Xaralabos Varelas, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Alberta

Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

Boston University
BU-BMC Cancer Center

Boston University
Pulmonary Center

Boston University
Center for Regenerative Medicine

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Defining epithelial polarity cues that direct cell fate
02/15/2020 - 01/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute

Mechanobiology of Lung Fibrosis
04/03/2019 - 03/31/2023 (Subcontract PI)
Mayo Clinic NIH NHLBI

Understanding aberrant YAP signaling in squamous cell lung cancer
07/01/2017 - 06/30/2021 (PI)
American Cancer Society, Inc.

Defining non-nuclear roles for Yap in the development of multi-ciliated cells
04/01/2018 - 03/31/2021 (PI)
NIH/National Institute of Child Health & Human Development

Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension
01/01/2018 - 12/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI

Intercepting aberrant YAP/TAZ activity for the treatment of lung cancer
12/29/2017 - 12/28/2020 (PI)
Janssen Research & Development, LLC

Defining Epithelial Cell Polarity Cues That Direct Cell Fate
08/15/2014 - 02/14/2020 (PI)
NIH/National Heart, Lung, and Blood Institute

Understanding the etiology of airway carcinomas via global proteomic, phospho-proteomic and metabolomic analyses
01/01/2019 - 12/31/2019 (PI)
Johnson & Johnson

Understanding the Molecular Mechanisms Controlling Multi-cilia Development
10/15/2018 - 10/14/2019 (PI)
Charles H. Hood Foundation

Mechanobiology of Lung Fibrosis
12/01/2014 - 11/30/2018 (Subcontract PI)
Mayo Clinic NIH NHLBI

Showing 10 of 21 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Zeng C, Motta-Ribeiro GC, Hinoshita T, Lessa MA, Winkler T, Grogg K, Kingston NM, Hutchinson JN, Sholl LM, Fang X, Varelas X, Layne MD, Baron RM, Vidal Melo MF. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology. 2020 11 01; 133(5):1060-1076.View Related Profiles. PMID: 32796202
  2. Maziarz M, Federico A, Zhao J, Dujmusic L, Zhao Z, Monti S, Varelas X, Garcia-Marcos M. Naturally-occurring hotspot cancer mutations in Ga13 promote oncogenic signaling. J Biol Chem. 2020 Oct 27.View Related Profiles. PMID: 33109615
  3. Pseftogas A, Xanthopoulos K, Poutahidis T, Ainali C, Dafou D, Panteris E, Kern JG, Varelas X, Hardas A, Gonidas C, Tsingotjidou A, Hatzivassiliou E, Mosialos G. The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF? Signaling. Cancers (Basel). 2020 Jul 24; 12(8).View Related Profiles. PMID: 32722292
  4. Dey A, Varelas X, Guan KL. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 07; 19(7):480-494. PMID: 32555376
  5. Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kandula MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN. The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun. 2020 01 31; 11(1):635.View Related Profiles. PMID: 32005814
  6. Stampouloglou E, Cheng N, Federico A, Slaby E, Monti S, Szeto GL, Varelas X. Yap suppresses T-cell function and infiltration in the tumor microenvironment. PLoS Biol. 2020 01; 18(1):e3000591.View Related Profiles. PMID: 31929526
  7. Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis. Sci Rep. 2019 11 15; 9(1):16904.View Related Profiles. PMID: 31729402
  8. Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 10 30; 11(516).View Related Profiles. PMID: 31666402
  9. Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. TGFß-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci. 2019 10 18; 132(20).View Related Profiles. PMID: 31527052
  10. Stampouloglou E, Federico A, Slabi E, Monti S, Szeto GL, Varelas X. Yap suppresses T cell function and infiltration in the tumor microenvironment. 2019; (BioRvix). View Publication
Showing 10 of 53 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 16 distinct years, with a maximum of 8 publications in 2017


Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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