Jeroen Eyckmans | Profiles RNS

Jeroen Eyckmans, PhD

Research Assistant Professor

Boston University College of Engineering

Biomedical Engineering

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	Eyckmans Lab
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ORCID : 0000-0003-1475-8149

Dr. Eyckmans’s research program aims to understands the mechanical and biochemical mechanisms that drive tissue repair (scarring) versus tissue regeneration in response to injury. Through an interdisciplinary approach combining microfabrication, nanotechnology and molecular biology, his group develops novel biomimetic models to study wound closure and extracellular matrix remodeling of soft (skin, tendon, ligament) and mineralized (bone, teeth) tissues. Ultimately, the goal is to harness tissue repair and regeneration mechanisms to rationally design targeted tissue engineering strategies for the healing of musculoskeletal tissues after injury.

BU Research

Targeting extracellular matrix-senescence crosstalk as a novel approach to improve tissue repair in aging
04/01/2024 - 03/31/2028 (Multi-PI)
PI: Jeroen Eyckmans, PhD
Hevolution Foundation

Understanding the Role of Mechanical Boundary Conditions on Tissue Assembly and Repair in 3D Fibrous Microtissues
08/31/2023 - 07/31/2026 (Multi-PI)
PI: Jeroen Eyckmans, PhD
National Science Foundation
CMMI-2311640

EAGER: (ST2) Engineering Biomaterials that Integrate in the Native ECM of Cells.
07/15/2022 - 06/30/2026 (PI)
National Science Foundation
DMR-2036842

Development of a wound-on-chip model to study stromal-epithelial interactions during tissue repair
04/01/2020 - 12/31/2023 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R21EB028491-03

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Uroz M, Stoddard AE, Sutherland BP, Courbot O, Oria R, Li L, Ravasio CR, Ngo MT, Yang J, Tefft JB, Eyckmans J, Han X, Elosegui-Artola A, Weaver VM, Chen CS. Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option. Nat Cell Biol. 2024 Oct 24.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39448802

Ewoldt JK, Wang MC, McLellan MA, Cloonan PE, Chopra A, Gorham J, Li L, DeLaughter DM, Gao X, Lee JH, Willcox JAL, Layton O, Luu RJ, Toepfer CN, Eyckmans J, Seidman CE, Seidman JG, Chen CS. Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling. Sci Adv. 2024 Oct 18; 10(42):eadi6927.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39413182; PMCID: PMC11482324; DOI: 10.1126/sciadv.adi6927;

Natarajan A, Kim S, Moreno GH, Eyckmans J, Chen CS, Dean D, Vijayan VM. 3D printing assisted surface patterning process on acrylated hydrogels for contact guidance of fibroblasts. Colloids Surf B Biointerfaces. 2024 Oct; 242:114099.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39024719

Gagnon KA, Huang J, Hix OT, Hui VW, Hinds A, Bullitt E, Eyckmans J, Kotton DN, Chen CS. Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma. APL Bioeng. 2024 Jun; 8(2):026126.View Related Profiles.

Chen, Christopher
Kotton, Darrell
Bullitt, Esther
Eyckmans, Jeroen

PMID: 38911024; PMCID: PMC11191334; DOI: 10.1063/5.0207228;

Lammers A, Hsu HH, Sundaram S, Gagnon KA, Kim S, Lee JH, Tung YC, Eyckmans J, Chen CS. Rapid Tissue Perfusion Using Sacrificial Percolation of Anisotropic Networks. Matter. 2024 Jun 05; 7(6):2184-2204.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39221109; PMCID: PMC11360881; DOI: 10.1016/j.matt.2024.04.001;

He S, Mierke CT, Sun Y, Eyckmans J, Guo M. Editorial: Mechanobiology of organoid systems. Front Cell Dev Biol. 2024; 12:1369713. PMID: 38352858; PMCID: PMC10861786; DOI: 10.3389/fcell.2024.1369713;

Li L, Griebel ME, Uroz M, Bubli SY, Gagnon KA, Trappmann B, Baker BM, Eyckmans J, Chen CS. A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses. Adv Funct Mater. 2024 Apr 25; 34(17).View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 38693998; PMCID: PMC11060701; DOI: 10.1002/adfm.202309567;

Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41):e2308941120.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 37782785; PMCID: PMC10576061; DOI: 10.1073/pnas.2308941120;

Griebel M, Vasan A, Chen C, Eyckmans J. Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues. APL Bioeng. 2023 Mar; 7(1):016112. PMID: 36938481; PMCID: PMC10017124; DOI: 10.1063/5.0133478;

Showing 10 of 49 results. Show More

Eyckmans J. Hacking mechanical memory. Biophys J. 2023 Mar 11. PMID: 36948191; PMCID: PMC10147823; DOI: 10.1016/j.bpj.2023.03.012;

Eyckmans J. Hacking mechanical memory. Biophys J. 2023 Apr 18; 122(8):1423-1425. PMID: 36948191; PMCID: PMC10147823; DOI: 10.1016/j.bpj.2023.03.012;

Das SL, Sutherland BP, Lejeune E, Eyckmans J, Chen CS. Mechanical response of cardiac microtissues to acute localized injury. Am J Physiol Heart Circ Physiol. 2022 Oct 01; 323(4):H738-H748.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 36053751; PMCID: PMC9662801; DOI: 10.1152/ajpheart.00305.2022;

Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS. Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 2022 Apr 22; 8(16):eabm3791.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 35452278; PMCID: PMC9032966; DOI: 10.1126/sciadv.abm3791;

Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, Chen CS. Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. Am J Physiol Cell Physiol. 2022 02 01; 322(2):C185-C196.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 34878922; PMCID: PMC8791789; DOI: 10.1152/ajpcell.00320.2021;

Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Sci Adv. 2021 Oct 15; 7(42):eabh3995.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 34652945; PMCID: PMC8519574; DOI: 10.1126/sciadv.abh3995;

Das SL, Bose P, Lejeune E, Reich DH, Chen C, Eyckmans J. Extracellular Matrix Alignment Directs Provisional Matrix Assembly and Three Dimensional Fibrous Tissue Closure. Tissue Eng Part A. 2021 12; 27(23-24):1447-1457. PMID: 33979548; PMCID: PMC8742281; DOI: 10.1089/ten.tea.2020.0332;

Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O'Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD, García AJ. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nat Commun. 2021 04 21; 12(1):2359.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 33883558; PMCID: PMC8060400; DOI: 10.1038/s41467-021-22602-5;

Tefft JB, Chen CS, Eyckmans J. Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure. APL Bioeng. 2021 Mar; 5(1):016102.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 33511324; PMCID: PMC7817247; DOI: 10.1063/5.0028651;

Song HG, Lammers A, Sundaram S, Rubio L, Chen AX, Li L, Eyckmans J, Bhatia SN, Chen CS. Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Adv Funct Mater. 2020 Nov 25; 30(48).View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 33613149; PMCID: PMC7891457; DOI: 10.1002/adfm.202003777;

Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Sci Adv. 2019 08; 5(8):eaav6789.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 31489365; PMCID: PMC6713506; DOI: 10.1126/sciadv.aav6789;

Mailand E, Li B, Eyckmans J, Bouklas N, Sakar MS. Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues. Biophys J. 2019 09 03; 117(5):975-986. PMID: 31427068; PMCID: PMC6731460; DOI: 10.1016/j.bpj.2019.07.041;

Yoon C, Choi C, Stapleton S, Mirabella T, Howes C, Dong L, King J, Yang J, Oberai A, Eyckmans J, Chen CS. Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting. Mol Biol Cell. 2019 07 22; 30(16):1974-1984.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 31318321; PMCID: PMC6727772; DOI: 10.1091/mbc.E19-02-0076;

Seeherman HJ, Berasi SP, Brown CT, Martinez RX, Juo ZS, Jelinsky S, Cain MJ, Grode J, Tumelty KE, Bohner M, Grinberg O, Orr N, Shoseyov O, Eyckmans J, Chen C, Morales PR, Wilson CG, Vanderploeg EJ, Wozney JM. A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med. 2019 04 24; 11(489).View Related Profiles.

Eyckmans, Jeroen
Tumelty, Kathleen

PMID: 31019025

Cheng D, Jayne RK, Tamborini A, Eyckmans J, White AE, Chen CS. Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography. Biofabrication. 2019 02 25; 11(2):021001.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 30721899; PMCID: PMC8117727; DOI: 10.1088/1758-5090/ab047f;

Bose P, Eyckmans J, Nguyen TD, Chen CS, Reich DH. Effects of Geometry on the Mechanics and Alignment of Three-Dimensional Engineered Microtissues. ACS Biomater Sci Eng. 2019 Aug 12; 5(8):3843-3855.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 33438424; DOI: 10.1021/acsbiomaterials.8b01183;

Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Force Generation via ß-Cardiac Myosin, Titin, and a-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018 01 08; 44(1):87-96.e5.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 29316444; PMCID: PMC6421364; DOI: 10.1016/j.devcel.2017.12.012;

Bose P, Huang CY, Eyckmans J, Chen CS, Reich DH. Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions. Methods Mol Biol. 2018; 1722:303-328.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 29264812; DOI: 10.1007/978-1-4939-7553-2_18;

Li L, Eyckmans J, Chen CS. Designer biomaterials for mechanobiology. Nat Mater. 2017 11 24; 16(12):1164-1168.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 29170549; PMCID: PMC7001850; DOI: 10.1038/nmat5049;

Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 29160307; PMCID: PMC5730479; DOI: 10.1038/nature24998;

Eyckmans J, Chen CS. Making bone via nanoscale kicks. Nat Biomed Eng. 2017 Sep; 1(9):689-690.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 31015669; DOI: 10.1038/s41551-017-0133-6;

Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS. Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8758-8763.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 28765370; PMCID: PMC5565405; DOI: 10.1073/pnas.1618333114;

Eyckmans J, Chen CS. 3D culture models of tissues under tension. J Cell Sci. 2017 01 01; 130(1):63-70.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 27909243; PMCID: PMC5394782; DOI: 10.1242/jcs.198630;

Sakar MS, Eyckmans J, Pieters R, Eberli D, Nelson BJ, Chen CS. Cellular forces and matrix assembly coordinate fibrous tissue repair. Nat Commun. 2016 Mar 16; 7:11036.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 26980715; PMCID: PMC4799373; DOI: 10.1038/ncomms11036;

Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS. Patterning vascular networks in vivo for tissue engineering applications. Tissue Eng Part C Methods. 2015 May; 21(5):509-17.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 25390971; PMCID: PMC4410304; DOI: 10.1089/ten.TEC.2014.0258;

Eyckmans J, Chen CS. Stem cell differentiation: sticky mechanical memory. Nat Mater. 2014 Jun; 13(6):542-3.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 24845990; DOI: 10.1038/nmat3989;

Baranski JD, Chaturvedi RR, Stevens KR, Eyckmans J, Carvalho B, Solorzano RD, Yang MT, Miller JS, Bhatia SN, Chen CS. Geometric control of vascular networks to enhance engineered tissue integration and function. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7586-91.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 23610423; PMCID: PMC3651499; DOI: 10.1073/pnas.1217796110;

Eyckmans J, Roberts SJ, Bolander J, Schrooten J, Chen CS, Luyten FP. Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors. Biomaterials. 2013 Jun; 34(19):4612-21.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 23537666; PMCID: PMC4037407; DOI: 10.1016/j.biomaterials.2013.03.011;

Eyckmans J, Lin GL, Chen CS. Adhesive and mechanical regulation of mesenchymal stem cell differentiation in human bone marrow and periosteum-derived progenitor cells. Biol Open. 2012 Nov 15; 1(11):1058-68.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 23213385; PMCID: PMC3507189; DOI: 10.1242/bio.20122162;

Wang YK, Yu X, Cohen DM, Wozniak MA, Yang MT, Gao L, Eyckmans J, Chen CS. Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cells Dev. 2012 May 01; 21(7):1176-86.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 21967638; PMCID: PMC3328763; DOI: 10.1089/scd.2011.0293;

Eyckmans J, Boudou T, Yu X, Chen CS. A hitchhiker's guide to mechanobiology. Dev Cell. 2011 Jul 19; 21(1):35-47.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 21763607; PMCID: PMC3155761; DOI: 10.1016/j.devcel.2011.06.015;

Demol J, Eyckmans J, Roberts SJ, Luyten FP, Van Oosterwyck H. Does tranexamic acid stabilised fibrin support the osteogenic differentiation of human periosteum derived cells? Eur Cell Mater. 2011 Mar 22; 21:272-85. PMID: 21432782

Raquez JM, Barone DT, Luklinska Z, Persenaire O, Belayew A, Eyckmans J, Schrooten J, Dubois P. Osteoconductive and bioresorbable composites based on poly(L,L-lactide) and pseudowollastonite: from synthesis and interfacial compatibilization to in vitro bioactivity and in vivo osseointegration studies. Biomacromolecules. 2011 Mar 14; 12(3):692-700. PMID: 21268574

Crabbe A, Vandeputte C, Dresselaers T, Sacido AA, Verdugo JM, Eyckmans J, Luyten FP, Van Laere K, Verfaillie CM, Himmelreich U. Effects of MRI contrast agents on the stem cell phenotype. Cell Transplant. 2010; 19(8):919-36. PMID: 20350351; DOI: 10.3727/096368910X494623;

Eyckmans J, Roberts SJ, Schrooten J, Luyten FP. A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling. J Cell Mol Med. 2010 Jun; 14(6B):1845-56. PMID: 19538476

Maréchal M, Eyckmans J, Schrooten J, Schepers E, Luyten FP, van Steenberghe D. Bone augmentation with autologous periosteal cells and two different calcium phosphate scaffolds under an occlusive titanium barrier: an experimental study in rabbits. J Periodontol. 2008 May; 79(5):896-904. PMID: 18454669; DOI: 10.1902/jop.2008.070043;

Eyckmans J, Luyten FP. Species specificity of ectopic bone formation using periosteum-derived mesenchymal progenitor cells. Tissue Eng. 2006 Aug; 12(8):2203-13. PMID: 16968161; DOI: 10.1089/ten.2006.12.2203;

De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, Jones EA, McGonagle D, Mitsiadis TA, Pitzalis C, Luyten FP. Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. Arthritis Rheum. 2006 Apr; 54(4):1209-21. PMID: 16575900; DOI: 10.1002/art.21753;

Van Damme A, Thorrez L, Ma L, Vandenburgh H, Eyckmans J, Dell'Accio F, De Bari C, Luyten F, Lillicrap D, Collen D, VandenDriessche T, Chuah MK. Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells. Stem Cells. 2006 Apr; 24(4):896-907. PMID: 16339997; DOI: 10.1634/stemcells.2003-0106;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 47 publications over 19 distinct years, with a maximum of 7 publications in 2024

Bar chart showing 47 publications over 19 distinct years, with a maximum of 7 publications in 2024

Year	Publications
2005	1
2006	2
2008	1
2009	1
2010	1
2011	4
2012	1
2013	2
2014	1
2015	1
2016	2
2017	4
2018	3
2019	5
2020	1
2021	5
2022	2
2023	3
2024	7

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