Xaralabos Varelas, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Alberta




Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.


Understanding aberrant YAP signaling in squamous cell lung cancer
07/01/2017 - 06/30/2021 (PI)
American Cancer Society, Inc.


Intercepting aberrant YAP/TAZ activity for the treatment of lung cancer
12/29/2017 - 12/28/2020 (PI)
Janssen Research & Development, LLC


Defining non-nuclear roles for Yap in the development of multi-ciliated cells
04/01/2018 - 03/31/2020 (PI)
NIH/National Institute of Child Health & Human Development
1R21HD094012-01

Understanding the etiology of airway carcinomas via global proteomic, phospho-proteomic and metabolomic analyses
01/01/2019 - 12/31/2019 (PI)
Johnson & Johnson


Understanding the molecular mechanisms controlling multi-cilia development
10/15/2018 - 10/14/2019 (PI)
Charles H. Hood Foundation


Defining Epithelial Cell Polarity Cues That Direct Cell Fate
08/15/2014 - 04/30/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL124392-05

Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension
01/01/2018 - 12/31/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
1R01HL137366-01A1

Mechanobiology of Lung Fibrosis
12/01/2014 - 11/30/2018 (PI)
Mayo Clinic NIH NHLBI
5R01HL092961-08

Understanding the Molecular Mechanisms Controlling Multi-cilia Development
06/01/2017 - 07/31/2018 (PI)
March of Dimes Foundation


Defining Epithelial Cues Contributing to Sjogren's Syndrome
07/01/2016 - 06/30/2018 (PI)
Sjogren's Syndrome Foundation


Showing 10 of 19 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Stampouloglou E, Federico A, Slabi E, Monti S, Szeto GL, Varelas X. Yap suppresses T cell function and infiltration in the tumor microenvironment. 2019; (BioRvix). View Publication
  2. Kern JG, Varelas X. TAZ Forces Lateral Inhibition. Dev Cell. 2019 Mar 25; 48(6):748-750.View Related Profiles. PMID: 30913406.
     
  3. Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S. CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features. Front Genet. 2019; 10:121.View Related Profiles. PMID: 30838036.
     
  4. Kingston NM, Tilston-Lunel AM, Hicks-Berthet J, Varelas X. Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells. Methods Mol Biol. 2019; 1893:107-113. PMID: 30565129.
     
  5. Stampouloglou E, Varelas X. Phosphatidic Acid Signals via the Hippo Pathway. Mol Cell. 2018 10 18; 72(2):205-206.View Related Profiles. PMID: 30340020.
     
  6. Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54.View Related Profiles. PMID: 30029671.
     
  7. Meriin AB, Narayanan A, Meng L, Alexandrov I, Varelas X, Cissé II, Sherman MY. Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):E7043-E7052.View Related Profiles. PMID: 29987014.
     
  8. Yang CS, Stampouloglou E, Kingston NM, Zhang L, Monti S, Varelas X. Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells. EMBO Rep. 2018 06; 19(6).View Related Profiles. PMID: 29661856; DOI: 10.15252/embr.201643577;.
     
  9. Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM. Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci Transl Med. 2017 Dec 13; 9(420). PMID: 29237758.
     
  10. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925.
     
Showing 10 of 44 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 44 publications over 15 distinct years, with a maximum of 8 publications in 2017

YearPublications
20031
20051
20061
20081
20092
20102
20113
20121
20134
20146
20154
20162
20178
20184
20194
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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