Jeroen Eyckmans, PhD
Research Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering

Dr. Eyckmans’s research program aims to understands the mechanical and biochemical mechanisms that drive tissue repair (scarring) versus tissue regeneration in response to injury. Through an interdisciplinary approach combining microfabrication, nanotechnology and molecular biology, his group develops novel biomimetic models to study wound closure and extracellular matrix remodeling of soft (skin, tendon, ligament) and mineralized (bone, teeth) tissues. Ultimately, the goal is to harness tissue repair and regeneration mechanisms to rationally design targeted tissue engineering strategies for the healing of musculoskeletal tissues after injury.

EAGER: (ST2) Engineering Biomaterials that Integrate in the Native ECM of Cells.
09/01/2020 - 06/30/2026 (PI)
National Science Foundation

Development of a wound-on-chip model to study stromal-epithelial interactions during tissue repair
04/01/2020 - 12/31/2022 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS. Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 2022 Apr 22; 8(16):eabm3791.View Related Profiles. PMID: 35452278; PMCID: PMC9032966; DOI: 10.1126/sciadv.abm3791;
  2. Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, Chen CS. Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. Am J Physiol Cell Physiol. 2022 02 01; 322(2):C185-C196.View Related Profiles. PMID: 34878922; PMCID: PMC8791789; DOI: 10.1152/ajpcell.00320.2021;
  3. Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Sci Adv. 2021 Oct 15; 7(42):eabh3995.View Related Profiles. PMID: 34652945; PMCID: PMC8519574; DOI: 10.1126/sciadv.abh3995;
  4. Das SL, Bose P, Lejeune E, Reich DH, Chen C, Eyckmans J. Extracellular Matrix Alignment Directs Provisional Matrix Assembly and Three Dimensional Fibrous Tissue Closure. Tissue Eng Part A. 2021 12; 27(23-24):1447-1457. PMID: 33979548; PMCID: PMC8742281; DOI: 10.1089/ten.tea.2020.0332;
  5. Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O'Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD, García AJ. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nat Commun. 2021 04 21; 12(1):2359.View Related Profiles. PMID: 33883558; PMCID: PMC8060400; DOI: 10.1038/s41467-021-22602-5;
  6. Tefft JB, Chen CS, Eyckmans J. Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure. APL Bioeng. 2021 Mar; 5(1):016102.View Related Profiles. PMID: 33511324; PMCID: PMC7817247; DOI: 10.1063/5.0028651;
  7. Song HG, Lammers A, Sundaram S, Rubio L, Chen AX, Li L, Eyckmans J, Bhatia SN, Chen CS. Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Adv Funct Mater. 2020 Nov 25; 30(48).View Related Profiles. PMID: 33613149; PMCID: PMC7891457; DOI: 10.1002/adfm.202003777;
  8. Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Sci Adv. 2019 08; 5(8):eaav6789.View Related Profiles. PMID: 31489365; PMCID: PMC6713506; DOI: 10.1126/sciadv.aav6789;
  9. Mailand E, Li B, Eyckmans J, Bouklas N, Sakar MS. Surface and Bulk Stresses Drive Morphological Changes in Fibrous Microtissues. Biophys J. 2019 09 03; 117(5):975-986. PMID: 31427068; PMCID: PMC6731460; DOI: 10.1016/j.bpj.2019.07.041;
  10. Yoon C, Choi C, Stapleton S, Mirabella T, Howes C, Dong L, King J, Yang J, Oberai A, Eyckmans J, Chen CS. Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting. Mol Biol Cell. 2019 07 22; 30(16):1974-1984.View Related Profiles. PMID: 31318321; PMCID: PMC6727772; DOI: 10.1091/mbc.E19-02-0076;
Showing 10 of 36 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 17 distinct years, with a maximum of 5 publications in 2019 and 2021


Contact for Mentoring:

610 Commonwealth Ave
Boston MA 02215
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