Paul Maglione | Profiles RNS

Paul J. Maglione, MD, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD/PhD, Albert Einstein College of Medicine
BS, University of Rochester

Websites

	Boston Medical Center Provider Profile
	Pulmonary Center
	ResearchGate
	Twitter
	Google Scholar

ORCID : 0000-0001-6805-7271

Background:
Paul J. (PJ) Maglione, MD, PhD is an Assistant Professor of Medicine in the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at the Chobanian and Avedisian School of Medicine. He is a physician-scientist with expertise in the clinical care of primary immunodeficiencies and runs a laboratory in the Pulmonary Center at the Boston University Medical Campus. Before arriving at the university, Dr. Maglione was an attending physician and researcher at the Icahn School of Medicine at Mount Sinai. He completed his MD/PhD training at the Albert Einstein College of Medicine and internal medicine residency at Mount Sinai Hospital in New York. Also at Mount Sinai, Dr. Maglione undertook fellowship training in clinical immunology and post-doctoral research under the mentorship of Charlotte Cunningham-Rundles, MD, PhD, a renowned expert in common variable immunodeficiency.

Clinical Focus:
Dr. Maglione is an attending physician at Boston Medical Center where he focuses on the diagnosis and treatment of primary immunodeficiency disorders, with special expertise in the care of common variable immunodeficiency and its complications. He also attends on the inpatient allergy/immunology service. Dr. Maglione is involved in the teaching of allergy/immunology clinical fellows in the Chobanian and Avedisian School of Medicine program. He has been invited to speak to patient audiences on numerous occasions by the Immune Deficiency Foundation, including their national conference, and cares for patients with immune deficiency disorders from around the country.

Research Focus:
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione's clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.

Member
Boston University
Pulmonary Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Underdiagnosis of primary immunodeficiency disorders among racial and ethnic minorities: Recognize and Educate
09/19/2022 - 05/31/2027 (Subcontract PI)
Harvard Pilgrim Health Care Inc NIH NIMHD
1R01MD017816-01

Define Gender-Specific Modifiers of Immune Predisposition to Long-haul COVID-19
03/19/2024 - 06/30/2025 (Subcontract PI)
Lahey Clinic, Inc. MA Life Sciences Ctr

Kayla Bell Lecture on Primary Immunodeficiency Diseases
04/24/2024 - 04/24/2024 (PI)
Takeda Development Center Americas, Inc.

How B cell developmental defects shape manifestations of common variable immunodeficiency
07/01/2019 - 06/30/2023 (PI)
American Academy of Allergy, Asthma, and Immunology

Immunomodulatory role of IgG replacement therapy in common variable immunodeficiency
04/29/2019 - 04/29/2023 (PI)
Shire, Inc.

Role of B cell activating factor in non-infectious complications of common variable immunodeficiency
02/01/2019 - 01/31/2023 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5K23AI137183-05

Kayla Bell Lecture on Primary Immunodeficiency Disease
07/16/2021 - 06/30/2022 (PI)
Takeda Pharmaceuticals North America, Inc.

Optimizing efficacy of interferon-y therapy in primary immunodeficiency patients
05/09/2019 - 05/09/2022 (PI)
Horizon Pharma USA

Mechanisms of immune dysregulation due to NFKB1 mutation in common variable immunodeficiency
03/01/2020 - 02/28/2022 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI151486-02

B cell maturation antigen in the diagnosis and management of antibody deficiency
09/01/2020 - 09/01/2021 (PI)
Immune Deficiency Foundation Inc.

Title

Identifying B cell maturation defects that shape manifestations of common variable immunodeficiency
07/01/2019 - 06/30/2022 (PI)
American Academy of Allergy, Asthma, and Immunology

Yr	Title	Project-Sub Proj	Pubs
2022	Role of B cell activating factor in non-infectious complications of common variable immunodeficiency	5K23AI137183-05
2021	Mechanisms of immune dysregulation due to NFKB1 mutation in common variable immunodeficiency	5R21AI151486-02
2021	Role of B cell activating factor in non-infectious complications of common variable immunodeficiency	5K23AI137183-04	7
2020	Mechanisms of immune dysregulation due to NFKB1 mutation in common variable immunodeficiency	1R21AI151486-01
2020	Role of B cell activating factor in non-infectious complications of common variable immunodeficiency	5K23AI137183-03	7
2019	Role of B cell activating factor in non-infectious complications of common variable immunodeficiency	7K23AI137183-02	7
2018	Role of B cell activating factor in non-infectious complications of common variable immunodeficiency	1K23AI137183-01	7

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP. B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front Immunol. 2024; 15:1382638.View Related Profiles.

Soucy, Alicia
Belkina, Anna
Nia, Hadi
Browning, Jeffrey
Mizgerd, Joseph
Traber, Katrina
Quinton, Lee
Jones, Matthew
Breen, Michael
Etesami, Neelou
Maglione, Paul
Pihl, Riley
Varelas, Xaralabos

PMID: 38715601; PMCID: PMC11074383; DOI: 10.3389/fimmu.2024.1382638;

Sullivan NP, Maniam N, Maglione PJ. Interstitial lung diseases in inborn errors of immunity. Curr Opin Allergy Clin Immunol. 2023 Dec 01; 23(6):500-506. PMID: 37823528

Ong MS, Rider NL, Stein S, Maglione PJ, Galbraith A, DiGiacomo DV, Farmer JR. Racial and ethnic disparities in early mortality among patients with inborn errors of immunity. J Allergy Clin Immunol. 2024 Jan; 153(1):335-340.e1.View Related Profiles.

Galbraith, Alison
Maglione, Paul

PMID: 37802474; PMCID: PMC10872997; DOI: 10.1016/j.jaci.2023.09.036;

Bintalib HM, van de Ven A, Jacob J, Davidsen JR, Fevang B, Hanitsch LG, Malphettes M, van Montfrans J, Maglione PJ, Milito C, Routes J, Warnatz K, Hurst JR. Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review. Front Immunol. 2023; 14:1190235. PMID: 37223103; PMCID: PMC10200864; DOI: 10.3389/fimmu.2023.1190235;

Chen Y, Bharrhan S, Xu J, Sharma T, Wang Y, Salgame P, Zhang J, Nargan K, Steyn AJC, Maglione PJ, Chan J. B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice. PLoS Pathog. 2023 Mar; 19(3):e1011187. PMID: 36888692; PMCID: PMC9994760; DOI: 10.1371/journal.ppat.1011187;

Gutierrez MJ, Nino G, Sun D, Restrepo-Gualteros S, Sadreameli SC, Fiorino EK, Wu E, Vece T, Hagood JS, Maglione PJ, Kurland G, Koumbourlis A, Sullivan KE. The lung in inborn errors of immunity: From clinical disease patterns to molecular pathogenesis. J Allergy Clin Immunol. 2022 Dec; 150(6):1314-1324. PMID: 36244852; PMCID: PMC9826631; DOI: 10.1016/j.jaci.2022.08.024;

Ye X, Maglione PJ, Wehr C, Li X, Wang Y, Abolhassani H, Deripapa E, Liu D, Borte S, Du L, Wan H, Plötner A, Giannoula Y, Ko HB, Hou Y, Zhu S, Grossman JK, Sander B, Grimbacher B, Hammarström L, Fedorova A, Rosenzweig SD, Shcherbina A, Wu K, Warnatz K, Cunningham-Rundles C, Pan-Hammarström Q. Genomic characterization of lymphomas in patients with inborn errors of immunity. Blood Adv. 2022 Sep 27; 6(18):5403-5414. PMID: 35687490; PMCID: PMC9631701; DOI: 10.1182/bloodadvances.2021006654;

Ameratunga R, Abolhassani H, Maglione PJ, Edwards ESJ. Editorial: Contemporary challenges in diagnosis and treatment of predominantly antibody deficiency. Front Immunol. 2022; 13:959720. PMID: 36052063; PMCID: PMC9425292; DOI: 10.3389/fimmu.2022.959720;

Maglione PJ, Gereige JD, Lee TK. Consideration of pulmonary hypertension in the evaluation of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 10; 127(4):513. PMID: 34593104; PMCID: PMC8525548; DOI: 10.1016/j.anai.2021.07.024;

Abyazi ML, Bell KA, Gyimesi G, Baker TS, Byun M, Ko HM, Cunningham-Rundles C, Feng F, Maglione PJ. Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications. J Allergy Clin Immunol. 2022 01; 149(1):315-326.e9.View Related Profiles.

Feng, Feng
Maglione, Paul

PMID: 34146579; PMCID: PMC8678401; DOI: 10.1016/j.jaci.2021.06.008;

Showing 10 of 43 results. Show More

Wallace LJ, Ware MS, Cunningham-Rundles C, Fuleihan RL, Maglione PJ. Clinical disparity of primary antibody deficiency patients at a safety net hospital. J Allergy Clin Immunol Pract. 2021 07; 9(7):2923-2925.e1. PMID: 33766581; PMCID: PMC8277688; DOI: 10.1016/j.jaip.2021.03.021;

Lee TK, Gereige JD, Maglione PJ. State-of-the-art diagnostic evaluation of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 07; 127(1):19-27. PMID: 33716149; PMCID: PMC8222108; DOI: 10.1016/j.anai.2021.03.005;

Matson EM, Abyazi ML, Bell KA, Hayes KM, Maglione PJ. B Cell Dysregulation in Common Variable Immunodeficiency Interstitial Lung Disease. Front Immunol. 2020; 11:622114. PMID: 33613556; PMCID: PMC7892472; DOI: 10.3389/fimmu.2020.622114;

Cowan J, Bonagura VR, Lugar PL, Maglione PJ, Patel NC, Vinh DC, Hofmann JH, Praus M, Rojavin MA. Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study. J Clin Immunol. 2021 01; 41(1):66-75. PMID: 33025378; PMCID: PMC7846525; DOI: 10.1007/s10875-020-00876-6;

Grasset EK, Chorny A, Casas-Recasens S, Gutzeit C, Bongers G, Thomsen I, Chen L, He Z, Matthews DB, Oropallo MA, Veeramreddy P, Uzzan M, Mortha A, Carrillo J, Reis BS, Ramanujam M, Sintes J, Magri G, Maglione PJ, Cunningham-Rundles C, Bram RJ, Faith J, Mehandru S, Pabst O, Cerutti A. Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells. Sci Immunol. 2020 07 31; 5(49). PMID: 32737068; PMCID: PMC8349226; DOI: 10.1126/sciimmunol.aat7117;

Maglione PJ. Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management. Immunol Allergy Clin North Am. 2020 08; 40(3):437-459. PMID: 32654691; PMCID: PMC7366316; DOI: 10.1016/j.iac.2020.03.003;

Gereige JD, Maglione PJ, Guenechea-Sola M. Delayed Diagnosis of Good Syndrome. J Allergy Clin Immunol Pract. 2020 04; 8(4):1396-1397.View Related Profiles.

Guenechea-Sola, Miren
Maglione, Paul

PMID: 31839563; PMCID: PMC7409509; DOI: 10.1016/j.jaip.2019.11.019;

Gereige JD, Maglione PJ. Current Understanding and Recent Developments in Common Variable Immunodeficiency Associated Autoimmunity. Front Immunol. 2019; 10:2753. PMID: 31921101; PMCID: PMC6914703; DOI: 10.3389/fimmu.2019.02753;

Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C. Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies. J Allergy Clin Immunol Pract. 2020 01; 8(1):283-291.e1. PMID: 31430592; PMCID: PMC6980522; DOI: 10.1016/j.jaip.2019.08.012;

Weinberger T, Fuleihan R, Cunningham-Rundles C, Maglione PJ. Factors Beyond Lack of Antibody Govern Pulmonary Complications in Primary Antibody Deficiency. J Clin Immunol. 2019 05; 39(4):440-447. PMID: 31089938; PMCID: PMC6939305; DOI: 10.1007/s10875-019-00640-5;

Maglione PJ, Gyimesi G, Cols M, Radigan L, Ko HM, Weinberger T, Lee BH, Grasset EK, Rahman AH, Cerutti A, Cunningham-Rundles C. BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency. JCI Insight. 2019 03 07; 4(5). PMID: 30843876; PMCID: PMC6483510; DOI: 10.1172/jci.insight.122728;

Filion CA, Taylor-Black S, Maglione PJ, Radigan L, Cunningham-Rundles C. Differentiation of Common Variable Immunodeficiency From IgG Deficiency. J Allergy Clin Immunol Pract. 2019 04; 7(4):1277-1284. PMID: 30557717; PMCID: PMC6519441; DOI: 10.1016/j.jaip.2018.12.004;

Gernez Y, Baker MG, Maglione PJ. Humoral immunodeficiencies: conferred risk of infections and benefits of immunoglobulin replacement therapy. Transfusion. 2018 12; 58 Suppl 3:3056-3064. PMID: 30536429; PMCID: PMC6939302; DOI: 10.1111/trf.15020;

Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu ML, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol. 2019 01; 143(1):258-265. PMID: 29935219; PMCID: PMC6400323; DOI: 10.1016/j.jaci.2018.06.012;

Bennett N, Maglione PJ, Wright BL, Zerbe C. Infectious Complications in Patients With Chronic Granulomatous Disease. J Pediatric Infect Dis Soc. 2018 May 09; 7(suppl_1):S12-S17. PMID: 29746678; PMCID: PMC5985728; DOI: 10.1093/jpids/piy013;

Maglione PJ, Cols M, Cunningham-Rundles C. Dysregulation of Innate Lymphoid Cells in Common Variable Immunodeficiency. Curr Allergy Asthma Rep. 2017 Oct 05; 17(11):77. PMID: 28983810; PMCID: PMC5897894; DOI: 10.1007/s11882-017-0746-6;

Schussler E, Beasley MB, Maglione PJ. Lung Disease in Primary Antibody Deficiencies. J Allergy Clin Immunol Pract. 2016 Nov - Dec; 4(6):1039-1052. PMID: 27836055; PMCID: PMC5129846; DOI: 10.1016/j.jaip.2016.08.005;

Gernez Y, Tsuang A, Smith TD, Shahjehan K, Hui Y, Maglione PJ, Cunningham-Rundles C. Hemoptysis in a Patient with Elevated Immunoglobulin E. J Allergy Clin Immunol Pract. 2016 Nov - Dec; 4(6):1054-1058. PMID: 27693026; PMCID: PMC5322743; DOI: 10.1016/j.jaip.2016.08.003;

Chen M, Ko HM, Riffle ME, Andreae DA, Cunningham-Rundles C, Chehade M, Maglione PJ. Eosinophilic esophagitis diagnosed in a patient with common variable immunodeficiency. J Allergy Clin Immunol Pract. 2016 Sep-Oct; 4(5):995-7. PMID: 27157654; PMCID: PMC5322739; DOI: 10.1016/j.jaip.2016.03.023;

Maglione PJ. Autoimmune and Lymphoproliferative Complications of Common Variable Immunodeficiency. Curr Allergy Asthma Rep. 2016 Mar; 16(3):19. PMID: 26857017; DOI: 10.1007/s11882-016-0597-6;

Cols M, Rahman A, Maglione PJ, Garcia-Carmona Y, Simchoni N, Ko HM, Radigan L, Cerutti A, Blankenship D, Pascual V, Cunningham-Rundles C. Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency. J Allergy Clin Immunol. 2016 Apr; 137(4):1206-1215.e6. PMID: 26542033; PMCID: PMC4866594; DOI: 10.1016/j.jaci.2015.09.013;

Stein CR, McGovern KJ, Pajak AM, Maglione PJ, Wolff MS. Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12-19 y: National Health and Nutrition Examination Survey. Pediatr Res. 2016 Feb; 79(2):348-57. PMID: 26492286; PMCID: PMC5065061; DOI: 10.1038/pr.2015.213;

Maglione PJ, Overbey JR, Cunningham-Rundles C. Progression of Common Variable Immunodeficiency Interstitial Lung Disease Accompanies Distinct Pulmonary and Laboratory Findings. J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3(6):941-50. PMID: 26372540; PMCID: PMC4641811; DOI: 10.1016/j.jaip.2015.07.004;

Egan M, Maglione PJ. Multiple reasonably tolerated percutaneous coronary interventions in a patient with iodide mumps. Ann Allergy Asthma Immunol. 2015 Sep; 115(3):253-4. PMID: 26195438; DOI: 10.1016/j.anai.2015.06.020;

Maglione PJ, Simchoni N, Cunningham-Rundles C. Toll-like receptor signaling in primary immune deficiencies. Ann N Y Acad Sci. 2015 Nov; 1356:1-21. PMID: 25930993; PMCID: PMC4629506; DOI: 10.1111/nyas.12763;

Maglione PJ, Simchoni N, Black S, Radigan L, Overbey JR, Bagiella E, Bussel JB, Bossuyt X, Casanova JL, Meyts I, Cerutti A, Picard C, Cunningham-Rundles C. IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens. Blood. 2014 Dec 04; 124(24):3561-71. PMID: 25320238; PMCID: PMC4256908; DOI: 10.1182/blood-2014-07-587824;

Maglione PJ, Overbey JR, Radigan L, Bagiella E, Cunningham-Rundles C. Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations. Ann Allergy Asthma Immunol. 2014 Oct; 113(4):452-9. PMID: 24880814; PMCID: PMC4177442; DOI: 10.1016/j.anai.2014.04.024;

Ramesh M, Resnick E, Hui Y, Maglione PJ, Mehta H, Kattan J, Bouvier NM, LaBombardi V, Victor TR, Chaturvedi S, Cunningham-Rundles C. Phellinus tropicalis abscesses in a patient with chronic granulomatous disease. J Clin Immunol. 2014 Feb; 34(2):130-3. PMID: 24310980; PMCID: PMC4080424; DOI: 10.1007/s10875-013-9967-1;

Maglione PJ, Ko HM, Beasley MB, Strauchen JA, Cunningham-Rundles C. Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency. J Allergy Clin Immunol. 2014 Feb; 133(2):535-42. PMID: 24131823; PMCID: PMC4109033; DOI: 10.1016/j.jaci.2013.08.022;

Cunningham-Rundles C, Maglione PJ. Common variable immunodeficiency. J Allergy Clin Immunol. 2012 May; 129(5):1425-1426.e3. PMID: 22541363; DOI: 10.1016/j.jaci.2012.03.025;

Maglione PJ, Chan J. How B cells shape the immune response against Mycobacterium tuberculosis. Eur J Immunol. 2009 Mar; 39(3):676-86. PMID: 19283721; PMCID: PMC2760469; DOI: 10.1002/eji.200839148;

Maglione PJ, Xu J, Casadevall A, Chan J. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. J Immunol. 2008 Mar 01; 180(5):3329-38. PMID: 18292558

Maglione PJ, Xu J, Chan J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J Immunol. 2007 Jun 01; 178(11):7222-34. PMID: 17513771

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 43 publications over 16 distinct years, with a maximum of 5 publications in 2015 and 2019 and 2021

Bar chart showing 43 publications over 16 distinct years, with a maximum of 5 publications in 2015 and 2019 and 2021

Year	Publications
2007	1
2008	1
2009	1
2012	1
2013	2
2014	2
2015	5
2016	4
2017	1
2018	4
2019	5
2020	3
2021	5
2022	3
2023	4
2024	1

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