Grogan J, Oppenheim FG, Costello CE. Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Anal Chem. 2002 Aug 15; 74(16):4124-32.View Related Profiles.

Costello, Catherine
Oppenheim, Frank
McComb, Mark
Leymarie, Nancy

PMID: 12199583

Lim A, Prokaeva T, McComb ME, O'Connor PB, Théberge R, Connors LH, Skinner M, Costello CE. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis. Anal Chem. 2002 Feb 15; 74(4):741-51.View Related Profiles.

Costello, Catherine
Connors, Lawreen
McComb, Mark
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 11866053

McComb ME, Oleschuk RD, Chow A, Perreault H, Dworschak RG, Znamirowski M, Ens W, Standing KG, Preston KR. Application of nonporous polyurethane membranes and porous PU thin films as sample supports for MALDI-MS of wheat proteins. Canadian Journal of Chemistry-Revue Canadienne De Chimie. 2001; 79(4):437-447.

Lee CH, McComb ME, Bromirski M, Jilkine A, Ens W, Standing KG, Perreault H. On-membrane digestion of beta-casein for determination of phosphorylation sites by matrix-assisted laser desorption/ionization quadrupole/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2001; 15(3):191-202. PMID: 11180550

Manley DM, McComb ME, Perreault H, Donald LJ, Duckworth HW, O'Neil JD. Secondary structure and oligomerization of the E. coli glycerol facilitator. Biochemistry. 2000 Oct 10; 39(40):12303-11. PMID: 11015209

Oleschuk RD, Mccomb ME, Chow A, Ens W, Standing KG, Perreault H, Marois Y, King M. Characterization of plasma proteins adsorbed onto biomaterials. By MALDI-TOFMS. Biomaterials. 2000 Aug; 21(16):1701-10. PMID: 10905411

McComb ME, Perreault H. Design of a sheathless capillary eletrophoresis-mass spectrometry probe for operation with a Z-spray ionization source. Electrophoresis. 2000 Apr; 21(7):1354-62. PMID: 10826681

Shojania S, Oleschuk RD, McComb ME, Gesser HD, Chow A. The active and passive sampling of benzene, toluene, ethyl benzene and xylenes compounds using the inside needle capillary adsorption trap device. Talanta. 1999 Aug 23; 50(1):193-205. PMID: 18967709

McComb ME, Gesser HD. Analysis of trace metals in water by in-situ sample pre-concentration combined with wavelength dispersive X-ray fluorescence spectroscopy and inductively coupled plasma-optical emission spectroscopy. Talanta. 1999 Jul 12; 49(4):869-79. PMID: 18967663

Shojania S, McComb ME, Oleschuk RD, Perreault H, Gesser HD, Chow A. Qualitative analysis of complex mixtures of VOCs using the inside needle capillary adsorption trap. Canadian Journal of Chemistry-Revue Canadienne De Chimie. 1999; 77(11):1716-1727.
McComb ME, Donald LJ, Perreault H. Electrospray ionization mass spectrometry and on-line capillary zone electrophoresis - mass spectrometry for the characterization of citrate synthase. Canadian Journal of Chemistry-Revue Canadienne De Chimie. 1999; 77(11):1752-1760.

McComb ME, Oleschuk RD, Chow A, Ens W, Standing KG, Perreault H, Smith M. Characterization of hemoglobin variants by MALDI-TOF MS using a polyurethane membrane as the sample support. Anal Chem. 1998 Dec 15; 70(24):5142-9. PMID: 9868911

McComb ME, Krutchinsky AN, Ens W, Standing KG, Perreault H. Sensitive high-resolution analysis of biological molecules by capillary zone electrophoresis coupled with reflecting time-of-flight mass spectrometry. J Chromatogr A. 1998 Mar 20; 800(1):1-11. PMID: 9583938

McComb ME, Oleschuk RD, Giller E, Gesser HD. Microextraction of volatile organic compounds using the inside needle capillary adsorption trap (INCAT) device. Talanta. 1997 Nov; 44(11):2137-43. PMID: 18966963

McComb ME, Gesser HD. Passive monitoring of trace metals in water by in situ sample preconcentration via chelation on a textile based solid sorbent. Anal Chim Acta. 1997; 341(2):229-239.
McComb ME, Gesser HD. Preparation of polyacryloamidoxime chelating cloth for the extraction of heavy metals from water. J Appl Polymer Sci. 1997; 65(6):1175-1192.

McComb ME, Oleschuk RD, Manley DM, Donald L, Chow A, O'Neil JD, Ens W, Standing KG, Perreault H. Use of a non-porous polyurethane membrane as a sample support for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of peptides and proteins. Rapid Commun Mass Spectrom. 1997; 11(15):1716-22. PMID: 9364798

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 24 distinct years, with a maximum of 5 publications in 2009

Bar chart showing 67 publications over 24 distinct years, with a maximum of 5 publications in 2009

Year	Publications
1997	4
1998	2
1999	4
2000	3
2001	2
2002	2
2003	3
2004	3
2006	4
2007	4
2008	2
2009	5
2010	1
2011	4
2012	1
2013	4
2014	2
2015	4
2016	3
2017	2
2018	1
2019	3
2020	2
2021	2

2000-2002 Boston University: National Sciences and Engineering Research Council of Canada Fellowship

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

bioinformatics
biomarkers
mass spectrometry
proteomics

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