Jeroen Eyckmans, PhD
Research Assistant Professor
Boston University College of Engineering
Biomedical Engineering




Dr. Eyckmans’s research program aims to understands the mechanical and biochemical mechanisms that drive tissue repair (scarring) versus tissue regeneration in response to injury. Through an interdisciplinary approach combining microfabrication, nanotechnology and molecular biology, his group develops novel biomimetic models to study wound closure and extracellular matrix remodeling of soft (skin, tendon, ligament) and mineralized (bone, teeth) tissues. Ultimately, the goal is to harness tissue repair and regeneration mechanisms to rationally design targeted tissue engineering strategies for the healing of musculoskeletal tissues after injury.


Targeting extracellular matrix-senescence crosstalk as a novel approach to improve tissue repair in aging
04/01/2024 - 03/31/2028 (Multi-PI)
PI: Jeroen Eyckmans, PhD
Hevolution Foundation


Understanding the Role of Mechanical Boundary Conditions on Tissue Assembly and Repair in 3D Fibrous Microtissues
08/31/2023 - 07/31/2026 (Multi-PI)
PI: Jeroen Eyckmans, PhD
National Science Foundation
CMMI-2311640

EAGER: (ST2) Engineering Biomaterials that Integrate in the Native ECM of Cells.
07/15/2022 - 06/30/2026 (PI)
National Science Foundation
DMR-2036842

Development of a wound-on-chip model to study stromal-epithelial interactions during tissue repair
04/01/2020 - 12/31/2023 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R21EB028491-03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. He S, Mierke CT, Sun Y, Eyckmans J, Guo M. Editorial: Mechanobiology of organoid systems. Front Cell Dev Biol. 2024; 12:1369713. PMID: 38352858; PMCID: PMC10861786; DOI: 10.3389/fcell.2024.1369713;
     
  2. Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41):e2308941120. PMID: 37782785; PMCID: PMC10576061; DOI: 10.1073/pnas.2308941120;
     
  3. Griebel M, Vasan A, Chen C, Eyckmans J. Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues. APL Bioeng. 2023 Mar; 7(1):016112. PMID: 36938481; PMCID: PMC10017124; DOI: 10.1063/5.0133478;
     
  4. Griebel M, Vasan A, Chen C, Eyckmans J. Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues. APL Bioeng. 2023 Mar; 7(1):016112. PMID: 36938481; PMCID: PMC10017124; DOI: 10.1063/5.0133478;
     
  5. Eyckmans J. Hacking mechanical memory. Biophys J. 2023 Mar 11. PMID: 36948191; PMCID: PMC10147823; DOI: 10.1016/j.bpj.2023.03.012;
     
  6. Eyckmans J. Hacking mechanical memory. Biophys J. 2023 Apr 18; 122(8):1423-1425. PMID: 36948191; PMCID: PMC10147823; DOI: 10.1016/j.bpj.2023.03.012;
     
  7. Das SL, Sutherland BP, Lejeune E, Eyckmans J, Chen CS. Mechanical response of cardiac microtissues to acute localized injury. Am J Physiol Heart Circ Physiol. 2022 Oct 01; 323(4):H738-H748.View Related Profiles. PMID: 36053751; PMCID: PMC9662801; DOI: 10.1152/ajpheart.00305.2022;
     
  8. Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS. Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 2022 Apr 22; 8(16):eabm3791.View Related Profiles. PMID: 35452278; PMCID: PMC9032966; DOI: 10.1126/sciadv.abm3791;
     
  9. Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, Chen CS. Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. Am J Physiol Cell Physiol. 2022 02 01; 322(2):C185-C196.View Related Profiles. PMID: 34878922; PMCID: PMC8791789; DOI: 10.1152/ajpcell.00320.2021;
     
  10. Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Sci Adv. 2021 Oct 15; 7(42):eabh3995.View Related Profiles. PMID: 34652945; PMCID: PMC8519574; DOI: 10.1126/sciadv.abh3995;
     
Showing 10 of 43 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 19 distinct years, with a maximum of 5 publications in 2019 and 2021

YearPublications
20051
20062
20081
20091
20101
20114
20121
20132
20141
20151
20162
20174
20183
20195
20201
20215
20222
20233
20241

Contact for Mentoring:

610 Commonwealth Ave
Boston MA 02215
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