Avrum Spira | Profiles RNS

Avrum Spira, MD

Alexander Graham Bell Professor in Health Care Entrepreneurship

Boston University Chobanian & Avedisian School of Medicine

Medicine

Computational Biomedicine

MD, McGill University
MSc, Boston University
DEC, Vanier College

Websites

	Pulmonary, Allergy, Sleep & Critical Care Medicine Faculty
	Boston Medical Center Provider Profile
	Computational Biomedicine Faculty
	BU Today: “Stand Up to Cancer” Dream Team
	ResearchGate
	Public Relations - BU Experts
	LinkedIn

ORCID : 0000-0003-1467-0489

Dr. Spira is a Professor of Medicine, Pathology and Bioinformatics, and the Alexander Graham Bell Professor in Health Care Entrepreneurship at Boston University. He is founding Chief of the Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center. He is also an attending physician in the Medical Intensive Care Unit at Boston Medical Center.

Dr. Spira is also the Global Head of the Lung Cancer Initiative (LCI) at Johnson & Johnson, which is developing solutions to prevent, intercept and cure lung cancer.

Dr. Spira obtained his MD from McGill University in Montreal, and completed his Internal medicine residency at the University of Toronto and his fellowship in Pulmonary and Critical Care Medicine at BMC. During his fellowship, Dr. Spira obtained a master’s degree in Bioinformatics from Boston University.

Since his 2003 appointment to the BU faculty, Dr. Spira has built a translational research program that focuses on genomic alterations associated with smoking-related lung disease, leading to a molecular test for the early detection of lung cancer that has successfully translated into the clinic (PerceptaTM) as well as a novel therapeutic for COPD that is in preclinical development. His research program is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He has co-founded both a molecular diagnostics company and a pharmaceutical company in order to translate these tools from “bench to bedside”.

He serves as Principal Investigator on grants from the National Cancer Institute (NCI); National Heart, Lung, Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS) and the Department of Defense (DoD), and has authored more than 100 peer-reviewed publications. Dr. Spira was a permanent member of the NIH’s Cancer Biomarker Study Section (CBSS) and currently serves as Senior Editor at Cancer Prevention Research as well as Associate Editor at the American Journal of Respiratory and Critical Care Medicine. He was elected a member of the American Society for Clinical Investigation (ASCI) in 2010 and a member of the Association of American Physicians (AAP) in 2017.

Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Computational Biomedicine

Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

Section Chief of Medicine in Computational Biomedicine
Boston University Chobanian & Avedisian School of Medicine
Medicine
Computational Biomedicine

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Pulmonary Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Bioinformatics Graduate Program

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy
09/30/2018 - 08/31/2024 (PI)
NIH/National Cancer Institute
3U2CCA233238-01S2

Intercept lung cancer through immune, imaging & molecular evaluation-InTime
03/01/2018 - 02/28/2023 (PI)
American Association for Cancer Research

Development of a lung cancer nasal gene expression classifier in patients with indeterminate pulmonary nodules
01/15/2021 - 12/31/2022 (PI)
International Association for the Study of Lung Cancer

The Boston University-UCLA Lung Cancer Biomarker Development Lab
09/20/2016 - 09/30/2022 (Multi PI of Sub-Project / SP)
PI: Marc Lenburg, PhD
NIH/National Cancer Institute
3U01CA214182-05S1

New England Centenarian Study
07/01/2016 - 06/30/2022 (Multi-PI)
PI: Avrum Spira, MD
The William M. Wood Foundation

Integrated molecular, cellular and imaging characterization of screen-detected lung cancer
09/16/2015 - 08/31/2021 (Co-Investigator of Sub-Project / SP)
PI: Marc Lenburg, PhD
University of California, Los Angeles NIH NCI
3U01CA196408-05S1

Detection of Early Lung Cancer Among Military Personnel (DECAMP)
09/30/2011 - 03/29/2019 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Correlating Histological, Radiological, and Gene Expression Patterns in the Lungs of IPF Patients
10/16/2015 - 10/15/2018 (PI)
Genentech, Inc.

mRNA expression array analysis among subjects exposed to outdoor ambient air pollution
09/22/2017 - 09/21/2018 (PI)
NIH/National Cancer Institute

Impact of smoking and its cessation on systemic and airway immune activation
08/15/2016 - 06/30/2018 (Subcontract PI)
Boston Medical Center Corporation NIH NIDA
5R01DA042685-02

Showing 10 of 36 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2021	The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy	3U2CCA233238-01S2	1
2021	Administrative Core	3U2CCA233238-01S2-8062	1
2020	The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy	3U2CCA233238-01S1	1
2018	The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy	1U2CCA233238-01	1
2018	Administrative Core	1U2CCA233238-01-8062	1
2018	Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung Cancer	5U01CA196408-04	7
2017	The Boston University-UCLA Lung Cancer Biomarker Development Lab	5U01CA214182-02	7
2017	Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung Cancer	5U01CA196408-03	7
2017	Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung Cancer	3U01CA196408-03S1	7
2016	Molecular and Imaging Biomarkers for Early Lung Cancer Detection in the Setting of Indeterminate Pulmonary Nodules	1R01CA210360-01	4

Showing 10 of 55 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Han G, Sinjab A, Rahal Z, Lynch AM, Treekitkarnmongkol W, Liu Y, Serrano AG, Feng J, Liang K, Khan K, Lu W, Hernandez SD, Liu Y, Cao X, Dai E, Pei G, Hu J, Abaya C, Gomez-Bolanos LI, Peng F, Chen M, Parra ER, Cascone T, Sepesi B, Moghaddam SJ, Scheet P, Negrao MV, Heymach JV, Li M, Dubinett SM, Stevenson CS, Spira AE, Fujimoto J, Solis LM, Wistuba II, Chen J, Wang L, Kadara H. Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Nature. 2024 Apr; 628(8006):E1. PMID: 38499683; PMCID: PMC10990920; DOI: 10.1038/s41586-024-07277-4;

Han G, Sinjab A, Rahal Z, Lynch AM, Treekitkarnmongkol W, Liu Y, Serrano AG, Feng J, Liang K, Khan K, Lu W, Hernandez SD, Liu Y, Cao X, Dai E, Pei G, Hu J, Abaya C, Gomez-Bolanos LI, Peng F, Chen M, Parra ER, Cascone T, Sepesi B, Moghaddam SJ, Scheet P, Negrao MV, Heymach JV, Li M, Dubinett SM, Stevenson CS, Spira AE, Fujimoto J, Solis LM, Wistuba II, Chen J, Wang L, Kadara H. An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Nature. 2024 Mar; 627(8004):656-663. PMID: 38418883

Lamb CR, Rieger-Christ KM, Reddy C, Huang J, Ding J, Johnson M, Walsh PS, Bulman WA, Lofaro LR, Wahidi MM, Feller-Kopman DJ, Spira A, Kennedy GC, Mazzone PJ. A Nasal Swab Classifier to Evaluate the Probability of Lung Cancer in Patients With Pulmonary Nodules. Chest. 2023 Nov 27. PMID: 38030063

Yanagawa J, Tran LM, Salehi-Rad R, Lim RJ, Dumitras C, Fung E, Wallace WD, Prosper AE, Fishbein G, Shea C, Hong R, Kahangi B, Deng JJ, Gower AC, Liu B, Campbell JD, Mazzilli SA, Beane JE, Kadara H, Lenburg ME, Spira AE, Aberle DR, Krysan K, Dubinett SM. Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma. Cancer Res. 2023 Oct 02; 83(19):3305-3319.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc
Mazzilli, Sarah

PMID: 37477508; PMCID: PMC10544016; DOI: 10.1158/0008-5472.CAN-23-0128;

Pavel AB, Garrison C, Luo L, Liu G, Taub D, Xiao J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Geraci MW, Sciurba F, Schwartz DA, Kaminski N, Beane J, Spira A, Lenburg ME, Campbell JD. Integrative genetic and genomic networks identify microRNA associated with COPD and ILD. Sci Rep. 2023 Aug 11; 13(1):13076.View Related Profiles.

Spira, Avrum
Taub, Daniel
Liu, Gang
Tedrow, John
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Alekseyev, Yuriy

PMID: 37567908; PMCID: PMC10421936; DOI: 10.1038/s41598-023-39751-w;

Bruhm DC, Mathios D, Foda ZH, Annapragada AV, Medina JE, Adleff V, Chiao EJ, Ferreira L, Cristiano S, White JR, Mazzilli SA, Billatos E, Spira A, Zaidi AH, Mueller J, Kim AK, Anagnostou V, Phallen J, Scharpf RB, Velculescu VE. Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer. Nat Genet. 2023 Aug; 55(8):1301-1310.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Mazzilli, Sarah

PMID: 37500728; PMCID: PMC10412448; DOI: 10.1038/s41588-023-01446-3;

Ning B, Tilston-Lunel AM, Simonetti J, Hicks-Berthet J, Matschulat A, Pfefferkorn R, Spira A, Edwards M, Mazzilli S, Lenburg ME, Beane JE, Varelas X. Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. J Exp Clin Cancer Res. 2023 May 08; 42(1):116.View Related Profiles.

Tilston-Lunel, Andrew
Spira, Avrum
Lenburg, Marc
Pfefferkorn, Roxana
Mazzilli, Sarah
Varelas, Xaralabos

PMID: 37150829; PMCID: PMC10165825; DOI: 10.1186/s13046-023-02674-5;

Xu K, Diaz AA, Duan F, Lee M, Xiao X, Liu H, Liu G, Cho MH, Gower AC, Alekseyev YO, Spira A, Aberle DR, Washko GR, Billatos E, Lenburg ME. Bronchial gene expression alterations associated with radiological bronchiectasis. Eur Respir J. 2023 Jan; 61(1).View Related Profiles.

Gower, Adam
Spira, Avrum
Billatos, Ehab
Liu, Gang
Liu, Hanqiao
Lenburg, Marc
Alekseyev, Yuriy

PMID: 36229050; PMCID: PMC9881226; DOI: 10.1183/13993003.00120-2022;

Hao D, Han G, Sinjab A, Gomez-Bolanos LI, Lazcano R, Serrano A, Hernandez SD, Dai E, Cao X, Hu J, Dang M, Wang R, Chu Y, Song X, Zhang J, Parra ER, Wargo JA, Swisher SG, Cascone T, Sepesi B, Futreal AP, Li M, Dubinett SM, Fujimoto J, Solis Soto LM, Wistuba II, Stevenson CS, Spira A, Shalapour S, Kadara H, Wang L. The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma. Cancer Discov. 2022 Nov 02; 12(11):2626-2645. PMID: 36098652; PMCID: PMC9633381; DOI: 10.1158/2159-8290.CD-21-1658;

Xu K, Shi X, Husted C, Hong R, Wang Y, Ning B, Sullivan TB, Rieger-Christ KM, Duan F, Marques H, Gower AC, Xiao X, Liu H, Liu G, Duclos G, Platt M, Spira AE, Mazzilli SA, Billatos E, Lenburg ME, Campbell JD, Beane JE. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Sci Rep. 2022 Oct 28; 12(1):18168.View Related Profiles.

Gower, Adam
Spira, Avrum
Billatos, Ehab
Liu, Gang
Duclos, Grant
Liu, Hanqiao
Campbell, Joshua
Lenburg, Marc
Platt, Michael
Mazzilli, Sarah

PMID: 36307504; PMCID: PMC9615627; DOI: 10.1038/s41598-022-17832-6;

Showing 10 of 176 results. Show More

Mazzone P, Dotson T, Wahidi MM, Bernstein M, Lee HJ, Feller Kopman D, Yarmus L, Whitney D, Stevenson C, Qu J, Johnson M, Walsh PS, Huang J, Lofaro LR, Bhorade SM, Kennedy GC, Spira A, Rivera MP. Clinical validation and utility of Percepta GSC for the evaluation of lung cancer. PLoS One. 2022; 17(7):e0268567. PMID: 35830375; PMCID: PMC9278743; DOI: 10.1371/journal.pone.0268567;

Garland LL, Guillen-Rodriguez J, Hsu CH, Davis LE, Szabo E, Husted CR, Liu H, LeClerc A, Alekseyev YO, Liu G, Bauman JE, Spira AE, Beane J, Wojtowicz M, Chow HS. Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers. Cancers (Basel). 2022 Jun 11; 14(12).View Related Profiles.

Spira, Avrum
Alekseyev, Yuriy

PMID: 35740559; PMCID: PMC9221101; DOI: 10.3390/cancers14122893;

Xu F, Vasilescu DM, Kinose D, Tanabe N, Ng KW, Coxson HO, Cooper JD, Hackett TL, Verleden SE, Vanaudenaerde BM, Stevenson CS, Lenburg ME, Spira A, Tan WC, Sin DD, Ng RT, Hogg JC. The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD. Eur Respir J. 2022 May; 59(5).View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 34675046

Kammer MN, Lakhani DA, Balar AB, Antic SL, Kussrow AK, Webster RL, Mahapatra S, Barad U, Shah C, Atwater T, Diergaarde B, Qian J, Kaizer A, New M, Hirsch E, Feser WJ, Strong J, Rioth M, Miller YE, Balagurunathan Y, Rowe DJ, Helmey S, Chen SC, Bauza J, Deppen SA, Sandler K, Maldonado F, Spira A, Billatos E, Schabath MB, Gillies RJ, Wilson DO, Walker RC, Landman B, Chen H, Grogan EL, Barón AE, Bornhop DJ, Massion PP. Integrated Biomarkers for the Management of Indeterminate Pulmonary Nodules. Am J Respir Crit Care Med. 2021 12 01; 204(11):1306-1316.View Related Profiles.

Spira, Avrum
Billatos, Ehab

PMID: 34464235; PMCID: PMC8786067; DOI: 10.1164/rccm.202012-4438OC;

Burks EJ, Zhang J, Sullivan TB, Shi X, Sands JM, Regis SM, McKee BJ, McKee AB, Zhang S, Liu H, Liu G, Spira A, Beane J, Lenburg ME, Rieger-Christ KM. Pathologic and gene expression comparison of CT- screen detected and routinely detected stage I/0 lung adenocarcinoma in NCCN risk-matched cohorts. Cancer Treat Res Commun. 2021; 29:100486.View Related Profiles.

Spira, Avrum
Burks, Eric
Lenburg, Marc

PMID: 34794107; PMCID: PMC8713084; DOI: 10.1016/j.ctarc.2021.100486;

Xu K, Shi X, Husted C, Hong R, Wang Y, Ning B, Sullivan T, Rieger-Christ K, Duan F, Marques H, Gower A, Xiao X, Liu H, Liu G, Duclos G, Platt M, Spira A, Mazzilli S, Billatos E, Lenburg M, Campbell J, Beane J. Smoking Modulates Different Secretory Subpopulations Expressing SARS-CoV-2 Entry Genes in the Nasal and Bronchial Airways. Res Sq. 2021 Oct 28.View Related Profiles.

Gower, Adam
Spira, Avrum
Billatos, Ehab
Liu, Gang
Duclos, Grant
Liu, Hanqiao
Lenburg, Marc
Platt, Michael
Mazzilli, Sarah

PMID: 34729557; PMCID: PMC8562543; DOI: 10.21203/rs.3.rs-887718/v1;

Maoz A, Merenstein C, Koga Y, Potter A, Gower AC, Liu G, Zhang S, Liu H, Stevenson C, Spira A, Reid ME, Campbell JD, Mazzilli SA, Lenburg ME, Beane J. Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions. J Immunother Cancer. 2021 09; 9(9).View Related Profiles.

Gower, Adam
Spira, Avrum
Liu, Gang
Liu, Hanqiao
Campbell, Joshua
Lenburg, Marc
Mazzilli, Sarah

PMID: 34580161; PMCID: PMC8477334; DOI: 10.1136/jitc-2021-002647;

Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD. Thorax. 2022 01; 77(1):31-39.View Related Profiles.

Spira, Avrum
Liu, Gang
O'Connor, George
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 33972452

Sinjab A, Han G, Treekitkarnmongkol W, Hara K, Brennan PM, Dang M, Hao D, Wang R, Dai E, Dejima H, Zhang J, Bogatenkova E, Sanchez-Espiridion B, Chang K, Little DR, Bazzi S, Tran LM, Krysan K, Behrens C, Duose DY, Parra ER, Raso MG, Solis LM, Fukuoka J, Zhang J, Sepesi B, Cascone T, Byers LA, Gibbons DL, Chen J, Moghaddam SJ, Ostrin EJ, Rosen D, Heymach JV, Scheet P, Dubinett SM, Fujimoto J, Wistuba II, Stevenson CS, Spira A, Wang L, Kadara H. Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing. Cancer Discov. 2021 10; 11(10):2506-2523. PMID: 33972311; PMCID: PMC8487926; DOI: 10.1158/2159-8290.CD-20-1285;

Tilston-Lunel A, Mazzilli S, Kingston NM, Szymaniak AD, Hicks-Berthet J, Kern JG, Abo K, Reid ME, Perdomo C, Wilson AA, Spira A, Beane J, Varelas X. Aberrant epithelial polarity cues drive the development of precancerous airway lesions. Proc Natl Acad Sci U S A. 2021 05 04; 118(18).View Related Profiles.

Szymaniak, Aleksander
Wilson, Andrew
Tilston-Lunel, Andrew
Spira, Avrum
Kern, Joseph
Mazzilli, Sarah
Varelas, Xaralabos

PMID: 33903236; PMCID: PMC8106308; DOI: 10.1073/pnas.2019282118;

Xu F, Tanabe N, Vasilescu DM, McDonough JE, Coxson HO, Ikezoe K, Kinose D, Ng KW, Verleden SE, Wuyts WA, Vanaudenaerde BM, Verschakelen J, Cooper JD, Lenburg ME, Morshead KB, Abbas AR, Arron JR, Spira A, Hackett TL, Colby TV, Ryerson CJ, Ng RT, Hogg JC. The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF). EBioMedicine. 2021 Apr; 66:103325.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 33862585; PMCID: PMC8054143; DOI: 10.1016/j.ebiom.2021.103325;

Han G, Sinjab A, Hara K, Treekitkarnmongkol W, Brennan P, Chang K, Bogatenkova E, Sanchez-Espiridion B, Behrens C, Solis LM, Gao B, Girard L, Zhang J, Sepesi B, Cascone T, Byers LA, Gibbons DL, Chen J, Moghaddam SJ, Ostrin EJ, Scheet P, Fujimoto J, Shay J, Heymach JV, Minna JD, Dubinett S, Wistuba II, Stevenson CS, Spira AE, Wang L, Kadara H. Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients. Cancers (Basel). 2021 Mar 12; 13(6). PMID: 33809063; PMCID: PMC7998226; DOI: 10.3390/cancers13061250;

Treekitkarnmongkol W, Hassane M, Sinjab A, Chang K, Hara K, Rahal Z, Zhang J, Lu W, Sivakumar S, McDowell TL, Kantrowitz J, Zhou J, Lang W, Xu L, Ochieng JK, Nunomura-Nakamura S, Deng S, Behrens C, Raso MG, Fukuoka J, Reuben A, Ostrin EJ, Parra E, Solis LM, Spira AE, McAllister F, Cascone T, Wistuba II, Moghaddam SJ, Scheet PA, Fujimoto J, Kadara H. Augmented Lipocalin-2 Is Associated with Chronic Obstructive Pulmonary Disease and Counteracts Lung Adenocarcinoma Development. Am J Respir Crit Care Med. 2021 01 01; 203(1):90-101. PMID: 32730093; PMCID: PMC7781147; DOI: 10.1164/rccm.202004-1079OC;

Ostrin EJ, Sidransky D, Spira A, Hanash SM. Biomarkers for Lung Cancer Screening and Detection. Cancer Epidemiol Biomarkers Prev. 2020 12; 29(12):2411-2415. PMID: 33093160; PMCID: PMC7710615; DOI: 10.1158/1055-9965.EPI-20-0865;

Faiz A, Imkamp K, van der Wiel E, Boudewijn IM, Koppelman GH, Brandsma CA, Kerstjens HAM, Timens W, Vroegop S, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Steiling K, Spira A, Lenburg ME, Heijink IH, Postma DS, van den Berge M. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Sci Rep. 2020 10 15; 10(1):17415.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 33060632; PMCID: PMC7562702; DOI: 10.1038/s41598-020-72551-0;

Billatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, San José Estépar R, Rosas IO, Ross JC, Xiao X, Liu H, Liu G, Sukumar G, Wilkerson M, Dalgard C, Stevenson C, Whitney D, Aberle D, Spira A, San José Estépar R, Lenburg ME, Washko GR. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features. Chest. 2021 02; 159(2):549-563.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Lenburg, Marc

PMID: 32946850; PMCID: PMC8039011; DOI: 10.1016/j.chest.2020.08.2115;

Lee HJ, Mazzone P, Feller-Kopman D, Yarmus L, Hogarth K, Lofaro LR, Griscom B, Johnson M, Choi Y, Huang J, Bhorade S, Spira A, Kennedy GC, Wahidi MM. Impact of the Percepta Genomic Classifier on Clinical Management Decisions in a Multicenter Prospective Study. Chest. 2021 01; 159(1):401-412. PMID: 32758562

Sofer T, Li R, Joehanes R, Lin H, Gower AC, Wang H, Kurniansyah N, Cade BE, Lee J, Williams S, Mehra R, Patel SR, Quan SF, Liu Y, Rotter JI, Rich SS, Spira A, Levy D, Gharib SA, Redline S, Gottlieb DJ. Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. EBioMedicine. 2020 Jun; 56:102803.View Related Profiles.

Gower, Adam
Spira, Avrum
Lin, Honghuang

PMID: 32512511; PMCID: PMC7276515; DOI: 10.1016/j.ebiom.2020.102803;

Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 2020 04 16; 181(2):236-249.View Related Profiles.

Spira, Avrum
Mazzilli, Sarah

PMID: 32302568; PMCID: PMC7376497; DOI: 10.1016/j.cell.2020.03.053;

Drizik E, Corbett S, Zheng Y, Vermeulen R, Dai Y, Hu W, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Zhang X, Yang J, Bassig B, Liu H, Ye M, Liu G, Jia X, Meng T, Bin P, Zhang J, Silverman D, Spira A, Rothman N, Lenburg ME, Lan Q. Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure. Environ Int. 2020 04; 137:105506.View Related Profiles.

Spira, Avrum
Liu, Gang
Liu, Hanqiao
Lenburg, Marc
Dai, Yan

PMID: 32044442; PMCID: PMC8725607; DOI: 10.1016/j.envint.2020.105506;

Duclos GE, Teixeira VH, Autissier P, Gesthalter YB, Reinders-Luinge MA, Terrano R, Dumas YM, Liu G, Mazzilli SA, Brandsma CA, van den Berge M, Janes SM, Timens W, Lenburg ME, Spira A, Campbell JD, Beane J. Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution. Sci Adv. 2019 12; 5(12):eaaw3413.View Related Profiles.

Spira, Avrum
Liu, Gang
Duclos, Grant
Campbell, Joshua
Lenburg, Marc
Mazzilli, Sarah
Dumas, Yves-Martine

PMID: 31844660; PMCID: PMC6905872; DOI: 10.1126/sciadv.aaw3413;

Kadara H, Sivakumar S, Jakubek Y, San Lucas FA, Lang W, McDowell T, Weber Z, Behrens C, Davies GE, Kalhor N, Moran C, El-Zein R, Mehran R, Swisher SG, Wang J, Zhang J, Fujimoto J, Fowler J, Heymach JV, Dubinett S, Spira AE, Ehli EA, Wistuba II, Scheet P. Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer. Am J Respir Crit Care Med. 2019 09 15; 200(6):742-750. PMID: 30896962; PMCID: PMC6775870; DOI: 10.1164/rccm.201806-1178OC;

Garland LL, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane JE, Wojtowicz M, Chow HS. Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial. Cancer Prev Res (Phila). 2019 11; 12(11):809-820. PMID: 31451521; PMCID: PMC7485120; DOI: 10.1158/1940-6207.CAPR-19-0036;

Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Buttard B, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier JP, Spira A, Galon J. Immune evasion before tumour invasion in early lung squamous carcinogenesis. Nature. 2019 07; 571(7766):570-575. PMID: 31243362; DOI: 10.1038/s41586-019-1330-0;

Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Xiao X, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME. Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users. Chest. 2019 10; 156(4):764-773.View Related Profiles.

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Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle DR, Spira AE, Elashoff DA, Wallace WD, Fishbein MC, Dubinett SM. The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy. Cancer Res. 2019 Oct 01; 79(19):5022-5033. PMID: 31142513; PMCID: PMC6774823; DOI: 10.1158/0008-5472.CAN-19-0153;

Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 05 06; 9(1):6978.View Related Profiles.

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Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019 04; 53(4).View Related Profiles.

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Billatos E, Duan F, Moses E, Marques H, Mahon I, Dymond L, Apgar C, Aberle D, Washko G, Spira A. Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols. BMC Pulm Med. 2019 Mar 07; 19(1):59.View Related Profiles.

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Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F. Electronic cigarettes: a task force report from the European Respiratory Society. Eur Respir J. 2019 02; 53(2). PMID: 30464018

Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions. Nat Med. 2019 03; 25(3):517-525.View Related Profiles.

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Wu AC, Kiley JP, Noel PJ, Amur S, Burchard EG, Clancy JP, Galanter J, Inada M, Jones TK, Kropski JA, Loyd JE, Nogee LM, Raby BA, Rogers AJ, Schwartz DA, Sin DD, Spira A, Weiss ST, Young LR, Himes BE. Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement. Am J Respir Crit Care Med. 2018 12 15; 198(12):e116-e136. PMID: 30640517; PMCID: PMC6835090; DOI: 10.1164/rccm.201810-1895ST;

Seijo LM, Peled N, Ajona D, Boeri M, Field JK, Sozzi G, Pio R, Zulueta JJ, Spira A, Massion PP, Mazzone PJ, Montuenga LM. Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges. J Thorac Oncol. 2019 03; 14(3):343-357. PMID: 30529598; PMCID: PMC6494979; DOI: 10.1016/j.jtho.2018.11.023;

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. J Clin Invest. 2019 01 02; 129(1):169-181. PMID: 30383540; PMCID: PMC6307967; DOI: 10.1172/JCI121087;

Khalil A, Dekmak B, Boulos F, Kantrowitz J, Spira A, Fujimoto J, Kadara H, El-Hachem N, Nemer G. Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes. Front Oncol. 2018; 8:482. PMID: 30425966; PMCID: PMC6218583; DOI: 10.3389/fonc.2018.00482;

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA. microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD. Eur Respir J. 2018 09; 52(3). PMID: 30072506

Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R. Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine. Am J Respir Crit Care Med. 2018 08 15; 198(4):440-446. PMID: 29624449; PMCID: PMC6118019; DOI: 10.1164/rccm.201801-0120PP;

Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics. 2018 09 01; 50(9):705-713.View Related Profiles.

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Spira A, Coleman D. Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective. Am J Med. 2018 07; 131(7):846-851.View Related Profiles.

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Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, Krysan K, Stass SA, Kukuruga D, Van Keuren-Jensen K, Courtright-Lim A, Thompson KL, Rosenzweig BA, Sorbara L, Srivastava S, Salit ML. Summarizing performance for genome scale measurement of miRNA: reference samples and metrics. BMC Genomics. 2018 03 06; 19(1):180.View Related Profiles.

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Billatos E, Vick JL, Lenburg ME, Spira AE. The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. Clin Cancer Res. 2018 07 01; 24(13):2984-2992.View Related Profiles.

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Dubinett SM, Spira AE. Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception. Am J Respir Crit Care Med. 2018 02 01; 197(3):278-280. PMID: 29072842

Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, Spira AE, Kadara H. Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma. Cancer Prev Res (Phila). 2018 04; 11(4):237-248. PMID: 29382653; PMCID: PMC6679600; DOI: 10.1158/1940-6207.CAPR-17-0295;

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respir Res. 2017 12 21; 18(1):213.View Related Profiles.

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Obeidat M, Nie Y, Fishbane N, Li X, Bossé Y, Joubert P, Nickle DC, Hao K, Postma DS, Timens W, Sze MA, Shannon CP, Hollander Z, Ng RT, McManus B, Miller BE, Rennard S, Spira A, Hackett TL, Lam W, Lam S, Faner R, Agusti A, Hogg JC, Sin DD, Paré PD. Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers. Am J Respir Cell Mol Biol. 2017 Oct; 57(4):411-418. PMID: 28459279; PMCID: PMC5650084; DOI: 10.1165/rcmb.2016-0284OC;

Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA. ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status. Cancer Lett. 2017 Dec 01; 410:191-200. PMID: 28965852; PMCID: PMC5675764; DOI: 10.1016/j.canlet.2017.09.038;

Sivakumar S, Lucas FAS, McDowell TL, Lang W, Xu L, Fujimoto J, Zhang J, Futreal PA, Fukuoka J, Yatabe Y, Dubinett SM, Spira AE, Fowler J, Hawk ET, Wistuba II, Scheet P, Kadara H. Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma. Cancer Res. 2017 Nov 15; 77(22):6119-6130. PMID: 28951454; PMCID: PMC5774855; DOI: 10.1158/0008-5472.CAN-17-1605;

Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. PLoS One. 2017; 12(9):e0183815.View Related Profiles.

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Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A. Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. Cancer Prev Res (Phila). 2017 Nov; 10(11):651-659.View Related Profiles.

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Suzuki M, Sze MA, Campbell JD, Brothers JF, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC. The cellular and molecular determinants of emphysematous destruction in COPD. Sci Rep. 2017 08 25; 7(1):9562.View Related Profiles.

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Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G, Kadara H. TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection. Oncotarget. 2017 Sep 15; 8(40):68230-68241. PMID: 28978111; PMCID: PMC5620251; DOI: 10.18632/oncotarget.19938;

Beane J, Campbell JD, Lel J, Vick J, Spira A. Genomic approaches to accelerate cancer interception. Lancet Oncol. 2017 Aug; 18(8):e494-e502.View Related Profiles.

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Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE. Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. Clin Cancer Res. 2017 Sep 01; 23(17):5091-5100.View Related Profiles.

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Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management. J Allergy Clin Immunol. 2017 Oct; 140(4):933-949.View Related Profiles.

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PMID: 28502823; PMCID: PMC5632590; DOI: 10.1016/j.jaci.2017.04.024;

Vachani A, Sequist LV, Spira A. AJRCCM: 100-Year Anniversary. The Shifting Landscape for Lung Cancer: Past, Present, and Future. Am J Respir Crit Care Med. 2017 May 01; 195(9):1150-1160. PMID: 28459327; PMCID: PMC5439022; DOI: 10.1164/rccm.201702-0433CI;

Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, Garber JE, Velculescu VE, Disis ML, Wallace DC, Lippman SM. Precancer Atlas to Drive Precision Prevention Trials. Cancer Res. 2017 Apr 01; 77(7):1510-1541.View Related Profiles.

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Rahman SM, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, Young JD, Massion PP. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. JCI Insight. 2016 11 17; 1(19):e88814.View Related Profiles.

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Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz JJ, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Lenburg M, Stevenson CS, Spira A, Cooper JD, Hackett TL, Hogg JC. Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue. J Appl Physiol (1985). 2017 Jan 01; 122(1):161-169.View Related Profiles.

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Kusko RL, Brothers JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, Geraci M, Yang I, Schwartz DA, Beane J, Spira A, Kaminski N. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Oct 15; 194(8):948-960.View Related Profiles.

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Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A. Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium. Toxicol Sci. 2017 Jan; 155(1):248-257.View Related Profiles.

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PMID: 27701119; PMCID: PMC5216655; DOI: 10.1093/toxsci/kfw198;

Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016 Dec; 9(12):906-914.View Related Profiles.

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PMID: 27658890; PMCID: PMC5136333; DOI: 10.1158/1940-6207.CAPR-15-0254;

Spira A, Disis ML, Schiller JT, Vilar E, Rebbeck TR, Bejar R, Ideker T, Arts J, Yurgelun MB, Mesirov JP, Rao A, Garber J, Jaffee EM, Lippman SM. Leveraging premalignant biology for immune-based cancer prevention. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):10750-8. PMID: 27638202; PMCID: PMC5047191; DOI: 10.1073/pnas.1608077113;

Spira A, Halmos B, Powell CA. Update in Lung Cancer 2015. Am J Respir Crit Care Med. 2016 Sep 15; 194(6):661-71. PMID: 27628077; PMCID: PMC5027233; DOI: 10.1164/rccm.201604-0898UP;

Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, Shen J, Takata Y, McNiece K, Polansky MA, Abbas HA, Rajapakshe K, Gower A, Spira A, Covington KR, Xiao W, Gunaratne P, Pickering C, Frederick M, Myers JN, Shen L, Yao H, Su X, Rapini RP, Wheeler DA, Hawk ET, Flores ER, Tsai KY. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nat Commun. 2016 08 30; 7:12601.View Related Profiles.

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Tellez CS, Juri DE, Do K, Picchi MA, Wang T, Liu G, Spira A, Belinsky SA. miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis. Cancer Res. 2016 Aug 15; 76(16):4741-51.View Related Profiles.

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Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW. The Importance of the Biological Impact of Exposure to the Concept of the Exposome. Environ Health Perspect. 2016 10; 124(10):1504-1510. PMID: 27258438; PMCID: PMC5047763; DOI: 10.1289/EHP140;

Faner R, Cruz T, Casserras T, López-Giraldo A, Noell G, Coca I, Tal-Singer R, Miller B, Rodriguez-Roisin R, Spira A, Kalko SG, Agustí A. Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema. Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1242-53. PMID: 26735770; DOI: 10.1164/rccm.201507-1311OC;

Jakubek Y, Lang W, Vattathil S, Garcia M, Xu L, Huang L, Yoo SY, Shen L, Lu W, Chow CW, Weber Z, Davies G, Huang J, Behrens C, Kalhor N, Moran C, Fujimoto J, Mehran R, El-Zein R, Swisher SG, Wang J, Fowler J, Spira AE, Ehli EA, Wistuba II, Scheet P, Kadara H. Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway. Cancer Res. 2016 Jul 01; 76(13):3676-83. PMID: 27216194; PMCID: PMC5393446; DOI: 10.1158/0008-5472.CAN-15-3064;

Ferguson JS, Van Wert R, Choi Y, Rosenbluth MJ, Smith KP, Huang J, Spira A. Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer. BMC Pulm Med. 2016 May 17; 16(1):66. PMID: 27184093; PMCID: PMC4869188; DOI: 10.1186/s12890-016-0217-1;

Kadara H, Scheet P, Wistuba II, Spira AE. Early Events in the Molecular Pathogenesis of Lung Cancer. Cancer Prev Res (Phila). 2016 Jul; 9(7):518-27. PMID: 27006378; DOI: 10.1158/1940-6207.CAPR-15-0400;

Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild AH. Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Mol Syst Biol. 2016 Mar 10; 12(3):860.View Related Profiles.

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PMID: 26969729; PMCID: PMC4812528; DOI: 10.15252/msb.20156506;

Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A. Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer. Chest. 2016 Jul; 150(1):210-8.View Related Profiles.

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PMID: 26896702; DOI: 10.1016/j.chest.2016.02.636;

Campbell JD, Mazzilli SA, Reid ME, Dhillon SS, Platero S, Beane J, Spira AE. The Case for a Pre-Cancer Genome Atlas (PCGA). Cancer Prev Res (Phila). 2016 Feb; 9(2):119-24.View Related Profiles.

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PMID: 26839336; DOI: 10.1158/1940-6207.CAPR-16-0024;

Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prev Res (Phila). 2016 Jan; 9(1):2-10. PMID: 26744449; PMCID: PMC4955753; DOI: 10.1158/1940-6207.CAPR-15-0406;

Piccolo SR, Andrulis IL, Cohen AL, Conner T, Moos PJ, Spira AE, Buys SS, Johnson WE, Bild AH. Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility. BMC Med Genomics. 2015; 8:72.View Related Profiles.

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Piccolo, Stephen
Johnson, William

PMID: 26538066; PMCID: PMC4634735; DOI: 10.1186/s12920-015-0145-6;

Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q. Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal. Carcinogenesis. 2015 Dec; 36(12):1494-501.View Related Profiles.

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Liu, Gang
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PMID: 26468118; PMCID: PMC4675833; DOI: 10.1093/carcin/bgv150;

Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC. Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Aug 15; 192(4):438-45.View Related Profiles.

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Campbell, Joshua
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PMID: 25945594; PMCID: PMC4595667; DOI: 10.1164/rccm.201502-0223OC;

Spira A, Halmos B, Powell CA. Update in Lung Cancer 2014. Am J Respir Crit Care Med. 2015 Aug 1; 192(3):283-94. PMID: 26230235; PMCID: PMC4584253; DOI: 10.1164/rccm.201504-0756UP;

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A. A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. N Engl J Med. 2015 Jul 16; 373(3):243-51.View Related Profiles.

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Brody, Jerome
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PMID: 25981554; PMCID: PMC4838273; DOI: 10.1056/NEJMoa1504601;

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. BMC Med Genomics. 2015; 8:18.View Related Profiles.

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Spira, Avrum
Brody, Jerome
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PMID: 25944280; PMCID: PMC4434538; DOI: 10.1186/s12920-015-0091-3;

Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's). Arthritis Rheumatol. 2015 May; 67(8):2233-9.View Related Profiles.

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Liu, Gang
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Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles.

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Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Apr 1; 191(7):758-66.View Related Profiles.

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Steiling, Katrina
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PMID: 25611785; PMCID: PMC4407484; DOI: 10.1164/rccm.201408-1458OC;

Maxwell EK, Campbell JD, Spira A, Baxevanis AD. SubmiRine: assessing variants in microRNA targets using clinical genomic data sets. Nucleic Acids Res. 2015 Apr 30; 43(8):3886-98. PMID: 25813044; PMCID: PMC4417167; DOI: 10.1093/nar/gkv256;

Gesthalter YB, Vick J, Steiling K, Spira A. Translating the transcriptome into tools for the early detection and prevention of lung cancer. Thorax. 2015 May; 70(5):476-81.View Related Profiles.

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Steiling, Katrina

PMID: 25628310; DOI: 10.1136/thoraxjnl-2014-206605;

Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Foronjy RF, Feronjy R, Spira A, Schadt EE, Powell CA, Zhu J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015 Jan; 11(1):e1004898.View Related Profiles.

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Campbell, Joshua

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Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 2015 Feb; 21(2):164-71.View Related Profiles.

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Liu, Gang
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Monti, Stefano
Johnson, William
Alekseyev, Yuriy

PMID: 25519487; PMCID: PMC4338344; DOI: 10.1261/rna.046060.114;

Yang IV, Pedersen BS, Rabinovich E, Hennessy CE, Davidson EJ, Murphy E, Guardela BJ, Tedrow JR, Zhang Y, Singh MK, Correll M, Schwarz MI, Geraci M, Sciurba FC, Quackenbush J, Spira A, Kaminski N, Schwartz DA. Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Dec 1; 190(11):1263-72.View Related Profiles.

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Tedrow, John

PMID: 25333685; PMCID: PMC4315819; DOI: 10.1164/rccm.201408-1452OC;

Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. Thorax. 2014 Nov; 69(11):997-1004.View Related Profiles.

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Campbell, Joshua
Steiling, Katrina
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PMID: 25182044; DOI: 10.1136/thoraxjnl-2014-205630;

Wang X, Pittman GS, Bandele OJ, Bischof JJ, Liu G, Brothers JF, Spira A, Bell DA. Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk. Hum Genet. 2014 Dec; 133(12):1467-76. PMID: 25179167; PMCID: PMC4225167; DOI: 10.1007/s00439-014-1483-8;

Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J. MODMatcher: multi-omics data matcher for integrative genomic analysis. PLoS Comput Biol. 2014 Aug; 10(8):e1003790.View Related Profiles.

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Campbell, Joshua

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Kathuria H, Gesthalter Y, Spira A, Brody JS, Steiling K. Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention. Cancers (Basel). 2014; 6(2):1157-79.View Related Profiles.

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Kathuria, Hasmeena
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PMID: 24840047; PMCID: PMC4074822; DOI: 10.3390/cancers6021157;

Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, Macaulay CE, Lam S, Lam WL. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol. 2014 May; 50(5):912-22.View Related Profiles.

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Steiling, Katrina
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PMID: 24298892; PMCID: PMC4068945; DOI: 10.1165/rcmb.2013-0304OC;

Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014 May; 7(5):487-95.View Related Profiles.

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Lenburg, Marc

PMID: 24618292; PMCID: PMC4059064; DOI: 10.1158/1940-6207.CAPR-13-0372;

Christmann RB, Sampaio-Barros P, Stifano G, Borges CL, de Carvalho CR, Kairalla R, Parra ER, Spira A, Simms R, Capellozzi VL, Lafyatis R. Association of Interferon- and transforming growth factor ß-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis. Arthritis Rheumatol. 2014 Mar; 66(3):714-25.View Related Profiles.

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Stifano, Giuseppina
Lafyatis, Robert
Simms, Robert
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PMID: 24574232; PMCID: PMC4439004; DOI: 10.1002/art.38288;

Kadara H, Fujimoto J, Yoo SY, Maki Y, Gower AC, Kabbout M, Garcia MM, Chow CW, Chu Z, Mendoza G, Shen L, Kalhor N, Hong WK, Moran C, Wang J, Spira A, Coombes KR, Wistuba II. Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer. J Natl Cancer Inst. 2014 Mar; 106(3):dju004.View Related Profiles.

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PMID: 24563515; PMCID: PMC3982778; DOI: 10.1093/jnci/dju004;

Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Mol Cancer Res. 2014 May; 12(5):765-74.View Related Profiles.

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Lenburg, Marc
Kusko, Rebecca

PMID: 24469837; PMCID: PMC4020971; DOI: 10.1158/1541-7786.MCR-13-0377;

Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med. 2013; 5(12):114.View Related Profiles.

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Campbell, Joshua
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PMID: 24380442; PMCID: PMC3971345; DOI: 10.1186/gm519;

Steiling K, Lenburg ME, Spira A. Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S190-6.View Related Profiles.

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Steiling, Katrina
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PMID: 24313772; PMCID: PMC3960986; DOI: 10.1513/AnnalsATS.201306-190AW;

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18946-51.View Related Profiles.

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Spira, Avrum
O'Hara, Carl
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PMID: 24158479; PMCID: PMC3839685; DOI: 10.1073/pnas.1220319110;

Dubinett SM, Spira A. Challenge and opportunity of targeted lung cancer chemoprevention. J Clin Oncol. 2013 Nov 20; 31(33):4169-71. PMID: 24002497; DOI: 10.1200/JCO.2013.51.2400;

Krysan K, Cui X, Gardner BK, Reckamp KL, Wang X, Hong L, Walser TC, Rodriguez NL, Pagano PC, Garon EB, Brothers JF, Elashoff D, Lee JM, Spira AE, Sharma S, Fishbein MC, Dubinett SM. Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer. Am J Transl Res. 2013; 5(5):481-96. PMID: 23977408; PMCID: PMC3745436

van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 2014 Jan; 69(1):14-23.View Related Profiles.

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Liu, Gang
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 23925644; PMCID: PMC3888587; DOI: 10.1136/thoraxjnl-2012-202878;

Brothers JF, Hijazi K, Mascaux C, El-Zein RA, Spitz MR, Spira A. Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. BMC Med. 2013; 11:168. PMID: 23870182; PMCID: PMC3717087; DOI: 10.1186/1741-7015-11-168;

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.View Related Profiles.

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Dumont, Charles
Liu, Gang
O'Connor, George
Duclos, Grant
Campbell, Joshua
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Lenburg, Marc
Sebastiani, Paola
Alekseyev, Yuriy

PMID: 23471465; PMCID: PMC3707363; DOI: 10.1164/rccm.201208-1449OC;

Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS One. 2013; 8(3):e58725.View Related Profiles.

Hossein-Nezhad, Arash
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Holick, Michael

PMID: 23527013; PMCID: PMC3604145; DOI: 10.1371/journal.pone.0058725;

Zhang X, Lenburg ME, Spira A. Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays. ScientificWorldJournal. 2013; 2013:951416.View Related Profiles.

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Lenburg, Marc
Zhang, Xiaoling

PMID: 23476154; PMCID: PMC3588192; DOI: 10.1155/2013/951416;

Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PLoS One. 2013; 8(1):e54806.View Related Profiles.

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Jean, Jyh-Chang
Joyce-Brady, Martin

PMID: 23372771; PMCID: PMC3553006; DOI: 10.1371/journal.pone.0054806;

Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Trans Am Clin Climatol Assoc. 2013; 124:275-82.View Related Profiles.

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Coleman, David
Ravid, Katya

PMID: 23874035; PMCID: PMC3715902

Sommer CA, Christodoulou C, Gianotti-Sommer A, Shen SS, Sailaja BS, Hezroni H, Spira A, Meshorer E, Kotton DN, Mostoslavsky G. Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. PLoS One. 2012; 7(12):e51711.View Related Profiles.

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Sommer, Cesar
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PMID: 23272148; PMCID: PMC3522693; DOI: 10.1371/journal.pone.0051711;

Gomperts BN, Walser TC, Spira A, Dubinett SM. Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer. Cancer Prev Res (Phila). 2013 Jan; 6(1):4-7. PMID: 23233734; PMCID: PMC3717378; DOI: 10.1158/1940-6207.CAPR-12-0470;

Spira A, Nana-Sinkam SP. Using microRNAs to inform clinical decision making in lung cancer: ready for prime time? Am J Respir Crit Care Med. 2012 Dec 1; 186(11):1077-9. PMID: 23204375

Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild AH. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. Cancer Res. 2012 Nov 15; 72(22):5702-11.View Related Profiles.

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Liu, Gang
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 22986747; PMCID: PMC4053174; DOI: 10.1158/0008-5472.CAN-12-1043;

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012; 4(8):67.View Related Profiles.

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Liu, Gang
Campbell, Joshua
Lenburg, Marc
Alekseyev, Yuriy

PMID: 22937864; PMCID: PMC4064320; DOI: 10.1186/gm368;

Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012 May 1; 122(5):1758-63.View Related Profiles.

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Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
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Sabharwal, Vishakha
Zhang, Xiaoling

PMID: 22466650; PMCID: PMC3336975; DOI: 10.1172/JCI59408;

Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. PLoS One. 2012; 7(1):e29907.View Related Profiles.

Gower, Adam
Spira, Avrum
Tagne, Jean-Bosco
Ramirez, Maria
Cao, Yu-Xia

PMID: 22242187; PMCID: PMC3252372; DOI: 10.1371/journal.pone.0029907;

Gower AC, Spira A, Lenburg ME. Discovering biological connections between experimental conditions based on common patterns of differential gene expression. BMC Bioinformatics. 2011; 12:381.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 21951600; PMCID: PMC3203354; DOI: 10.1186/1471-2105-12-381;

Cohen AL, Soldi R, Zhang H, Gustafson AM, Wilcox R, Welm BE, Chang JT, Johnson E, Spira A, Jeffrey SS, Bild AH. A pharmacogenomic method for individualized prediction of drug sensitivity. Mol Syst Biol. 2011; 7:513.View Related Profiles.

Spira, Avrum
Johnson, William

PMID: 21772261; PMCID: PMC3159972; DOI: 10.1038/msb.2011.47;

Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res (Phila). 2011 Jun; 4(6):803-17.View Related Profiles.

Gower, Adam
Spira, Avrum
Schembri, Frank
Beane-Ebel, Jennifer
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Alekseyev, Yuriy

PMID: 21636547; PMCID: PMC3694393; DOI: 10.1158/1940-6207.CAPR-11-0212;

Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest. 2011 Jun; 121(6):2313-25.View Related Profiles.

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Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo
Gouon-Evans, Valerie

PMID: 21537085; PMCID: PMC3104741; DOI: 10.1172/JCI43853;

Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. Transcriptomic studies of the airway field of injury associated with smoking-related lung disease. Proc Am Thorac Soc. 2011 May; 8(2):173-9.View Related Profiles.

Gower, Adam
Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 21543797; PMCID: PMC3159071; DOI: 10.1513/pats.201011-066MS;

Perdomo C, Spira A, Schembri F. MiRNAs as regulators of the response to inhaled environmental toxins and airway carcinogenesis. Mutat Res. 2011 Dec 1; 717(1-2):32-7.View Related Profiles.

Spira, Avrum
Schembri, Frank

PMID: 21549133; DOI: 10.1016/j.mrfmmm.2011.04.005;

Gomperts BN, Spira A, Massion PP, Walser TC, Wistuba II, Minna JD, Dubinett SM. Evolving concepts in lung carcinogenesis. Semin Respir Crit Care Med. 2011 Feb; 32(1):32-43. PMID: 21500122; PMCID: PMC3423907; DOI: 10.1055/s-0031-1272867;

Campbell JD, Spira A, Lenburg ME. Applying gene expression microarrays to pulmonary disease. Respirology. 2011 Apr; 16(3):407-18.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 21299687; DOI: 10.1111/j.1440-1843.2011.01942.x;

Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ. A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. Lung Cancer. 2011 May; 72(2):177-83.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 20832896; DOI: 10.1016/j.lungcan.2010.08.014;

Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Res. 2010 Aug 15; 70(16):6639-48.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 20710044; PMCID: PMC2924777; DOI: 10.1158/0008-5472.CAN-10-0455;

Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J, Liu G, Spira A, Bell DA. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. PLoS One. 2010; 5(8):e11934.View Related Profiles.

Spira, Avrum
Liu, Gang

PMID: 20689807; PMCID: PMC2914741; DOI: 10.1371/journal.pone.0011934;

Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010 May; 9(9):1809-18.View Related Profiles.

Spira, Avrum
Anderlind, Christina
Vaziri, Cyrus
Kotton, Darrell
Lu, Jining
Qian, Jun
Wu, Junjie
Cardoso, Wellington

PMID: 20404570

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2010 Apr 7; 2(26):26ra25.View Related Profiles.

Spira, Avrum
Anderlind, Christina
Liu, Gang
Brody, Jerome
Qian, Jun
Lenburg, Marc

PMID: 20375364; PMCID: PMC3694402; DOI: 10.1126/scitranslmed.3000251;

Gomperts BN, Spira A, Elashoff DE, Dubinett SM. Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection. Cancer Prev Res (Phila). 2010 Apr; 3(4):420-3. PMID: 20332300; DOI: 10.1158/1940-6207.CAPR-10-0052;

Spira A. Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis? Cancer Prev Res (Phila). 2010 Mar; 3(3):255-8. PMID: 20179303; DOI: 10.1158/1940-6207.CAPR-10-0013;

Steiling K, Spira A. In: UpToDate, Basow DS (Ed). Topics in genetics and genomics: Gene Expression. UpToDate. Waltham, MA. 2010.

Steiling K, Lenburg ME, Spira A. Airway gene expression in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec; 6(8):697-700.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 20008878; PMCID: PMC2797071; DOI: 10.1513/pats.200907-076DP;

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Schembri, Frank
Liu, Gang
O'Connor, George
Lenburg, Marc
Sebastiani, Paola
Zhang, Xiaoling
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;

Silverman EK, Spira A, Paré PD. Genetics and genomics of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Sep 15; 6(6):539-42. PMID: 19741265; PMCID: PMC3266048; DOI: 10.1513/pats.200904-021DS;

Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. PLoS One. 2009; 4(4):e5043.View Related Profiles.

Bergerat, Agnes M
Spira, Avrum
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Steffen, Martin

PMID: 19357784; PMCID: PMC2664466; DOI: 10.1371/journal.pone.0005043;

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24.View Related Profiles.

Spira, Avrum
Vaziri, Cyrus
Schembri, Frank
Liu, Gang
Brody, Jerome
Lu, Jining
Lenburg, Marc
Zhang, Xiaoling

PMID: 19168627; PMCID: PMC2650144; DOI: 10.1073/pnas.0806383106;

Beane J, Spira A, Lenburg ME. Clinical impact of high-throughput gene expression studies in lung cancer. J Thorac Oncol. 2009 Jan; 4(1):109-18.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 19096318; PMCID: PMC2731413; DOI: 10.1097/JTO.0b013e31819151f8;

Kathuria, H, Spira A, Brody J. Genomics in the Diagnosis and Management of Lung Cancer. In Ginsburg G (Ed): Essential Genomic and Personalized Medicine. Elsevier. 2009.

Zeskind JE, Lenburg ME, Spira A. Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management. Proc Am Thorac Soc. 2008 Dec 1; 5(8):834-41.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 19017738; PMCID: PMC2645236; DOI: 10.1513/pats.200807-074TH;

Steiling K, Ryan J, Brody JS, Spira A. The field of tissue injury in the lung and airway. Cancer Prev Res (Phila). 2008 Nov; 1(6):396-403.View Related Profiles.

Spira, Avrum
Brody, Jerome
Steiling, Katrina

PMID: 19138985; PMCID: PMC2705781; DOI: 10.1158/1940-6207.CAPR-08-0174;

Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics. 2008; 9:259.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Dumas, Yves-Martine

PMID: 18513428; PMCID: PMC2435556; DOI: 10.1186/1471-2164-9-259;

Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prev Res (Phila). 2008 Jun; 1(1):56-64.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 19138936; PMCID: PMC4167688; DOI: 10.1158/1940-6207.CAPR-08-0011;

Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan; 8(2):124-39.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lu, Jining
Lenburg, Marc
Ramirez, Maria

PMID: 18023262; PMCID: PMC2440337; DOI: 10.1016/j.modgep.2007.09.003;

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 2007 Mar; 13(3):361-6.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 17334370

Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 2007; 8(9):R201.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Lenburg, Marc
Sebastiani, Paola

PMID: 17894889; PMCID: PMC2375039; DOI: 10.1186/gb-2007-8-9-r201;

Beane J, Kadar A, DeLisi C, Spira A. Diagnostic and Prognostic Impact of high-throughput genomic and proteomic technologies in the post-genomic era. In McPherson and Pincus M (ed): Henry’s Clinical Diagnosis and Management by Laboratory Methods, 21st Edition. Saunders/Elsevier. Philadelphia. 2007.

Zhang X, Liu G, Lenburg ME, Spira A. Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays. Genome Inform. 2007; 18:247-57.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc
Zhang, Xiaoling

PMID: 18546492

Brody JS, Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc. 2006 Aug; 3(6):535-7.View Related Profiles.

Spira, Avrum
Brody, Jerome

PMID: 16921139

DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.View Related Profiles.

Spira, Avrum
Sparrow, David
Beane-Ebel, Jennifer

PMID: 16921128

Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol. 2006; 6:35.View Related Profiles.

Spira, Avrum
Ramirez, Maria

PMID: 16869965; PMCID: PMC1562362; DOI: 10.1186/1471-213X-6-35;

Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.View Related Profiles.

Spira, Avrum
Sparrow, David
Beane-Ebel, Jennifer

PMID: 16358219; PMCID: PMC1380249; DOI: 10.1086/499828;

Kadar A, Spira A. Smoking and the Molecular Mechanisms of Atherogenesis. In Loscalzo J (ed): Molecular Mechanisms in Atherosclerosis. The Partheon Publishing Group. Lancaster, UK. 2005; 209-220.

Shah V, Sridhar S, Beane J, Brody JS, Spira A. SIEGE: Smoking Induced Epithelial Gene Expression Database. Nucleic Acids Res. 2005 Jan 1; 33(Database issue):D573-9.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Brody, Jerome

PMID: 15608264; PMCID: PMC539989; DOI: 10.1093/nar/gki035;

Spira A, Beane J, Pinto-Plata V, Kadar A, Liu G, Shah V, Celli B, Brody JS. Gene expression profiling of human lung tissue from smokers with severe emphysema. Am J Respir Cell Mol Biol. 2004 Dec; 31(6):601-10.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome

PMID: 15374838

Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J, Brody JS. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci U S A. 2004 Jul 6; 101(27):10143-8.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome

PMID: 15210990; PMCID: PMC454179

Spira A, Schembri F, Beane J, Shah V, Liu G, Brody JS. Impact of cigarette smoke on the normal airway transcriptome. Chest. 2004 May; 125(5 Suppl):115S.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome

PMID: 15136455

Spira A, Beane J, Schembri F, Liu G, Ding C, Gilman S, Yang X, Cantor C, Brody JS. Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling. Biotechniques. 2004 Mar; 36(3):484-7.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome

PMID: 15038164

Hoffman A, Awad T, Spira A, Palma J, Webster T, Wright G, Buckley J, Davis R, Hubbell E, Jones W, Tibshirani R, Tompkins R, Triche T, Xiao W ,West M, Warrington J. Expression profiling — best practices for data generation and interpretation in clinical trials. Nature Reviews Genetics. 2004; 5:229-38.

Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld H, Keane J. Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. Am J Respir Cell Mol Biol. 2003 Nov; 29(5):545-51. PMID: 12748057

Powell CA, Spira A, Derti A, DeLisi C, Liu G, Borczuk A, Busch S, Sahasrabudhe S, Chen Y, Sugarbaker D, Bueno R, Richards WG, Brody JS. Gene expression in lung adenocarcinomas of smokers and nonsmokers. Am J Respir Cell Mol Biol. 2003 Aug; 29(2):157-62.View Related Profiles.

Spira, Avrum
Brody, Jerome

PMID: 12600827

Spira A, Yanai I, Chettier R, Wu J, DeLisi C. High-Throughput Functional Inference in the Post-Genomic Era. In Appasani K (ed): Perspectives in Gene Expression. Eaton Publishing. Westboro, MA. 2003; 345-357.
Spira A. To tell or not to tell: Genetic testing and the physician’s duty to disclose results to relatives. The Journal of Biolaw and Business. Special Bio-Ethix Supplement. 2002; 3-9.

Spira A, Brecher S, Karlinsky J. Pulmonary mucormycosis in the setting of chronic obstructive pulmonary disease. A case report and review of the literature. Respiration. 2002; 69(6):560-3.View Related Profiles.

Spira, Avrum
Karlinsky, Joel
Brecher, Stephen

PMID: 12457013

Spira A, Gutierrez C, Chaparro C, Hutcheon MA, Chan CK. Osteoporosis and lung transplantation: a prospective study. Chest. 2000 Feb; 117(2):476-81. PMID: 10669693

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 176 publications over 24 distinct years, with a maximum of 18 publications in 2016

Bar chart showing 176 publications over 24 distinct years, with a maximum of 18 publications in 2016

Year	Publications
2000	1
2002	2
2003	3
2004	5
2005	3
2006	3
2007	5
2008	4
2009	7
2010	8
2011	8
2012	7
2013	12
2014	11
2015	12
2016	18
2017	13
2018	12
2019	12
2020	7
2021	10
2022	5
2023	6
2024	2

Media Mentions

Reasons to Hope During the COVID-19 Pandemic

Cancer Today 10/5/2020

The Transformers

BU Today 9/20/2019

Invigorating The Immune System: Key To Preventing Lung Cancer?

Medical Daily 4/26/2019

Could Invigorating The Immune System Prevent Lung Cancer?

Medical News Today 4/25/2019

J&J's Quest To Detect Lung Cancer Before It Emerges

FierceBiotech 4/24/2019

What If We Could Stop Lung Cancer Before It Starts?

BU Today 4/23/2019

Can Differences In Genomic Immune System Signatures Detect Lung Cancer Before It Takes Hold?

Endpoint News 4/23/2019

Baystate Business: The Fed, Wynn, and Durgin Park (Radio)

Bloomberg 1/4/2019

Blowing smoke: Vaping has become 'epidemic' among area teens

DL - Online 9/24/2018

BU, Johnson & Johnson team up to seek earlier detection of lung cancer

The Boston Globe 6/6/2018

BU and Johnson & Johnson Innovation Team Up to Fight Lung Cancer

BU Today 6/6/2018

J&J, BU Partner on Multi-Year Lung Cancer Detection Initiative

Genome Web 6/6/2018

J&J, Boston U partner to map early detection biomarkers for lung cancer

BioCentury Innovations 6/6/2018

Is 'Juuling' at local schools creating a new generation of nicotine addicts?

WCVB ABC 5 4/5/2018

2011-2011 ASCI: Elected member ASCI

2010-2010 Uniting Against Lung Cancer: Caine Halter Hope Now Award, Uniting Against Lung Cancer

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

airway epithelium
airway gene expression
bioinformatics
cancer biomarkers
COPD
gene-expression
genomics
lung cancer
smoking

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