Xaralabos Varelas, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Alberta




Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Defining the Beta-catenin/CBP axis in head and neck cancer
12/07/2020 - 11/30/2025 (Multi-PI)
PI: Xaralabos Varelas, PhD
NIH/National Institute of Dental & Craniofacial Research
5R01DE030350-02

Defining epithelial polarity cues that direct cell fate
02/15/2020 - 01/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL124392-08

Defining molecular signals that influence airway basal cell renewal and growth
01/01/2020 - 06/30/2023 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F31HL149381-03

Mechanobiology of Lung Fibrosis
04/03/2019 - 03/31/2023 (Subcontract PI)
Mayo Clinic NIH NHLBI
5R01HL092961-11

Intercepting aberrant YAP/TAZ activity for the treatment of lung cancer
12/29/2017 - 12/31/2022 (PI)
Janssen Research & Development, LLC


Understanding aberrant YAP signaling in squamous cell lung cancer
07/01/2017 - 12/31/2022 (PI)
American Cancer Society, Inc.


Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension
01/01/2018 - 12/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL137366-04

Defining non-nuclear roles for Yap in the development of multi-ciliated cells
04/01/2018 - 03/31/2021 (PI)
NIH/National Institute of Child Health & Human Development
5R21HD094012-02

YAP/TAZ-NRG1 crosstalk in airway epithelial cell fate control
03/01/2019 - 02/28/2021 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F31HL146163-02

Defining Epithelial Cell Polarity Cues That Direct Cell Fate
08/15/2014 - 02/14/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL124392-05

Showing 10 of 24 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Defining the ß-catenin/CBP-catenin/CBP axis in head and neck cancer 5R01DE030350-02
2022 Defining epithelial polarity cues that direct cell fate 5R01HL124392-08
2021 Enhancement and Cloud Deployment of CaDrA, a software tool for Candidate Driver Analysis of Multiomics Data 3R01DE030350-01A1S1
2021 Defining the ß-catenin/CBP-catenin/CBP axis in head and neck cancer 1R01DE030350-01A1
2021 Defining epithelial polarity cues that direct cell fate 5R01HL124392-07 17
2020 Defining epithelial polarity cues that direct cell fate 2R01HL124392-06 17
2019 Defining non-nuclear roles for Yap in the development of multi-ciliated cells 5R21HD094012-02
2018 Defining non-nuclear roles for Yap in the development of multi-ciliated cells 1R21HD094012-01
2018 Defining epithelial cell polarity cues that direct cell fate 5R01HL124392-05 17
2017 Defining epithelial cell polarity cues that direct cell fate 5R01HL124392-04 17
Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Alhousami T, Diny M, Ali F, Shin J, Kumar G, Kumar V, Campbell JD, Noonan V, Hanna GJ, Denis GV, Monti S, Kukuruzinska MA, Varelas X, Bais MV. Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition. Mol Cancer Res. 2022 May 04; 20(5):712-721.View Related Profiles. PMID: 35105672; PMCID: PMC9081163; DOI: 10.1158/1541-7786.MCR-21-0310;
     
  2. Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance. 2022 05; 5(5).View Related Profiles. PMID: 35181634; PMCID: PMC8860101; DOI: 10.26508/lsa.202101286;
     
  3. Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563.View Related Profiles. PMID: 35137631; PMCID: PMC8957336; DOI: 10.1152/ajplung.00325.2021;
     
  4. Baldan S, Meriin AB, Yaglom J, Alexandrov I, Varelas X, Xiao ZJ, Sherman MY. The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap. J Cell Sci. 2021 12 01; 134(23).View Related Profiles. PMID: 34761265; PMCID: PMC8714078; DOI: 10.1242/jcs.259107;
     
  5. Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636.View Related Profiles. PMID: 34469722; PMCID: PMC8432578; DOI: 10.1016/j.celrep.2021.109636;
     
  6. Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347.View Related Profiles. PMID: 34260916; PMCID: PMC8346236; DOI: 10.1016/j.celrep.2021.109347;
     
  7. Dela Cruz A, Kartha V, Tilston-Lunel A, Mi R, Reynolds TL, Mingueneau M, Monti S, Jensen JL, Skarstein K, Varelas X, Kukuruzinska MA. Gene expression alterations in salivary gland epithelia of Sjögren's syndrome patients are associated with clinical and histopathological manifestations. Sci Rep. 2021 05 27; 11(1):11154.View Related Profiles. PMID: 34045583; PMCID: PMC8159963; DOI: 10.1038/s41598-021-90569-w;
     
  8. Tilston-Lunel A, Mazzilli S, Kingston NM, Szymaniak AD, Hicks-Berthet J, Kern JG, Abo K, Reid ME, Perdomo C, Wilson AA, Spira A, Beane J, Varelas X. Aberrant epithelial polarity cues drive the development of precancerous airway lesions. Proc Natl Acad Sci U S A. 2021 05 04; 118(18).View Related Profiles. PMID: 33903236; PMCID: PMC8106308; DOI: 10.1073/pnas.2019282118;
     
  9. Jones DL, Meridew JA, Link PA, Ducharme MT, Lydon KL, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ. ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation. J Cell Biol. 2021 05 03; 220(5).View Related Profiles. PMID: 33625469; PMCID: PMC7918622; DOI: 10.1083/jcb.202007152;
     
  10. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020; 8:608044.View Related Profiles. PMID: 33490071; PMCID: PMC7817781; DOI: 10.3389/fcell.2020.608044;
     
Showing 10 of 66 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 66 publications over 18 distinct years, with a maximum of 8 publications in 2017 and 2020 and 2021

YearPublications
20031
20051
20061
20081
20092
20102
20113
20121
20134
20146
20154
20162
20178
20184
20197
20208
20218
20223
Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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