Keywords
Last Name

Jeffrey R. Moore, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address72 E. Concord St
Boston MA 02118
Phone(617) 638-4251
ORCID ORCID Icon0000-0001-7190-9332
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.

 Self-Described Keywords
  • actin
  • cardiomyopathy
  • cytoskeleton
  • molecular motors
  • muscle contraction
  • myosin
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Huang W, Liang J, Kazmierczak K, Muthu P, Duggal D, Farman GP, Sorensen L, Pozios I, Abraham TP, Moore JR, Borejdo J, Szczesna-Cordary D. Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice. J Mol Cell Cardiol. 2014 Sep; 74:318-29.
    View in: PubMed
  2. Jensen MH, Morris EJ, Gallant CM, Morgan KG, Weitz DA, Moore JR. Mechanism of calponin stabilization of cross-linked actin networks. Biophys J. 2014 Feb 18; 106(4):793-800.
    View in: PubMed
  3. Orzechowski M, Moore JR, Fischer S, Lehman W. Tropomyosin movement on F-actin during muscle activation explained by energy landscapes. Arch Biochem Biophys. 2014 Mar 1; 545:63-8.
    View in: PubMed
  4. Muthu P, Liang J, Schmidt W, Moore JR, Szczesna-Cordary D. In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain. Arch Biochem Biophys. 2014 Jun 15; 552-553:29-39.
    View in: PubMed
  5. Guo M, Ehrlicher AJ, Mahammad S, Fabich H, Jensen MH, Moore JR, Fredberg JJ, Goldman RD, Weitz DA. The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics. Biophys J. 2013 Oct 1; 105(7):1562-8.
    View in: PubMed
  6. Saphirstein RJ, Gao YZ, Jensen MH, Gallant CM, Vetterkind S, Moore JR, Morgan KG. The focal adhesion: a regulated component of aortic stiffness. PLoS One. 2013; 8(4):e62461.
    View in: PubMed
  7. Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. Cardiomyopathies: classification, clinical characterization, and functional phenotypes. Biochem Res Int. 2012; 2012:870942.
    View in: PubMed
  8. Moore JR, Leinwand L, Warshaw DM. Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor. Circ Res. 2012 Jul 20; 111(3):375-85.
    View in: PubMed
  9. Jensen MH, Morris EJ, Huang R, Rebowski G, Dominguez R, Weitz DA, Moore JR, Wang CL. The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex. J Biol Chem. 2012 Sep 7; 287(37):31447-53.
    View in: PubMed
  10. Jensen MH, Watt J, Hodgkinson JL, Gallant C, Appel S, El-Mezgueldi M, Angelini TE, Morgan KG, Lehman W, Moore JR. Effects of basic calponin on the flexural mechanics and stability of F-actin. Cytoskeleton (Hoboken). 2012 Jan; 69(1):49-58.
    View in: PubMed
  11. Collins A, Huang R, Jensen MH, Moore JR, Lehman W, Wang CL. Structural studies on maturing actin filaments. Bioarchitecture. 2011 5; 1(3):127-133.
    View in: PubMed
  12. Lu X, Kazmierczak K, Jiang X, Jones M, Watt J, Helfman DM, Moore JR, Szczesna-Cordary D, Lossos IS. Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin. FEBS J. 2011 Jun; 278(11):1922-31.
    View in: PubMed
  13. Lin T, Greenberg MJ, Moore JR, Ostap EM. A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity. Biochemistry. 2011 Mar 22; 50(11):1831-8.
    View in: PubMed
  14. Greenberg MJ, Kazmierczak K, Szczesna-Cordary D, Moore JR. Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17403-8.
    View in: PubMed
  15. Greenberg MJ, Moore JR. The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors. Cytoskeleton (Hoboken). 2010 May; 67(5):273-85.
    View in: PubMed
  16. Greenberg MJ, Mealy TR, Jones M, Szczesna-Cordary D, Moore JR. The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R989-96.
    View in: PubMed
  17. Greenberg MJ, Moore JR. Actin in action and inaction: the differential effects of hypertrophic and dilated cardiomyopathy actin mutations on thin filament regulation. J Mol Cell Cardiol. 2010 Feb; 48(2):277-8.
    View in: PubMed
  18. Pant K, Watt J, Greenberg M, Jones M, Szczesna-Cordary D, Moore JR. Removal of the cardiac myosin regulatory light chain increases isometric force production. FASEB J. 2009 Oct; 23(10):3571-80.
    View in: PubMed
  19. Greenberg MJ, Mealy TR, Watt JD, Jones M, Szczesna-Cordary D, Moore JR. The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation. Am J Physiol Regul Integr Comp Physiol. 2009 Aug; 297(2):R265-74.
    View in: PubMed
  20. Greenberg MJ, Watt JD, Jones M, Kazmierczak K, Szczesna-Cordary D, Moore JR. Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics. J Mol Cell Cardiol. 2009 Jan; 46(1):108-15.
    View in: PubMed
  21. Greenberg MJ, Wang CL, Lehman W, Moore JR. Modulation of actin mechanics by caldesmon and tropomyosin. Cell Motil Cytoskeleton. 2008 Feb; 65(2):156-64.
    View in: PubMed
  22. Szczesna-Cordary D, Jones M, Moore JR, Watt J, Kerrick WG, Xu Y, Wang Y, Wagg C, Lopaschuk GD. Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients. FASEB J. 2007 Dec; 21(14):3974-85.
    View in: PubMed
  23. Debold EP, Schmitt JP, Patlak JB, Beck SE, Moore JR, Seidman JG, Seidman C, Warshaw DM. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H284-91.
    View in: PubMed
  24. Moore JR, Krementsova EB, Trybus KM, Warshaw DM. Does the myosin V neck region act as a lever? J Muscle Res Cell Motil. 2004; 25(1):29-35.
    View in: PubMed
  25. Moore JR, Krementsova EB, Trybus KM, Warshaw DM. Myosin V exhibits a high duty cycle and large unitary displacement. J Cell Biol. 2001 Nov 12; 155(4):625-35.
    View in: PubMed
  26. Irving T, Bhattacharya S, Tesic I, Moore J, Farman G, Simcox A, Vigoreaux J, Maughan D. Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. J Muscle Res Cell Motil. 2001; 22(8):675-83.
    View in: PubMed
  27. Moore JR, Dickinson MH, Vigoreaux JO, Maughan DW. The effect of removing the N-terminal extension of the Drosophila myosin regulatory light chain upon flight ability and the contractile dynamics of indirect flight muscle. Biophys J. 2000 Mar; 78(3):1431-40.
    View in: PubMed
  28. Vigoreaux JO, Moore JR, Maughan DW. Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. Adv Exp Med Biol. 2000; 481:237-47; discussion 247-50.
    View in: PubMed
  29. Moore JR, Vigoreaux JO, Maughan DW. The Drosophila projectin mutant, bentD, has reduced stretch activation and altered indirect flight muscle kinetics. J Muscle Res Cell Motil. 1999 Nov; 20(8):797-806.
    View in: PubMed
  30. Vigoreaux JO, Hernandez C, Moore J, Ayer G, Maughan D. A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles. J Exp Biol. 1998 Jul; 201(Pt 13):2033-44.
    View in: PubMed
  31. Maughan D, Moore J, Vigoreaux J, Barnes B, Mulieri LA. Work production and work absorption in muscle strips from vertebrate cardiac and insect flight muscle fibers. Adv Exp Med Biol. 1998; 453:471-80.
    View in: PubMed
  32. Dickinson MH, Hyatt CJ, Lehmann FO, Moore JR, Reedy MC, Simcox A, Tohtong R, Vigoreaux JO, Yamashita H, Maughan DW. Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys J. 1997 Dec; 73(6):3122-34.
    View in: PubMed
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