Xaralabos Varelas, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Alberta




Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Defining epithelial polarity cues that direct cell fate
02/15/2020 - 01/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL124392-06

Mechanobiology of Lung Fibrosis
04/03/2019 - 03/31/2023 (Subcontract PI)
Mayo Clinic NIH NHLBI
5R01HL092961-10

Understanding aberrant YAP signaling in squamous cell lung cancer
07/01/2017 - 06/30/2021 (PI)
American Cancer Society, Inc.


Defining non-nuclear roles for Yap in the development of multi-ciliated cells
04/01/2018 - 03/31/2021 (PI)
NIH/National Institute of Child Health & Human Development
5R21HD094012-02

Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension
01/01/2018 - 12/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL137366-03

Intercepting aberrant YAP/TAZ activity for the treatment of lung cancer
12/29/2017 - 12/28/2020 (PI)
Janssen Research & Development, LLC


Defining Epithelial Cell Polarity Cues That Direct Cell Fate
08/15/2014 - 02/14/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL124392-05

Understanding the etiology of airway carcinomas via global proteomic, phospho-proteomic and metabolomic analyses
01/01/2019 - 12/31/2019 (PI)
Johnson & Johnson


Understanding the Molecular Mechanisms Controlling Multi-cilia Development
10/15/2018 - 10/14/2019 (PI)
Charles H. Hood Foundation


Mechanobiology of Lung Fibrosis
12/01/2014 - 11/30/2018 (Subcontract PI)
Mayo Clinic NIH NHLBI
5R01HL092961-08

Showing 10 of 21 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Defining the β-catenin/CBP axis in head and neck cancer 1R01DE030350-01A1
2021 Defining epithelial polarity cues that direct cell fate 5R01HL124392-07 17
2020 Defining epithelial polarity cues that direct cell fate 2R01HL124392-06 17
2020 Defining epithelial polarity cues that direct cell fate 2R01HL124392-06 17
2019 Defining non-nuclear roles for Yap in the development of multi-ciliated cells 5R21HD094012-02
2018 Defining non-nuclear roles for Yap in the development of multi-ciliated cells 1R21HD094012-01
2018 Defining epithelial cell polarity cues that direct cell fate 5R01HL124392-05 17
2017 Defining epithelial cell polarity cues that direct cell fate 5R01HL124392-04 17
2016 Defining epithelial cell polarity cues that direct cell fate 5R01HL124392-03 17
2015 Defining epithelial cell polarity cues that direct cell fate 5R01HL124392-02 17
Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Jones DL, Meridew JA, Link PA, Ducharme MT, Lydon KL, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ. ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation. J Cell Biol. 2021 May 03; 220(5).View Related Profiles. PMID: 33625469
     
  2. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854
     
  3. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020; 8:608044.View Related Profiles. PMID: 33490071
     
  4. Maziarz M, Federico A, Zhao J, Dujmusic L, Zhao Z, Monti S, Varelas X, Garcia-Marcos M. Naturally occurring hotspot cancer mutations in Ga13 promote oncogenic signaling. J Biol Chem. 2020 Dec 04; 295(49):16897-16904.View Related Profiles. PMID: 33453920
     
  5. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; DOI: 10.1016/j.molcel.2020.11.028;
     
  6. Zeng C, Motta-Ribeiro GC, Hinoshita T, Lessa MA, Winkler T, Grogg K, Kingston NM, Hutchinson JN, Sholl LM, Fang X, Varelas X, Layne MD, Baron RM, Vidal Melo MF. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology. 2020 11 01; 133(5):1060-1076.View Related Profiles. PMID: 32796202
     
  7. Maziarz M, Federico A, Zhao J, Dujmusic L, Zhao Z, Monti S, Varelas X, Garcia-Marcos M. Naturally occurring hotspot cancer mutations in Ga13 promote oncogenic signaling. J Biol Chem. 2020 Dec 04; 295(49):16897-16904.View Related Profiles. PMID: 33109615
     
  8. Pseftogas A, Xanthopoulos K, Poutahidis T, Ainali C, Dafou D, Panteris E, Kern JG, Varelas X, Hardas A, Gonidas C, Tsingotjidou A, Hatzivassiliou E, Mosialos G. The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF? Signaling. Cancers (Basel). 2020 Jul 24; 12(8).View Related Profiles. PMID: 32722292
     
  9. Dey A, Varelas X, Guan KL. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 07; 19(7):480-494. PMID: 32555376
     
  10. Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kandula MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun. 2020 01 31; 11(1):635.View Related Profiles. PMID: 32005814
     
Showing 10 of 58 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 17 distinct years, with a maximum of 8 publications in 2017 and 2020

YearPublications
20031
20051
20061
20081
20092
20102
20113
20121
20134
20146
20154
20162
20178
20184
20197
20208
20213

Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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